NCT06358872 Azithromycin for Child Survival in Niger II Phase 4 Recruiting 2024-04-29 3300000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06358872 NCT04224987 Azithromycin for Child Survival in Niger: Mortality and Resistance Trial Phase 4 Completed 2020-11-24 864493 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04224987 NCT00222547 Deworming and Enhanced Vitamin A Every 6 Month in Rural Indian Children Aged 1-6 Phase 4 Completed 1999-01 720000 University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00222547 NCT04716712 Infant Mortality Reduction by the Mass Administration of Azithromycin Phase 4 Active not recruiting 2021-10-04 694400 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04716712 NCT06684743 Vaccine Effectiveness of a Bivalent RSV Prefusion F Protein-Based Vaccine for Preventing RSV Hospitalizations in Adults Respiratory Tract Diseases Phase 4 Active not recruiting 2024-11-18 690000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06684743 NCT05148845 Sisonke 2 - A COVID-19 Vaccine Boost Open Label Study. COVID-19 Phase 3 Completed 2021-11-10 500000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05148845 NCT04838795 Sisonke (Together): OPEN LABEL TRIAL COVID-19 Severe Acute Respiratory Syndrome Phase 3 Completed 2021-02-17 477102 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04838795 NCT06506812 Pooled Analysis of Methodologically Harmonized Pragmatic Randomized Trials of High-Dose vs. Standard-Dose Influenza Vaccine Against Severe Clinical Outcomes Influenza, Human; Pneumonia Phase 4 Completed 2025-05-31 466320 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06506812 NCT07790523 Effectiveness of An Influenza/COVID-19 Vaccine (mCombriax [mRNA-1083]) in Adults ≥ 65 Years COVID-19; Influenza, Human; Respiratory Tract Diseases Phase 4 Not yet recruiting 2026-09-01 410000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07790523 NCT06934239 A Trial Comparing Screening Mammography With and Without Assistance From Artificial Intelligence for Breast Cancer Detection and Recall Rates in Adult Patients Phase 4 Recruiting 2025-10-15 400000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06934239 NCT02556242 Targeted Indoor Residual Spraying Against Malaria Malaria Phase 4 Completed 2015-10 393387 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02556242 NCT03014167 Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH) Helminthiasis; Filariasis Phase 3 Completed 2017-10-04 357716 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03014167 NCT03140423 Mupirocin-Iodophor ICU Decolonization Swap Out Trial Staphylococcal Infections; Cross Infection Phase 4 Completed 2017-05-01 353323 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03140423 NCT05517174 A Pragmatic Randomized Trial to Evaluate the Effectiveness of High-Dose Quadrivalent Influenza Vaccine vs. Standard-Dose Quadrivalent Influenza Vaccine in Older Adults Influenza, Human; Pneumonia Phase 4 Completed 2022-09-22 332438 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05517174 NCT03335072 Kebele Elimination of Trachoma for Ocular Health Trachoma Phase 4 Active not recruiting 2022-02-07 320000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03335072 NCT04177043 Model Towards Elimination of Hepatitis C Infection in Egypt: Feasibility and Effectiveness in 73 Villages Hepatitis C, Chronic Phase 4 Completed 2015-06 221855 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04177043 NCT02027207 Single Dose Oral Cholera Vaccine Study in Dhaka, Bangladesh Cholera Phase 3 Completed 2012-12-09 204438 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02027207 NCT00203749 Community Mobilization, Mobile Testing, Same-Day Results, and Post-Test Support for HIV in Sub-Saharan Africa and Thailand HIV Infections Phase 3 Completed 2004-12 192814 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00203749 NCT02047981 Mortality Reduction After Oral Azithromycin: Mortality Study Infections Phase 4 Completed 2014-12 190238 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02047981 NCT05288023 Azithromycin for Child Survival in Niger: Programmatic Trial (AVENIR) Phase 4 Terminated 2022-12-01 169707 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05288023 NCT07485283 Recombinant Herpes Zoster Vaccine for Prevention of Cardiovascular Events and Dementia Cardiovascular Diseases; Dementia; Herpes Zoster Phase 4 Active not recruiting 2026-04-28 168460 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07485283 NCT02079701 Effectiveness of the Pneumococcal Polysaccharide Vaccine in Military Recruits Pneumonia Phase 4 Completed 2000-10 152723 Actual U.S. federal https://clinicaltrials.gov/study/NCT02079701 NCT07314307 Vaccine Effectiveness of One Dose of the Nonavalent Human Papillomavirus (HPV) Vaccine Among Young-adult Women in Sweden Among Women Participating in a Clinical Trial of Concomitant HPV Vaccination and Screening Phase 4 Active not recruiting 2021-05-03 150000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07314307 NCT04910802 Concomitant HPV Vaccination and HPV Screening HPV Infection and Cervical Cancer in Sweden Papillomavirus Infections; Uterine Cervical Neoplasms Phase 4 Recruiting 2021-05-03 150000 Estimated Other government https://clinicaltrials.gov/study/NCT04910802 NCT04424511 Effects of Mass Drug Administration of Azithromycin on Mortality and Other Outcomes Among 1-11 Month Old Infants in Mali Inflammation; Infections Phase 3 Completed 2020-10-15 149201 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04424511 NCT03662022 Post ExpOsure Prophylaxis for LEprosy in the Comoros and Madagascar Leprosy Phase 3 Completed 2019-01-02 144000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03662022 NCT06141655 HD vs SD Quadrivalent Influenza Vaccine in Adults Aged 65 to 79 Years in Galicia Influenza, Human Phase 4 Completed 2023-10-26 134476 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06141655 NCT04911790 Safety of an Inactivated SARS-CoV-2 Vaccine for Prevention of COVID-19 in Adults COVID-19 Phase 4 Completed 2021-06-05 131650 Actual Industry https://clinicaltrials.gov/study/NCT04911790 NCT06719193 DeMONSTRATE-TB Study in Ethiopia Phase 2, Phase 3 Recruiting 2023-02-27 131438 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06719193 NCT05597280 Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy Leprosy Phase 3 Recruiting 2023-03-22 124000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05597280 NCT01014845 Clinical Trial of Recombinant Hepatitis E Vaccine Hepatitis E Phase 3 Completed 2007-08 112604 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01014845 NCT03233191 Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer Phase 3 Active not recruiting 2017-09-28 108508 Estimated Network https://clinicaltrials.gov/study/NCT03233191 NCT00131820 Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central Vietnam Typhoid Fever; Paratyphoid Fever Phase 4 Completed 2001-12 100742 University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00131820 NCT00211341 Trial of the Impact of Vitamin A on Maternal Mortality Vitamin A Deficiency; Maternal Death Phase 3 Completed 2000-12 100000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00211341 NCT06536855 Faster Elimination of HPV Infection and Cervical Cancer Using Concomitant HPV Vaccination and HPV Screening: A Demonstration Project in Rwanda Uterine Cervical Neoplasms Phase 4 Unknown 2024-09-01 100000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06536855 NCT05890521 Safety Study of COVID19 Vaccine on the Market COVID-19 Phase 4 Unknown 2022-04-02 100000 Estimated Industry https://clinicaltrials.gov/study/NCT05890521 NCT04353180 Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized) COVID-19 Phase 3 Unknown 2021-08 100000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04353180 NCT00712374 Evaluation of the Public Health Impact of Seasonal Intermittent Preventive Treatment (IPT) in Children in Senegal Malaria Phase 4 Unknown 2008-09 100000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00712374 NCT03909737 Oral Azithromycin to Prevent Stillbirths and Infant Mortality in Mali Stillbirth; Infant Death Phase 4 Active not recruiting 2020-09-24 99700 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03909737 NCT00131833 Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, China Typhoid Fever; Paratyphoid Fever Phase 4 Completed 2001-10 96468 University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00131833 NCT00883792 The Northern-European Initiative on Colorectal Cancer Colorectal Neoplasms Phase 3 Active not recruiting 2009-05 95000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00883792 NCT02590315 Tomosynthesis Versus Digital Mammography in a Population-based Screening Program Breast Neoplasms Phase 4 Unknown 2014-12 92000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02590315 NCT01528449 Babesia Testing in Blood Donors Phase 3 Completed 2011-12 90116 Actual Industry https://clinicaltrials.gov/study/NCT01528449 NCT02987270 Evaluation of Community-based Mass Screening and Treatment for Malaria in Western Kenya Malaria, Falciparum; Malaria; Asymptomatic Infections Phase 3 Completed 2013-04 90000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02987270 NCT00744263 Study Evaluating the Effiacy of a 13-Valent Pneumococcal Conjugate Vaccine (13vPnC) in Adults Pneumonia, Pneumococcal; Pneumococcal Infections Phase 4 Completed 2008-09 84496 Actual Industry https://clinicaltrials.gov/study/NCT00744263 NCT00222664 Qidong Hepatitis B Intervention Study Hepatitis B; Liver Neoplasms; Liver Diseases Phase 4 Completed 1983-09 80000 University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00222664 NCT07177352 Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies Alzheimer Disease; Cognitive Dysfunction Phase 3 Recruiting 2025-07-02 80000 Estimated Industry https://clinicaltrials.gov/study/NCT07177352 NCT03923699 Telemedicine Control Tower for the Operating Room: Navigating Information, Care and Safety Postoperative Complications Phase 3 Completed 2019-07-01 79560 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03923699 NCT03676764 Community Health Azithromycin Trial in Burkina Faso Phase 4 Completed 2019-08-01 77664 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03676764 NCT01241318 Zambia Chlorhexidine Application Trial Sepsis Phase 2, Phase 3 Completed 2011-02 77535 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01241318 NCT04914832 Effectiveness of Covid-19 Vaccination in Eswatini Against SARS-CoV-2 Associated Hospitalization and Death COVID-19; Pneumonia, Viral; Pneumonia Phase 4 Completed 2021-08-30 75012 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04914832 NCT00244777 Introduction of Hypo-osmolar ORS for Routine Use Diarrhea; Seizures; Hyponatremia Phase 4 Completed 2002-12 75000 University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00244777 NCT07436104 Mortality Control Program for Economically Productive Age Group in Tribal Area of Melghat. Hypertension; Diarrhea; Pneumonia Phase 4 Completed 2004-01-01 72564 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07436104 NCT05500482 Vellore Typhoid Vaccine Impact Trial Typhoid Fever Phase 4 Completed 2023-05-01 72400 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05500482 NCT02048007 Mortality Reduction After Oral Azithromycin: Morbidity Study Infections; Bacterial Infections; Trachoma Phase 4 Completed 2014-11 72000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02048007 NCT06270355 Stockholm Mammography Risk Stratified Trial Breast Neoplasms Phase 3 Not yet recruiting 2024-04-08 70000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06270355 NCT04381936 Randomised Evaluation of COVID-19 Therapy Pneumonia; COVID-19; Community-Acquired Pneumonia Phase 3 Recruiting 2020-03-19 70000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04381936 NCT07038837 Comparison of Two Strategies for Administering the R21-Matrix M Vaccine in a Context of Seasonal Malaria Transmission in Chad Malaria Phase 4 Recruiting 2025-06-16 70000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07038837 NCT00289224 Randomized Controlled Trial of Killed Oral Cholera Vaccine in Kolkata Diarrhea; Cholera; Vibrio Infections Phase 3 Completed 2006-07 69329 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00289224 NCT00090233 Rotavirus Efficacy and Safety Trial (REST)(V260-006) Rotavirus Infections Phase 3 Completed 2001-01 69274 Actual Industry https://clinicaltrials.gov/study/NCT00090233 NCT03338244 Mortality Reduction After Oral Azithromycin Contingency: Mortality Study Infections Phase 4 Completed 2017-10-20 66228 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03338244 NCT02106221 Transforming Outcomes for Patients Through Medical Home Evaluation & reDesign Phase 3 Completed 2011-07 65500 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02106221 NCT06020560 Study of Low Molecular Weight Heparins Venous Thromboembolism Phase 4 Unknown 2023-03-23 65000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06020560 NCT00140673 A Study to Test 2 Doses of the HRV Vaccine in Healthy Infants. Rotavirus Infections Phase 3 Completed 2003-08-05 63227 Actual Industry https://clinicaltrials.gov/study/NCT00140673 NCT01890603 Enhancing Complex Care Through an Integrated Care Coordination Information System Phase 3 Completed 2008-09 60000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01890603 NCT03244072 Safety and Efficacy of Intracameral Zimoxin for Prevention of Endophthalmitis After Cataract Surgery Endophthalmitis Phase 2, Phase 3 Not yet recruiting 2027-06-01 60000 Estimated Industry https://clinicaltrials.gov/study/NCT03244072 NCT01908114 To Develop, Implement and Evaluate the Polio Demonstration Project Comprising of a Community Based Intervention Package for Polio Eradication in Pakistan Poliomyelitis Phase 4 Unknown 2013-07 60000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01908114 NCT00785525 Filgrastim-Mobilized Stem Cells for Transplantation Using Unrelated Donors Phase 3 Recruiting 1997-02 60000 Estimated Network https://clinicaltrials.gov/study/NCT00785525 NCT00198822 Impact of Maternal Vitamin A or Beta-Carotene Supplementation on Maternal and Infant Mortality in Bangladesh Vitamin A Deficiency; Maternal Death; Infant Death Phase 3 Completed 2001-08 59666 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00198822 NCT03871491 Azithromycin-Prevention in Labor Use Study (A-PLUS) Maternal Death; Neonatal Sepsis; Perinatal Death Phase 3 Completed 2020-09-01 58747 Actual Network https://clinicaltrials.gov/study/NCT03871491 NCT00109551 Community Trial of Zinc Supplementation on Preschool Child Mortality and Morbidity in Southern Nepal Phase 3 Completed 2001-10 58000 NIH https://clinicaltrials.gov/study/NCT00109551 NCT03490123 Evaluation of an Intensive 3-round MDA Strategy Towards Yaws Eradication Yaws Phase 4 Completed 2018-04-16 56000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03490123 NCT04941300 ColoRectal Cancer Screening for Southern California Community Health Centers Colorectal Neoplasms Phase 3 Completed 2021-06-08 55999 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04941300 NCT00581711 Improving Otitis Media Care With Clinical Decision Support Otitis Media Phase 3 Completed 2007-12 55779 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00581711 NCT06976723 Nerivio Efficacy by Time of Treatment Onset Migraine Disorders Phase 4 Completed 2025-05-07 55261 Actual Industry https://clinicaltrials.gov/study/NCT06976723 NCT02251704 Epidemiology Study of Malaria Transmission Intensity in Sub-Saharan Africa Malaria; Malaria, Falciparum Phase 4 Completed 2014-10-22 54115 Actual Industry https://clinicaltrials.gov/study/NCT02251704 NCT07805707 A Study on the Efficacy of a Vaccine Against Influenza in Adults ≥65 Years of Age Influenza, Human Phase 3 Recruiting 2026-09-02 54000 Estimated Industry https://clinicaltrials.gov/study/NCT07805707 NCT00047385 National Lung Screening Trial (NLST) Screening Lung Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Non-Small-Cell Lung Phase 3 Completed 2002-08 53454 Actual NIH https://clinicaltrials.gov/study/NCT00047385 NCT07145736 Moxidectin Versus Ivermectin as Mass Drug Administration for the Control of Onchocerciasis and Other Neglected Tropical Diseases Onchocerciasis; Trichuriasis; Hookworm Infections Phase 4 Recruiting 2025-08-04 52000 Estimated Other government https://clinicaltrials.gov/study/NCT07145736 NCT02823821 Randomised Evaluation of Sodium Dialysate Levels on Vascular Events Kidney Failure, Chronic Phase 4 Recruiting 2016-06 50000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02823821 NCT01830283 The Safety, Immunogenicity and Immune Effect Research of the Varicella Vaccine After the 2nd Dose Vaccination Chickenpox Phase 4 Unknown 2013-04 50000 Estimated Other government https://clinicaltrials.gov/study/NCT01830283 NCT00118443 Evaluation of a School-Based Training Program for Suicide Prevention Suicide; Suicide Prevention; Depression Phase 2, Phase 3 Completed 2004-03 50000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00118443 NCT00344513 Organized Program To Initiate Lifesaving Treatment In Hospitalized Patients With Heart Failure (OPTIMIZE-HF) Heart Failure Phase 4 Completed 2002-12-16 50000 Industry https://clinicaltrials.gov/study/NCT00344513 NCT04220515 Inactivated Poliomyelitis Vaccine Made From Sabin Strain Poliomyelitis Phase 4 Completed 2018-02-08 49731 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04220515 NCT04966702 Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA) Malaria Phase 3 Completed 2022-03-17 48145 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04966702 NCT05119426 Effectiveness of a Typhoid Conjugate Vaccine in DRC Typhoid Fever Phase 4 Unknown 2022-02-11 48000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05119426 NCT02754583 Sanitation, Water, and Instruction in Face-washing for Trachoma I/II Trachoma Phase 3 Completed 2015-12-05 47605 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02754583 NCT04609423 Cod Liver Oil for Covid-19 Prevention Study COVID-19; Respiratory Tract Infections Phase 4 Completed 2020-11-10 47210 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04609423 NCT04368728 Study to Describe the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Individuals COVID-19; Coronavirus Infections Phase 2, Phase 3 Completed 2020-04-29 46969 Actual Industry https://clinicaltrials.gov/study/NCT04368728 NCT00222573 Efficacy and Safety of Adding Clopidogrel to Aspirin or Use of Metoprolol in Myocardial Infarction Myocardial Infarction Phase 4 Completed 1999-07 46000 University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00222573 NCT05540522 A Study to Evaluate a Modified RNA Vaccine Against Influenza in Adults 18 Years of Age or Older Influenza, Human Phase 3 Completed 2022-09-12 45789 Actual Industry https://clinicaltrials.gov/study/NCT05540522 NCT05470855 Protective Effect, Safety and Immunogenicity of Live Attenuated Varicella Vaccine in Anhui Province Chickenpox Phase 4 Unknown 2022-07-06 45400 Estimated Industry https://clinicaltrials.gov/study/NCT05470855 NCT05175014 Mass Campaigns With Fractional Dose Pneumococcal Vaccines in Sub-Saharan Africa (fPCV) Phase 4 Completed 2021-12-30 44618 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05175014 NCT00860470 Antenatal Micronutrient Supplementation and Infant Survival Infant Death; Premature Birth; Perinatal Death Phase 3 Completed 2008-01 44567 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00860470 NCT04505722 A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants Phase 3 Completed 2020-09-07 44325 Actual Industry https://clinicaltrials.gov/study/NCT04505722 NCT04526990 Phase III Trial of A COVID-19 Vaccine of Adenovirus Vector in Adults 18 Years Old and Above COVID-19; Alzheimer Disease 5 Phase 3 Completed 2020-09-15 44247 Actual Industry https://clinicaltrials.gov/study/NCT04526990 NCT04510207 A Study to Evaluate The Efficacy, Safety and Immunogenicity of Inactivated SARS-CoV-2 Vaccines (Vero Cell) in Healthy Population Aged 18 Years Old and Above COVID-19; Coronavirus Infections Phase 3 Completed 2020-07-16 44101 Actual Industry https://clinicaltrials.gov/study/NCT04510207 NCT00753272 Trial to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine GSK2186877A in Adults 65 Year of Age and Older Influenza, Human Phase 3 Completed 2008-09-15 43695 Actual Industry https://clinicaltrials.gov/study/NCT00753272 NCT04512950 Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients Hypovolemia Phase 4 Completed 2016-08-15 43626 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04512950 NCT06856772 Randomized Comparison of Morning Versus Bedtime Administration of Statins: A Cardiovascular Circadian Chronotherapy (C3) Trial Cardiovascular Diseases Phase 4 Not yet recruiting 2025-02-28 42000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06856772 NCT00861380 Evaluation of Effectiveness of GSK Biologicals' Pneumococcal Conjugate Vaccine 1024850A Against Invasive Disease Streptococcal Infections; Respiratory Tract Infections; Haemophilus Infections Phase 3 Completed 2009-05-04 41188 Actual Industry https://clinicaltrials.gov/study/NCT00861380 NCT07279766 Effectiveness of mRNA-1273 Variant-Containing Vaccine Formulation Against Severe Outcomes in Adults Aged 50-64 Years Without Risk Factors for Severe COVID-19 COVID-19; Respiratory Tract Diseases Phase 4 Completed 2025-12-11 41060 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07279766 NCT06602024 A Study of mRNA-1010 Compared With a Licensed Influenza Vaccine in Adults ≥50 Years of Age Influenza, Human Phase 3 Completed 2024-09-16 40805 Actual Industry https://clinicaltrials.gov/study/NCT06602024 NCT03001986 The Phase IVb of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Children Hand, Foot and Mouth Disease Phase 4 Completed 2016-09 40724 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03001986 NCT06788522 The Effects of Orexin Antagonism on Fear Extinction in PTSD Sleep Initiation and Maintenance Disorders; Stress Disorders, Post-Traumatic Phase 4 Not yet recruiting 2026-06-01 40120 Estimated U.S. federal https://clinicaltrials.gov/study/NCT06788522 NCT00097097 Neonatal Resuscitation in Zambia Asphyxia Neonatorum; Hypoxia-Ischemia, Brain; Asphyxia Phase 3 Completed 2004-10 40000 Network https://clinicaltrials.gov/study/NCT00097097 NCT00662480 Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark Aortic Aneurysm, Abdominal; Peripheral Arterial Disease; Hypertension Phase 4 Unknown 2008-09 40000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00662480 NCT03582761 Efficacy Evaluation for Inactivated Vaccine (Vero Cell) Against EV71 Hand, Foot and Mouth Disease Phase 4 Completed 2019-05-01 40000 Actual Network https://clinicaltrials.gov/study/NCT03582761 NCT06860178 Integrating Malaria Vaccine With Seasonal Malaria Chemoprevention in West Africa Malaria Phase 4 Recruiting 2025-06-10 40000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06860178 NCT03783299 Targeted Active Case Detection Among High Risk Populations in Southern Lao Peoples Democratic Republic Malaria, Falciparum