d
digoxin
Plant-derived medication used in certain heart conditions
Also known as Lanoxicaps · Lanoxin · Vanoxin · Lanoxin Pediatric · Digoxin Pediatric · 12beta-Hydroxydigitoxin
- Formula
- C₄₁H₆₄O₁₄
1
- C₄₁H₆₄O₁₄
- Mass
- 780.43 Da
1
- 780.43 Da
Overview
Chemistry
All data
178 statements · 78% with external sources · numbers in brackets are citations
- Medical condition treated
- atrial fibrillation
2
Sources- 1.Stated in NDF-RTRetrieved 2016-12-13
- 2.Stated in Drug Indications Extracted from FAERSRetrieved 2018-10-02
- congestive heart failure
2
Sources- 1.Stated in NDF-RTRetrieved 2016-12-13
- 2.Stated in Drug Indications Extracted from FAERSRetrieved 2018-10-02
- supraventricular tachycardia
1
- heart arrhythmia
1
Sources- 1.Stated in Drug Indications Extracted from FAERSRetrieved 2018-10-02
- atrial fibrillation
- Isomeric SMILES
- C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O
1
- C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O
- Canonical SMILES
- CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CC(C7(C6(CCC7C8=CC(=O)OC8)O)C)O)C)C)C)O)O
1
- CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CC(C7(C6(CCC7C8=CC(=O)OC8)O)C)O)C)C)C)O)O
- Subject has role
- enzyme inhibitor
2
Sources- 1.Stated in NDF-RTRetrieved 2018-03-05
- 2.Stated in Medical Subject HeadingsRetrieved 2018-03-15
- antiarrhythmic agent
1
- cardiotonic
1
- WHO essential medicines
- enzyme inhibitor
- Physically interacts with
- ATPase Na+/K+ transporting subunit alpha 1 subject has role: enzyme inhibitor
1
- ATPase Na+/K+ transporting subunit alpha 1 subject has role: enzyme inhibitor
- Found in taxon
- Digitalis lanata
14
Sources- 1.Stated in Long-Term Cultivation of Digitalis lanata Clones Propagated in Vitro: Cardenolide Content of the Regenerated Plants1.
- 2.Stated in Quantitative determination of cardiac glycosides in Digitalis lanata leaves by reversed-phase thin-layer chromatography
- 3.Stated in Isolation and quantitative determination of some cardioactive glycosides from Digitalis lanata by high-performance liquid chromatography
- 4.Stated in Immobilized plant cells for the production and transportation of natural products
- 5.Stated in Determination of some cardiac glycosides by high-performance liquid chromatography
- 6.Stated in Isolation of cardenolides from a Brazilian cultivar of Digitalis lanata by rotation locular counter-current chromatography
- Digitalis obscura
- Digitalis parviflora
- Digitalis viridiflora
- Digitalis lanata
- Defined daily dose
- 0.25 milligram route of administration: oral administration
- 0.25 milligram route of administration: parenteral route of administration
- Significant drug interaction
- (RS)-metoprolol side effect: sinus bradycardia
- nadolol side effect: sinus bradycardia
- atenolol side effect: sinus bradycardia
- nebivolol side effect: sinus bradycardia
- acebutolol side effect: sinus bradycardia
- betaxolol side effect: sinus bradycardia
- bisoprolol side effect: sinus bradycardia
- pindolol side effect: sinus bradycardia
Show 52 moreShow less
- propranolol side effect: sinus bradycardia
- labetalol side effect: sinus bradycardia
- celiprolol side effect: sinus bradycardia
- esmolol side effect: sinus bradycardia
- crizotinib side effect: sinus bradycardia
- fingolimod side effect: sinus bradycardia
- verapamil side effect: sinus bradycardia
- amiodarone side effect: sinus bradycardia
- diltiazem side effect: sinus bradycardia
- carvedilol side effect: sinus bradycardia
