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Desa was the Grand Prince of Serbia from 1162 to 1166. He was one of several sons of grand prince Uroš I. Sometime between 1153 and 1155, Desa tried to depose his brother, the ruling grand prince Uroš II, but failed to establish himself as a new ruler. Only later, after the abdication of their other brother, the next grand prince Beloš c. 1162, Desa became the new ruler of Serbia. He tried to challenge the Byzantine suzerainty over Serbia, but was deposed by emperor Manuel I Komnenos. Before he became the grand prince, Desa ruled as prince of Duklja, Travunija and Zahumlje, ca. from 1149 to 1162.