Phase 4 Completed 2017-11-28 39968 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03783299 NCT00000479 Women's Health Study (WHS): A Randomized Trial of Low-dose Aspirin and Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer Cardiovascular Diseases; Cerebrovascular Disorders; Coronary Disease Phase 3 Completed 1992-09 39876 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00000479 NCT04652102 A Phase 2b/3, Randomized, Observer-Blinded, Placebo-Controlled, Multicenter Clinical Study Evaluating the Efficacy and Safety of Investigational SARS-CoV-2 mRNA Vaccine CVnCoV in Adults 18 Years of Age and Older COVID-19 Phase 2, Phase 3 Completed 2020-12-11 39680 Actual Industry https://clinicaltrials.gov/study/NCT04652102 NCT04904471 A Global Phase III Clinical Trial of Recombinant COVID- 19 Vaccine (Sf9 Cells) COVID-19 Phase 3 Completed 2021-06-15 39663 Actual Industry https://clinicaltrials.gov/study/NCT04904471 NCT04505098 A Pragmatic Randomized Trial of Icosapent Ethyl for High-Cardiovascular Risk Adults COVID-19; Atherosclerosis; Cardiovascular Diseases Phase 4 Terminated 2020-08-07 39600 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04505098 NCT05035212 Study to Evaluate the Efficacy, Immunogenicity, and Safety of RSVpreF in Adults. Phase 3 Active not recruiting 2021-08-31 38861 Actual Industry https://clinicaltrials.gov/study/NCT05035212 NCT06087640 A Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of an Adjuvanted Influenza Vaccine Compared to a Non-adjuvanted Influenza Vaccine in Adults ≥65 Years of Age Influenza, Human Phase 3 Completed 2023-10-23 38769 Actual Industry https://clinicaltrials.gov/study/NCT06087640 NCT00007501 Shingles Prevention Study Herpes Zoster; Neuralgia, Postherpetic Phase 3 Completed 1998-11 38456 Actual U.S. federal https://clinicaltrials.gov/study/NCT00007501 NCT06567808 Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial Surgical Wound Infection Phase 4 Not yet recruiting 2026-03-01 38000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06567808 NCT05460429 Immunogenicity, Safety and Protective Effect of Live Attenuated Varicella Vaccine and Study on Antibody Level and Etiology of Varicella Zoster Virus Chickenpox Phase 4 Unknown 2022-07-30 37920 Estimated Industry https://clinicaltrials.gov/study/NCT05460429 NCT06592794 A Study to Investigate the Safety and Efficacy of mRNA-1403 in Participants ≥18 Years of Age for the Prevention of Acute Gastroenteritis Phase 3 Active not recruiting 2024-09-24 37864 Actual Industry https://clinicaltrials.gov/study/NCT06592794 NCT00125008 Evaluation of the Vi Polysaccharide Vaccine Against Typhoid Fever Typhoid Fever; Paratyphoid Fever Phase 4 Completed 2003-05 37673 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00125008 NCT01528852 Chlorhexidine Cordcare for Reduction in Neonatal Mortality and Omphalitis Phase 3 Completed 2011-05-19 36911 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01528852 NCT05127434 A Study to Evaluate the Safety and Efficacy of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus (RSV) in Adults ≥60 Years of Age Virus Diseases Phase 2, Phase 3 Completed 2021-11-17 36814 Actual Industry https://clinicaltrials.gov/study/NCT05127434 NCT00006392 S0000 Selenium and Vitamin E in Preventing Prostate Cancer Prostatic Neoplasms Phase 3 Completed 2001-07 35533 Actual Network https://clinicaltrials.gov/study/NCT00006392 NCT01949857 The Immunogenicity and Safety of Inactivated and Live Attenuated Hepatitis A Vaccines Hepatitis A Phase 4 Completed 2013-09 35000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01949857 NCT01363765 Xpert MTB/Rif, a New Tool for the Diagnosis of Pulmonary Tuberculosis in Two Municipalities in Brazil Tuberculosis; Disease Phase 4 Completed 2012-02 34758 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01363765 NCT05634759 Enhancing the A in SAFE for Trachoma Trachoma Phase 4 Completed 2022-05-04 34630 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05634759 NCT03089086 South Australian Meningococcal B Vaccine Herd Immunity Study Meningococcal Infections Phase 4 Completed 2017-04-01 34489 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03089086 NCT00534638 Effectiveness, Safety and Immunogenicity of GSK Biologicals' HPV Vaccine GSK580299 (Cervarix) Administered in Healthy Adolescents Papillomavirus Infections; Uterine Cervical Neoplasms Phase 4 Completed 2007-10-04 34412 Actual Industry https://clinicaltrials.gov/study/NCT00534638 NCT04659239 The Efficacy, Safety and Immunogenicity Study of Inactivated SARS-CoV-2 Vaccine for Preventing Against COVID-19 COVID-19 Phase 3 Unknown 2021-01-28 34020 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04659239 NCT05682638 A Global Multi-center Clinical Study of SARS-CoV-2 mRNA Vaccine for the Prevention of COVID-19 Phase 3 Unknown 2023-01-30 34000 Estimated Industry https://clinicaltrials.gov/study/NCT05682638 NCT04530396 Clinical Trial of Efficacy, Safety, and Immunogenicity of Gam-COVID-Vac Vaccine Against COVID-19 COVID-19 Phase 3 Unknown 2020-09-07 33758 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04530396 NCT07502560 A Study to Evaluate the Effect of Recombinant Zoster Vaccine on New Diagnosis of Dementia in an Older Adult Population Aged 76 Years or Older in Finland Herpes Zoster; Alzheimer Disease Phase 4 Recruiting 2026-03-31 33609 Estimated Industry https://clinicaltrials.gov/study/NCT07502560 NCT01665690 Washington State Community Expedited Partner Treatment (EPT) Trial Gonorrhea; Chlamydia Infections Phase 4 Completed 2007-07 33222 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01665690 NCT04137887 Study to Evaluate the Effectiveness of a High-Dose Quadrivalent Influenza Vaccine (QIV-HD) Compared to a Standard-Dose Quadrivalent Influenza Vaccine (QIV-SD) in Adults 65 Years of Age and Older Influenza, Human Phase 3 Terminated 2019-11-04 33096 Actual Industry https://clinicaltrials.gov/study/NCT04137887 NCT00322972 Trachoma Amelioration in Northern Amhara (TANA) Trachoma; Chlamydia Infections; Bacterial Infections Phase 4 Completed 2006-06 33000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00322972 NCT01119482 Study on the Impact of Vaccination With a Conjugate Vaccine on Meningococcal Carriage Meningitis Phase 4 Completed 2010-05 33000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01119482 NCT04611802 A Study to Evaluate the Efficacy, Immune Response, and Safety of a COVID-19 Vaccine in Adults ≥ 18 Years With a Pediatric Expansion in Adolescents (12 to<18 Years) at Risk for SARS-CoV-2 Severe Acute Respiratory Syndrome; COVID-19; Coronavirus Infections Phase 3 Completed 2020-12-27 33000 Actual Industry https://clinicaltrials.gov/study/NCT04611802 NCT05932472 Randomized Comparison of Morning Versus Bedtime Administration of Aspirin: A Cardiovascular Circadian Chronotherapy (C3) Trial Atherosclerosis; Cardiovascular Diseases Phase 4 Recruiting 2024-01-15 32706 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05932472 NCT07886281 Humanitarian Evaluation of Spatial Emanators for Malaria Control Malaria Phase 4 Not yet recruiting 2026-10-26 32584 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07886281 NCT07282665 A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older Phase 3 Recruiting 2025-12-10 32500 Estimated Industry https://clinicaltrials.gov/study/NCT07282665 NCT04516746 Phase III Double-blind, Placebo-controlled Study of AZD1222 for the Prevention of COVID-19 in Adults COVID-19 Phase 3 Completed 2020-08-28 32450 Actual Industry https://clinicaltrials.gov/study/NCT04516746 NCT04974138 China Stroke Primary Prevention Trial 2 for Participants With H-type Hypertension and MTHFR 677 CC/CT Genotype (CSPPT2-CC/CT) Hypertension; Ischemic Stroke Phase 4 Recruiting 2024-08-22 32000 Estimated Industry https://clinicaltrials.gov/study/NCT04974138 NCT01427309 A Study of Fluzone® High-Dose Vaccine Compared With Fluzone® Vaccine In Elderly Adults Influenza, Human Phase 4 Completed 2011-09 31989 Actual Industry https://clinicaltrials.gov/study/NCT01427309 NCT04614948 A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-mediated COVID-19 in Adults Phase 3 Completed 2020-11-12 31835 Actual Industry https://clinicaltrials.gov/study/NCT04614948 NCT00153101 Effectiveness and Safety of Ramipril Alone Compared With Telmisartan Alone and in Combination With Ramipril in Patients at High Risk for Cardiovascular Events. Patients Intolerant to Ramipril Were Entered in TRANSCEND, Telmisartan Compared to Placebo. Cardiovascular Diseases Phase 4 Completed 2001-11 31546 Actual Industry https://clinicaltrials.gov/study/NCT00153101 NCT04672395 A Controlled Phase 2/3 Study of Adjuvanted Recombinant SARS-CoV-2 Trimeric S-protein Vaccine (SCB-2019) for the Prevention of COVID-19 COVID-19 Phase 2, Phase 3 Completed 2021-03-24 31454 Actual Industry https://clinicaltrials.gov/study/NCT04672395 NCT04992208 Safety of an Inactivated SARS-CoV-2 Vaccine for Prevention of COVID-19 in Children and Adolescents COVID-19 Phase 4 Completed 2021-07-24 31041 Actual Industry https://clinicaltrials.gov/study/NCT04992208 NCT04636697 Study of a Recombinant Coronavirus-Like Particle COVID-19 Vaccine in Adults COVID-19 Phase 2, Phase 3 Active not recruiting 2020-11-19 30918 Estimated Industry https://clinicaltrials.gov/study/NCT04636697 NCT00663598 Levitra® - Real Life Safety and Efficacy of Levitra Erectile Dysfunction Phase 4 Completed 2003-10 30825 Actual Industry https://clinicaltrials.gov/study/NCT00663598 NCT01252953 REVEAL: Randomized EValuation of the Effects of Anacetrapib Through Lipid-modification Atherosclerosis; Vascular Diseases; Inhibition, Psychological Phase 3 Active not recruiting 2011-06 30449 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01252953 NCT04470427 A Study to Evaluate Efficacy, Safety, and Immunogenicity of mRNA-1273 Vaccine in Adults Aged 18 Years and Older to Prevent COVID-19 Coronavirus Infections; Virus Diseases; COVID-19 Phase 3 Completed 2020-07-27 30415 Actual Industry https://clinicaltrials.gov/study/NCT04470427 NCT01506986 Helicobacter Eradication Aspirin Trial Phase 4 Completed 2012-03 30024 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01506986 NCT02047994 Multicentric Randomized Study of H. Pylori Eradication and Pepsinogen Testing for Prevention of Gastric Cancer Mortality Gastritis, Atrophic; Stomach Neoplasms Phase 4 Recruiting 2013-03 30000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02047994 NCT07266558 A Study to Evaluate the Efficacy and Safety of mRNA-1283 and mRNA-1273 in Participants 50 to 64 Years of Age Without High-Risk Conditions for Severe Coronavirus Disease 2019 (COVID-19) Coronavirus Infections; COVID-19 Phase 4 Active not recruiting 2025-11-26 30000 Actual Industry https://clinicaltrials.gov/study/NCT07266558 NCT04035837 The Clinical Cure Project of Chronic Hepatitis B in China Hepatitis B, Chronic Phase 4 Active not recruiting 2018-05-16 30000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04035837 NCT03314103 Efficacy Trial of a Vaccine to Prevent Herpes Zoster in Adults Over 40 Years of Age Herpes Zoster Phase 3 Completed 2017-10-06 30000 Actual Network https://clinicaltrials.gov/study/NCT03314103 NCT06306300 Safety and Efficacy of Decentralized HCV Treatment vs Standard-of-Care in Rio de Janeiro (Brazil) Hepatitis C Phase 4 Recruiting 2022-07-04 30000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06306300 NCT05562609 Tranexamic Acid to Prevent Heavy Bleeding After Childbirth in Women At Higher Risk Postpartum Hemorrhage; Hemorrhage Phase 3 Recruiting 2024-04-22 30000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05562609 NCT03299426 Clinical Efficacy of Typhoid Conjugate Vaccine (Vi-TCV) Among Children Age 9 Months Through 12 Years in Blantyre, Malawi Typhoid Fever Phase 3 Active not recruiting 2018-02-21 30000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03299426 NCT05059106 EFFECTIVENESS, SAFETY AND IMMUNOGENICITY OF THE HALF DOSE OF THE VACCINE ChadOx1 nCoV-19 (AZD1222) for COVID-19 COVID-19 Phase 2, Phase 3 Unknown 2021-06-01 29637 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05059106 NCT01177111 Impact of Sunflower Seed Oil Massage on Neonatal Mortality and Morbidity in Nepal Neonatal Sepsis Phase 3 Completed 2010-11-01 29260 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01177111 NCT00138294 Control of Epidemic Influenza Through a School-based Influenza Vaccination Program Influenza, Human Phase 4 Completed 1998-10 29255 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00138294 NCT01202331 Tripartite International Research for the Elimination of Trachoma Trachoma; Chlamydia Infections; Bacterial Infections Phase 4 Completed 2010-11 29000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01202331 NCT05407142 An Open Comprative Study of the Prophylactic Efficacy and a Non-comparative Study of the Immunogenicity and Safety of the Inactivated Whole-virion Concentrated Purified Coronavirus Vaccine (CoviVac) Coronavirus Infections; COVID-19 Phase 3 Unknown 2021-07-07 29000 Estimated Other government https://clinicaltrials.gov/study/NCT05407142 NCT04646590 A Phase III Clinical Trial to Determine the Safety and Efficacy of ZF2001 for Prevention of COVID-19 Phase 3 Unknown 2020-12-16 28904 Actual Industry https://clinicaltrials.gov/study/NCT04646590 NCT00434408 Impact of Umbilical Cord Cleansing With 4.0% Chlorhexidine on Neonatal Mortality Infections; Infant Death Phase 3 Completed 2007-05 28797 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00434408 NCT01453621 Traumatic Brain Injury - Knowledge Translation Brain Injuries, Traumatic Phase 3 Completed 2011-11 28669 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01453621 NCT03460002 Vaccine Campaign Effects on General Hospital Admissions and Mortality Among Children Phase 4 Completed 2016-11 28612 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03460002 NCT01713517 Impact of Insecticide Resistance on Vector Control Malaria, Falciparum Phase 4 Unknown 2011-04 28000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01713517 NCT04847102 A Phase III Clinical Study of a SARS-CoV-2 Messenger Ribonucleic Acid (mRNA) Vaccine Candidate Against COVID-19 in Population Aged 18 Years and Above COVID-19 Phase 3 Unknown 2021-07-22 28000 Estimated Industry https://clinicaltrials.gov/study/NCT04847102 NCT04852705 A Study to Evaluate the Efficacy, Safety and Immunogenicity of SARS-CoV-2 Vaccine (Vero Cells), Inactivated in Healthy Adults Aged 18 Years and Older (COVID-19) COVID-19 Phase 3 Unknown 2021-05 28000 Estimated Industry https://clinicaltrials.gov/study/NCT04852705 NCT00490932 New Hypo-Osmolar ORS (Recommended by WHO) for Routine Use in the Diarrhea Management- Surveillance Study for Adverse Effects Diarrhea; Dysentery Phase 4 Completed 2005-03 27966 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00490932 NCT03180034 Comparing One or Two Doses of the Human Papillomavirus Vaccine for the Prevention of Human Papillomavirus Infection, ESCUDDO Study Papillomavirus Infections Phase 4 Active not recruiting 2017-11-29 27945 Actual NIH https://clinicaltrials.gov/study/NCT03180034 NCT04747821 An Effectiveness Study of the Sinovac's Adsorbed COVID-19 (Inactivated) Vaccine COVID-19 Phase 4 Completed 2021-02-07 27711 Actual Other government https://clinicaltrials.gov/study/NCT04747821 NCT01764633 Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk Dyslipidemias; Hypercholesterolemia Phase 3 Completed 2013-02-08 27564 Actual Industry https://clinicaltrials.gov/study/NCT01764633 NCT01776424 Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease Coronary Artery Disease; Peripheral Arterial Disease; Stroke Phase 3 Completed 2013-02-28 27395 Actual Industry https://clinicaltrials.gov/study/NCT01776424 NCT00125047 Combined Vi Vaccination and Health Education Program on the Burden of Typhoid in Childhood Typhoid Fever; Paratyphoid Fever; Salmonella Infections Phase 4 Completed 2001-10 27231 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00125047 NCT04886596 Efficacy Study of GSK's Investigational Respiratory Syncytial Virus (RSV) Vaccine in Adults Aged 60 Years and Above Respiratory Syncytial Virus Infections Phase 3 Completed 2021-05-25 26675 Actual Industry https://clinicaltrials.gov/study/NCT04886596 NCT00526474 Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Patients With Atherosclerosis (TRA 2°P - TIMI 50) (P04737) Atherosclerosis; Ischemia; Myocardial Infarction Phase 3 Completed 2007-09-01 26449 Actual Industry https://clinicaltrials.gov/study/NCT00526474 NCT01169259 Vitamin D and Omega-3 Trial (VITAL) Neoplasms; Cardiovascular Diseases Phase 3 Active not recruiting 2010-07 25871 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01169259 NCT02271230 Intervention With Vitamin D and Omega-3 Supplements and Incident Heart Failure Heart Failure Phase 3 Completed 2014-08 25871 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02271230 NCT04641481 An Efficacy and Safety Clinical Trial of an Investigational COVID-19 Vaccine (BBV152) in Adult Volunteers COVID-19; Severe Acute Respiratory Syndrome Phase 3 Unknown 2020-11-16 25800 Actual Industry https://clinicaltrials.gov/study/NCT04641481 NCT00977938 The Dual Antiplatelet Therapy Study (DAPT Study) Coronary Artery Disease; Acute Coronary Syndrome; Myocardial Infarction Phase 4 Completed 2009-10 25682 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00977938 NCT00461630 Treatment of HDL to Reduce the Incidence of Vascular Events HPS2-THRIVE Cardiovascular Diseases; Peripheral Arterial Disease; Diabetes Mellitus Phase 3 Completed 2007-01 25673 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00461630 NCT04666792 PrEParing Family Planning Clinics to Streamline Integration of HIV Prevention Services for Young Women in Kenya HIV Infections; Sexually Transmitted Diseases Phase 4 Completed 2021-03-01 25457 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04666792 NCT03287882 Effect of Micronutrients and Life Skills Education on the Health and Nutrition of Adolescent and Young Women in Pakistan Anemia; Empowerment Phase 3 Unknown 2017-06-30 25447 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03287882 NCT04908683 A Study of an Adenovirus Serotype 26 Pre-fusion Conformation-stabilized F Protein (Ad26. RSV. preF) Based Respiratory Syncytial Virus (RSV) Vaccine in the Prevention of Lower Respiratory Tract Disease in Adults Aged 60 Years and Older Phase 3 Completed 2021-07-21 25236 Actual Industry https://clinicaltrials.gov/study/NCT04908683 NCT02178410 VITAL Rhythm Study Cardiovascular Diseases; Atrial Fibrillation Phase 3 Active not recruiting 2012-10 25119 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02178410 NCT00335452 Clopidogrel Optimal Loading Dose Usage to Reduce Recurrent EveNTs/Optimal Antiplatelet Strategy for InterventionS Angina, Unstable Phase 3 Completed 2006-06 25086 Actual Industry https://clinicaltrials.gov/study/NCT00335452 NCT01024426 Impact of Enhanced Health Facility Care in Uganda Malaria Phase 4 Completed 2010-12 25000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01024426 NCT04334577 Study on Efficacy of Attenuated Zoster Vaccine, Live Herpes Zoster Phase 3 Completed 2020-04-20 25000 Actual Industry https://clinicaltrials.gov/study/NCT04334577 NCT07272434 Phase III Clinical Trial of the Recombinant Respiratory Syncytial Virus Vaccine ( CHO Cell) Phase 3 Recruiting 2025-10-22 25000 Estimated Industry https://clinicaltrials.gov/study/NCT07272434 NCT04957719 Selatogrel Outcome Study in Suspected Acute Myocardial Infarction Phase 3 Enrolling by invitation 2021-08-14 25000 Estimated Industry https://clinicaltrials.gov/study/NCT04957719 NCT07860216 Phase III Clinical Trial of Recombinant Respiratory Syncytial Virus Vaccine (CHO Cells) Phase 3 Recruiting 2026-08-21 25000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07860216 NCT06447779 Efficacy, Safety and Immunogenicity Study of Recombinant Zoster Vaccine(CHO Cell) in Adults Aged 40 Years and Older Herpes Zoster Phase 3 Active not recruiting 2024-07-13 25000 Estimated Industry https://clinicaltrials.gov/study/NCT06447779 NCT00686205 Evaluation of a Human Immunodeficiency Virus (HIV) Blood Screening Assay HIV Seropositivity Phase 3 Completed 2007-08 24111 Actual Industry https://clinicaltrials.gov/study/NCT00686205 NCT00346216 Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen Arthritis, Rheumatoid Phase 4 Completed 2006-10-04 24081 Actual Industry https://clinicaltrials.gov/study/NCT00346216 NCT04844905 Adjunctive Ivermectin Mass Drug Administration for Malaria Control Malaria, Falciparum; Neglected Diseases; Strongyloidiasis Phase 3 Unknown 2021-05-03 24000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04844905 NCT04974151 China Stroke Primary Prevention Trial 2 for Participants With Hypertension and MTHFR 677 TT Genotype Hypertension; Ischemic Stroke Phase 4 Recruiting 2024-08-22 24000 Estimated Industry https://clinicaltrials.gov/study/NCT04974151 NCT00466947 COMPAS (Clinical Otitis Media & Pneumonia Study): Pneumonia & Acute Otitis Media (AOM ) Efficacy Study of the Pneumococcal Conjugate Vaccine Streptococcal Infections; Otitis Media; Pneumonia Phase 3 Completed 2007-06-28 23802 Actual Industry https://clinicaltrials.gov/study/NCT00466947 NCT01372748 Continuous Chest Compressions vs AHA Standard CPR of 30:2 Out-of-Hospital Cardiac Arrest; Heart Arrest Phase 4 Completed 2011-06 23711 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01372748 NCT04904549 Study of Monovalent and Bivalent Recombinant Protein Vaccines Against COVID-19 in Adults 18 Years of Age and Older COVID-19 Phase 3 Terminated 2021-05-26 23670 Actual Industry https://clinicaltrials.gov/study/NCT04904549 NCT00250445 A Study to Evaluate the Safety of an Investigational Drug (Etoricoxib) in Patients With Osteoarthritis (OA) or Rheumatoid Arthritis (RA)(0663-066) Arthritis, Rheumatoid; Osteoarthritis Phase 3 Completed 2003-01 23498 Actual Industry https://clinicaltrials.gov/study/NCT00250445 NCT04852185 Evaluation of Typhoid Conjugate Vaccine Effectiveness in Ghana Typhoid Fever Phase 4 Unknown 2021-08-24 23000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04852185 NCT04658680 Can BCG Vaccination at First Health-facility Contact Reduce Early Infant Mortality? Infant Death Phase 4 Active not recruiting 2021-02-25 22800 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04658680 NCT00923702 Trial of Two Versus Three Doses of Human Papillomavirus (HPV) Vaccine in India Uterine Cervical Neoplasms Phase 4 Unknown 2009-09 22729 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00923702 NCT05566639 A Study of mRNA-1010 Seasonal Influenza Vaccine in Adults 50 Years Old and Older Influenza, Human Phase 3 Completed 2022-09-14 22502 Actual Industry https://clinicaltrials.gov/study/NCT05566639 NCT05096845 Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01) Phase III COVID-19 Phase 3 Unknown 2021-08-25 22500 Estimated Industry https://clinicaltrials.gov/study/NCT05096845 NCT00534248 Study to Evaluate the Safety and Effectiveness of Zostavax™ in Subjects 50 - 59 Years of Age (V211-022) Herpes Zoster Phase 3 Completed 2007-10 22439 Actual Industry https://clinicaltrials.gov/study/NCT00534248 NCT01697852 The Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) for Malaria Prevention Malaria Phase 4 Unknown 2011-01 22300 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01697852 NCT01633177 Study of Vitamin D and Omega-3 Supplementation for Preventing Diabetes Diabetes Mellitus, Type 2; Insulin Resistance Phase 3 Completed 2011-11 22220 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01633177 NCT02211729 A Trial of Seasonal Malaria Chemoprevention Plus Azithromycin in African Children Malaria; Respiratory Tract Infections Phase 3 Completed 2014-05 22090 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02211729 NCT03350516 Non-inferiority of Lower Dose Calcium Supplementation During Pregnancy Phase 3 Completed 2018-11-30 22000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03350516 NCT00133692 INVEST: INternational VErapamil SR Trandolapril STudy Hypertension; Coronary Artery Disease; Diabetes Mellitus Phase 4 Completed 1997-09 22000 University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00133692 NCT00741585 Prognostic Value of the Circadian Pattern of Ambulatory Blood Pressure for Multiple Risk Assessment Essential Hypertension; Cardiovascular Diseases; Stroke Phase 4 Completed 2008-09-01 21983 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00741585 NCT03682653 Neonates and Azithromycin, an Innovation in the Treatment of Children in Burkina Faso Phase 4 Completed 2019-04-11 21832 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03682653 NCT00070720 Improving Perinatal Care in Latin America Phase 4 Completed 2003-09 21780 Network https://clinicaltrials.gov/study/NCT00070720 NCT02397772 Impact of Alternative Treatment Strategies and Delivery Systems for Soil-transmitted Helminths in Kenya Helminthiasis; Nematode Infections; Communicable Diseases Phase 4 Completed 2015-03 21761 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02397772 NCT02422745 COcoa Supplement and Multivitamin Outcomes Study Cardiovascular Diseases; Neoplasms Phase 4 Completed 2015-06 21442 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02422745 NCT05510375 Cocoa Supplementation, Inflammaging, and Epigenetic Aging Inflammation; Cardiovascular Diseases Phase 4 Unknown 2015-06 21442 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05510375 NCT03205202 Cataract and AMD in a Trial of a Multivitamin and Cocoa Extract Cataract; Macular Degeneration Phase 4 Unknown 2015-06-01 21442 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03205202 NCT01225562 Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin Myocardial Infarction; Thrombosis; Stroke Phase 3 Completed 2010-10 21379 Actual Industry https://clinicaltrials.gov/study/NCT01225562 NCT05441267 A Study of Cardiovascular Events iN Diabetes Plus Diabetes Mellitus, Type 2 Phase 4 Active not recruiting 2023-03-13 21296 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05441267 NCT00781391 Global Study to Assess the Safety and Effectiveness of Edoxaban (DU-176b) vs Standard Practice of Dosing With Warfarin in Patients With Atrial Fibrillation Stroke; Atrial Fibrillation; Embolism Phase 3 Completed 2008-11 21105 Actual Industry https://clinicaltrials.gov/study/NCT00781391 NCT06126614 Infection Prophylaxis in Total Joint Replacement Phase 3 Recruiting 2024-05-07 21006 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06126614 NCT05156528 Efficacy, Immunogenicity and Safety of S. Flexneriza-S. Sonnei Bivalent Conjugate Vaccine in Volunteers Aged From 6 Months to 5 Years Dysentery; Dysentery, Bacillary Phase 3 Unknown 2021-12-11 21000 Estimated Industry https://clinicaltrials.gov/study/NCT05156528 NCT00412984 Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation Atrial Fibrillation; Atrial Flutter Phase 3 Completed 2006-12-31 20976 Actual Industry https://clinicaltrials.gov/study/NCT00412984 NCT02889497 Safety, Three Batches Consistency and Immunity Duration of the Post-marketing Inactivated Enterovirus Type 71 (EV71) Vaccine in Children Aged 6-71 Months Hand, Foot and Mouth Disease Phase 4 Unknown 2016-09 20900 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02889497 NCT01374516 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children and Adolescents Aged 9 to 16 Years in Latin America Dengue; Severe Dengue Phase 3 Completed 2011-06-08 20869 Actual Industry https://clinicaltrials.gov/study/NCT01374516 NCT02999828 The Phase IVa of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell, KMB-17) Phase 4 Unknown 2016-09 20770 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02999828 NCT02185417 Diuretic Comparison Project Hypertension Phase 3 Completed 2016-06-15 20723 Actual U.S. federal https://clinicaltrials.gov/study/NCT02185417 NCT00794885 China Stroke Primary Prevention Trial Essential Hypertension; Hypertension; Stroke Phase 4 Completed 2008-05 20702 Actual Industry https://clinicaltrials.gov/study/NCT00794885 NCT04235816 Improving Care Through Azithromycin Research for Infants in Africa Malaria Phase 3 Active not recruiting 2021-03-15 20560 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04235816 NCT00077792 Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment Thrombolysis in Myocardial Infarction - Study 25 (ExTRACT-TIMI25) Myocardial Infarction Phase 3 Completed 2002-10 20506 Actual Industry https://clinicaltrials.gov/study/NCT00077792 NCT04152486 Effectiveness and Safety of a Heterologous, Two-dose Ebola Vaccine in the DRC Hemorrhagic Fever, Ebola Phase 3 Unknown 2019-11-14 20426 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04152486 NCT05238025 MVA-BN-RSV Vaccine Trial Respiratory Syncytial Virus Infections Phase 3 Terminated 2022-04-19 20419 Actual Industry https://clinicaltrials.gov/study/NCT05238025 NCT02536222 Accelerating the Reduction of Malaria Transmission in Kanel, Ranérou and Linguère Districts Malaria Phase 4 Completed 2015-09 20379 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02536222 NCT00153062 PRoFESS - Prevention Regimen For Effectively Avoiding Second Strokes Stroke Phase 4 Completed 2003-08 20332 Actual Industry https://clinicaltrials.gov/study/NCT00153062 NCT05757869 A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation Atrial Fibrillation Phase 3 Active not recruiting 2023-04-11 20284 Actual Industry https://clinicaltrials.gov/study/NCT05757869 NCT00375258 Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage Hemorrhage Phase 3 Completed 2005-05 20211 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00375258 NCT02747927 Efficacy, Safety and Immunogenicity of Takeda's Tetravalent Dengue Vaccine (TDV) in Healthy Children Phase 3 Completed 2016-04-26 20099 Actual Industry https://clinicaltrials.gov/study/NCT02747927 NCT06062238 Study to Assess Efficacy and Safety of M72/AS01E-4 Mycobacterium Tuberculosis (Mtb) Vaccine in Adolescents and Adults Tuberculosis Phase 3 Active not recruiting 2024-03-05 20080 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06062238 NCT00139815 Michelangelo - Oasis 5 Thromboembolism; Angina, Unstable; Acute Coronary Syndrome Phase 3 Completed 2003-04 20078 Actual Industry https://clinicaltrials.gov/study/NCT00139815 NCT00872469 World Maternal Antifibrinolytic Trial Postpartum Hemorrhage Phase 3 Completed 2009-05 20060 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00872469 NCT02389036 Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients Critical Illness; Sepsis; Shock, Septic Phase 3 Completed 2017-05-01 20010 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02389036 NCT07784569 APEX-STROKE Adaptive Platform Trial for Stroke Stroke Phase 3 Not yet recruiting 2026-09-01 20000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07784569 NCT00000432 Lyme Disease Prevention Program Lyme Disease; Tick-Borne Diseases Phase 3 Completed 1997-04 20000 University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00000432 NCT02735707 Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia Community-Acquired Pneumonia; Influenza, Human; COVID-19 Phase 3 Recruiting 2016-04-11 20000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02735707 NCT00003016 Prolonged Tamoxifen Compared With Shorter Tamoxifen in Treating Patients Who Have Breast Cancer Breast Neoplasms Phase 3 Unknown 1995-10 20000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00003016 NCT00003678 Tamoxifen in Treating Women With Breast Cancer Breast Neoplasms Phase 3 Unknown 1991-05 20000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00003678 NCT00221364 Trachoma Elimination Follow-up Trachoma; Chlamydia Infections Phase 4 Completed 2003-03 20000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00221364 NCT06072300 Effects of Physical Activity Calorie Equivalent Labelling on Hot Drink Vending Transactions Phase 3 Unknown 2023-10-30 20000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06072300 NCT06282315 Real World Evaluation of an Albendazole-Ivermectin Coformulation Safety and Effectiveness Hookworm Infections Phase 3 Recruiting 2025-09-01 20000 Estimated Industry https://clinicaltrials.gov/study/NCT06282315 NCT06352632 ACT-GLOBAL Adaptive Platform Trial for Stroke Stroke; Ischemic Stroke; Cerebral Hemorrhage Phase 3 Recruiting 2024-09-26 20000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06352632 NCT03275584 Safety of PET MPI Using the CRCHUM N-13 Ammonia Phase 4 Recruiting 2018-01-30 20000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03275584 NCT07903350 BRAVO is a Phased Outbreak-response Study in the DRC Evaluating ERVEBO® Vaccination in ~20,000 Frontline Workers During the 2026 BDV Outbreak, Step A Assesses Real-world Effectiveness, Safety, and Impact on Severe Disease and Mortality, While Generating Evidence for Future BDV Vaccination Strategies Hemorrhagic Fever, Ebola; Communicable Diseases, Emerging Phase 4 Recruiting 2026-09-19 20000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07903350 NCT03676140 Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs ) Trachoma; Yaws; Elephantiasis, Filarial Phase 3 Completed 2018-10-01 20000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03676140 NCT04262206 Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults Cognitive Dysfunction; Dementia; Cardiovascular Diseases Phase 4 Recruiting 2020-09-01 20000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04262206 NCT02806531 Safety Study of Enterovirus 71 Vaccine in Children Aged 6-35 Months Old Phase 4 Unknown 2016-07 20000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02806531 NCT01251666 Comparison of Hemoccult, Magstream and OC-Sensor Faecal Occult Blood Tests in Colorectal Cancer Screening Colorectal Neoplasms Phase 3 Completed 2008-06 19797 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01251666 NCT00003906 Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer in Postmenopausal Women Breast Neoplasms Phase 3 Completed 1999-05 19747 Actual Network https://clinicaltrials.gov/study/NCT00003906 NCT05012943 The ARCT-154 Self-Amplifying RNA Vaccine Efficacy Study (ARCT-154-01) COVID-19 Phase 2, Phase 3 Completed 2021-08-15 19474 Actual Industry https://clinicaltrials.gov/study/NCT05012943 NCT02759991 Effectiveness Trial to Evaluate Protection of Pregnant Women by Hepatitis E Vaccine in Bangladesh. Phase 4 Completed 2017-10-02 19460 Actual Other government https://clinicaltrials.gov/study/NCT02759991 NCT01991795 A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus Diabetes Mellitus, Type 2; Diabetes Mellitus; Coronary Artery Disease Phase 3 Completed 2014-02-10 19271 Actual Industry https://clinicaltrials.gov/study/NCT01991795 NCT06923592 Serological Testing and Treatment for Plasmodium Vivax Malaria: a Trial in Ethiopia and Madagascar Malaria, Vivax; Malaria, Falciparum Phase 3 Recruiting 2025-05-12 19200 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06923592 NCT02446990 Effects of Ivabradine in Patients With Stable Coronary Artery Disease Without Clinical Heart Failure Coronary Artery Disease Phase 3 Completed 2009-09 19102 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02446990 NCT00133744 Impact of Prenatal Vitamin/Mineral Supplements on Perinatal Mortality Perinatal Death; Stillbirth; Anemia Phase 3 Completed 2006-05 18962 Actual U.S. federal https://clinicaltrials.gov/study/NCT00133744 NCT01663402 ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab Atherosclerosis Phase 3 Completed 2012-10 18924 Actual Industry https://clinicaltrials.gov/study/NCT01663402 NCT02810704 Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement Pulmonary Embolism; Venous Thrombosis; Venous Thromboembolism Phase 4 Completed 2016-12 18883 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02810704 NCT00122681 Human Papilloma Virus (HPV) Vaccine Efficacy Trial Against Cervical Pre-cancer in Young Adults With GlaxoSmithKline (GSK) Biologicals HPV-16/18 Papillomavirus Infections Phase 3 Completed 2004-05-06 18729 Actual Industry https://clinicaltrials.gov/study/NCT00122681 NCT02538952 Evaluating Accuracy, Impact, and Operational Challenges of GeneXpert Use for TB Case Finding Among HIV-infected Persons Tuberculosis; Acquired Immunodeficiency Syndrome; Tooth, Impacted Phase 4 Completed 2012-08-01 18696 Actual U.S. federal https://clinicaltrials.gov/study/NCT02538952 NCT00263042 Comprehensive Rimonabant Evaluation Study of Cardiovascular ENDpoints and Outcomes Cardiovascular Diseases; Myocardial Infarction; Stroke Phase 3 Terminated 2005-12 18695 Actual Industry https://clinicaltrials.gov/study/NCT00263042 NCT02961231 Evaluation of PCV Schedules in a Naive Population in Vietnam Pneumonia, Pneumococcal Phase 4 Completed 2016-10-01 18652 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02961231 NCT00391872 A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome Acute Coronary Syndrome; Myocardial Infarction; Angina, Unstable Phase 3 Completed 2006-10 18624 Actual Industry https://clinicaltrials.gov/study/NCT00391872 NCT01895517 CervIcal Cancer Screening Trial by Randomization of HPV Testing Intervention for Upcoming Screening （CITRUS Study） Uterine Cervical Neoplasms Phase 4 Completed 2013-06-07 18471 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01895517 NCT06917040 Enhancing Protection Against Vector-borne Diseases in Forcibly Displaced Communities: Evaluating the Efficacy of Spatial Repellents for Cutaneous Leishmaniasis Control in North-East Syria Leishmaniasis, Cutaneous; Vector Borne Diseases Phase 3 Completed 2021-02-01 18404 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06917040 NCT00712647 Carotene and Retinol Efficacy Trial Lung Neoplasms Phase 4 Completed 1985-05 18314 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00712647 NCT00418171 Large Simple Trial (LST) Of Cardiovascular Safety Of Ziprasidone And Olanzapine- (Zodiac) Schizophrenia Phase 4 Completed 2002-02 18239 Actual Industry https://clinicaltrials.gov/study/NCT00418171 NCT03473223 Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome Acute Coronary Syndrome; Coronary Artery Disease; Heart Diseases Phase 3 Completed 2018-03-21 18226 Actual Industry https://clinicaltrials.gov/study/NCT03473223 NCT01107886 Does Saxagliptin Reduce the Risk of Cardiovascular Events When Used Alone or Added to Other Diabetes Medications Diabetes Mellitus, Type 2 Phase 4 Completed 2010-05 18206 Actual Industry https://clinicaltrials.gov/study/NCT01107886 NCT01680679 Influenza Immunization of Children in India Influenza, Human Phase 4 Completed 2012-05 18163 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01680679 NCT00710060 Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk Populations HIV Infections; Sexually Transmitted Diseases Phase 3 Completed 2002-09 18147 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00710060 NCT00202878 IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome: Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (P04103) Hypercholesterolemia; Myocardial Infarction; Acute Coronary Syndrome Phase 3 Completed 2005-10-17 18144 Actual Industry https://clinicaltrials.gov/study/NCT00202878 NCT00262600 Randomized Evaluation of Long Term Anticoagulant Therapy (RE-LY) With Dabigatran Etexilate Atrial Fibrillation; Stroke Phase 3 Completed 2005-12 18113 Actual Industry https://clinicaltrials.gov/study/NCT00262600 NCT06596577 Nudging Effective and Equitable Delivery of Specialty Palliative Care Phase 3 Enrolling by invitation 2025-08-06 18000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06596577 NCT06041061 A Study to Evaluate the Efficacy, Safety, and Immunogenicity of SCT1000 in Healthy Women Aged 18-45 Years Papillomavirus Infections Phase 3 Active not recruiting 2023-08-13 18000 Actual Industry https://clinicaltrials.gov/study/NCT06041061 NCT06802224 The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery Acute Kidney Injury Phase 4 Recruiting 2025-04-01 18000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06802224 NCT05602558 The Phase Ⅱ/Ⅲ Trial of LYB001 COVID-19 Phase 2, Phase 3 Unknown 2022-12 18000 Estimated Industry https://clinicaltrials.gov/study/NCT05602558 NCT00231738 Protective Effect of EPA on Cardiovascular Events Myocardial Infarction; Angina, Unstable; Death, Sudden, Cardiac Phase 4 Completed 1996-11 18000 Industry https://clinicaltrials.gov/study/NCT00231738 NCT07817108 Phase III Clinical Trial of Lyophilized Herpes Zoster mRNA Vaccine in Adults Aged 40 Years or Above Chickenpox Phase 3 Recruiting 2026-06-27 18000 Estimated Industry https://clinicaltrials.gov/study/NCT07817108 NCT00239681 JUPITER - Crestor 20mg Versus Placebo in Prevention of Cardiovascular (CV) Events Cardiovascular Diseases Phase 3 Terminated 2003-02 17802 Actual Industry https://clinicaltrials.gov/study/NCT00239681 NCT04899336 A Study of Vaccination With 9-valent Extraintestinal Pathogenic Escherichia Coli Vaccine (ExPEC9V) in the Prevention of Invasive Extraintestinal Pathogenic Escherichia Coli Disease in Adults Aged 60 Years And Older With a History of Urinary Tract Infection in the Past 2 Years Phase 3 Completed 2021-06-30 17797 Actual Industry https://clinicaltrials.gov/study/NCT04899336 NCT03574597 Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity Overweight; Obesity Phase 3 Completed 2018-10-24 17604 Actual Industry https://clinicaltrials.gov/study/NCT03574597 NCT03090191 Clostridium Difficile Vaccine Efficacy Trial Clostridium Infections Phase 3 Completed 2017-03-29 17535 Actual Industry https://clinicaltrials.gov/study/NCT03090191 NCT03400878 Comparing Morbidity and Mortality Effects of Two Different Strains of BCG Infant Death Phase 4 Completed 2017-10-14 17505 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03400878 NCT00107887 TB (Tuberculosis) Preventive Therapy for HIV Patients With Access to HAART (Highly Active Antiretroviral Therapy) Tuberculosis; HIV Infections Phase 4 Completed 2005-06 17415 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00107887 NCT06292013 A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a) Atherosclerosis Phase 3 Active not recruiting 2024-03-05 17300 Estimated Industry https://clinicaltrials.gov/study/NCT06292013 NCT06642272 A Pragmatic Trial Comparing Empagliflozin and Dapagliflozin Through Cluster Randomization Embedded in the Electronic Health Record Diabetes Mellitus, Type 2; Heart Failure; Renal Insufficiency, Chronic Phase 4 Recruiting 2024-10-10 17200 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06642272 NCT01730534 Multicenter Trial to Evaluate the Effect of Dapagliflozin on the Incidence of Cardiovascular Events Diabetes Mellitus, Type 2 Phase 3 Completed 2013-04-25 17190 Actual Industry https://clinicaltrials.gov/study/NCT01730534 NCT01126437 Comparison of Tiotropium in the HandiHaler Versus the Respimat in Chronic Obstructive Pulmonary Disease Pulmonary Disease, Chronic Obstructive Phase 3 Completed 2010-05 17183 Actual Industry https://clinicaltrials.gov/study/NCT01126437 NCT05183178 Switching From Ticagrelor to Prasugrel in Patients With Acute Coronary Syndrome Acute Coronary Syndrome Phase 4 Completed 2022-02-01 17095 Actual Other government https://clinicaltrials.gov/study/NCT05183178 NCT05030428 Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease Atherosclerosis; Hypercholesterolemia; Dyslipidemias Phase 3 Active not recruiting 2021-11-23 17004 Actual Industry https://clinicaltrials.gov/study/NCT05030428 NCT00109616 Community Trial of Newborn Skin and Umbilical Cord Cleansing on Neonatal Mortality in Nepal Phase 3 Completed 2002-10 17000 NIH https://clinicaltrials.gov/study/NCT00109616 NCT06526507 PrEPARE-SCALE: Scaling up Integrated PrEP Delivery in Kenyan Maternal and Child Health Clinics Acquired Immunodeficiency Syndrome Phase 4 Enrolling by invitation 2025-01-01 17000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06526507 NCT02406729 Phase III Trial to Evaluate Efficacy and Safety of a Tetravalent Dengue Vaccine Dengue Phase 3 Unknown 2016-02-22 16935 Estimated Other government https://clinicaltrials.gov/study/NCT02406729 NCT05005559 Phase III Clinical Trial of CinnaGen COVID-19 Vaccine (SpikoGen) COVID-19 Phase 3 Completed 2021-08-07 16876 Actual Industry https://clinicaltrials.gov/study/NCT05005559 NCT01975376 The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects Cardiovascular Diseases; Myocardial Infarction; Stroke Phase 3 Terminated 2013-10-29 16784 Actual Industry https://clinicaltrials.gov/study/NCT01975376 NCT01313676 Study to Evaluate the Effect of Fluticasone Furoate/Vilanterol on Survival in Subjects With Chronic Obstructive Pulmonary Disease Pulmonary Disease, Chronic Obstructive; Cardiovascular Diseases Phase 3 Completed 2011-01-25 16568 Actual Industry https://clinicaltrials.gov/study/NCT01313676 NCT02409667 Plaque Psoriasis Efficacy and Safety With Secukinumab Plaque, Amyloid; Psoriasis Phase 3 Completed 2015-05-07 16487 Actual Industry https://clinicaltrials.gov/study/NCT02409667 NCT00223080 HIV Vaccine Trial in Thai Adults HIV Infections Phase 3 Completed 2003-10 16402 Actual U.S. federal https://clinicaltrials.gov/study/NCT00223080 NCT07872046 A Study on the Impact of Recombinant Zoster Vaccine on Major Adverse Cardiovascular Events in Adults >=50 Years of Age With Established Cardiovascular Disease or With >=2 Cardiovascular Risk Factors Cardiovascular Diseases Phase 3 Not yet recruiting 2026-11-30 16390 Estimated Industry https://clinicaltrials.gov/study/NCT07872046 NCT04383925 Trial to Compare Two Strains of BCG Infant Death Phase 4 Completed 2020-05-04 16390 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04383925 NCT04955626 To Evaluate the Safety, Tolerability, Efficacy and Immunogenicity of BNT162b2 Boosting Strategies Against COVID-19 in Participants ≥12 Years of Age. COVID-19; Coronavirus Infections Phase 3 Completed 2021-07-01 16372 Actual Industry https://clinicaltrials.gov/study/NCT04955626 NCT05726084 Immunogenicity, Efficacy and Safety Trial of the Convacell Vaccine in Healthy Volunteers Aged 18 Years and Older COVID-19; Coronavirus Infections; Respiratory Tract Infections Phase 2, Phase 3 Unknown 2022-10-24 16304 Estimated Other government https://clinicaltrials.gov/study/NCT05726084 NCT06578572 Seasonal R21 Mass Vaccination for Malaria Elimination Malaria Phase 3 Unknown 2024-05-30 16200 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06578572 NCT01165177 Study