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bromocriptine
Medication which has significant effects on dopamine levels in the brain
Also known as PLO154 · 2-bromoergocryptine · bromocryptine · CB-154 · Parlodel® · (5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-3',6',18-trioxoergotaman
- Formula
- C₃₂H₄₀BrN₅O₅
1
- C₃₂H₄₀BrN₅O₅
- Mass
- 653.221 Da
1
- 653.221 Da
Overview
Chemistry
All data
144 statements · 71% with external sources · numbers in brackets are citations
- Medical condition treated
- neuroleptic malignant syndrome
1
- amenorrhea
1
- acromegaly
1
- Parkinson's disease
2
Sources- 1.Stated in NDF-RTRetrieved 2016-12-13
- 2.Stated in Drug Indications Extracted from FAERSRetrieved 2018-10-02
- infertility
1
- hyperprolactinemia
1
- hypogonadism
1
- prolactin producing pituitary tumor
1
Sources- 1.Stated in Drug Indications Extracted from FAERSRetrieved 2018-10-02
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- prolactinoma
1
Sources- 1.Stated in Drug Indications Extracted from FAERSRetrieved 2018-10-02
- neuroleptic malignant syndrome
- Isomeric SMILES
- CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]3(N1C(=O)[C@](O3)(C(C)C)NC(=O)[C@H]4CN([C@@H]5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O
1
- CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]3(N1C(=O)[C@](O3)(C(C)C)NC(=O)[C@H]4CN([C@@H]5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O
- Canonical SMILES
- CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O
1
- CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O
- World Health Organisation international non-proprietary name
- bromocriptine
1
- bromocriptine
- Defined daily dose
- 40 milligram route of administration: oral administration
- Subject has role
- dopamine agonist
2
Sources- 1.Stated in NDF-RTRetrieved 2018-03-05
- 2.Stated in Medical Subject HeadingsRetrieved 2018-03-15
- antiparkinson
1
- hormone antagonist
1
- dopamine agonist
- Physically interacts with
- 5-hydroxytryptamine receptor 1A subject has role: agonist
1
- 5-hydroxytryptamine receptor 1B subject has role: agonist
1
- 5-hydroxytryptamine receptor 1D subject has role: agonist
1
- 5-hydroxytryptamine receptor 2A subject has role: agonist
1
- 5-hydroxytryptamine receptor 2B subject has role: agonist
1
- 5-hydroxytryptamine receptor 2C subject has role: agonist
1
- 5-hydroxytryptamine receptor 6 subject has role: agonist
1
- Adrenoceptor alpha 2A subject has role: agonist
1
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- Adrenoceptor alpha 2B subject has role: agonist
1
- Adrenoceptor alpha 2C subject has role: agonist
1
- Dopamine receptor D1 subject has role: agonist
1
- Dopamine receptor D2 subject has role: agonist
1
- Dopamine receptor D3 subject has role: agonist
1
- Dopamine receptor D4 subject has role: antagonist
1
- Dopamine receptor D5 subject has role: agonist
1
- 5-hydroxytryptamine receptor 1A subject has role: agonist
- LiverTox likelihood score
- LiverTox toxicity likelihood category D
1
Sources- 1.Stated in LiverToxncbi.nlm.nih.gov/books/n/livertox/BromocriptineRetrieved 2021-04-08
- LiverTox toxicity likelihood category D
- Significant drug interaction
- verapamil side effect: hypotension
- lisinopril dihydrate side effect: hypotension
- diltiazem side effect: hypotension
- quinapril side effect: hypotension
- ramipril side effect: hypotension
- captopril side effect: hypotension
- enalapril side effect: hypotension
- trandolapril side effect: hypotension
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- fosinopril side effect: hypotension
- perindopril side effect: hypotension
- chlorthalidone side effect: hypotension
- (RS)-sulpiride side effect: hypotension
- risperidone side effect: hypotension
- droperidol side effect: hypotension
- pimozide side effect: hypotension
- fluphenazine side effect: hypotension
- haloperidol side effect: hypotension
- chlorpromazine side effect: hypotension
- furosemide side effect: hypotension
- hydrochlorothiazide side effect: hypotension
- indapamide side effect: hypotension
- lisinopril dihydrate side effect: hyperinsulinism
- quinapril side effect: hyperinsulinism
- ramipril side effect: hyperinsulinism
- captopril side effect: hyperinsulinism
- enalapril side effect: hyperinsulinism
- trandolapril side effect: hyperinsulinism
- fosinopril side effect: hyperinsulinism
- perindopril side effect: hyperinsulinism
- chlorthalidone side effect: hyperglycemia
- chlorthalidone side effect: increased insulin requirement
- furosemide side effect: hyperglycemia
- furosemide side effect: increased insulin requirement
- hydrochlorothiazide side effect: hyperglycemia
- hydrochlorothiazide side effect: increased insulin requirement
- indapamide side effect: hyperglycemia
- indapamide side effect: increased insulin requirement
On other databases
47 identifiers linking bromocriptine across the web's reference databases
- ATC codeN04BC01
- CAS Registry Number25614-03-3
- ChEBI ID3181
- ChEMBL IDCHEMBL493
- ChemSpider ID28858
- DrugBank IDDB01200
- DrugCentral ID403
- DSSTOX compound identifierDTXCID602687
- DSSTox substance IDDTXSID1022687
- EC number247-128-5
- ECHA Substance Infocard ID100.042.829
- Electronic Essential Medicines List medicine ID592
- Elhuyar ZTH ID021884
- Encyclopædia Britannica Online IDscience/bromocriptine
- Encyclopædia Universalis IDbromocriptine
- Freebase ID/m/02xpx1
- Gran Enciclopèdia Catalana IDbromocriptina
- Gran Enciclopèdia Catalana ID (former scheme)0223410
- Guide to Pharmacology Ligand ID35
- Human Metabolome Database IDHMDB0015331
- InChIInChI=1S/C32H40BrN5O5/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39)/t18-,23-,24+,25+,31-,32+/m1/s1
- InChIKeyOZVBMTJYIDMWIL-AYFBDAFISA-N
- KEGG IDC06856
- LiverTox IDBromocriptine
- MassBank accession IDMSBNK-Waters-WA001779
- MedlinePlus drug identifiera682079
- MeSH concept IDM0002948
- MeSH descriptor IDD001971
- MeSH tree codeD03.132.327.412.100
- Microsoft Academic ID (discontinued)2776856834
- NALT ID19966
- NDF-RT IDN0000147732
- OpenAlex IDC2776856834
- PDB ligand ID08Y
- PDB structure ID3UA1
- Probes And Drugs IDPD009743
- PubChem CID31101
- Reaxys registry number741357
- Römpp online IDRD-02-02707
- RxNorm CUI1760
- Store medisinske leksikon IDbromokriptin
- SureChEMBL ID25297
- UMLS CUIC0006230
- UniChem compound ID16129
- UNII3A64E3G5ZO
- WikiProjectMed IDBromocriptine
- World Health Organisation international non-proprietary name numeric ID3365