c
cortisol
Steroid hormone, in the glucocorticoid class of hormones; when used as a medication
Also known as 4-pregnen-11beta,17alpha,21-triol-3,20-dione · (11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione · 11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione · 11beta-hydrocortisone · HC · (1S,2R,10S,11S,14S,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
- Formula
- C₂₁H₃₀O₅
1
- C₂₁H₃₀O₅
- Mass
- 362.209 Da
1
- 362.209 Da
- Melting point
- 214°C
1
- , 212.5°C
1
- 214°C
Overview
Chemistry
All data
253 statements · 57% with external sources · numbers in brackets are citations
- Medical condition treated
- scalp dermatosis
1
- pruritus ani
1
- congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency
1
- enthesopathy
1
Sources- 1.Stated in NDF-RTncbi.nlm.nih.gov/m/pubmed/9235656/Retrieved 2016-12-13
- leg dermatosis
1
- facial dermatosis
1
- neurogenic shock
1
- ulcerative colitis
1
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- status asthmaticus
1
- hand dermatosis
1
- hemorrhoid
1
- inflammation
1
- adrenal cortical hypofunction
1
Sources- 1.Stated in Drug Indications Extracted from FAERSRetrieved 2018-10-02
- chronic primary adrenal insufficiency
1
Sources- 1.Stated in Drug Indications Extracted from FAERSRetrieved 2018-10-02
- pituitary deficiency
1
Sources- 1.Stated in Drug Indications Extracted from FAERSRetrieved 2018-10-02
- scalp dermatosis
- Found in taxon
- Homo sapiens
3
Sources- 1.Stated in WikiPathwaysidentifiers.org/wikipathways/WP1984_r82941Retrieved 2016-09-10
- 2.Stated in Recon 2.2: from reconstruction to model of human metabolism
- 3.Stated in A community-driven global reconstruction of human metabolism.
- Phlomoides rotata
- Ganoderma boninense
- house mouse
- Homo sapiens
- Canonical SMILES
- CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
1
- CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
- Isomeric SMILES
- C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
1
- C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
- World Health Organisation international non-proprietary name
- hydrocortisone
1
- hydrocortisone
- MCN code
- 2937.21.20
- Physically interacts with
- Nuclear receptor subfamily 3 group C member 1 subject has role: agonist
1
- Nuclear receptor subfamily 3 group C member 2 subject has role: agonist
1
- Nuclear receptor subfamily 3 group C member 1 subject has role: agonist
- Part of
- cortisol receptor activity subject has role: reactant
1
- cortisol binding subject has role: reactant
1
- response to cortisol subject has role: reactant
1
- cellular response to cortisol stimulus subject has role: reactant
1
- cortisol secretion subject has role: cargo
1
- cortisol metabolic process subject has role: participant
1
- cortisol biosynthetic process subject has role: product
1
- cortisol O-acetyltransferase activity
1
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- cortisol receptor activity subject has role: reactant
- Significant drug interaction
- hydrochlorothiazide side effect: Achor-Smith syndrom
- furosemide side effect: Achor-Smith syndrom
- chlorthalidone side effect: Achor-Smith syndrom
- moxifloxacin side effect: Achor-Smith syndrom
- moxifloxacin side effect: tendon rupture
- hydrochlorothiazide side effect: heart arrhythmia
- Stereoisomer of
- (8S,9S,10R,11R,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
- (8S,9S,10R,11S,13S,14R,17R)-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
- Active ingredient in
Show 37 moreShow less
- Cortifoam