to Evaluate Efficacy, Safety and Immunogenicity of GSK Biologicals' Herpes Zoster (HZ) Vaccine GSK1437173A in Adults Aged 50 Years and Older Herpes Zoster Phase 3 Completed 2010-08-02 16165 Actual Industry https://clinicaltrials.gov/study/NCT01165177 NCT03705234 A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Disease Atherosclerosis Phase 3 Active not recruiting 2018-10-30 16124 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03705234 NCT00529373 A Study of MK-0822 in Postmenopausal Women With Osteoporosis to Assess Fracture Risk (MK-0822-018) Osteoporosis, Postmenopausal Phase 3 Terminated 2007-09-13 16071 Actual Industry https://clinicaltrials.gov/study/NCT00529373 NCT02270151 Improving DEtection of Atrial fibriLlation in Primary Care With the MyDiagnostick Atrial Fibrillation; Disease Phase 3 Completed 2014-11 16000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02270151 NCT05599516 Recombinant COVID-19 Vaccine (CHO Cell, NVSI-06-09) Phase III Clinical Trial COVID-19; Coronavirus Infections Phase 3 Unknown 2022-11-04 16000 Estimated Industry https://clinicaltrials.gov/study/NCT05599516 NCT01955252 Effect of WHO-yaws Elimination Strategy in Lihir Island, Papua New Guinea Yaws Phase 3 Completed 2013-03 16000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01955252 NCT01813435 GLOBAL LEADERS: A Clinical Study Comparing Two Forms of Anti-platelet Therapy After Stent Implantation Coronary Artery Disease Phase 3 Completed 2013-07-01 15991 Actual Industry https://clinicaltrials.gov/study/NCT01813435 NCT00128557 Community Trial of Newborn Vitamin A Supplementation to Reduce Infant Mortality in Rural Bangladesh Vitamin A Deficiency; Infant Death Phase 3 Completed 2004-01 15937 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00128557 NCT00658515 A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome Coronary Disease Phase 3 Completed 2008-04 15871 Actual Industry https://clinicaltrials.gov/study/NCT00658515 NCT00799903 The Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial Atherosclerosis; Heart Diseases; Cardiovascular Diseases Phase 3 Completed 2008-12-01 15828 Actual Industry https://clinicaltrials.gov/study/NCT00799903 NCT03074435 Insecticide Resistance Management in Burkina Faso and Côte D'Ivoire Malaria Phase 3 Completed 2016-07 15776 Actual Other government https://clinicaltrials.gov/study/NCT03074435 NCT05485051 Daily Chlorexidine Bath for Health Care Associated Infection Prevention Cross Infection; Pneumonia, Ventilator-Associated Phase 3 Completed 2022-08-03 15730 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05485051 NCT00050817 Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) Arteriosclerosis; Embolism Phase 3 Completed 2002-10 15603 Actual Industry https://clinicaltrials.gov/study/NCT00050817 NCT00809965 An Efficacy and Safety Study for Rivaroxaban in Patients With Acute Coronary Syndrome Acute Coronary Syndrome; Myocardial Infarction; Myocardial Ischemia Phase 3 Completed 2008-11 15526 Actual Industry https://clinicaltrials.gov/study/NCT00809965 NCT03903926 Efficacy Trial of a Commercial EV71 Vaccine Hand, Foot and Mouth Disease Phase 4 Completed 2019-03-26 15500 Actual Industry https://clinicaltrials.gov/study/NCT03903926 NCT00135226 ASCEND: A Study of Cardiovascular Events iN Diabetes Diabetes Mellitus; Cardiovascular Diseases; Diabetes Mellitus, Type 1 Phase 4 Active not recruiting 2005-03 15480 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00135226 NCT00866619 Efficacy of GSK Biologicals' Candidate Malaria Vaccine 257049 Against Malaria Disease in Infants and Children in Africa Malaria Phase 3 Completed 2009-03-27 15459 Actual Industry https://clinicaltrials.gov/study/NCT00866619 NCT03734237 A Pragmatic Assessment of Influenza Vaccine Effectiveness in the DoD Influenza, Human Phase 4 Active not recruiting 2018-11-06 15448 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03734237 NCT05556512 A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity Obesity; Overweight Phase 3 Active not recruiting 2022-10-11 15374 Actual Industry https://clinicaltrials.gov/study/NCT05556512 NCT07626411 Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation Atrial Fibrillation; Hemorrhage; Stroke Phase 3 Recruiting 2026-08-10 15364 Estimated Industry https://clinicaltrials.gov/study/NCT07626411 NCT06395194 Effects of Valsartan vs Amlodipine and Low BP on Kidney Outcomes in Essential Hypertension Essential Hypertension; Hypertension; Kidney Diseases Phase 3 Completed 1997-09-27 15313 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06395194 NCT04583995 A Study Looking at the Effectiveness, Immune Response, and Safety of a COVID-19 Vaccine in Adults in the United Kingdom COVID-19; Coronavirus Infections Phase 3 Completed 2020-09-28 15185 Actual Industry https://clinicaltrials.gov/study/NCT04583995 NCT07665853 Optimizing the Use of Aspirin for the Prevention of Preeclampsia Pre-Eclampsia Phase 3 Not yet recruiting 2026-07-01 15160 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07665853 NCT07000357 A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event Cardiovascular Diseases; Atherosclerosis Phase 3 Recruiting 2025-06-04 15100 Estimated Industry https://clinicaltrials.gov/study/NCT07000357 NCT03475342 World Maternal Antifibrinolytic Trial_2 Anemia; Postpartum Hemorrhage; Pain Phase 3 Completed 2019-08-24 15068 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03475342 NCT00134264 A Study Examining Torcetrapib/Atorvastatin And Atorvastatin Effects On Clinical CV Events In Patients With Heart Disease Coronary Disease; Diabetes Mellitus Phase 3 Terminated 2004-07 15067 Actual Industry https://clinicaltrials.gov/study/NCT00134264 NCT00060476 Treatment With MK0966 for the Prevention of Prostate Cancer (0966-201) Prostatic Neoplasms Phase 3 Completed 2003-01-08 15000 Actual Industry https://clinicaltrials.gov/study/NCT00060476 NCT00623337 Ghana Newborn Home Visits Neonatal Mortality Trial Phase 3 Completed 2009-01 15000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00623337 NCT00001127 Study of a Flu Vaccine in Children Influenza, Human Phase 3 Completed 15000 NIH https://clinicaltrials.gov/study/NCT00001127 NCT05169021 Folic Acid and Intensive Antihypertensive Therapy for Hypertension With CSVD Cerebral Small Vessel Diseases; Stroke; Hypertension Phase 4 Not yet recruiting 2021-12-31 15000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05169021 NCT00438919 A Multi-center Post-Market Surveillance Registry Coronary Artery Disease Phase 4 Completed 2006-05 15000 Estimated Industry https://clinicaltrials.gov/study/NCT00438919 NCT01050972 Effectiveness of a Cognitive and Physical Intervention to Reduce Head and Muscle Pain in a Large Population Migraine Disorders; Tension-Type Headache; Neck Pain Phase 3 Unknown 2009-06 15000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01050972 NCT05397678 Trial to Compare BCG-Bulgaria and BCG-Denmark Perinatal Death; Infant Death Phase 4 Unknown 2022-10-21 15000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05397678 NCT00543543 Broad Spectrum HPV (Human Papillomavirus) Vaccine Study in 16-to 26-Year-Old Women (V503-001) Uterine Cervical Neoplasms; Vulvar Neoplasms; Vaginal Neoplasms Phase 3 Completed 2007-09-24 14840 Actual Industry https://clinicaltrials.gov/study/NCT00543543 NCT05643573 A Study to Learn How Well the Study Treatment Asundexian Works and How Safe it is Compared to Apixaban to Prevent Stroke or Systemic Embolism in People With Irregular and Often Rapid Heartbeat (Atrial Fibrillation), and at Risk for Stroke Atrial Fibrillation Phase 3 Terminated 2022-12-05 14830 Actual Industry https://clinicaltrials.gov/study/NCT05643573 NCT01165229 Study to Evaluate Efficacy, Safety and Immunogenicity of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster (HZ) Vaccine GSK1437173A in Adults Aged 70 Years and Older Herpes Zoster Phase 3 Completed 2010-08-02 14819 Actual Industry https://clinicaltrials.gov/study/NCT01165229 NCT01144338 Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL): A Trial To Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly In Patients With Type 2 Diabetes Mellitus Diabetes Mellitus, Type 2 Phase 3 Completed 2010-06-18 14752 Actual Industry https://clinicaltrials.gov/study/NCT01144338 NCT04424316 A Trial to Evaluate the Efficacy and Safety of RSVpreF in Infants Born to Women Vaccinated During Pregnancy. Respiratory Tract Infections Phase 3 Completed 2020-06-17 14727 Actual Industry https://clinicaltrials.gov/study/NCT04424316 NCT02019264 A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors Cardiovascular Diseases; Obesity; Overweight Phase 4 Completed 2014-01-24 14673 Actual Industry https://clinicaltrials.gov/study/NCT02019264 NCT00790205 Sitagliptin Cardiovascular Outcomes Study (MK-0431-082) Diabetes Mellitus, Type 2 Phase 3 Completed 2008-12-10 14671 Actual Industry https://clinicaltrials.gov/study/NCT00790205 NCT06008756 Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Cardiovascular Outcomes Study (MK-0616-015) CORALreef Outcomes Arteriosclerosis; Hypercholesterolemia Phase 3 Active not recruiting 2023-10-09 14550 Estimated Industry https://clinicaltrials.gov/study/NCT06008756 NCT01968798 ASPREE Cancer Endpoints Study Neoplasms Phase 4 Unknown 2013-09 14500 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01968798 NCT00403767 An Efficacy and Safety Study of Rivaroxaban With Warfarin for the Prevention of Stroke and Non-Central Nervous System Systemic Embolism in Patients With Non-Valvular Atrial Fibrillation Atrial Fibrillation; Stroke; Embolism Phase 3 Completed 2006-12 14269 Actual Industry https://clinicaltrials.gov/study/NCT00403767 NCT05168813 Efficacy Study of COVID-19 mRNA Vaccine in Regions With SARS-CoV-2 Variants of Concern COVID-19; HIV Infections Phase 2, Phase 3 Completed 2021-12-01 14237 Actual Network https://clinicaltrials.gov/study/NCT05168813 NCT05754957 A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome Acute Coronary Syndrome Phase 3 Completed 2023-04-07 14194 Actual Industry https://clinicaltrials.gov/study/NCT05754957 NCT05636319 A Study to Evaluate the Efficacy, Safety, and Immunogenicity of SARS-CoV-2 Variant (BA.4 /5) mRNA Vaccine COVID-19 Phase 2, Phase 3 Unknown 2022-11-23 14168 Actual Industry https://clinicaltrials.gov/study/NCT05636319 NCT01256658 A Community Setting Study of Malaria After Systematic Treatment of Symptomatic Carriers of P. Falciparum With COA566 (Coartem®) Malaria; Trigeminal Neuralgia Phase 4 Completed 2010-11 14075 Actual Industry https://clinicaltrials.gov/study/NCT01256658 NCT00114868 Vitamin A Supplementation in Newborns Study Phase 3 Completed 1998-06 14035 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00114868 NCT05739383 A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients. Cardiovascular Diseases; Myocardial Infarction; Stroke Phase 3 Active not recruiting 2023-03-09 14012 Actual Industry https://clinicaltrials.gov/study/NCT05739383 NCT00376155 Comparison of Two Strategies for the Delivery of IPTc Malaria Phase 4 Completed 2006-05 14000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00376155 NCT02625155 Standard of Care Versus Urine Testing With Selective PHarmacogenomics for Effective Drug and Dosing REgimens Muscle Hypotonia Phase 4 Unknown 2015-12 14000 Estimated Industry https://clinicaltrials.gov/study/NCT02625155 NCT07890415 Using an Artificial Intelligence (AI) Tool for Melanoma Diagnosis Melanoma; Hemangioma; Nevus, Pigmented Phase 3 Recruiting 2026-10-15 14000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07890415 NCT02993406 Evaluation of Major Cardiovascular Events in Participants With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant Treated With Bempedoic Acid (ETC-1002) or Placebo Cardiovascular Diseases Phase 3 Completed 2016-12-22 13970 Actual Industry https://clinicaltrials.gov/study/NCT02993406 NCT03118232 Project PROTECT: Protecting Nursing Homes From Infections and Hospitalization Infections Phase 4 Completed 2017-04-03 13952 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03118232 NCT01732822 A Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease Peripheral Arterial Disease Phase 3 Completed 2012-12-04 13885 Actual Industry https://clinicaltrials.gov/study/NCT01732822 NCT00093158 Comparison of Angiomax Versus Heparin in Acute Coronary Syndromes (ACS) Angina, Unstable; Myocardial Infarction; Acute Disease Phase 3 Completed 2003-08 13800 Industry https://clinicaltrials.gov/study/NCT00093158 NCT07706673 ESCUDDO Long Term Follow Up Papillomavirus Infections Phase 4 Enrolling by invitation 2026-08-11 13700 Estimated NIH https://clinicaltrials.gov/study/NCT07706673 NCT00097591 A Comparison of Prasugrel (CS-747) and Clopidogrel in Acute Coronary Syndrome Subjects Who Are to Undergo Percutaneous Coronary Intervention Coronary Artery Disease; Acute Coronary Syndrome Phase 3 Completed 2004-11 13619 Actual Industry https://clinicaltrials.gov/study/NCT00097591 NCT05815498 A Study of mRNA-1283 Injection Compared With mRNA-1273 Injection in Participants ≥12 Years of Age to Prevent COVID-19 COVID-19; Coronavirus Infections; Virus Diseases Phase 3 Completed 2023-03-28 13553 Actual Industry https://clinicaltrials.gov/study/NCT05815498 NCT01011660 Effects of Angiotensin II Receptor Blocker Compared With Diuretics in High-risk Hypertensive Patients Essential Hypertension; Hypertension Phase 4 Unknown 2007-10 13542 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01011660 NCT03570814 Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin Trachoma; Elephantiasis, Filarial Phase 4 Completed 2021-12-01 13511 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03570814 NCT02601040 Immunogenicity and Safety of Inactivated and Live Attenuated Hepatitis A Vaccines Hepatitis A Phase 4 Completed 2011-11 13500 Actual Network https://clinicaltrials.gov/study/NCT02601040 NCT05262010 A Phase III Clinical Trial of a 11-valent Recombinant Human Papillomavirus Vaccine (Hansenulapolymorpha) in Chinese Women Aged 18-45 Years Papillomavirus Infections Phase 3 Active not recruiting 2022-06-04 13500 Estimated Industry https://clinicaltrials.gov/study/NCT05262010 NCT00784225 S0000B: Vitamin E and/or Selenium in Preventing Cataract and Age-Related Macular Degeneration in Men on SELECT SWOG-S0000 Cataract; Macular Degeneration Phase 3 Completed 2004-07 13475 Actual Network https://clinicaltrials.gov/study/NCT00784225 NCT01994720 [SOCRATES -Acute Stroke Or Transient IsChaemic Attack TReated With Aspirin or Ticagrelor and Patient OutcomES] Ischemic Attack, Transient Phase 3 Completed 2014-01-07 13307 Actual Industry https://clinicaltrials.gov/study/NCT01994720 NCT04255433 A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes Diabetes Mellitus, Type 2; Diabetes Mellitus; Glucose Metabolism Disorders Phase 3 Completed 2020-05-29 13299 Actual Industry https://clinicaltrials.gov/study/NCT04255433 NCT00004800 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Acellular and Whole-Cell Pertussis Vaccines Whooping Cough; Bacterial Infections; Immune System Diseases Phase 3 Completed 1992-09 13250 NIH https://clinicaltrials.gov/study/NCT00004800 NCT01076764 Effect of Otamixaban Versus Unfractionated Heparin + Eptifibatide in Patients With Unstable Angina/Non ST Elevation Myocardial Infarction Undergoing Early Invasive Strategy Acute Coronary Syndrome Phase 3 Completed 2010-04 13220 Actual Industry https://clinicaltrials.gov/study/NCT01076764 NCT02104817 Outcomes Study to Assess STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia Phase 3 Completed 2014-10-30 13078 Actual Industry https://clinicaltrials.gov/study/NCT02104817 NCT01000727 The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial Acute Coronary Syndrome; Atherosclerosis; Heart Diseases Phase 3 Completed 2009-12-01 13026 Actual Industry https://clinicaltrials.gov/study/NCT01000727 NCT04922788 Study to Evaluate the Safety, Immunogenicity, and Efficacy of Nanocovax Vaccine Against COVID-19 COVID-19 Phase 3 Completed 2021-06-07 13006 Actual Industry https://clinicaltrials.gov/study/NCT04922788 NCT00152204 The Community Effectiveness of IPTi in Southern Tanzania Malaria, Falciparum; Anemia; Patient Acceptance of Health Care Phase 3 Unknown 2005-03 13000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00152204 NCT00272428 Primary Prevention Trial of the Health Effects of Antioxidant Vitamins and Minerals. Neoplasms Phase 3 Completed 1994-10 13000 Other government https://clinicaltrials.gov/study/NCT00272428 NCT05946642 Innovative Intermittent Preventive Treatment Approaches to Reduce Malaria Burden in School-age Children in Burkina Faso Malaria Phase 3 Unknown 2023-07-15 13000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05946642 NCT04962451 Comparison of the Efficacy of Ticagrelor Combined With ASA to ASA Alone in Patients With Stroke Stroke Phase 4 Completed 2017-09-01 13000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04962451 NCT06955728 A Clinical Trial on Safety in Pregnant Women and How Well the Infant is Protected Against RSV-associated Lower Respiratory Tract Infection When the Pregnant Woman Receives the Approved RSV Vaccine Compared to a Placebo. Respiratory Syncytial Virus Infections; Obstetric Labor, Premature Phase 3 Recruiting 2025-09-03 13000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06955728 NCT04311671 Safety of a Single Dose of Moxidectin Compared With Ivermectin in Individuals Living in Onchocerciasis Endemic Areas and in Individuals Living in Onchocerciasis Endemic Areas With High Levels of Lymphatic Filariasis Co-endemicity Receiving Concomitant Albendazole Onchocerciasis Phase 3 Completed 2021-05-03 12979 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04311671 NCT00527943 Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Particpants With Acute Coronary Syndrome (TRA•CER) (Study P04736) Atherosclerosis; Myocardial Ischemia; Myocardial Infarction Phase 3 Terminated 2007-12-01 12944 Actual Industry https://clinicaltrials.gov/study/NCT00527943 NCT04256798 Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery Infections; Pneumonia; Surgical Wound Infection Phase 3 Recruiting 2020-11-13 12942 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04256798 NCT00973362 Clinical Evaluation of the APTIMA® HPV Assay Using the TIGRIS® System Papillomavirus Infections; Uterine Cervical Neoplasms; Uterine Cervical Dysplasia Phase 3 Completed 2008-03 12896 Actual Industry https://clinicaltrials.gov/study/NCT00973362 NCT01628666 Prevention of Arrhythmia Device Infection Trial (PADIT) Arrhythmias, Cardiac; Infections Phase 4 Completed 2012-12 12814 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01628666 NCT07037433 Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity Atherosclerosis; Overweight; Obesity Phase 3 Active not recruiting 2025-07-25 12800 Estimated Industry https://clinicaltrials.gov/study/NCT07037433 NCT03739112 Efficacy of a Plant-derived Quadrivalent Virus-like Particle (VLP) Vaccine in the Elderly Virus Diseases; RNA Virus Infections; Respiratory Tract Diseases Phase 3 Completed 2018-09-18 12794 Actual Industry https://clinicaltrials.gov/study/NCT03739112 NCT01402882 Clinical Randomisation of an Antifibrinolytic in Significant Head Injury Brain Injuries, Traumatic Phase 3 Completed 2012-07 12737 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01402882 NCT00468923 Heart Outcomes Prevention Evaluation-3 Cardiovascular Diseases; Stroke Phase 4 Completed 2007-05 12705 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00468923 NCT04456595 Clinical Trial of Efficacy and Safety of Sinovac's Adsorbed COVID-19 (Inactivated) Vaccine in Healthcare Professionals COVID-19 Phase 3 Completed 2020-07-21 12688 Actual Other government https://clinicaltrials.gov/study/NCT04456595 NCT05477524 An Efficacy, Safety, Tolerability, Immunogenicity, and Lot-Consistency Clinical Trial of a 6-Valent OspA-Based Lyme Disease Vaccine (VLA15) Lyme Disease Phase 3 Completed 2022-08-04 12546 Actual Industry https://clinicaltrials.gov/study/NCT05477524 NCT00501059 A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease Stroke Phase 3 Completed 2007-07-05 12546 Actual Industry https://clinicaltrials.gov/study/NCT00501059 NCT00069784 The ORIGIN Trial (Outcome Reduction With Initial Glargine Intervention) Diabetes Mellitus, Type 2; Glucose Intolerance Phase 3 Completed 2003-08 12537 Actual Industry https://clinicaltrials.gov/study/NCT00069784 NCT05702034 A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE Ischemic Stroke Phase 3 Active not recruiting 2023-02-15 12523 Actual Industry https://clinicaltrials.gov/study/NCT05702034 NCT00317707 Risk and Prevention Study: Evaluation of the Efficacy of n-3 PUFA in Subjects at High Cardiovascular Risk Cardiovascular Diseases; Diabetes Mellitus; Hypertension Phase 3 Completed 2004-02 12513 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00317707 NCT05150808 Vectron T500 (Broflanilide 50WP) for IRS in Tanzania Tanzania Malaria, Falciparum Phase 3 Unknown 2020-10-01 12500 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05150808 NCT01444430 A 6 Month Safety Study Comparing Symbicort With Inhaled Corticosteroid Only in Asthmatic Adults and Adolescents Asthma Phase 3 Completed 2011-12 12460 Actual Industry https://clinicaltrials.gov/study/NCT01444430 NCT03450915 A Pivotal Trial to Assess the Safety and Clinical Efficacy of the M-001 as a Standalone Universal Flu Vaccine Influenza, Human Phase 3 Completed 2018-08-01 12460 Actual Industry https://clinicaltrials.gov/study/NCT03450915 NCT05669625 A Phase III Clinical Trial to Evaluate the Efficacy and Safety of the Live Attenuated Varicella Vaccine Chickenpox Phase 3 Unknown 2022-12-26 12440 Actual Industry https://clinicaltrials.gov/study/NCT05669625 NCT02984384 PREVENTion of Clot in Orthopaedic Trauma Thrombosis; Wounds and Injuries; Venous Thromboembolism Phase 3 Completed 2017-04-24 12424 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02984384 NCT05683821 BREATHE 2 Clinic Stop-Smoking Treatment Outreach Study Smoking Cessation; Cigarette Smoking Phase 4 Completed 2023-07-24 12376 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05683821 NCT05686070 A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke Phase 3 Completed 2023-01-26 12327 Actual Industry https://clinicaltrials.gov/study/NCT05686070 NCT03872401 Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke Coronary Disease; Multiple Endocrine Neoplasia Type 1 Phase 3 Completed 2019-06-11 12301 Actual Industry https://clinicaltrials.gov/study/NCT03872401 NCT01295203 Internet-based Physical Activity Intervention Motor Activity Phase 3 Completed 2008-05 12287 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01295203 NCT04263363 Applying Best Clinical Practices to Patients at High Risk of Respiratory Complications Sleep Apnea, Obstructive Phase 4 Completed 2022-02-18 12248 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04263363 NCT00092534 Cervical Intraepithelial Neoplasm (CIN) in Women (Gardasil) (V501-015) Uterine Cervical Neoplasms; Condylomata Acuminata Phase 3 Completed 2002-06-14 12167 Actual Industry https://clinicaltrials.gov/study/NCT00092534 NCT01687998 A Study of Evacetrapib in High-Risk