Efraín is a masculine Spanish given name, a cognate of Ephraim. Notable people with the name include:Efrain Chacurian (1924–2019), Argentine-born naturalised American soccer player
Efraín Cortés, Colombian football defender
Efraín Escudero, Mexican mixed martial arts fighter
Efraín Flores, Mexican football manager
Efraín Forero Triviño (1932–2022), Colombian cyclist
Efraín Goldenberg (1929–2025), Peruvian politician
Efrain Gonzalez Jr., Puerto-Rico born New York senator
Efraín González Luna (1898–1964), Mexican politician and presidential candidate
Efraín González Morfín (1929–2012), Mexican politician and presidential candidate, son of the above
Efrain Guigui (1925–2007), US-based Panamanian clarinetist and conductor.
Efraín Guzmán, Colombian guerrilla leader
Efraín Huerta (1914–1982), Mexican poet
Efraïn Jonckheer (1917–1987), Netherlands Antilles prime minister
Efraín Juárez, Mexican football player
Efraín López Neris, Puerto Rican actor
Efraín Medina, Mexican singer
Efraín Morote (1921–1989), Peruvian anthropologist
Efraín Ríos Montt (1926–2018), former de facto President of Guatemala
Efraín Rivera Pérez (1951–2013), Associate Justice of the Supreme Court of Puerto Rico
Efraín Sánchez (1926–2020), Colombian footballer
Efraín Valdez, Dominican Republic baseball player
Efraín Velarde, Mexican football player