l
lomustine
Chemical compound
Also known as CCNU · CeeNU® · N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea · 1-(2-chloroethyl)-3-cyclohexylnitrosourea · CINU · cyclohexyl chloroethyl nitrosourea
- Formula
- C₉H₁₆ClN₃O₂
1
- C₉H₁₆ClN₃O₂
- Mass
- 233.093 Da
1
- 233.093 Da
Overview
Chemistry
All data
63 statements · 75% with external sources · numbers in brackets are citations
- Medical condition treated
- lung benign neoplasm
1
- lymphosarcoma
1
- kidney cancer
1
- melanoma
1
- Hodgkin's lymphoma, mixed cellularity
1
- brain cancer
1
- colonic benign neoplasm
1
- brain cancer(since 1976) approved by: United States Food and Drug Administration
1
Sources- 1.Stated in Inxight: Drugs Databasedrugs.ncats.io/drug/7BRF0Z81KGRetrieved 2018-11-02
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- Hodgkin lymphoma(since 1976) approved by: United States Food and Drug Administration
1
Sources- 1.Stated in Inxight: Drugs Databasedrugs.ncats.io/drug/7BRF0Z81KGRetrieved 2018-11-02
- lung benign neoplasm
- Canonical SMILES
- C1CCC(CC1)NC(=O)N(CCCl)N=O
1
- C1CCC(CC1)NC(=O)N(CCCl)N=O
- Subject has role
- alkylating agent
1
- alkylating antineoplastic agent
1
- developmental toxicant(since 1990)
1
Sources- 1.Stated in California Proposition 65 list of chemicalsoehha.ca.gov/chemicals/1-2-chloroethyl-3-cyclohexyl-1-nitrosourea-ccnu-lomustineRetrieved 2020-02-21
- carcinogen
1
Sources- 1.Stated in California Proposition 65 list of chemicalsoehha.ca.gov/chemicals/1-2-chloroethyl-3-cyclohexyl-1-nitrosourea-ccnu-lomustineRetrieved 2020-02-25
- alkylating agent
- LiverTox likelihood score
- LiverTox toxicity likelihood category D
1
Sources- 1.Stated in LiverToxncbi.nlm.nih.gov/books/n/livertox/LomustineRetrieved 2021-04-08
- LiverTox toxicity likelihood category D
- Legal status (medicine)
- boxed warning
1
Sources- 1.“FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.”nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802
- boxed warning
On other databases
37 identifiers linking lomustine across the web's reference databases
- ATC codeL01AD02
- CA PROP 65 ID1-2-chloroethyl-3-cyclohexyl-1-nitrosourea-ccnu-lomustine
- CAS Registry Number13010-47-4
- ChEBI ID6520
- ChEMBL IDCHEMBL514
- ChemSpider ID3813
- DrugBank IDDB01206
- DrugCentral ID1596
- DSSTOX compound identifierDTXCID103222
- DSSTox substance IDDTXSID2023222
- EC number235-859-2
- ECHA Substance Infocard ID100.032.585
- Freebase ID/m/0f0_nn
- Guide to Pharmacology Ligand ID7214
- HSDB ID6519
- Human Metabolome Database IDHMDB0015337
- InChIInChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
- InChIKeyGQYIWUVLTXOXAJ-UHFFFAOYSA-N
- KEGG IDC07079
- LiverTox IDLomustine
- MedlinePlus drug identifiera682207
- MeSH descriptor IDD008130
- MeSH tree codeD02.065.950.594.440
- Microsoft Academic ID (discontinued)2779434656
- NDF-RT IDN0000146475
- NSC number79037
- OpenAlex IDC2779434656
- Probes And Drugs IDPD001312
- PubChem CID3950
- Reaxys registry number2125058
- RxNorm CUI6466
- SureChEMBL ID3995
- UMLS CUIC0023972
- UniChem compound ID187727
- UNII7BRF0Z81KG
- WikiProjectMed IDLomustine
- WordNet 3.1 Synset ID03693014-n