Vascular Disease Cardiovascular Diseases Phase 3 Terminated 2012-10 12092 Actual Industry https://clinicaltrials.gov/study/NCT01687998 NCT00064428 OASIS-6 : The Safety and Efficacy of Fondaparinux Versus Control Therapy in Patients With ST Segment Elevation Acute Myocardial Infarction Thromboembolism; ST Elevation Myocardial Infarction; Acute Coronary Syndrome Phase 3 Completed 2003-08 12092 Actual Industry https://clinicaltrials.gov/study/NCT00064428 NCT00124072 Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine Cardiovascular Diseases; Myocardial Infarction; Coronary Disease Phase 3 Completed 1998-07 12064 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00124072 NCT01439360 An Efficacy Study of GlaxoSmithKline (GSK) Biologicals' Candidate Influenza Vaccine GSK2321138A in Children Influenza, Human Phase 3 Completed 2011-10-01 12046 Actual Industry https://clinicaltrials.gov/study/NCT01439360 NCT02111564 A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients Heart Failure; Respiratory Insufficiency; Stroke Phase 3 Completed 2014-01-07 12024 Actual Industry https://clinicaltrials.gov/study/NCT02111564 NCT01658124 Haemorrhage Alleviation With Tranexamic Acid- Intestinal System Gastrointestinal Hemorrhage; Hemorrhage Phase 3 Completed 2013-07 12009 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01658124 NCT02447536 Trial of Two Strains of BCG Phase 4 Completed 2014-12-08 12006 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02447536 NCT01569581 A Protected Study of Inactivated EV71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants and Children Hand, Foot and Mouth Disease Phase 3 Completed 2012-03 12000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01569581 NCT05055908 Efficacy and Biomarker Development for Lung Cancer Treated With Immune Checkpoint Inhibitors Lung Neoplasms Phase 3 Recruiting 2021-10-01 12000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05055908 NCT01108614 Injecting Drug Use Community Intervention Trial Hepatitis C; Syphilis; HIV Infections Phase 3 Unknown 2009-06 12000 Estimated Other government https://clinicaltrials.gov/study/NCT01108614 NCT04646954 DNA Methylation Testing for the Screening of Uterine Cervical Lesion Uterine Cervical Neoplasms; Uterine Cervical Dysplasia Phase 3 Unknown 2020-11-26 12000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04646954 NCT02033187 Daily Chlorhexidine Bathing and Infection Rates in Critically-ill Patients Cross Infection Phase 4 Completed 2012-07 12000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02033187 NCT05668572 A Phase III Trial Evaluates the Efficacy, Immunogenicity and Safety Profile of HPV Vaccine Papillomavirus Infections Phase 3 Unknown 2020-12-05 12000 Actual Industry https://clinicaltrials.gov/study/NCT05668572 NCT04837170 Safety and Efficacy Evaluation of S (+) - Ketamine in Adults Pain, Postoperative; Acute Pain; Depression Phase 4 Unknown 2021-05-01 12000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04837170 NCT02733068 A Phase III Study of Human Papillomavirus (HPV)-16/18 Vaccine. Uterine Cervical Dysplasia Phase 3 Completed 2014-11-02 12000 Actual Industry https://clinicaltrials.gov/study/NCT02733068 NCT04612972 Efficacy, Safety and Immunogenicity of Inactivated SARS-CoV-2 Vaccines (Vero Cell) to Prevent COVID-19 in Healthy Adult Population In Peru Healthy Adult Population In Peru COVID-19 Phase 3 Completed 2020-09-09 12000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04612972 NCT07013487 A Study to Evaluate V181 Dengue Vaccine in Healthy Participants 2 to 17 Years of Age (V181-005/MOBILIZE-1) Phase 3 Active not recruiting 2025-06-11 12000 Estimated Industry https://clinicaltrials.gov/study/NCT07013487 NCT00242047 Randomized Controlled Trial of Percutaneous and Intradermal BCG Vaccination. Tuberculosis Phase 4 Unknown 2001-03 12000 University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00242047 NCT00164580 Community Intervention Trial for Youth (CITY) Study HIV Infections; Homosexuality, Male Phase 2, Phase 3 Completed 1996-10 12000 U.S. federal https://clinicaltrials.gov/study/NCT00164580 NCT07293065 A Phase III Clinical Trial to Evaluate Long-Term Protective Efficacy of Recombinant Zoster Vaccine (CHO Cell) Herpes Zoster Phase 3 Active not recruiting 2025-12-15 12000 Estimated Industry https://clinicaltrials.gov/study/NCT07293065 NCT04591405 Phase II/III of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Healthy Children Aged 5-11 Mumps Phase 2, Phase 3 Unknown 2020-10-12 11999 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04591405 NCT00550745 ZOSTAVAX™ Safety Study in Subjects ≥ 60 Years of Age (V211-020) Herpes Zoster Phase 4 Completed 2007-09 11999 Actual Industry https://clinicaltrials.gov/study/NCT00550745 NCT00268476 Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy Prostatic Neoplasms Phase 2, Phase 3 Active not recruiting 2005-07-08 11992 Actual Other government https://clinicaltrials.gov/study/NCT00268476 NCT03199547 Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis & Death Neonatal Sepsis Phase 3 Completed 2017-10-21 11985 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03199547 NCT04796896 A Study to Evaluate Safety and Effectiveness of mRNA-1273 COVID-19 Vaccine in Healthy Children Between 6 Months of Age and Less Than 12 Years of Age Coronavirus Infections; Virus Diseases; COVID-19 Phase 2, Phase 3 Completed 2021-03-15 11942 Actual Industry https://clinicaltrials.gov/study/NCT04796896 NCT04126486 A Study to Determine if Identification of Undiagnosed Atrial Fibrillation in People at Least 70 Years of Age Reduces the Risk of Stroke Atrial Fibrillation; Atrial Flutter Phase 4 Completed 2019-12-17 11931 Actual Industry https://clinicaltrials.gov/study/NCT04126486 NCT02608502 A Study to Evaluate the Efficacy of an RSV F Vaccine in Older Adults Phase 3 Completed 2015-11 11850 Actual Industry https://clinicaltrials.gov/study/NCT02608502 NCT04816643 Study to Evaluate the Safety, Tolerability, and Immunogenicity of an RNA Vaccine Candidate Against COVID-19 in Healthy Children COVID-19 Phase 3 Completed 2021-03-24 11837 Actual Industry https://clinicaltrials.gov/study/NCT04816643 NCT00290875 Implementation of the Canadian C-Spine Rule Phase 3 Completed 2003-01 11824 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00290875 NCT07064473 EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease Diabetes Mellitus, Type 2; Hypertension; Cardiovascular Diseases Phase 3 Recruiting 2025-07-22 11800 Estimated Industry https://clinicaltrials.gov/study/NCT07064473 NCT01475721 SAS115359: A 6-month Study to Assess the Safety and Benefit of Inhaled Fluticasone Propionate/Salmeterol Combination Compared With Inhaled Fluticasone Propionate in the Treatment of Adolescents and Adults (12 Years of Age and Older) With Asthma. Asthma Phase 4 Completed 2011-11-18 11751 Actual Industry https://clinicaltrials.gov/study/NCT01475721 NCT01471340 A Serious Asthma Outcome Study With Mometasone Furoate/Formoterol Versus Mometasone Furoate in Asthmatics 12 Years and Over (P06241) Asthma Phase 4 Completed 2012-01-09 11744 Actual Industry https://clinicaltrials.gov/study/NCT01471340 NCT00394706 Resuscitation Outcomes Consortium (ROC) Prehospital Resuscitation Using an Impedance Valve Heart Arrest Phase 3 Terminated 2007-06 11738 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00394706 NCT00170950 Avoiding Cardiovascular Events Through Combination Therapy in Patients Living With Systolic Hypertension Hypertension Phase 3 Terminated 2003-10 11506 Actual Industry https://clinicaltrials.gov/study/NCT00170950 NCT02151578 Home Management of Malaria and Pneumonia Malaria; Pneumonia Phase 4 Completed 2009-01 11500 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02151578 NCT03264352 Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes Diabetes Mellitus, Type 2; Prehypertension Phase 4 Recruiting 2018-02-01 11414 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03264352 NCT00630331 Efficacy Study of Two Influenza Vaccines and Placebo in Healthy Adult Subjects Influenza, Human Phase 3 Completed 2007-10 11404 Actual Industry https://clinicaltrials.gov/study/NCT00630331 NCT04992260 Efficacy, Immunogenicity and Safety of COVID-19 Vaccine , Inactivated in Children and Adolescents COVID-19 Phase 3 Completed 2021-09-10 11349 Actual Industry https://clinicaltrials.gov/study/NCT04992260 NCT06677060 Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin Heart Failure Phase 3 Recruiting 2025-03-14 11300 Estimated Industry https://clinicaltrials.gov/study/NCT06677060 NCT04605159 A Phase III, Double-blind Study to Assess Safety and Efficacy of an RSV Maternal Unadjuvanted Vaccine, in Pregnant Women and Infants Born to Vaccinated Mothers Respiratory Syncytial Virus Infections Phase 3 Terminated 2020-11-20 11194 Actual Industry https://clinicaltrials.gov/study/NCT04605159 NCT01156571 A Clinical Trial Comparing Cangrelor to Clopidogrel Standard Therapy in Subjects Who Require Percutaneous Coronary Intervention (PCI) (CHAMPION PHOENIX) Atherosclerosis; Acute Coronary Syndrome Phase 3 Completed 2010-09 11145 Actual Industry https://clinicaltrials.gov/study/NCT01156571 NCT00145925 Blood Pressure and Glucose Lowering for the Prevention of Vascular Disease in High Risk Patients With Type 2 Diabetes Diabetes Mellitus, Type 2; Stroke Phase 3 Completed 2001-06 11140 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00145925 NCT05845489 Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- CloPidogREl for Primary preVENTION (HOST-PREVENTION) Coronary Artery Disease Phase 4 Recruiting 2023-03-22 11086 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05845489 NCT06840756 Effects of Donor-recipient Sex-matched Blood Transfusion on Patient Outcomes Phase 4 Recruiting 2025-09-11 11082 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06840756 NCT02875873 Balanced Solution Versus Saline in Intensive Care Study Critical Illness; Acute Kidney Injury Phase 3 Completed 2017-05-27 11075 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02875873 NCT03354429 THALES - Acute STroke or Transient IscHaemic Attack Treated With TicAgreLor and ASA for PrEvention of Stroke and Death Ischemic Attack, Transient; Stroke Phase 3 Completed 2018-01-22 11016 Actual Industry https://clinicaltrials.gov/study/NCT03354429 NCT02406677 Affordability and Real-world Antiplatelet Treatment Effectiveness After Myocardial Infarction Study Acute Coronary Syndrome; Myocardial Infarction; ST Elevation Myocardial Infarction Phase 4 Completed 2015-06-05 11001 Actual Industry https://clinicaltrials.gov/study/NCT02406677 NCT07136012 OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events Cardiovascular Diseases; Coronary Disease; Myocardial Infarction Phase 3 Recruiting 2025-08-22 11000 Estimated Industry https://clinicaltrials.gov/study/NCT07136012 NCT02804815 Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours Neoplasms; Breast Neoplasms; Prostatic Neoplasms Phase 3 Active not recruiting 2015-10 11000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02804815 NCT03129490 The Danish Non-vitamin K Antagonist Oral Anticoagulation Study in Patients With Atrial Fibrillation Atrial Fibrillation; Atrial Flutter Phase 4 Active not recruiting 2023-04-01 11000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03129490 NCT03364491 Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean Hemorrhage Phase 3 Completed 2018-03-15 11000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03364491 NCT00168636 Different Doses of Vitamin A Supplementation and Male and Female Morbidity and Mortality Coitus Phase 4 Completed 2004-11 11000 University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00168636 NCT07181109 Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease Hypertension; Cardiovascular Diseases Phase 3 Recruiting 2025-09-06 11000 Estimated Industry https://clinicaltrials.gov/study/NCT07181109 NCT04885530 ACTIV-6: COVID-19 Study of Repurposed Medications COVID-19 Phase 3 Completed 2021-06-08 10956 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04885530 NCT04774991 Azithromycin for Child Survival in Niger: Delivery Trial Phase 4 Completed 2021-06-28 10925 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04774991 NCT00143507 The BEAUTIFUL Study: Effects of Ivabradine in Patients With Stable Coronary Artery Disease and Left Ventricular Systolic Dysfunction Coronary Disease; Ventricular Dysfunction, Left Phase 3 Completed 2004-12 10917 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00143507 NCT05715944 Incidence of COVID-19 Following Vaccination in Botswana Against SARS CoV 2 COVID-19 Phase 3 Completed 2021-09-15 10888 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05715944 NCT00123760 Study of 18F-Fluorodeoxyglucose (FluGlucoScan) in Patients With Cancer or Suspected Cancer Brain Neoplasms; Lung Neoplasms; Thyroid Neoplasms Phase 2, Phase 3 Completed 2004-02 10838 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00123760 NCT04400838 Investigating a Vaccine Against COVID-19 Coronavirus Infections; COVID-19 Phase 2, Phase 3 Completed 2020-05-28 10811 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04400838 NCT00234832 A Long Term Study of Sibutramine and the Role of Obesity Management in Relation to Cardiovascular Disease in Overweight and Obese Patients Obesity Phase 3 Completed 2003-01 10777 Actual Industry https://clinicaltrials.gov/study/NCT00234832 NCT02009215 School-Based Treatment With ACT to Reduce Transmission Malaria Phase 4 Completed 2014-02 10746 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02009215 NCT06468202 Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL Pre-Eclampsia; Hypertension, Pregnancy-Induced Phase 4 Recruiting 2024-10-18 10742 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06468202 NCT00197210 A Study to Test 2 Doses of GSK Biologicals' Oral Live Attenuated Human Rotavirus (HRV) Vaccine in Healthy Infants Rotavirus Infections Phase 3 Completed 2003-12 10708 Actual Industry https://clinicaltrials.gov/study/NCT00197210 NCT01964989 Clinical Study to Evaluate the Safety, Immunogenicity and Efficacy of Investigational Flu Vaccine Compared to Approved Flu Vaccine in Children. Influenza, Human Phase 3 Completed 2013-11 10644 Actual Industry https://clinicaltrials.gov/study/NCT01964989 NCT03315143 Effect of Sotagliflozin on Cardiovascular and Renal Events in Participants With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk Heart Failure; Diabetes Mellitus, Type 2; Renal Insufficiency, Chronic Phase 3 Terminated 2017-12-19 10584 Actual Industry https://clinicaltrials.gov/study/NCT03315143 NCT01975389 The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects Cardiovascular Diseases; Myocardial Infarction; Stroke Phase 3 Terminated 2013-10-29 10564 Actual Industry https://clinicaltrials.gov/study/NCT01975389 NCT03071692 Pemafibrate to Reduce Cardiovascular OutcoMes by Reducing Triglycerides IN patiENts With diabeTes (PROMINENT) Dyslipidemias Phase 3 Terminated 2017-03-23 10544 Actual Industry https://clinicaltrials.gov/study/NCT03071692 NCT01821911 The Post-Marketing Safety and Immunogenicity Research of Speeda® Rabies Vaccine for Human Use Phase 4 Completed 2012-07 10500 Actual Other government https://clinicaltrials.gov/study/NCT01821911 NCT07157774 Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a) Atherosclerosis Phase 3 Recruiting 2025-09-02 10450 Estimated Industry https://clinicaltrials.gov/study/NCT07157774 NCT04953130 Adding Male Single Dose HPV Vaccination to Female HPV Vaccination in Tanzania Papillomavirus Infections; Vaccine-Preventable Diseases Phase 4 Recruiting 2022-08-01 10400 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04953130 NCT05096832 Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01) Booster Study COVID-19 Phase 3 Completed 2021-11-03 10381 Actual Industry https://clinicaltrials.gov/study/NCT05096832 NCT02164513 A Study Comparing the Efficacy, Safety and Tolerability of Fixed Dose Combination (FDC) of FF/UMEC/VI With the FDC of FF/VI and UMEC/VI; Administered Once-daily Via a Dry Powder Inhaler (DPI) in Subjects With Chronic Obstructive Pulmonary Disease (COPD) Pulmonary Disease, Chronic Obstructive Phase 3 Completed 2014-06-30 10355 Actual Industry https://clinicaltrials.gov/study/NCT02164513 NCT06516042 Targeted Antimalarial Drug Administration for Seasonal Migrant Populations in Amhara Region, Ethiopia Malaria, Falciparum; Malaria Phase 3 Active not recruiting 2024-08-21 10350 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06516042 NCT04791423 Study of GRAd-COV2 for the Prevention of COVID-19 in Adults COVID-19 Phase 2, Phase 3 Completed 2021-03-15 10300 Actual Industry https://clinicaltrials.gov/study/NCT04791423 NCT04536051 A Study of a Candidate COVID-19 Vaccine (COV003) Coronavirus Infections; COVID-19 Phase 3 Unknown 2020-06-02 10300 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04536051 NCT05204589 Heterologous Boost Immunization with an Aerosolised Ad5-nCoV After Two-dose Priming with an Inactivated SARS-CoV-2 Vaccine COVID-19 Phase 3 Completed 2022-01-22 10285 Actual Network https://clinicaltrials.gov/study/NCT05204589 NCT01373281 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia Dengue; Severe Dengue Phase 3 Completed 2011-06-03 10275 Actual Industry https://clinicaltrials.gov/study/NCT01373281 NCT00310180 Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial) Breast Neoplasms Phase 3 Active not recruiting 2006-04-07 10273 Actual NIH https://clinicaltrials.gov/study/NCT00310180 NCT00000620 Action to Control Cardiovascular Risk in Diabetes (ACCORD) Atherosclerosis; Cardiovascular Diseases; Hypercholesterolemia Phase 3 Completed 1999-09 10251 Actual NIH https://clinicaltrials.gov/study/NCT00000620 NCT01508247 A Clinical Trial to Assess the Efficacy and Safety of an Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Aged 6-35 Months Hand, Foot and Mouth Disease; Herpangina Phase 3 Completed 2012-01 10245 Actual Network https://clinicaltrials.gov/study/NCT01508247 NCT04582344 Clinical Trial For SARS-CoV-2 Vaccine (COVID-19) COVID-19 Phase 3 Completed 2020-09-14 10214 Actual Other government https://clinicaltrials.gov/study/NCT04582344 NCT06534892 An Extension and Crossover Vaccination Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus Given to Adults 60 Years of Age and Above Who Participated in RSV OA=ADJ-006 Study Respiratory Syncytial Virus Infections Phase 3 Active not recruiting 2024-08-01 10212 Actual Industry https://clinicaltrials.gov/study/NCT06534892 NCT03301051 Efficacy, Safety, and Immunogenicity of a Plant-Derived Quadrivalent Virus-Like Particles (VLPs) Influenza Vaccine in Adults Virus Diseases; RNA Virus Infections; Respiratory Tract Diseases Phase 3 Completed 2017-08-31 10160 Actual Industry https://clinicaltrials.gov/study/NCT03301051 NCT00135707 Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS) Pre-Eclampsia; Hypertension Phase 3 Completed 2003-06 10154 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00135707 NCT06581965 inDividual, Targeted thrombosIS Prophylaxis Versus the Standard 'One Size Fits All' Approach in Patients Undergoing Total hIp or Total kNee replaCemenT Venous Thromboembolism; Venous Thrombosis; Pulmonary Embolism Phase 4 Recruiting 2024-11-11 10078 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06581965 NCT04425629 Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for the Treatment of Ambulatory Adult and Pediatric Patients With COVID-19 COVID-19; Coronavirus Infections Phase 3 Terminated 2020-06-16 10078 Actual Industry https://clinicaltrials.gov/study/NCT04425629 NCT01507857 An Efficacy Trial in Inactivated Enterovirus Type 71 (EV71) Vaccine Hand, Foot and Mouth Disease Phase 3 Completed 2012-01 10077 Actual Industry https://clinicaltrials.gov/study/NCT01507857 NCT01327846 Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events) Atherosclerosis; Myocardial Infarction; Stroke Phase 3 Completed 2011-04-11 10066 Actual Industry https://clinicaltrials.gov/study/NCT01327846 NCT06370273 Thromboprophylaxis in Lower Limb Immobilisation Thrombosis; Leg Injuries Phase 3 Recruiting 2024-11-12 10044 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06370273 NCT01738074 Phase Three Clinical Trials of Trivalent Rotavirus Genetic Reassortment Vaccine Phase 3 Unknown 2012-08 10020 Actual Other government https://clinicaltrials.gov/study/NCT01738074 NCT05563675 Once Daily Long-Acting Muscarinic Antagonists Administered in the Evening for Prevention of Chronic Obstructive Pulmonary Disease Exacerbations Requiring Hospitalization or Death from Any Cause Phase 4 Completed 2023-01-27 10011 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05563675 NCT01082874 PeriOperative ISchemic Evaluation-2 Trial Cardiovascular Diseases Phase 3 Completed 2010-07 10010 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01082874 NCT03073863 Evaluation of Statin Mechanism Preventing Cardiovascular Disease by Post-hoc Analysis of Treating to New Targets Study Cardiovascular Diseases Phase 4 Completed 1998-04-03 10001 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03073863 NCT00004799 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Acellular and Whole-Cell Pertussis Vaccines Whooping Cough; Bacterial Infections; Immune System Diseases Phase 3 Completed 1991-04 10000 NIH https://clinicaltrials.gov/study/NCT00004799 NCT01184638 Long-term Outcome of General Anesthesia on Dysgnosia Delirium; Dementia; Cognitive Dysfunction Phase 4 Unknown 2010-08 10000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01184638 NCT05308576 A Study to Evaluate the Efficacy and Safety of SCTV01E (a COVID-19 Vaccine) in Population Aged ≥18 Years COVID-19 Phase 3 Unknown 2022-12-26 10000 Estimated Industry https://clinicaltrials.gov/study/NCT05308576 NCT02251899 A Disease Management Study Targeted to Reduce Health Care Utilization for Patients With Congestive Heart Failure Phase 3 Unknown 2010-01 10000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02251899 NCT06953726 Comparing the Safety and Efficacy of Apixaban and Rivaroxaban Atrial Fibrillation; Ischemic Stroke; Hemorrhage Phase 4 Recruiting 2026-06-01 10000 Estimated U.S. federal https://clinicaltrials.gov/study/NCT06953726 NCT06667999 The Intensive Care Platform Trial Critical Illness Phase 4 Recruiting 2025-06-26 10000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06667999 NCT00893906 Inactivated Influenza Vaccine Effectiveness in Tropical Africa Influenza, Human Phase 4 Completed 2009-05 10000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00893906 NCT07619729 Evaluate the Efficacy of an Oral Health Behavioral Intervention in People With Diabetes Diabetes Mellitus, Type 2; Periodontal Diseases Phase 4 Enrolling by invitation 2026-05-26 10000 Estimated Industry https://clinicaltrials.gov/study/NCT07619729 NCT02992457 Safety and Efficacy of Sofosbuvir-Based Regimens in the Treatment of Egyptian Patients With Hepatitis C Infection Hepatitis C Phase 4 Completed 2015-01 10000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02992457 NCT00190593 Raloxifene Use for The Heart Cardiovascular Diseases; Breast Neoplasms Phase 3 Completed 1998-06 10000 Industry