diazepam
Benzodiazepine sedative
Also known as Diastat® · LA-III · Valium® · WY-3467 · Methyl diazepinone · 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
- Formula
- C₁₆H₁₃ClN₂O
1
- C₁₆H₁₃ClN₂O
- Mass
- 284.072 Da
1
- 284.072 Da
Overview
Chemistry
All data
243 statements · 53% with external sources · numbers in brackets are citations
- Medical condition treated
- panic disorder
1
- anxiety disorder
1
- status epilepticus
1
- spasticity
1
- psychosis
1
Sources- 1.Stated in Drug Indications Extracted from FAERSRetrieved 2018-10-02
- insomnia
1
Sources- 1.Stated in Drug Indications Extracted from FAERSRetrieved 2018-10-02
- substance abuse
1
Sources- 1.Stated in Drug Indications Extracted from FAERSRetrieved 2018-10-02
- epilepsy
1
Sources- 1.Stated in Drug Indications Extracted from FAERSRetrieved 2018-10-02
Show 3 moreShow less
- anxiety
1
Sources- 1.Stated in Drug Indications Extracted from FAERSRetrieved 2018-10-02
- sleep-wake disorder
1
Sources- 1.Stated in Drug Indications Extracted from FAERSRetrieved 2018-10-02
- alcohol withdrawal syndrome
- panic disorder
- Canonical SMILES
- CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
1
- CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
- Subject has role
- GABAA receptor positive allosteric modulators
1
- anticonvulsant agent
1
- antiemetic
1
- hypnotics and sedatives
1
- central muscle relaxants
1
- anxiolytic
1
- GABA Modulators
1
- anesthesia adjuvants
1
Show 4 moreShow less
- intravenous anesthetics
1
- WHO essential medicines
- developmental toxicant(since 1992)
1
Sources- 1.Stated in California Proposition 65 list of chemicalsoehha.ca.gov/chemicals/diazepamRetrieved 2020-02-24
- benzodiazepine drug
- GABAA receptor positive allosteric modulators
- Physically interacts with
- Adrenoceptor alpha 1A subject has role: allosteric modulator
1
- Gamma-aminobutyric acid type A receptor subunit alpha1 subject has role: allosteric modulator
1
- Gamma-aminobutyric acid type A receptor subunit alpha2 subject has role: allosteric modulator
1
- Gamma-aminobutyric acid type A receptor subunit alpha3 subject has role: allosteric modulator
1
- Gamma-aminobutyric acid type A receptor subunit gamma2 subject has role: positive allosteric modullator
1
Sources- 1.Stated in Open Targets Platformplatform.opentargets.org/drug/CHEMBL12Retrieved 2023-08-14
- Gamma-aminobutyric acid type A receptor subunit theta subject has role: positive allosteric modullator
1
Sources- 1.Stated in Open Targets Platformplatform.opentargets.org/drug/CHEMBL12Retrieved 2023-08-14
- Gamma-aminobutyric acid type A receptor subunit beta2 subject has role: positive allosteric modullator
1
Sources- 1.Stated in Open Targets Platformplatform.opentargets.org/drug/CHEMBL12Retrieved 2023-08-14
- Gamma-aminobutyric acid type A receptor subunit alpha3 subject has role: positive allosteric modullator
1
Sources- 1.Stated in Open Targets Platformplatform.opentargets.org/drug/CHEMBL12Retrieved 2023-08-14
Show 5 moreShow less
- Gamma-aminobutyric acid type A receptor subunit beta1 subject has role: positive allosteric modullator
1
Sources- 1.Stated in Open Targets Platformplatform.opentargets.org/drug/CHEMBL12Retrieved 2023-08-14
- Gamma-aminobutyric acid type A receptor subunit gamma1 subject has role: positive allosteric modullator
1
Sources- 1.Stated in Open Targets Platformplatform.opentargets.org/drug/CHEMBL12Retrieved 2023-08-14
- Gamma-aminobutyric acid type A receptor subunit delta subject has role: positive allosteric modullator
1
Sources- 1.Stated in Open Targets Platformplatform.opentargets.org/drug/CHEMBL12Retrieved 2023-08-14
- Gamma-aminobutyric acid type A receptor subunit beta3 subject has role: positive allosteric modullator
1
Sources- 1.Stated in Open Targets Platformplatform.opentargets.org/drug/CHEMBL12Retrieved 2023-08-14
- Gamma-aminobutyric acid type A receptor subunit alpha4 subject has role: positive allosteric modullator
1
Sources- 1.Stated in Open Targets Platformplatform.opentargets.org/drug/CHEMBL12Retrieved 2023-08-14
- Adrenoceptor alpha 1A subject has role: allosteric modulator
- Part of
- diazepam binding subject has role: reactant
1
- diazepam binding subject has role: reactant
- Found in taxon
- Agaricus
- soybean
- Oryza molida
- potato
4
Sources- 1.Stated in Occurrence of pharmacologically active benzodiazepines in trace amounts in wheat and potato
- 2.Stated in Occurrence of “natural” benzodiazepines
- 3.Stated in Detection of desmethyldiazepam and diazepam in brain of different species and plants
- 4.Stated in Potato (Solanum tuberosum) juice exerts an anticonvulsant effect in mice through binding to GABA receptors
- Triticum aestivum
- maize
1
- Fagopyrum esculentum
1
- Lens culinaris
1
Show 3 moreShow less
- Stylized name
- diazePAM has characteristic: Tall Man lettering · issued by: Institute for Safe Medication Practices
1
Sources- 1.ismp.org/recommendations/tall-man-letters-listRetrieved 2022-09-02
- diazePAM has characteristic: Tall Man lettering · issued by: Institute for Safe Medication Practices
- Defined daily dose
- 10 milligram route of administration: oral administration
- 10 milligram route of administration: parenteral route of administration