1
- Texacort
1
- Cortef
1
- Proctocream
1
- Proctozone HC
1
- Recort Plus
1
- Kera-HC
1
- Cortaid
1
- Hydroskin
1
- Proctocort
1
- Coraz
1
- Caldecort
1
- Anusol HC
1
- Colocort
1
- Nucort
1
- Aveeno Hydrocortisone Anti-Itch
1
- Carmol HC
1
- Preparation H Hydrocortisone
1
- Cortizone
1
- Procto-Kit
1
- Ala-Scalp
1
- Dermacort
1
- Maximum-H
1
- A-Hydrocort
1
- Dermasorb HC
1
- Dermarest Dricort
1
- Psoriasin Itch
1
- Proctosol
1
- Ala-Cort
1
- Blue-Emu Anti-Itch
1
- Procto-Pak
1
- Pediaderm HC
1
- Procto-Med
1
- Gynecort
1
- Neosporin Eczema
1
- Scalacort
1
- Dermtex HC
1
- Cortifoam
- Stylized name
- Solu-CORTEF has characteristic: Tall Man lettering · issued by: Institute for Safe Medication Practices
1
Sources- 1.ismp.org/recommendations/tall-man-letters-listRetrieved 2022-09-02
- Solu-CORTEF has characteristic: Tall Man lettering · issued by: Institute for Safe Medication Practices
- Defined daily dose
- 30 milligram route of administration: oral administration
- 30 milligram route of administration: parenteral route of administration
On other databases
72 identifiers linking cortisol across the web's reference databases
- ATC codeS02BA01
- Bibliothèque nationale de France ID12397497t
- BNCF Thesaurus ID20974
- CAS Registry Number50-23-7
- CCDC Number2010417
- ChEBI ID17650
- ChEMBL IDCHEMBL389621
- ChemSpider ID5551
- Dewey Decimal Classification615.364
- DrugBank IDDB00741
- DrugCentral ID1388
- DSSTOX compound identifierDTXCID10714
- DSSTox substance IDDTXSID7020714
- EC number200-020-1
- ECHA Substance Infocard ID100.000.019
- Encyclopaedia Beliana IDkortizol
- Encyclopædia Britannica Online IDscience/cortisol
- Freebase ID/m/01xf7l
- GND ID4160902-5
- Golden ID (archived)Cortisol-ZD69E
- Google Knowledge Graph ID/g/11c53146q3
- Gran Enciclopèdia Catalana IDcortisol
- Gran Enciclopèdia Catalana ID (former scheme)0094412
- Great Russian Encyclopedia Online ID (2017)2358480
- Guide to Pharmacology Ligand ID2868
- Human Metabolome Database IDHMDB0000063
- IEDB Epitope ID174851
- InChIInChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
- InChIKeyJYGXADMDTFJGBT-VWUMJDOOSA-N
- Interlingual Index IDi114517
- J9U entity ID987007533630205171
- KBpedia IDHydrocortisone
- KEGG IDD00088
- Krugosvet article (archived)biologiya/kortizol
- Library of Congress Authorities IDsh85063384
- LIPID MAPS IDLMST02030001
- MassBank accession IDMSBNK-Eawag-EQ320101
- MedlinePlus drug identifiera682206
- MeSH descriptor IDD006854
- MeSH tree codeD04.210.500.745.745.654.600
- Microsoft Academic ID (discontinued)2778709874
- NALT ID29332
- National Library of Latvia ID000334100
- NDF-RT IDN0000146291
- NL CR AUT IDph358657
- NSC number10483
- OmegaWiki Defined Meaning1329156
- OpenAlex IDC2778709874
- PDB ligand IDHCY
- PDB structure ID4P6X
- PesticideInfo chemical IDPRI3571
- Probes And Drugs IDPD002713
- PubChem CID5754
- Quora topic IDHydrocortisone
- Reaxys registry number1354819
- RxNorm CUI5492
- ScienceDirect topic IDagricultural-and-biological-sciences/cortisol
- SPLASHsplash10-07r1-1985000000-b6d756bd554367393be3
- Store medisinske leksikon IDkortisol
- SureChEMBL ID4148
- SwissLipids IDSLM:000485329
- UK Parliament thesaurus ID564860
- UMLS CUIC0020268
- UniChem compound ID176236
- UNIIWI4X0X7BPJ
- WikiKids IDCortisol
- WikiProjectMed IDHydrocortisone
- WikiSkripta article ID32377
- WordNet 3.1 Synset ID14776881-n
- World Health Organisation international non-proprietary name numeric ID38
- Yale LUX IDconcept/4109bf1c-1d2e-40b0-86c7-1e5e0c5ffc19
- YSO ID11874