https://clinicaltrials.gov/study/NCT00190593 NCT06068530 Mass Vaccine and Drug Administration, Bangladesh Malaria, Falciparum Phase 4 Recruiting 2025-02-15 10000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06068530 NCT00225849 Japanese Primary Prevention Project With Aspirin Hypertension; Hyperlipidemias; Diabetes Mellitus Phase 4 Unknown 2005-03 10000 Other government https://clinicaltrials.gov/study/NCT00225849 NCT00248469 MEMA Kwa Vijana Trial: Impact of an Adolescent Sexual and Reproductive Health Intervention in Mwanza, Tanzania HIV Infections; Sexually Transmitted Diseases; Sexual Behavior Phase 3 Completed 1998-07 10000 University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00248469 NCT06118281 ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack Phase 3 Active not recruiting 2024-06-25 10000 Estimated Industry https://clinicaltrials.gov/study/NCT06118281 NCT05855408 Effectiveness of a Second COVID-19 Vaccine Booster in Chinese Adults COVID-19 Phase 4 Unknown 2023-05-18 10000 Estimated Network https://clinicaltrials.gov/study/NCT05855408 NCT04615156 18F-2-fluoro-2-deoxy-D-glucose in Positron Emission Tomography Computed Tomography Solitary Pulmonary Nodule; Neoplasms Phase 3 Not yet recruiting 2020-11-01 10000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04615156 NCT05633810 COLchicine and Non-enteric Coated Aspirin in the Cardiovascular Outcomes Trial of Patients With Type 2 Diabetes Diabetes Mellitus, Type 2; Cardiovascular Diseases; Heart Diseases Phase 3 Recruiting 2022-12-21 10000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05633810 NCT05002530 Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell. Anosmia Phase 4 Unknown 2021-11 10000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05002530 NCT00098709 Fetal Pulse Oximetry Trial (FOX) Phase 3 Terminated 2002-05 10000 University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00098709 NCT07159763 A Study to Evaluate the Safety and Efficacy of MK-1406/CD388 for Prevention of Influenza (MK-1406-005/CD388.SQ.3.06) Influenza, Human Phase 3 Recruiting 2025-09-25 10000 Estimated Industry https://clinicaltrials.gov/study/NCT07159763 NCT01979900 Phase III Clinical Study of Efficacy and Safety of Vaccae™ to Prevent Tuberculosis Tuberculosis Phase 3 Completed 2013-10 10000 Actual Industry https://clinicaltrials.gov/study/NCT01979900 NCT01924325 Apixaban Versus Dual-antiplatelet Therapy (Clopidogrel and Aspirin) in Acute Non-disabling Cerebrovascular Events Ischemic Stroke Phase 2, Phase 3 Unknown 2014-01 10000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01924325 NCT01203813 A Risk Based Approach to Improving Chronic Kidney Disease Management Renal Insufficiency, Chronic Phase 3 Completed 2011-05 10000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01203813 NCT03418974 Safety and Efficacy of Statins for Chinese Patients With Dyslipidemia Dyslipidemias; Cardiovascular Diseases; Hypertension Phase 4 Unknown 2017-11-01 10000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03418974 NCT06383390 The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes) Atherosclerosis; Renal Insufficiency, Chronic; Cardiovascular Diseases Phase 3 Active not recruiting 2024-04-30 10000 Estimated Industry https://clinicaltrials.gov/study/NCT06383390 NCT03851445 Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Recruiting 2019-02-06 10000 Estimated Network https://clinicaltrials.gov/study/NCT03851445 NCT01293071 Effect of Antibiotic Rotation in the ICU on the Prevalence of Antibiotic Resistant Gram-negative Colonisation Infections Phase 4 Completed 2011-01 10000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01293071 NCT01981967 Post-licensure Safety Study of IMOJEV® in Thailand Encephalitis, Japanese Phase 4 Completed 2013-11 10000 Actual Industry https://clinicaltrials.gov/study/NCT01981967 NCT02099123 A Clinical Trial of STAtin Therapy for Reducing Events in the Elderly (STAREE) Cardiovascular Diseases; Diabetes Mellitus; Dementia Phase 4 Active not recruiting 2015-07 9971 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02099123 NCT05212948 A Study of S-268019 for the Prevention of COVID-19 Phase 3 Completed 2021-12-25 9902 Actual Industry https://clinicaltrials.gov/study/NCT05212948 NCT01394952 Researching Cardiovascular Events With a Weekly Incretin in Diabetes (REWIND) Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes Mellitus Phase 3 Completed 2011-07-22 9901 Actual Industry https://clinicaltrials.gov/study/NCT01394952 NCT02610400 Evaluation of Reactive Focal Mass Drug Administration (rfMDA) +/- Reactive Focal Vector Control (RAVC) in Namibia Malaria Phase 3 Completed 2016-02 9845 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02610400 NCT00856583 Safety Study of Sertindole Versus Risperidone Under Normal Conditions of Use Schizophrenia Phase 3 Completed 2002-07 9809 Actual Industry https://clinicaltrials.gov/study/NCT00856583 NCT00682006 Topical Application of Chlorhexidine to the Umbilical Cord for Prevention of Omphalitis and Neonatal Mortality in Rural District of Pakistan Phase 3 Completed 2008-01 9800 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00682006 NCT05812014 Clinical Trail of SARS-CoV-2 Bivalent mRNA Vaccine (LVRNA021) in Participants Aged 18 Years and Older Phase 3 Unknown 2023-03-25 9800 Estimated Industry https://clinicaltrials.gov/study/NCT05812014 NCT00036270 Randomized Phase III Study Of Exemestane (Aromasin) For 5 Years Versus Tamoxifen for 2.5 to 3 Years Followed By Exemestane Breast Neoplasms Phase 3 Completed 2001-08 9779 Actual Industry https://clinicaltrials.gov/study/NCT00036270 NCT00279448 Exemestane As Treatment In Adjuvant For Post-Menopausal Patients With Non-Metastatic Breast Cancer Breast Neoplasms Phase 3 Completed 2002-01 9779 Actual Industry https://clinicaltrials.gov/study/NCT00279448 NCT02870790 Expanded PrEP Implementation in Communities in NSW Sexually Transmitted Diseases Phase 3 Completed 2016-03 9733 Actual Other government https://clinicaltrials.gov/study/NCT02870790 NCT03914326 A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes Diabetes Mellitus, Type 2 Phase 3 Completed 2019-06-17 9651 Actual Industry https://clinicaltrials.gov/study/NCT03914326 NCT07798232 Penicillin to Prevent Early Rheumatic Heart Disease in School-Aged Children Rheumatic Heart Disease Phase 3 Not yet recruiting 2027-02-01 9622 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07798232 NCT07153744 Efficacy and Safety of Shexiang Baoxin Pill(MUSKARDIA) in the Treatment of Acute Myocardial Infarction Phase 4 Not yet recruiting 2025-09-01 9588 Estimated Industry https://clinicaltrials.gov/study/NCT07153744 NCT05202509 Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Disease Atherosclerosis Phase 3 Active not recruiting 2022-02-07 9541 Actual Industry https://clinicaltrials.gov/study/NCT05202509 NCT03505723 PeriOperative ISchemic Evaluation-3 Trial Venous Thrombosis; Hypotension; Hypertension Phase 3 Completed 2018-06-27 9535 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03505723 NCT04975737 Study of the Safety and Efficacy of the Subunit Recombinant Tuberculosis Vaccine GamTBvac Tuberculosis Phase 3 Active not recruiting 2022-01-20 9500 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04975737 NCT00514891 Impact of the WHO Recommended Vitamin A Supplementation at Immunisation Contacts Phase 4 Terminated 2007-08 9500 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00514891 NCT02465515 Effect of Albiglutide, When Added to Standard Blood Glucose Lowering Therapies, on Major Cardiovascular Events in Subjects With Type 2 Diabetes Mellitus Diabetes Mellitus; Diabetes Mellitus, Type 2 Phase 4 Completed 2015-07-01 9463 Actual Industry https://clinicaltrials.gov/study/NCT02465515 NCT00125593 Study of Heart and Renal Protection Renal Insufficiency, Chronic; Cardiovascular Diseases; Atherosclerosis Phase 4 Completed 2003-06 9438 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00125593 NCT00089895 EARLY ACS: Early Glycoprotein IIb/IIIa Inhibition in Patients With Non-ST-segment Elevation Acute Coronary Syndrome (Study P03684AM2)(COMPLETED) Myocardial Ischemia; Acute Coronary Syndrome; Myocardial Infarction Phase 3 Completed 2004-11-01 9406 Actual Industry https://clinicaltrials.gov/study/NCT00089895 NCT00262106 Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection HIV Infections; Gonorrhea; Chlamydia Infections Phase 3 Completed 2005-10 9404 Actual Industry https://clinicaltrials.gov/study/NCT00262106 NCT00088010 Effects of Arzoxifene on Bone Fractures and Incidence of Breast Cancer Osteoporosis, Postmenopausal Phase 3 Completed 2004-06 9369 Actual Industry https://clinicaltrials.gov/study/NCT00088010 NCT00849030 ATAC - Arimidex, Tamoxifen Alone or in Combination Breast Neoplasms Phase 3 Completed 1996-07 9358 Actual Industry https://clinicaltrials.gov/study/NCT00849030 NCT00784862 ATAC - Pharmacokinetics (PK) Sub-Protocol Breast Neoplasms Phase 3 Completed 1998-06 9358 Actual Industry https://clinicaltrials.gov/study/NCT00784862 NCT01190930 Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Down Syndrome Phase 3 Completed 2010-08-11 9350 Actual Network https://clinicaltrials.gov/study/NCT01190930 NCT00549003 Efficacy and Cost Effectiveness of Malaria Diagnosis Procedures and the Rational Use of ACT in Zanzibar Malaria Phase 4 Completed 2005-02 9346 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00549003 NCT01179048 Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results Diabetes Mellitus; Diabetes Mellitus, Type 2 Phase 3 Completed 2010-08-31 9341 Actual Industry https://clinicaltrials.gov/study/NCT01179048 NCT04537156 Efficacy, Immunogenicity and Safety Study of Recombinant Human Papillomavirus Vaccine(6,11,16,18,31,33,45,52,58 Type)(E.Coli) Uterine Cervical Dysplasia; Uterine Cervical Neoplasms; Condylomata Acuminata Phase 3 Active not recruiting 2020-09-05 9327 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04537156 NCT00699998 A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects Acute Coronary Syndrome Phase 3 Completed 2008-06 9326 Actual Industry https://clinicaltrials.gov/study/NCT00699998 NCT06291857 A Study to Evaluate the Safety and Immunogenicity of COVID-19 Vaccine and Influenza Combination Vaccine COVID-19; Influenza, Human Phase 3 Completed 2024-12-09 9320 Actual Industry https://clinicaltrials.gov/study/NCT06291857 NCT00097786 Long-term Study of Nateglinide+Valsartan to Prevent or Delay Type II Diabetes Mellitus and Cardiovascular Complications Diabetes Mellitus, Type 2 Phase 3 Completed 2002-01 9306 Actual Industry https://clinicaltrials.gov/study/NCT00097786 NCT01887912 Study of a Candidate Clostridium Difficile Toxoid Vaccine in Subjects at Risk for C. Difficile Infection Clostridium Infections Phase 3 Terminated 2013-07-30 9302 Actual Industry https://clinicaltrials.gov/study/NCT01887912 NCT06866574 A Phase III Trial to Evaluate the Efficacy, Immunogenicity and Safety of a Recombinant Human Papillomavirus 9-Valent (Types 6, 11, 16, 18, 31, 33, 45, 52, 58) Vaccine (E.Coli) in Chinese Males Anus Neoplasms; Condylomata Acuminata Phase 3 Active not recruiting 2025-04-11 9300 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06866574 NCT07551492 A Phase III Study To Evaluate the Efficacy And Safety Of HRS9531 In Participants With Atherosclerotic Cardiovascular Disease Atherosclerosis Phase 3 Recruiting 2026-05-29 9262 Estimated Industry https://clinicaltrials.gov/study/NCT07551492 NCT03665207 Tight Versus Liberal Blood Glucose Control in Adult Critically Ill Patients Critical Illness; Hyperglycemia Phase 3 Active not recruiting 2018-09-18 9230 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03665207 NCT07140211 Short-term Low-dose Low-molecular-weight Heparin to Prevent Postpartum Thrombosis Venous Thromboembolism Phase 3 Recruiting 2025-10-15 9200 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07140211 NCT05330884 BCG Revaccination in Children and Adolescents Latent Tuberculosis; Tuberculosis Phase 3 Suspended 2024-07-15 9200 Estimated Other government https://clinicaltrials.gov/study/NCT05330884 NCT05447559 Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study Surgical Wound Infection Phase 4 Recruiting 2023-02-07 9180 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05447559 NCT00976027 Multi-Year Study of Fluzone High-Dose Influenza Vaccine Compared With Fluzone® Vaccine in Adults Aged 65 Years and Older Influenza, Human; Respiratory Tract Infections Phase 3 Terminated 2009-09 9172 Actual Industry https://clinicaltrials.gov/study/NCT00976027 NCT04381143 ASPIrin in Reducing Events in Dialysis ( ASPIRED ) Renal Insufficiency, Chronic; Kidney Failure, Chronic Phase 4 Active not recruiting 2020-07-30 9082 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04381143 NCT04102371 Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis Shock; Sepsis; Shock, Septic Phase 3 Completed 2020-08-25 9041 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04102371 NCT00249795 Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE I) Atrial Fibrillation; Cardiovascular Diseases Phase 3 Completed 2003-06 9016 Actual Industry https://clinicaltrials.gov/study/NCT00249795 NCT02270242 Ticagrelor With Aspirin or Alone in High-Risk Patients After Coronary Intervention Cardiovascular Diseases Phase 4 Completed 2015-07 9006 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02270242 NCT02285998 Protective Efficacy of Flublok® Quadrivalent Versus Licensed Inactivated Influenza Vaccine in Adults ≥50 Years of Age Influenza, Human Phase 3 Completed 2014-10 9003 Actual Industry https://clinicaltrials.gov/study/NCT02285998 NCT06465914 A Phase III Study to Evaluate the Efficacy, Immunogenicity and Safety of the 9-valent HPV Vaccine in Chinese Males Condylomata Acuminata; Penile Neoplasms; Anus Neoplasms Phase 3 Active not recruiting 2024-07-11 9000 Actual Industry https://clinicaltrials.gov/study/NCT06465914 NCT02964065 A Trial on the Efficacy, Safety and Immunogenicity of Live-Attenuated Influenza Vaccine (LAIV) Influenza, Human Phase 3 Completed 2016-11 9000 Actual Industry https://clinicaltrials.gov/study/NCT02964065 NCT02000089 The Cancer of the Pancreas Screening-5 CAPS5)Study Pancreatic Neoplasms; Peutz-Jeghers Syndrome; Colorectal Neoplasms, Hereditary Nonpolyposis Phase 3 Recruiting 2014-01-06 9000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02000089 NCT01601704 Cardiovascular Outcomes Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects With Cardiovascular Risk Factors (The Light Study) Obesity; Overweight; Body Weight Phase 3 Terminated 2012-06 8910 Actual Industry https://clinicaltrials.gov/study/NCT01601704 NCT00305162 A Clinical Trial to Demonstrate the Efficacy of Cangrelor Myocardial Infarction; Acute Coronary Syndrome; Non-ST Elevated Myocardial Infarction Phase 3 Terminated 2006-04 8882 Actual Industry https://clinicaltrials.gov/study/NCT00305162 NCT06472908 Efficacy and Safety of Colchicine After PCI Coronary Disease Phase 3 Active not recruiting 2024-07-09 8862 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06472908 NCT02276755 Vitamin D Supplementation in TB Prevention Latent Tuberculosis Phase 3 Completed 2015-09 8851 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02276755 NCT03344887 An Innovative Trial Assessing Donor Sex on Recipient Mortality Anemia Phase 4 Unknown 2018-09-04 8850 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03344887 NCT04984408 Efficacy, Immunogenicity and Safety of BBIBP-CorV Vaccine Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. Phase 3 Unknown 2021-10-01 8825 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04984408 NCT06494878 The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity Venous Thromboembolism; Venous Thrombosis; Pulmonary Embolism Phase 3 Recruiting 2026-06-04 8805 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06494878 NCT07543458 Therapeutics for Moderate and Severe Dengue Dengue; Severe Dengue; Mosquito-Borne Diseases Phase 3 Not yet recruiting 2026-10-01 8800 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07543458 NCT06178991 A Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Combined Modified RNA Vaccine Candidate Against COVID-19 and Influenza. Influenza, Human; COVID-19 Phase 3 Completed 2023-12-20 8795 Actual Industry https://clinicaltrials.gov/study/NCT06178991 NCT00476957 Randomized Study Comparing Endeavor With Cypher Stents (PROTECT) Myocardial Ischemia Phase 4 Completed 2007-06 8709 Actual Industry https://clinicaltrials.gov/study/NCT00476957 NCT00329745 Year 3 Extension for Efficacy Follow-up in Subjects Vaccinated in Studies Rota-028, 029 or 030 (NCT00197210) Rotavirus Infections Phase 3 Completed 2007-01 8687 Actual Industry https://clinicaltrials.gov/study/NCT00329745 NCT02690207 Cross-vaccination Study of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine (GSK 1437173A) in Subjects Who Previously Received Placebo in ZOSTER-006 (NCT01165177) and ZOSTER-022 (NCT01165229) Studies. Herpes Zoster Phase 3 Completed 2016-03-16 8687 Actual Industry https://clinicaltrials.gov/study/NCT02690207 NCT06223919 Efficacy/Effectiveness, Safety, and Immunogenicity of LC16m8 Mpox Vaccine in Colombia Mpox, Monkeypox Phase 3 Active not recruiting 2023-12-16 8686 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06223919 NCT02654912 Community-led Responses for Elimination: Controlled Trial of Reactive Case Detection Versus Reactive Drug Administration Malaria Phase 4 Completed 2016-02 8682 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02654912 NCT02208154 Ecological Effects of Decolonisation Strategies in Intensive Care Phase 3 Completed 2013-12-01 8665 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02208154 NCT02378753 STRIVE (Sierra Leone Trial to Introduce a Vaccine Against Ebola) Hemorrhagic Fever, Ebola Phase 2, Phase 3 Completed 2015-04 8651 Actual U.S. federal https://clinicaltrials.gov/study/NCT02378753 NCT00549757 Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints (Core and Extension Phases) Diabetes Mellitus, Type 2; Cardiovascular Diseases Phase 3 Terminated 2007-10 8606 Actual Industry https://clinicaltrials.gov/study/NCT00549757 NCT00327691 A Study to Determine the Degree of Additional Reduction in CV Risk in Lowering LDL Below Minimum Target Levels Cardiovascular Diseases; Stroke; Coronary Disease Phase 4 Completed 1998-04 8600 Industry https://clinicaltrials.gov/study/NCT00327691 NCT00159835 Atorvastatin Versus Simvastatin In The Prevention Of Coronary Heart Disease (CHD) In Patients With Known CHD Cardiovascular Diseases Phase 4 Completed 1999-02 8600 Industry https://clinicaltrials.gov/study/NCT00159835 NCT06098079 Effect of Naltrexone Hydrochloride ER and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on Major Adverse Cardiovascular Events (MACE) Obesity Phase 4 Active not recruiting 2024-01-03 8600 Estimated Industry https://clinicaltrials.gov/study/NCT06098079 NCT02465567 Study to Assess the Efficacy and Safety of PT010 Relative to PT003 and PT009 in Subjects With Moderate to Very Severe COPD (Ethos) Pulmonary Disease, Chronic Obstructive Phase 3 Completed 2015-06-30 8588 Actual Industry https://clinicaltrials.gov/study/NCT02465567 NCT03201770 Cohort Event Monitoring Study of Pyramax® Malaria, Falciparum Phase 4 Completed 2017-06-22 8572 Actual Industry https://clinicaltrials.gov/study/NCT03201770 NCT00141323 Postmenopausal Evaluation and Risk-reduction With Lasofoxifene (PEARL) Osteoporosis Phase 3 Completed 2001-11 8556 Estimated Industry https://clinicaltrials.gov/study/NCT00141323 NCT05155137 Polypill and RiscOMeter to Prevent StrOke and CogniTive ImpairmEnt (PROMOTE) Stroke; Cognitive Dysfunction Phase 3 Recruiting 2021-12-20 8518 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05155137 NCT02130856 Newborn Kit to Save Lives in Pakistan Phase 3 Completed 2014-04 8518 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02130856 NCT03596385 TREatment With Beta-blockers After myOcardial Infarction withOut Reduced Ejection fracTion" Myocardial Infarction Phase 4 Completed 2018-10-31 8505 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03596385 NCT07861100 A Research Study to Look at How Well Zenagamtide Works Compared to Placebo in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity Obesity Phase 3 Not yet recruiting 2026-10-26 8500 Estimated Industry https://clinicaltrials.gov/study/NCT07861100 NCT00128167 Trivalent, Live, Cold Adapted Influenza Vaccine (CAIV-T) Against Inactivated Influenza Vaccine (TIV) in Children 6-59 Months of Age Influenza, Human Phase 3 Completed 2004-10 8500 Industry https://clinicaltrials.gov/study/NCT00128167 NCT03523962 Pre-operative Alcohol Skin Solutions in Fractured Extremities Surgical Wound Infection; Hip Fractures; Fractures, Open Phase 4 Completed 2018-08-21 8485 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03523962 NCT00197548 A Trial of Micronutrients and Adverse Pregnancy Outcomes Premature Birth Phase 3 Completed 2001-08 8468 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00197548 NCT01035255 This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure Phase 3 Terminated 2009-12 8442 Actual Industry https://clinicaltrials.gov/study/NCT01035255 NCT00463866 Local Phase 4 Pan-European SMART Study Asthma Phase 4 Completed 2007-03 8424 Actual Industry https://clinicaltrials.gov/study/NCT00463866 NCT04803747 A Trial of a Hospital Policy of Tranexamic Acid Use to Reduce Transfusion in Major Non-cardiac Surgery Venous Thromboembolism; Venous Thrombosis Phase 4 Completed 2022-02-16 8421 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04803747 NCT05827978 Study of mRNA-1010 Seasonal Influenza Vaccine in Adults Virus Diseases; Influenza, Human Phase 3 Completed 2023-04-17 8411 Actual Industry https://clinicaltrials.gov/study/NCT05827978 NCT01271985 Prevention of Cardiovascular Disease in Middle-aged and Elderly Iranians Using a Single PolyPill Cardiovascular Diseases Phase 3 Completed 2011-02 8410 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01271985 NCT00115869 Hutchinson Smoking Prevention Project Tobacco Use Cessation Phase 3 Completed 1984-09 8388 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00115869 NCT00490139 ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D Breast Neoplasms Phase 3 Completed 2007-05-16 8381 Actual Industry https://clinicaltrials.gov/study/NCT00490139 NCT02117934 Safety and Immunogenicity Study of the Hepatitis B Vaccine, HEPLISAV™, Compared to Engerix-B® Vaccine Hepatitis B; Hepatitis Phase 3 Completed 2014-04 8374 Actual Industry https://clinicaltrials.gov/study/NCT02117934 NCT06531824 EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin) Renal Insufficiency, Chronic Phase 3 Active not recruiting 2024-08-30 8371 Actual Industry https://clinicaltrials.gov/study/NCT06531824 NCT00182039 POISE Trial: Perioperative Ischemic Evaluation Study Cardiovascular Diseases Phase 3 Terminated 2002-10 8351 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00182039 NCT05439356 Colchicine in High-risk Patients With Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3) Ischemic Stroke Phase 3 Completed 2022-08-11 8343 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05439356 