Jefferies is an English surname. Notable people with the surname include:Alan Jefferies, Australian writer
Annalee Jefferies, American actress
Axcil Jefferies, Zimbabwean racing driver
Chris Jefferies, American basketball player
Cindy Jefferies, English writer of fiction for children
Darren Jefferies, English footballer
Daulton Jefferies, American baseball player
Dinah Jefferies, English writer
Gregg Jefferies, American baseball infielder
Jim Jefferies (comedian), Australian comedian
Jim Jefferies (footballer), Scottish football player and manager
Jim Jeffries (baseball) (1893–1938), American baseball player
Matt Jefferies (1921–2003), American artist, set designer and writer
Richard Jefferies (1848–1887), English nature writer
Thomas Jeffries, also known as Thomas Jefferies, Australian outlaw & prisoner