- 10 milligram route of administration: rectal route of administration
- Legal status (medicine)
- boxed warning
1
Sources- 1.“FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.”nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802
- boxed warning
- Significant drug interaction
- pethidine side effect: depressed level of consciousness
- pethidine side effect: central respiratory depression
- periciazine side effect: depressed level of consciousness
- tramadol side effect: depressed level of consciousness
- tramadol side effect: central respiratory depression
- (RS)-methadone side effect: depressed level of consciousness
- (RS)-methadone side effect: central respiratory depression
- morphine side effect: depressed level of consciousness
Show 28 moreShow less
- morphine side effect: central respiratory depression
- oxycodone side effect: depressed level of consciousness
- oxycodone side effect: central respiratory depression
- hydromorphone side effect: depressed level of consciousness
- hydromorphone side effect: central respiratory depression
- dihydrocodeine side effect: depressed level of consciousness
- dihydrocodeine side effect: central respiratory depression
- codeine side effect: depressed level of consciousness
- codeine side effect: central respiratory depression
- tapentadol side effect: depressed level of consciousness
- tapentadol side effect: central respiratory depression
- buprenorphine side effect: central respiratory depression
- fentanyl side effect: depressed level of consciousness
- mirtazapine side effect: depressed level of consciousness
- alfentanil side effect: depressed level of consciousness
- alfentanil side effect: central respiratory depression
- alfentanil side effect: hypotension
- sufentanil side effect: depressed level of consciousness
- sufentanil side effect: hypotension
- (±)-thiopental side effect: central respiratory depression
- phenobarbital side effect: central respiratory depression
- primidone side effect: central respiratory depression
- sodium oxybate side effect: central respiratory depression
- loxapine side effect: cognitive disorder
- loxapine side effect: central respiratory depression
- loxapine side effect: hypotension
- loxapine side effect: sedation
- loxapine side effect: syncope
- World Health Organisation international non-proprietary name
- diazepam
1
- diazepamum
1
- diazepam
- Substance control status
- Schedule III (Russia) applies to jurisdiction: Russia
1
Sources- 1.Stated in Government Decree No. 681 of 30 June 1998 (Russia)consultant.ru/document/cons_doc_LAW_19243/Retrieved 2026-08-31
- Schedule IV (Canada) applies to jurisdiction: Canada
- Anlage III (Germany) applies to jurisdiction: Germany
- Class C (United Kingdom) applies to jurisdiction: United Kingdom
- Schedule IV (United States) applies to jurisdiction: United States
- Schedule III (Russia) applies to jurisdiction: Russia
On other databases
70 identifiers linking diazepam across the web's reference databases
- ATC codeN05BA01
- BabelNet ID00026905n
- CA PROP 65 IDdiazepam
- CAMEO Chemicals ID20115
- CAS Registry Number439-14-5
- CCDC Number1142317
- ChEBI ID49575
- ChEMBL IDCHEMBL12
- ChemSpider ID2908
- CSD RefcodeDIZPAM10
- DeCS ID4003
- DrugBank IDDB00829
- DrugCentral ID852
- DSSTOX compound identifierDTXCID20406
- DSSTox substance IDDTXSID4020406
- EC number207-122-5
- ECHA Substance Infocard ID100.006.476
- Electronic Essential Medicines List medicine ID22
- Elhuyar ZTH ID022289
- Encyclopædia Britannica Online IDscience/diazepam
- Encyclopædia Universalis IDvalium
- Freebase ID/m/01j3v_
- Gmelin number124061
- GND ID4149530-5
- Gran Enciclopèdia Catalana IDdiazepam
- Gran Enciclopèdia Catalana ID (former scheme)0098985
- Guide to Pharmacology Ligand ID3364
- HSDB ID3057
- Human Metabolome Database IDHMDB0014967
- InChIInChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
- InChIKeyAAOVKJBEBIDNHE-UHFFFAOYSA-N
- J9U entity ID987007530086805171
- JSTOR topic ID (archived)valium
- KBpedia IDDiazepam
- KEGG IDC06948
- Lex IDdiazepam
- Library of Congress Authorities IDsh88005436
- MassBank accession IDSM856001
- MedlinePlus drug identifiera682047
- MeSH concept IDM0006229
- MeSH descriptor IDD003975
- MeSH tree codeD03.633.100.079.080.070.216
- Microsoft Academic ID (discontinued)2776175493
- NALT ID8804
- Naver Encyclopedia ID (pre-August 2026)5665827
- NDF-RT IDN0000146157
- NMRShiftDB structure ID10016206
- NSC number77518
- OpenAlex IDC2776175493
- PatientsLikeMe treatment IDdiazepam
- PDB ligand IDDZP
- PDB structure ID2BXF
- PesticideInfo chemical IDPRI2562
- Probes And Drugs IDPD003026
- PubChem CID3016
- Reaxys registry number754371
- Römpp online IDRD-04-01115
- RxNorm CUI3322
- SPLASHsplash10-000i-0490000000-fbdfb84836374f27ffc7
- SureChEMBL ID21442
- UK Parliament thesaurus ID438608
- UM-BBD compound IDc1524
- UMLS CUIC0012010
- UniChem compound ID304698
- UNIIQ3JTX2Q7TU
- UNSPSC code51141920
- WikiProjectMed IDDiazepam
- WordNet 3.1 Synset ID03194679-n
- World Health Organisation international non-proprietary name numeric ID1295
- Yale LUX IDconcept/0e8e9529-5b78-4fce-9f4f-15734f25ebf4