NCT00622648 Study to Evaluate the Mortality Reduction of Enoxaparin in Hospitalized Acutely Ill Medical Receiving Enoxaparin Phase 4 Completed 2008-01 8329 Actual Industry https://clinicaltrials.gov/study/NCT00622648 NCT04023552 Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD Cardiovascular Diseases; Myocardial Infarction; Stroke Phase 3 Completed 2019-12-12 8323 Actual Industry https://clinicaltrials.gov/study/NCT04023552 NCT00057330 HerpeVac Trial for Young Women Herpes Simplex Phase 3 Completed 2003-01-14 8323 Actual Industry https://clinicaltrials.gov/study/NCT00057330 NCT00986154 Comparative Investigation of Low Molecular Weight (LMW) Heparin/Edoxaban Tosylate (DU176b) Versus (LMW) Heparin/Warfarin in the Treatment of Symptomatic Deep-Vein Blood Clots and/or Lung Blood Clots. (The Edoxaban Hokusai-VTE Study). Venous Thromboembolism; Venous Thrombosis; Pulmonary Embolism Phase 3 Completed 2009-10 8292 Actual Industry https://clinicaltrials.gov/study/NCT00986154 NCT03130114 Antibiotics for Children With Severe Diarrhoea Diarrhea Phase 3 Completed 2017-05-13 8268 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03130114 NCT02929329 Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction Heart Failure Phase 3 Completed 2017-01-06 8256 Actual Industry https://clinicaltrials.gov/study/NCT02929329 NCT04624854 Dual Anti-Platelet Therapy in Patients With Coronary Multi-Vessel Disease (DAPT-MVD) Coronary Artery Disease; Myocardial Ischemia; Acute Coronary Syndrome Phase 4 Completed 2020-10-28 8250 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04624854 NCT01986881 Cardiovascular Outcomes Following Ertugliflozin Treatment in Type 2 Diabetes Mellitus Participants With Vascular Disease, The VERTIS CV Study (MK-8835-004) Diabetes Mellitus, Type 2 Phase 3 Completed 2013-11-04 8246 Actual Industry https://clinicaltrials.gov/study/NCT01986881 NCT00056407 "REDUCE" - A Clinical Research Study To Reduce The Incidence Of Prostate Cancer In Men Who Are At Increased Risk Prostatic Neoplasms Phase 3 Completed 2003-03 8231 Actual Industry https://clinicaltrials.gov/study/NCT00056407 NCT04010448 A Trial to Assess the Safety, Immunogenicity and Efficacy of a Trivalent Rotavirus P2-VP8 Subunit Vaccine in Prevention of Severe Rotavirus Gastroenteritis in Healthy Infants in Africa and India Phase 3 Unknown 2019-10-10 8200 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04010448 NCT01492361 A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin Cardiovascular Diseases; Coronary Artery Disease; Myocardial Ischemia Phase 3 Completed 2011-11 8179 Actual Industry https://clinicaltrials.gov/study/NCT01492361 NCT01456936 Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders Smoking Cessation; Mental Disorders Phase 4 Completed 2011-11 8144 Actual Industry https://clinicaltrials.gov/study/NCT01456936 NCT00571649 Venous Thromboembolic Event (VTE) Prophylaxis in Medically Ill Patients Venous Thromboembolism; Venous Thrombosis; Pulmonary Embolism Phase 3 Completed 2007-12 8101 Actual Industry https://clinicaltrials.gov/study/NCT00571649 NCT05285826 Efficacy, Immunogenicity, and Safety of V503 in Chinese Males (V503-052) Papillomavirus Infections Phase 3 Active not recruiting 2022-02-18 8100 Estimated Industry https://clinicaltrials.gov/study/NCT05285826 NCT07507500 Dual Antiplatelet Therapy Strategies After Acute Myocardial Infarction Undergoing PCI: Prasugrel vs Ticagrelor & 12 Months vs 1-3 Months Myocardial Infarction; Acute Coronary Syndrome; Infarction Phase 4 Recruiting 2026-09-02 8100 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07507500 NCT00706121 S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000 Colorectal Neoplasms; Precancerous Conditions; Colonic Neoplasms Phase 3 Completed 2008-06 8094 Actual Network https://clinicaltrials.gov/study/NCT00706121 NCT00373685 GI-Reasons- A Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS) Osteoarthritis Phase 4 Completed 2006-10 8067 Actual Industry https://clinicaltrials.gov/study/NCT00373685 NCT06097273 A Study of mRNA-1083 (SARS-CoV-2 and Influenza) Vaccine in Healthy Adult Participants, ≥50 Years of Age Influenza, Human; Coronavirus Infections; Virus Diseases Phase 3 Completed 2023-10-19 8061 Actual Industry https://clinicaltrials.gov/study/NCT06097273 NCT05437510 Study of a Single Intramuscular Dose of Nirsevimab in the Prevention of Hospitalizations Due to Respiratory Syncytial Virus (RSV) Infection in Healthy Term and Preterm Infants During the First Year of Life Phase 3 Completed 2022-08-08 8057 Actual Industry https://clinicaltrials.gov/study/NCT05437510 NCT00023452 Three Months of Weekly Rifapentine and Isoniazid for M. Tuberculosis Infection Tuberculosis Phase 3 Completed 2001-06 8053 Actual U.S. federal https://clinicaltrials.gov/study/NCT00023452 NCT00518687 Efficacy, Immunogenicity, and Safety of a Single Dose of V710 in Adult Patients Scheduled for Cardiothoracic Surgery (V710-003 AM2) Staphylococcal Infections; Bacteremia; Mediastinitis Phase 2, Phase 3 Terminated 2007-12 8031 Actual Industry https://clinicaltrials.gov/study/NCT00518687 NCT00004205 Letrozole or Tamoxifen in Treating Postmenopausal Women With Breast Cancer Breast Neoplasms; Breast Carcinoma In Situ; Carcinoma, Ductal, Breast Phase 3 Completed 1998-03 8028 Actual Network https://clinicaltrials.gov/study/NCT00004205 NCT06838195 Clinical Trial of the S. Flexneri-S. Sonnei Bivalent Conjugate Vaccine Dysentery; Dysentery, Bacillary Phase 3 Active not recruiting 2025-05-12 8000 Estimated Industry https://clinicaltrials.gov/study/NCT06838195 NCT05916326 Phase III Clinical Trial to Evaluate the Human Norovirus Bivalent (GⅠ.1/GⅡ.4)Vaccine，Recombinant (Hansenula Polymorpha) Caliciviridae Infections Phase 3 Completed 2023-06-30 8000 Actual Industry https://clinicaltrials.gov/study/NCT05916326 NCT00043784 SYNERGY: Open Study of Enoxaparin Versus Unfractionated Heparin in Patients With Acute Coronary Syndromes Angina, Unstable; Myocardial Infarction; Myocardial Ischemia Phase 3 Completed 2001-08 8000 Industry https://clinicaltrials.gov/study/NCT00043784 NCT00379249 Rosuvastatin ORBITAL Germany Hypercholesterolemia; Patient Compliance Phase 3 Completed 2002-02 8000 Industry https://clinicaltrials.gov/study/NCT00379249 NCT05137119 Staphylococcus Aureus Network Adaptive Platform Trial Staphylococcal Infections Phase 4 Recruiting 2022-02-16 8000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05137119 NCT00479726 Lilly's Emotional and Physical Symptoms of Depression Study (LEAPS) Depressive Disorder, Major Phase 4 Completed 2004-08 8000 Industry https://clinicaltrials.gov/study/NCT00479726 NCT05580666 Reducing Mortality in Adults With Advanced HIV Disease (REVIVE) Acquired Immunodeficiency Syndrome Phase 3 Recruiting 2023-05-08 8000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05580666 NCT06605118 Azithromycin Prophylaxis for PRElabor CEsarean DElivery Trial Infections Phase 3 Recruiting 2024-11-06 8000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06605118 NCT05688579 Effect of MRA on Cardiovascular Disease in Patients With Hypertension and Hyperaldosteronemia Hypertension; Hyperaldosteronism Phase 4 Enrolling by invitation 2023-04-16 8000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05688579 NCT00950430 Imaging of Brain Amyloid Plaques in the Aging Population Alzheimer Disease; Lewy Body Disease; Frontotemporal Dementia Phase 4 Enrolling by invitation 2008-04 8000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00950430 NCT01196260 Combination Chemotherapy Treatments in Patients With Colorectal Cancer Stage II and III Colorectal Neoplasms Phase 2, Phase 3 Unknown 2004-01 8000 Estimated Network https://clinicaltrials.gov/study/NCT01196260 NCT00674375 Risk Score Alerts for Chest Pain Care Chest Pain Phase 3 Completed 2008-11 8000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00674375 NCT00211705 Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese(MEGA Study) Hyperlipidemias; Coronary Disease; Stroke Phase 4 Completed 1994-02 8000 Industry https://clinicaltrials.gov/study/NCT00211705 NCT00442442 Clinical Evaluation of Mosquito Coils to Control Malaria in China Malaria Phase 3 Unknown 2007-04 8000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00442442 NCT00159848 Effect Of A Treatment Optimization Program To Improve Satisfaction With Viagra Erectile Dysfunction Phase 4 Completed 2003-09 8000 Industry https://clinicaltrials.gov/study/NCT00159848 NCT04422366 Evaluate the Efficacy, Immunogenicity and Safety of 9-valent HPV Recombinant Vaccine in Chinese Healthy Females Uterine Cervical Neoplasms; Vulvar Neoplasms; Vaginal Neoplasms Phase 3 Recruiting 2020-04-28 8000 Estimated Industry https://clinicaltrials.gov/study/NCT04422366 NCT05514054 A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer Breast Neoplasms Phase 3 Active not recruiting 2022-10-04 8000 Estimated Industry https://clinicaltrials.gov/study/NCT05514054 NCT06734832 Efficacy, Safety, and Immunogenicity of the Bivalent Inactivated Enterovirus Vaccine (Vero Cell) Hand, Foot and Mouth Disease Phase 3 Recruiting 2024-12-13 8000 Estimated Industry https://clinicaltrials.gov/study/NCT06734832 NCT05173324 Integration of HPV Vaccination and HPV-based Cervical Screening Into ARV Clinics: the H2VICTORY Trial Papillomavirus Infections; HIV Infections Phase 3 Not yet recruiting 2023-02-01 8000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05173324 NCT00136370 Prevention of Perinatal Sepsis (PoPS): Evaluation of Chlorhexidine Wipes of Birth Canal and Newborn Infant, Newborn, Diseases; Sepsis; Puerperal Infection Phase 3 Unknown 2004-04 8000 Estimated U.S. federal https://clinicaltrials.gov/study/NCT00136370 NCT02296138 Comparing the Efficacy of Tiotropium + Olodaterol (5/5 µg) Fixed Dose Combination (FDC) Over Tiotropium 5µg in Reducing Moderate to Severe Exacerbations in Patients With Severe to Very Severe Chronic Obstructive Pulmonary Disease. Pulmonary Disease, Chronic Obstructive Phase 3 Completed 2015-01-13 7903 Actual Industry https://clinicaltrials.gov/study/NCT02296138 NCT00961337 Evaluation of a School-based Influenza Vaccination Program Influenza, Human Phase 4 Completed 2008-10 7854 Actual Other government https://clinicaltrials.gov/study/NCT00961337 NCT01794143 A Comparative Effectiveness Study of Major Glycemia-lowering Medications for Treatment of Type 2 Diabetes Diabetes Mellitus, Type 2 Phase 3 Completed 2013-05 7850 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01794143 NCT04727424 Repurposed Approved and Under Development Therapies for Patients With Early-Onset COVID-19 and Mild Symptoms COVID-19; Severe Acute Respiratory Syndrome Phase 3 Unknown 2021-01-19 7819 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04727424 NCT00089791 A Study to Evaluate Denosumab in the Treatment of Postmenopausal Osteoporosis Osteoporosis; Osteoporosis, Postmenopausal Phase 3 Completed 2004-08-01 7808 Actual Industry https://clinicaltrials.gov/study/NCT00089791 NCT00168662 Non-Specific Effects of Standard Titre Measles Vaccination Measles; Infant Death Phase 4 Completed 1995-03 7800 University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00168662 NCT07186634 PeRiOperative Medicine Platform Trial Phase 4 Recruiting 2026-04-06 7800 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07186634 NCT01646437 The International Polycap Study 3 (TIPS-3) Cardiovascular Diseases; Fractures, Bone; Neoplasms Phase 3 Completed 2012-06 7793 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01646437 NCT02344290 Evaluating the Use of Pitavastatin to Reduce the Risk of Cardiovascular Disease in HIV-Infected Adults Cardiovascular Diseases; Myocardial Infarction; Inflammation Phase 3 Completed 2015-03-26 7769 Actual NIH https://clinicaltrials.gov/study/NCT02344290 NCT03431142 Optimal antiPlatelet Therapy for High Bleeding and Ischemic RISK Patients Trial Hemorrhage Phase 4 Completed 2018-02-12 7758 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03431142 NCT00806195 Study to Evaluate the Safety of Novartis MenACWY Conjugate Vaccine When Administered With Routine Infant Vaccinations to Healthy Infants Meningitis; Meningococcal Infections Phase 3 Completed 2008-12 7744 Actual Industry https://clinicaltrials.gov/study/NCT00806195 NCT06015282 The Celljuvant Study: A Phase 3 Immunogenicity and Safety Study of aQIVc Vaccine in Adults Aged 50 Years and Older Influenza, Human Phase 3 Completed 2023-11-03 7741 Actual Industry https://clinicaltrials.gov/study/NCT06015282 NCT06930885 Polypill and Colchicine for Risk Reduction in Atherosclerotic Cardiovascular Disease Atherosclerosis Phase 3 Recruiting 2025-06-12 7713 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06930885 NCT00670319 Comparison of Raloxifene Hydrochloride and Placebo in the Treatment of Postmenopausal Women With Osteoporosis Osteoporosis, Postmenopausal Phase 3 Completed 1994-11 7705 Actual Industry https://clinicaltrials.gov/study/NCT00670319 NCT00049829 HORIZON-PFT: Pivotal Fracture Trial Osteoporosis Phase 3 Completed 2002-01 7700 Industry https://clinicaltrials.gov/study/NCT00049829 NCT00336180 Adolescent Drug and HIV Prevention in South Africa Substance-Related Disorders; Sexually Transmitted Diseases; Adolescent Behavior Phase 2, Phase 3 Completed 2003-09 7695 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00336180 NCT01959529 A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular Events Diabetes Mellitus; Diabetes Mellitus, Type 2 Phase 3 Completed 2013-10-29 7637 Actual Industry https://clinicaltrials.gov/study/NCT01959529 NCT00363870 A Study to Demonstrate the Efficacy of GSK Biologicals' Influenza Vaccine in Adults Influenza, Human Phase 4 Completed 2006-09 7632 Industry https://clinicaltrials.gov/study/NCT00363870 NCT05398848 Efficacy, Safety and Immunogenicity Study of the Recombinant Two-component COVID-19 Vaccine (CHO Cell)(Recov) COVID-19 Phase 3 Completed 2022-10-31 7623 Actual Industry https://clinicaltrials.gov/study/NCT05398848 NCT00663806 A Phase IV Study of Cipro XR in Uncomplicated UTI Urinary Tract Infections Phase 4 Completed 2003-02 7614 Actual Industry https://clinicaltrials.gov/study/NCT00663806 NCT00205777 Study Evaluating Bazedoxifene Acetate In Osteoporosis In Postmenopausal Women Osteoporosis Phase 3 Completed 2001-12 7609 Actual Industry https://clinicaltrials.gov/study/NCT00205777 NCT03848312 Preventing Alzheimer's With Cognitive Training Alzheimer Disease Phase 3 Active not recruiting 2019-02-19 7600 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03848312 NCT04760132 National Cohort Study of Effectiveness and Safety of SARS-CoV-2/COVID-19 Vaccines (ENFORCE) Severe Acute Respiratory Syndrome; COVID-19 Phase 4 Completed 2021-02-08 7600 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04760132 NCT00168610 Vitamin A Supplementation With Bacille Calmette Guerin (BCG) Vaccine Infant Death Phase 4 Unknown 2004-11 7600 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00168610 NCT00066573 Exemestane or Anastrozole in Treating Postmenopausal Women Who Have Undergone Surgery for Primary Breast Cancer Breast Neoplasms Phase 3 Completed 2003-06-06 7576 Actual Network https://clinicaltrials.gov/study/NCT00066573 NCT00249873 Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE A) Atrial Fibrillation Phase 3 Completed 2003-06 7554 Actual Industry https://clinicaltrials.gov/study/NCT00249873 NCT02723773 A Long-term Follow-up Study (ZOE-LTFU) of Two Studies 110390 (ZOSTER-006) and 113077 (ZOSTER-022) to Assess the Efficacy, Safety, and Immunogenicity Persistence of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine and Assessment of 1 or 2 Additional Doses in Two Subgroups of Older Adults Herpes Zoster Phase 3 Completed 2016-04-16 7539 Actual Industry https://clinicaltrials.gov/study/NCT02723773 NCT05690841 FocaL Mass Drug Administration for Vivax Malaria Elimination Malaria, Vivax; Malaria; Parasitic Diseases Phase 3 Recruiting 2024-10-14 7530 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05690841 NCT01583218 Acute Medically Ill VTE Prevention With Extended Duration Betrixaban Study (The APEX Study) Venous Thromboembolism Phase 3 Completed 2012-03 7513 Actual Industry https://clinicaltrials.gov/study/NCT01583218 NCT00427388 Steroids In caRdiac Surgery Trial (SIRS Trial) Systemic Inflammatory Response Syndrome; Myocardial Infarction Phase 4 Unknown 2007-06 7507 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00427388 NCT00362648 Developing World Study for RotaTeq™ (V260-015)(COMPLETED) Vomiting; Diarrhea; Fever Phase 3 Completed 2007-03 7504 Actual Industry https://clinicaltrials.gov/study/NCT00362648 NCT07035405 Colchicine for Secondary Prevention After Ischemic Stroke (CHANCE-3 EX) Stroke Phase 3 Not yet recruiting 2025-07-04 7500 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07035405 NCT02133690 A Clinical Trial to Study the Effect and Safety of Rotavirus Vaccine Against Severe Rotavirus Gastroenteritis in Healthy Indian Infants Phase 3 Completed 2014-05 7500 Actual Industry https://clinicaltrials.gov/study/NCT02133690 NCT00562484 A Study of the Efficacy, Safety and Tolerability Profile of CSL Limited's Influenza Virus Vaccine (CSL's IVV) Administered Intramuscularly in Healthy Adults Influenza, Human Phase 4 Completed 2008-03 7500 Actual Industry https://clinicaltrials.gov/study/NCT00562484 NCT05746611 Phase IV Clinical Study of Recombinant Mycobacterium Tuberculosis Fusion Protein Latent Tuberculosis Phase 4 Completed 2023-04-17 7500 Actual Industry https://clinicaltrials.gov/study/NCT05746611 NCT00831441 Phase III Acute Coronary Syndrome Acute Coronary Syndrome Phase 3 Terminated 2009-03 7484 Actual Industry https://clinicaltrials.gov/study/NCT00831441 NCT00128661 Vaccine To Prevent Cervical Intraepithelial Neoplasia or Cervical Cancer in Younger Healthy Participants Uterine Cervical Neoplasms; Precancerous Conditions; Uterine Cervical Dysplasia Phase 3 Completed 2004-06-30 7466 Actual Industry https://clinicaltrials.gov/study/NCT00128661 NCT00698568 Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects Herpes Simplex Phase 3 Completed 1996-10 7460 Actual Industry https://clinicaltrials.gov/study/NCT00698568 NCT05085366 A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of Age Cytomegalovirus Infections; Virus Diseases; DNA Virus Infections Phase 3 Terminated 2021-10-26 7454 Actual Industry https://clinicaltrials.gov/study/NCT05085366 NCT06722521 GUIDE-CAC: Statin-Ezetimibe Without Aspirin vs. Statin Monotherapy With Aspirin in High Coronary Calcification Vascular Calcification; Cardiovascular Diseases Phase 4 Recruiting 2025-07-09 7435 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06722521 NCT02915198 Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes Prediabetic State; Atherosclerosis; Coronary Artery Disease Phase 4 Recruiting 2023-04-03 7410 Estimated U.S. federal https://clinicaltrials.gov/study/NCT02915198 NCT00216242 Study of the Protective Effect of an Injectable Influenza Vaccine Against Influenza Illness in Adults Under 50 y.o. Influenza, Human Phase 3 Unknown 2005-09 7400 Industry https://clinicaltrials.gov/study/NCT00216242 NCT00399724 A Trial Comparing Lantus Algorithms to Achieve Normal Blood Glucose Targets in Subjects With Uncontrolled Blood Sugar With Type 2 Diabetes Mellitus Diabetes Mellitus, Type 2 Phase 4 Completed 2002-03 7376 Industry https://clinicaltrials.gov/study/NCT00399724 NCT00563381 Tiotropium Once Daily 18 Mcg Versus Salmeterol Twice Daily 50 Mcg on Time to First Exacerbation in COPD Patients. Pulmonary Disease, Chronic Obstructive Phase 4 Completed 2008-01 7376 Actual Industry https://clinicaltrials.gov/study/NCT00563381 NCT01735006 Efficacy and Immunogenicity Study of Recombinant Human Papillomavirus Bivalent（Type 16/18 ）Vaccine Uterine Cervical Dysplasia; Uterine Cervical Neoplasms; Persistent Infection Phase 3 Completed 2012-11-22 7372 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01735006 NCT02545049 Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease Diabetic Nephropathies; Diabetes Mellitus, Type 2; Kidney Diseases Phase 3 Completed 2015-09-17 7352 Actual Industry https://clinicaltrials.gov/study/NCT02545049 NCT05700877 Screening and Intervention for Subclinical Coronary Artery Disease in Patients With Type 2 Diabetes Diabetes Mellitus, Type 2; Cardiovascular Diseases Phase 4 Recruiting 2023-01-12 7300 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05700877 NCT01803841 Korea Transradial Coronary Intervention Prospective Registry (KOTRI) Coronary Artery Disease Phase 4 Completed 2013-02 7300 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01803841 NCT05581303 Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial Atherosclerosis Phase 3 Active not recruiting 2022-12-14 7297 Actual Industry https://clinicaltrials.gov/study/NCT05581303 NCT00447759 The Standard Care Versus Celecoxib Outcome Trial Osteoarthritis; Arthritis, Rheumatoid; Arthritis Phase 4 Completed 2007-06 7297 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00447759 NCT00324350 Intensive Glycemic Control and Skeletal Health Study Atherosclerosis; Cardiovascular Diseases; Hypercholesterolemia Phase 3 Completed 2003-10 7287 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00324350 NCT03048825 Colchicine and Spironolactone in Patients with MI / SYNERGY Stent Registry ST Elevation Myocardial Infarction; Non-ST Elevated Myocardial Infarction Phase 3 Completed 2018-02-01 7264 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03048825 NCT00493922 Trial of Rapid Diagnostic Tests in Rural Ghana Malaria; Bacterial Infections; Disease Phase 4 Completed 2007-07 7263 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00493922 NCT00800605 Immunogenicity Study of an Inactivated Influenza Vaccine (Split Virus, Vero Cell Derived) to Prevent Culture Confirmed Influenza Infection Influenza, Human Phase 3 Completed 2008-12 7250 Actual Industry https://clinicaltrials.gov/study/NCT00800605 NCT01042769 A Study With Aleglitazar in Patients With a Recent Acute Coronary Syndrome and Type 2 Diabetes Mellitus Diabetes Mellitus, Type 2 Phase 3 Completed 2010-02 7226 Actual Industry https://clinicaltrials.gov/study/NCT01042769 NCT02313909 Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS) Stroke; Ischemic Stroke; Ischemic Attack, Transient Phase 3 Terminated 2014-12-23 7213 Actual Industry https://clinicaltrials.gov/study/NCT02313909 NCT00740935 Impact of Systematic Infants Vaccination Against Rotavirus on Gastroenteritis Hospitalization: a Prospective Study in Brest District, France. Gastroenteritis Phase 4 Completed 2007-05 7204 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00740935 NCT00942812 Community Based Intervention and Evaluation of the Impact of Social Marketing of a Diarrhea Management Pack Diarrhea Phase 4 Completed 2009-07 7200 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00942812 NCT01433627 Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX Acute Coronary Syndrome; ST Elevation Myocardial Infarction; Non-ST Elevated Myocardial Infarction Phase 3 Unknown 2011-10 7200 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01433627 NCT03984591 A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart