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mitomycin
Chemical compound
Also known as NSC-26980 · MMC · 7-amino-9alpha-methoxymitosane · mitomycin C
- Formula
- C₁₅H₁₈N₄O₅
1
- C₁₅H₁₈N₄O₅
- Mass
- 334.1277 Da
1
- 334.1277 Da
Overview
Chemistry
All data
80 statements · 63% with external sources · numbers in brackets are citations
- Medical condition treated
- cribriform carcinoma
1
- large intestine cancer
1
- glaucoma
1
- bladder cancer
2
Sources- 1.Stated in NDF-RTRetrieved 2016-12-13
- 2.Stated in Drug Indications Extracted from FAERSRetrieved 2018-10-02
- cribriform carcinoma
- Isomeric SMILES
- CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
1
- CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
- Canonical SMILES
- CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N
1
- CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N
- Subject has role
- alkylating agent
2
Sources- 1.Stated in NDF-RTRetrieved 2018-03-05
- 2.Stated in Medical Subject HeadingsRetrieved 2018-03-15
- DNA polymerase inhibitors
2
Sources- 1.Stated in NDF-RTRetrieved 2018-03-05
- 2.Stated in Medical Subject HeadingsRetrieved 2018-03-15
- antineoplastic antibiotics
1
- cross-linking reagent
1
- carcinogen
1
Sources- 1.Stated in California Proposition 65 list of chemicalsoehha.ca.gov/chemicals/mitomycin-cRetrieved 2020-03-18
- alkylating agent
- Part of
- mitomycin C metabolic process subject has role: participant
1
- mitomycin C catabolic process subject has role: reactant
1
- mitomycin C biosynthetic process subject has role: product
1
- mitomycin C metabolic process subject has role: participant
- Found in taxon
- Streptomyces lavendulae
2
Sources- 1.Stated in Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564
- 2.Stated in Characterization of a mitomycin-binding drug resistance mechanism from the producing organism, Streptomyces lavendulae
- Streptomyces purpurascens
- Streptomyces violaceus
- Streptomyces
- Streptomyces caespitosus
- Streptomyces lavendulae
- Significant drug interaction
- vinblastine side effect: bone marrow failure
- vinblastine side effect: embolism
- Legal status (medicine)
- boxed warning
1
Sources- 1.“FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.”nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802
- boxed warning
On other databases
41 identifiers linking mitomycin across the web's reference databases
- CA PROP 65 IDmitomycin-c
- CAMEO Chemicals ID5080
- CAS Registry Number50-07-7
- ChEBI ID27504
- ChEMBL IDCHEMBL105
- ChemSpider ID5544
- DrugBank IDDB00305
- DrugCentral ID1819
- DSSTOX compound identifierDTXCID00898
- DSSTox substance IDDTXSID2020898
- EC number200-008-6
- ECHA Substance Infocard ID100.000.008
- Google Knowledge Graph ID/g/11bc7p_4hz
- Guide to Pharmacology Ligand ID7089
- HSDB ID3239
- Human Metabolome Database IDHMDB0014450
- InChIInChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
- InChIKeyNWIBSHFKIJFRCO-WUDYKRTCSA-N
- KEGG IDD00208
- KNApSAcK IDC00018668
- MassBank accession IDMSBNK-Waters-WA000767
- MedlinePlus drug identifiera682415
- MeSH descriptor IDD016685
- MeSH tree codeD02.806.400.249.350
- Microsoft Academic ID (discontinued)2779338040
- Natural Product Atlas IDNPA020531
- NDF-RT IDN0000146471
- NSC number26980
- OpenAlex IDC2779338040
- Probes And Drugs IDPD003405
- PubChem CID5746
- Reaxys registry number3570056
- RxNorm CUI632
- SureChEMBL ID3760
- UMLS CUIC0002475
- UniChem compound ID244088
- UNII50SG953SK6
- Wellcome Collection concept IDp9kfyxec
- WikiProjectMed IDMitomycin C
- YSO ID28070
- ZVG number490041