thyroxine

Group of stereoisomers

Chemical compoundgroup of stereoisomersQ216852

Also known as DL-thyroxine

Formula: C₁₅H₁₁I₄NO₄
1
Sources
1.Stated in PubChem
View statement on Wikidata ↗
Mass: 776.6867 Da

Overview

From Wikipedia, the free encyclopedia · Read full article · Text CC BY-SA 4.0

Thyroxine, also known as tetraiodothyronine or T4, is a hormone produced by the thyroid gland. It is the primary form of thyroid hormone found in the blood and acts as a prohormone of the more active thyroid hormone, triiodothyronine (T3). Thyroxine and its active metabolites are essential for regulating metabolic rate, supporting heart and muscle function, promoting brain development, and maintaining bone health.

Overview

Chemistry

Computed by PubChem CID 853 (NIH) · Public domain

Molecular formula: C15H11I4NO4
Molecular weight: 776.87 g/mol
IUPAC name: 2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
SMILES: C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)O)N
InChIKey: XUIIKFGFIJCVMT-UHFFFAOYSA-N
XLogP: 2.4
Topological polar surface area: 92.8 Å²
H-bond donors / acceptors: 3 / 5
Complexity: 420

Chemistry

All data

59 statements · 24% with external sources · numbers in brackets are citations

Subclass of: chemical compound
Part of: cellular response to thyroxine stimulus subject has role: reactant
1
Sources
1.Stated in Gene Ontology release 2019-11-16
View statement on Wikidata ↗
Canonical SMILES: O=C(O)C(N)CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1

On other databases

47 identifiers linking thyroxine across the web's reference databases

Data quality

statements

24%

externally sourced

Source last edited August 23, 2026. AIDB refreshes this page daily.

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AIDB. (2026). thyroxine (Q216852). Retrieved from https://aidb.si/e/thyroxine-Q216852