Plotkin is a surname of Russian Jewish origin, which indicates a person from Plotki, a name of several villages in Russia, Belarus, and Ukraine. It may also refer to:Alice Playten (1947–2011), born Alice Plotkin, American actress and singer
Andrew Plotkin, American writer
Brian Plotkin, American soccer player
Chuck Plotkin, American record producer
Diana Plotkin, American political activist
Faith Plotkin, American writer
Gabriel Plotkin, Melvin Capital CEO
Gordon Plotkin, British computer scientist
Gregory Plotkin, American film editor and director
Hal Plotkin, American journalist and public servant
James Plotkin, American guitarist
Joshua B. Plotkin, Evolutionary biologist and applied mathematician
Mark Plotkin, American botanist
Mark Plotkin, Canadian chess player
Stanley Plotkin, American physician, vaccinologist, and immunologist
Tom Plotkin, American actor