- sotalol side effect: sinus bradycardia
- (RS)-metoprolol side effect: toxicity
- nadolol side effect: toxicity
- atenolol side effect: toxicity
- nebivolol side effect: toxicity
- acebutolol side effect: toxicity
- betaxolol side effect: toxicity
- bisoprolol side effect: toxicity
- pindolol side effect: toxicity
- propranolol side effect: toxicity
- labetalol side effect: toxicity
- celiprolol side effect: toxicity
- esmolol side effect: toxicity
- verapamil side effect: third-degree atrioventricular block
- verapamil side effect: toxicity
- fingolimod side effect: atrioventricular block
- amiodarone side effect: heart arrhythmia
- amiodarone side effect: nausea
- amiodarone side effect: vomiting
- (RS)-propafenone side effect: heart arrhythmia
- (RS)-propafenone side effect: nausea
- (RS)-propafenone side effect: vomiting
- (RS)-bendroflumethiazide side effect: heart arrhythmia
- (RS)-bendroflumethiazide side effect: vomiting
- (RS)-bendroflumethiazide side effect: nausea
- (RS)-bendroflumethiazide side effect: toxicity
- chlorthalidone side effect: heart arrhythmia
- chlorthalidone side effect: vomiting
- chlorthalidone side effect: nausea
- chlorthalidone side effect: toxicity
- (2RS,6RS)-clopamide side effect: heart arrhythmia
- (2RS,6RS)-clopamide side effect: vomiting
- (2RS,6RS)-clopamide side effect: nausea
- (2RS,6RS)-clopamide side effect: toxicity
- hydrochlorothiazide side effect: heart arrhythmia
- hydrochlorothiazide side effect: vomiting
- hydrochlorothiazide side effect: nausea
- hydrochlorothiazide side effect: toxicity
- indapamide side effect: heart arrhythmia
- indapamide side effect: vomiting
- indapamide side effect: nausea
- indapamide side effect: toxicity
On other databases
55 identifiers linking digoxin across the web's reference databases
- ATC codeC01AA05
- CAMEO Chemicals ID4956
- CAS Registry Number20830-75-5
- CCDC Number1140600
- ChEBI ID4551
- ChEMBL IDCHEMBL1751
- ChemSpider ID2006532
- CSD RefcodeDIGOXN10
- DrugBank IDDB00390
- DrugCentral ID882
- DSSTOX compound identifierDTXCID502934
- DSSTox substance IDDTXSID5022934
- EC number244-068-1
- ECHA Substance Infocard ID100.040.047
- Electronic Essential Medicines List medicine ID134
- Encyclopædia Britannica Online IDscience/digoxin
- Freebase ID/m/01xc5b
- Gran Enciclopèdia Catalana IDdigoxina
- Gran Enciclopèdia Catalana ID (former scheme)0281884
- Guide to Pharmacology Ligand ID4726
- HSDB ID214
- Human Metabolome Database IDHMDB0001917
- IEDB Epitope ID122964
- InChIInChI=1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1
- InChIKeyLTMHDMANZUZIPE-PUGKRICDSA-N
- J9U entity ID987007555312405171
- KEGG IDC06956
- Library of Congress Authorities IDsh85037995
- LIPID MAPS IDLMST01120023
- MassBank accession IDMSBNK-Waters-WA000561
- MedlinePlus drug identifiera682301
- MeSH concept IDM0006386
- MeSH descriptor IDD004077
- MeSH tree codeD04.210.500.155.580.130.500.436
- Microsoft Academic ID (discontinued)2777707475
- NDF-RT IDN0000146388
- NSC number95100
- OpenAlex IDC2777707475
- PDB ligand IDDGX
- PDB structure ID3B0W
- Probes And Drugs IDPD010075
- PubChem CID2724385
- Quora topic IDDigoxin
- Reaxys registry number77011
- Römpp online IDRD-04-01507
- RxNorm CUI3407
- SureChEMBL ID20506
- UMLS CUIC0012265
- UniChem compound ID52141
- UNII73K4184T59
- Wellcome Collection concept IDdwmp8pyq
- WikiProjectMed IDDigoxin
- WordNet 3.1 Synset ID03202488-n
- World Health Organisation international non-proprietary name numeric ID389
- ZVG number36180