Lock is a surname, and may refer to:Bob Lock, Welsh science fiction and fantasy writer
Charles Lock (1770–1804), British consul-general in Naples who quarrelled with Admiral Horatio Nelson regarding the latter's military actions
Charlie Lock, Zimbabwean cricketer
C. N. H. Lock (1894–1949), English aerodynamicist
David Lock, barrister and Labour Party politician in the United Kingdom
Don Lock (1936–2017), Major League Baseball outfielder
Drew Lock, American football quarterback
Édouard Lock, Canadian dance choreographer
Emily Lock, British gymnast
Eric Lock (1919–1941), British Royal Air Force fighter ace of the Second World War
Herbert Lock (1887–1957), English goalkeeper who played for Southampton and Rangers
James Lock (1939–2009), English two-time Grammy Award winner in the area of classical music
James Lock, an early owner and head of James Lock & Co., hatters in London
John Bascombe Lock (1849–1921), bursar of Gonville and Caius College, Cambridge
Matthias Lock, English 18th-century furniture designer and cabinetmaker
Mi Kwan Lock, French actress
Patti Frazer Lock, American mathematician and statistician
Ray Lock, a Royal Air Force air vice-marshal
Robert Heath Lock (1879–1915), English geneticist
Sean Lock (1963–2021), English comedy writer, comedian and actor
Tony Lock (1929–1995), English Test cricketer
Trevor Lock, English comedian, actor and playwright
Ulla Lock (1934–2012), Danish film actress