Failure Heart Failure, Systolic Phase 4 Enrolling by invitation 2020-11-01 7200 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03984591 NCT01088958 Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya Anemia, Iron-Deficiency; Child Nutrition Disorders Phase 4 Completed 2007-01 7200 Actual U.S. federal https://clinicaltrials.gov/study/NCT01088958 NCT05728775 REmimazolam vs Propofol Total Intravenous Anesthesia on Outcomes After Major Noncardiac SurgEry Phase 4 Recruiting 2023-04-03 7188 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05728775 NCT01575834 Efficacy and Safety of Romosozumab Treatment in Postmenopausal Women With Osteoporosis Osteoporosis, Postmenopausal; Osteoporosis; Bone Diseases, Metabolic Phase 3 Completed 2012-03-15 7180 Actual Industry https://clinicaltrials.gov/study/NCT01575834 NCT00002644 Tamoxifen for the Prevention of Breast Cancer in High-Risk Women Breast Neoplasms Phase 3 Completed 1994-01 7154 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00002644 NCT00475852 A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure Heart Failure; Dyspnea Phase 3 Completed 2007-05 7141 Actual Industry https://clinicaltrials.gov/study/NCT00475852 NCT07241390 A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes) Renal Insufficiency, Chronic; Heart Diseases; Kidney Diseases Phase 3 Recruiting 2025-12-01 7140 Estimated Industry https://clinicaltrials.gov/study/NCT07241390 NCT00233727 Screen and Treat for Cervical Cancer Prevention Uterine Cervical Neoplasms; Uterine Cervical Dysplasia Phase 3 Terminated 2000-01 7123 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00233727 NCT05112900 Health Information Technology for COVID-19 Testing in Schools (SCALE-UP Counts) COVID-19 Phase 3 Completed 2022-01-11 7122 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05112900 NCT04975178 Efficacy, Safety and Immunogenicity Evaluation of MTBVAC in Newborns in Sub-Saharan Africa Tuberculosis Phase 3 Recruiting 2022-10-17 7120 Estimated Industry https://clinicaltrials.gov/study/NCT04975178 NCT04193215 V114 and Acute Otitis Media (V114-032/PNEU-ERA) Otitis Media Phase 3 Completed 2020-09-12 7119 Actual Industry https://clinicaltrials.gov/study/NCT04193215 NCT00430989 The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial Coronary Artery Disease Phase 4 Completed 2007-04 7112 Actual Other government https://clinicaltrials.gov/study/NCT00430989 NCT01162122 Safety and Immunogenicity of MF59C.1 Adjuvanted Trivalent Subunit Influenza Vaccine in Elderly Subjects Influenza, Human Phase 3 Completed 2010-08 7109 Actual Industry https://clinicaltrials.gov/study/NCT01162122 NCT04210349 Study of Shenzhen Quadrivalent Inactivated Influenza Vaccine Versus the Shenzhen Trivalent Inactivated Influenza Vaccine in Chinese Subjects From 6 Months of Age Influenza, Human Phase 3 Completed 2020-01-09 7106 Actual Industry https://clinicaltrials.gov/study/NCT04210349 NCT05669755 REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels Cardiovascular Diseases Phase 3 Active not recruiting 2023-03-01 7101 Actual Industry https://clinicaltrials.gov/study/NCT05669755 NCT02277990 World-wide Randomized Antibiotic Envelope Infection Prevention Trial Phase 4 Completed 2015-01 7075 Actual Industry https://clinicaltrials.gov/study/NCT02277990 NCT01131676 BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME). Diabetes Mellitus, Type 2 Phase 3 Completed 2010-07 7064 Actual Industry https://clinicaltrials.gov/study/NCT01131676 NCT00853658 Efficacy and Safety of Aliskiren and Aliskiren/Enalapril Combination on Morbidity-mortality in Patients With Chronic Heart Failure Phase 3 Completed 2009-03 7064 Actual Industry https://clinicaltrials.gov/study/NCT00853658 NCT07318610 Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery Disease Peripheral Arterial Disease; Thrombosis Phase 3 Recruiting 2026-07-10 7050 Estimated Industry https://clinicaltrials.gov/study/NCT07318610 NCT01014273 A Trial of Trans-radial Versus Trans-femoral Percutaneous Coronary Intervention (PCI) Access Site Approach in Patients With Unstable Angina or Myocardial Infarction Managed With an Invasive Strategy Acute Coronary Syndrome Phase 3 Completed 2006-06 7021 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01014273 NCT00047411 Home Use of Automatic External Defibrillators to Treat Sudden Cardiac Arrest Cardiovascular Diseases; Myocardial Infarction; Heart Diseases Phase 3 Completed 2002-09 7001 Estimated NIH https://clinicaltrials.gov/study/NCT00047411 NCT00935168 Crystalloid Versus Hydroxyethyl Starch Trials Phase 3 Completed 2009-12 7000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00935168 NCT07640841 Health Economic Evaluation of Influenza and Pneumococcal Vaccination in COPD Patients Influenza, Human; Pneumonia Phase 4 Not yet recruiting 2026-06-15 7000 Estimated Network https://clinicaltrials.gov/study/NCT07640841 NCT07753993 A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease. Renal Insufficiency, Chronic Phase 3 Recruiting 2026-08-21 7000 Estimated Industry https://clinicaltrials.gov/study/NCT07753993 NCT07795398 DAN-RELEASE - Reconsidering Long-Term Aspirin in the Elderly Patients With Stable Ischemic Heart Disease Myocardial Ischemia; Myocardial Infarction Phase 4 Recruiting 2026-09-30 7000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07795398 NCT00885404 Chloride High Level Of Resuscitation Infusion Chloride High Level Of Resuscitation Infusion Delivered Evaluation Shock; Critical Illness; Acidosis Phase 4 Unknown 2009-02 7000 Estimated Other government https://clinicaltrials.gov/study/NCT00885404 NCT07854795 Reconsidering Long-Term Apirin in the Elderly in Secondary Prevention of Coronary Artery Disease Norway Phase 4 Not yet recruiting 2027-02-01 7000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07854795 NCT05164081 Dual vs. Single-Antibiotic Impregnated Cement in Hemiarthroplasty for Femoral Neck Fracture Femoral Neck Fractures Phase 3 Active not recruiting 2022-01-01 7000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05164081 NCT07015957 Kupewa: Optimizing Implementation Strategies for Cervical Cancer Prevention Phase 4 Active not recruiting 2025-07-08 7000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07015957 NCT01585298 STudy to vAlidate telemetRic ECG Systems for firsT Dose Administration of Fingolimod (START) Multiple Sclerosis Phase 4 Completed 2012-04-29 6998 Actual Industry https://clinicaltrials.gov/study/NCT01585298 NCT01897532 Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA) Diabetes Mellitus, Type 2 Phase 4 Completed 2013-07-10 6991 Actual Industry https://clinicaltrials.gov/study/NCT01897532 NCT00336336 GISSI-HF- Effects of n-3 PUFA and Rosuvastatin on Mortality-Morbidity of Patients With Symptomatic CHF Heart Failure Phase 3 Completed 2002-08 6975 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00336336 NCT07761117 A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF Heart Failure Phase 3 Recruiting 2026-08-24 6950 Estimated Industry https://clinicaltrials.gov/study/NCT07761117 NCT04351685 Evaluation of Efficacy and Safety of VPM1002 in Comparison to BCG in Prevention of Tb Infection in Infants Tuberculosis; Mycoses Phase 3 Completed 2020-11-09 6940 Actual Industry https://clinicaltrials.gov/study/NCT04351685 NCT04327206 BCG Vaccination to Protect Healthcare Workers Against COVID-19 COVID-19; Coronavirus Infections Phase 3 Completed 2020-03-30 6828 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04327206 NCT05323721 Effectiveness and Chemoprevention Efficacy of Implementing Seasonal Malaria Chemoprevention in Karamoja Region, Uganda Malaria Phase 4 Unknown 2022-06-01 6805 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05323721 NCT00641914 Inhaled Steroid Treatment as Regular Therapy in Early Asthma Asthma Phase 4 Completed 1996-10 6800 Estimated Industry https://clinicaltrials.gov/study/NCT00641914 NCT01305109 A Phase III Clinical Trial to Evaluate the Protective Efficacy of Three Doses of Oral Rotavirus Vaccine (ORV) 116E Phase 3 Unknown 2011-03 6800 Estimated Industry https://clinicaltrials.gov/study/NCT01305109 NCT05680415 Clinical Trial of Mica Latent Tuberculosis Phase 4 Active not recruiting 2023-04-19 6800 Estimated Industry https://clinicaltrials.gov/study/NCT05680415 NCT02288832 Medico-economic Impact of Screening Atopobium Vaginae and Gardnerella Vaginalis in Molecular Biology by "Point-of-care" During Pregnancy Phase 2, Phase 3 Completed 2015-03-06 6800 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02288832 NCT05175274 Colchicine Use for Primary Prevention of Coronary Artery Disease Coronary Artery Disease Phase 3 Not yet recruiting 2022-12-06 6792 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05175274 NCT02587221 Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of an MF59-Adjuvanted Quadrivalent Influenza Vaccine Compared to Non-influenza Vaccine Comparator in Adults ≥ 65 Years of Age Influenza, Human Phase 3 Completed 2016-09-30 6790 Actual Industry https://clinicaltrials.gov/study/NCT02587221 NCT00457002 Study of Apixaban for the Prevention of Thrombosis-related Events in Patients With Acute Medical Illness Venous Thrombosis; Pulmonary Embolism Phase 3 Completed 2007-06 6758 Actual Industry https://clinicaltrials.gov/study/NCT00457002 NCT00142246 Study of the Impact of Intermittent Preventive Treatment in Schools on Malaria, Anaemia and Education. Malaria, Falciparum; Malaria; Anemia Phase 3 Completed 2005-01 6758 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00142246 NCT07572747 Aspirin Versus Clopidogrel in Chronic Coronary Syndrome in Arabian Gulf Countries Phase 3 Not yet recruiting 2027-04-01 6740 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07572747 NCT03914625 A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia Burkitt Lymphoma; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Down Syndrome Phase 3 Active not recruiting 2019-07-03 6720 Estimated NIH https://clinicaltrials.gov/study/NCT03914625 NCT06424288 A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure Heart Failure Phase 3 Recruiting 2024-06-17 6712 Estimated Industry https://clinicaltrials.gov/study/NCT06424288 NCT00243178 Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE W) Atrial Fibrillation Phase 3 Terminated 2003-07 6706 Actual Industry https://clinicaltrials.gov/study/NCT00243178 NCT05121324 Pediatric Dose Optimization for Seizures in Emergency Medical Services Seizures Phase 3 Recruiting 2022-08-08 6700 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05121324 NCT02936661 Tranexamic Acid for Preventing Postpartum Hemorrhage After Cesarean Section Phase 4 Unknown 2017-04 6700 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02936661 NCT07133802 Clinical Trial to Evaluate the Protective Efficacy and Safety of a Nasal Spray Live Attenuated Influenza Vaccine (LAIV) in Adults Aged 18-59 Years Post-Vaccination Phase 3 Not yet recruiting 2025-08 6680 Estimated Industry https://clinicaltrials.gov/study/NCT07133802 NCT04324463 Anti-Coronavirus Therapies to Prevent Progression of Coronavirus Disease 2019 (COVID-19) Trial Coronavirus Infections; Severe Acute Respiratory Syndrome; COVID-19 Phase 3 Completed 2020-04-21 6667 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04324463 NCT00922779 A Study of Ribavirin in Combination With PEGASYS (Peginterferon Alfa-2a (40KD))in Patients With Chronic Hepatitis C Hepatitis C, Chronic Phase 4 Completed 2002-06 6661 Actual Industry https://clinicaltrials.gov/study/NCT00922779 NCT00129766 Study of MEDI-524 (Motavizumab) for the Prophylaxis of Serious Respiratory Syncytial Virus (RSV) Disease in High-Risk Children Respiratory Syncytial Virus Infections Phase 3 Completed 2004-11 6635 Actual Industry https://clinicaltrials.gov/study/NCT00129766 NCT01787110 An Efficacy and Outcome Study of Supplemental Oxygen Treatment in Patients With Suspected Myocardial Infarction Acute Coronary Syndrome; Non-ST Elevated Myocardial Infarction; Myocardial Infarction Phase 3 Completed 2013-04 6629 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01787110 NCT03838575 ROSSINI 2 - Reduction of Surgical Site Infection Using Several Novel Interventions Surgical Wound Infection Phase 3 Unknown 2019-03-01 6610 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03838575 NCT00448383 A Study to Assess the Safety and Efficacy of Adalimumab When Added to Inadequate Standard Anti-Rheumatic Therapy in Patients With Active Rheumatoid Arthritis Arthritis, Rheumatoid Phase 3 Completed 2002-09 6610 Actual Industry https://clinicaltrials.gov/study/NCT00448383 NCT03594110 EMPA-KIDNEY (The Study of Heart and Kidney Protection With Empagliflozin) Renal Insufficiency, Chronic Phase 3 Completed 2019-01-31 6609 Actual Industry https://clinicaltrials.gov/study/NCT03594110 NCT00433589 Genetic Testing or Clinical Assessment in Determining the Need for Chemotherapy in Women With Breast Cancer That Involves No More Than 3 Lymph Nodes Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular Phase 3 Completed 2007-02 6600 Estimated Network https://clinicaltrials.gov/study/NCT00433589 NCT06524947 Clinical Trial of Protective Efficacy of Quadrivalent Recombinant Norovirus Vaccine (Pichia Pastoris) Phase 3 Active not recruiting 2024-07-27 6600 Actual Industry https://clinicaltrials.gov/study/NCT06524947 NCT01870778 Efficacy, Safety and Tolerability of Serelaxin When Added to Standard Therapy in AHF Phase 3 Completed 2013-10-02 6600 Actual Industry https://clinicaltrials.gov/study/NCT01870778 NCT00949910 An Expanded Access Program of Tarceva (Erlotinib) in Participants With Advanced Non-Small Cell Lung Cancer (NSCLC) Carcinoma, Non-Small-Cell Lung Phase 4 Completed 2004-11 6586 Actual Industry https://clinicaltrials.gov/study/NCT00949910 NCT02145000 Efficacy and Safety of a Pentavalent Rotavirus Vaccine (BRV-PV) Against Severe Rotavirus Gastroenteritis in Niger Gastroenteritis; Diarrhea Phase 3 Completed 2014-06 6586 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02145000 NCT02504216 Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities Peripheral Arterial Disease Phase 3 Completed 2015-08-18 6564 Actual Industry https://clinicaltrials.gov/study/NCT02504216 NCT00099788 Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST Elevation Acute Coronary Syndromes Myocardial Ischemia; Acute Coronary Syndrome; Myocardial Infarction Phase 3 Completed 2004-10 6560 Actual Industry https://clinicaltrials.gov/study/NCT00099788 NCT03780179 MMR at 6 Months Trial Phase 4 Completed 2019-04-15 6540 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03780179 NCT00244673 Randomized Study of Not Giving Diphteria-tetanus-pertussis Vaccination With or After Measles Vaccination Coitus Phase 4 Completed 2005-10 6534 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00244673 NCT00829660 Acarbose Cardiovascular Evaluation Trial Coronary Disease; Acute Coronary Syndrome; Glucose Intolerance Phase 4 Completed 2009-02-17 6526 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00829660 NCT04509674 EMPACT-MI: A Study to Test Whether Empagliflozin Can Lower the Risk of Heart Failure and Death in People Who Had a Heart Attack (Myocardial Infarction) Myocardial Infarction Phase 3 Completed 2020-12-16 6522 Actual Industry https://clinicaltrials.gov/study/NCT04509674 NCT02441218 Effects of Ivabradine on Cardiovascular Events in Patients With Moderate to Severe Chronic Heart Failure and Left Ventricular Systolic Dysfunction. A Three-year International Multicentre Study Phase 3 Completed 2006-09 6505 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02441218 NCT07086222 Efficacy and Safety of NVX-CoV2705 COVID-19 Phase 4 Terminated 2025-11-20 6500 Actual Industry https://clinicaltrials.gov/study/NCT07086222 NCT04307576 A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia Phase 3 Recruiting 2020-07-13 6430 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04307576 NCT00496769 A Phase III Study of Apixaban in Patients With Atrial Fibrillation Atrial Fibrillation Phase 3 Completed 2007-08-31 6421 Actual Industry https://clinicaltrials.gov/study/NCT00496769 NCT04078737 Clopidogrel With Aspirin in High-risk Patients With Acute Non-disabling Cerebrovascular Events II Stroke; Ischemic Attack, Transient Phase 3 Completed 2019-09-23 6412 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04078737 NCT04386070 Preventing Pulmonary Complications in Surgical Patients at Risk of COVID-19 Severe Acute Respiratory Syndrome; Pneumonia; COVID-19 Phase 3 Suspended 2022-05-16 6400 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04386070 NCT00317330 A Randomized Trial of DOTS Versus Enhanced DOTS for Community Control of Tuberculosis Tuberculosis Phase 3 Completed 2004-12 6400 NIH https://clinicaltrials.gov/study/NCT00317330 NCT05021835 ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation Renal Insufficiency, Chronic; Inflammation Phase 3 Completed 2021-08-30 6385 Actual Industry https://clinicaltrials.gov/study/NCT05021835 NCT06079918 Multiple Micronutrient Supplementation for Maternal Anemia Prevention in Tanzania Anemia Phase 3 Recruiting 2025-03-03 6381 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06079918 NCT00139347 Study of 2 Doses of HRV Vaccine Given Concomitantly With Routine EPI Vaccinations Including OPV in Healthy Infants Rotavirus Infections Phase 3 Completed 2003-12 6360 Industry https://clinicaltrials.gov/study/NCT00139347 NCT06186037 Clinical Comparison of Low-dose Rosuvastatin Plus Ezetimibe Combination Therapy and High-dose Rosuvastatin Monotherapy in Patients With Minimal to Intermediate Coronary Artery Disease Without Percutaneous Coronary Intervention Coronary Artery Disease; Dyslipidemias Phase 4 Recruiting 2024-02-01 6356 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06186037 NCT01133184 Improved Prevention of Perinatal Hepatitis B Transmission Liver Cirrhosis Phase 4 Unknown 2010-09 6343 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01133184 NCT01958957 A Safety Study of Ginkgolides Meglumine Injection in the Treatment of Ischemic Stroke. Ischemic Stroke Phase 4 Completed 2013-06 6300 Actual Industry https://clinicaltrials.gov/study/NCT01958957 NCT04915261 A Randomized Trial of Lenient Versus Strict Arm Instruction Post Cardiac Device Surgery Postoperative Complications; Infections; Hematoma Phase 4 Recruiting 2021-08-19 6300 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04915261 NCT03430284 Multifactorial Intervention on Diabetes (MIDiab Study) Diabetes Mellitus, Type 2; Diabetic Angiopathies Phase 4 Unknown 2018-04-01 6300 Estimated Other government https://clinicaltrials.gov/study/NCT03430284 NCT06252285 Efficacy, Immunogenicity, and Safety Study of a Respiratory Syncytial Virus Vaccine in Infants and Toddlers Phase 3 Terminated 2024-02-06 6300 Actual Industry https://clinicaltrials.gov/study/NCT06252285 NCT00981513 Direct and Indirect Benefits of Influenza Vaccination in Schools and Households Phase 4 Completed 2009-09 6300 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00981513 NCT00634400 Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity (CHARM Alternative) Heart Failure Phase 3 Completed 1999-03 6268 Estimated Industry https://clinicaltrials.gov/study/NCT00634400 NCT03619213 Dapagliflozin Evaluation to Improve the LIVEs of Patients With PReserved Ejection Fraction Heart Failure. Phase 3 Completed 2018-08-27 6263 Actual Industry https://clinicaltrials.gov/study/NCT03619213 NCT04934683 The GUARDIAN Trial - Induction Agent Sub-Study Phase 4 Enrolling by invitation 2021-07-25 6254 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04934683 NCT04934748 The GUARDIAN Trial - Vasopressor Sub-Study Phase 4 Enrolling by invitation 2021-07-25 6254 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04934748 NCT01462344 6-month Safety and Benefit Study of ADVAIR in Children 4-11 Years Old Asthma Phase 4 Completed 2011-11-17 6250 Actual Industry https://clinicaltrials.gov/study/NCT01462344 NCT06594341 Optimization of the Simplified Protocol in Mali: a Cluster Randomised Pragmatic Trial Severe Acute Malnutrition Phase 4 Completed 2023-04-10 6249 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06594341 NCT04789356 Effectiveness of the Adsorbed Vaccine COVID-19 (Coronavac) Among Education and Public Safety Workers With Risk Factors for Severity COVID-19 Phase 4 Unknown 2021-03-18 6233 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04789356 NCT00268216 Survival Of Subjects With Chronic Obstructive Pulmonary Disease (COPD) Pulmonary Disease, Chronic Obstructive Phase 3 Completed 2000-09 6228 Actual Industry https://clinicaltrials.gov/study/NCT00268216 NCT00497393 Clinical Decision Unit (CDU) - Evaluation of a Novel Approach to Address Emergency Department Overcrowding Emergencies; Crowding Phase 4 Completed 2007-07 6217 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00497393 NCT00197223 Post-marketing Study to Evaluate the Efficacy of Influenza Vaccine Influenza, Human Phase 3 Completed 2005-09 6213 Actual Industry https://clinicaltrials.gov/study/NCT00197223 NCT00213083 Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission HIV Infections; Acquired Immunodeficiency Syndrome; Sexually Transmitted Diseases Phase 3 Completed 2004-04 6203 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00213083 NCT00168623 Vitamin A Supplementation With Routine Childhood Vaccines and Mortality and Morbidity Phase 4 Unknown 2003-11 6200 University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00168623 NCT04579640 Trial of Vitamin D to Reduce Risk and Severity of COVID-19 and Other Acute Respiratory Infections COVID-19 Phase 3 Completed 2020-10-27 6200 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04579640 NCT01021904 Primary and Secondary Prevention of Human Papillomavirus (HPV) Disease in China Papillomavirus Infections; Uterine Cervical Neoplasms Phase 4 Unknown 2010-06 6200 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01021904 NCT01101035 Cardiovascular Safety of Febuxostat and Allopurinol in Participants With Gout and Cardiovascular Comorbidities (CARES) Cardiovascular Diseases; Myocardial Infarction; Stroke Phase 3 Completed 2010-04-23 6198 Actual Industry https://clinicaltrials.gov/study/NCT01101035 NCT00839254 Impact on Carriage, Acute Otitis Media, Immuno & Safety of GSK Biologicals' Pneumococcal Conjugate Vaccine 1024850A Streptococcal Infections; Otitis Media; Haemophilus Infections Phase 3 Completed 2009-02-18 6181 Actual Industry https://clinicaltrials.gov/study/NCT00839254 NCT01051661 Safety and Efficacy of H1N1 Vaccines in Children Aged 6 Months to Less Than 10 Years of Age Influenza, Human Phase 3 Completed 2010-02-12 6154 Actual Industry https://clinicaltrials.gov/study/NCT01051661 NCT04774159 Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk Peripheral Arterial Disease; Inflammation; Myocardial Infarction Phase 3 Recruiting 2021-05-06 6150 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04774159 NCT02525939 Effect of Dalcetrapib vs Placebo on CV Risk in a Genetically Defined Population With a Recent ACS Acute Coronary Syndrome Phase 3 Completed 2016-04 6147 Actual Industry https://clinicaltrials.gov/study/NCT02525939 NCT07467707 An Efficacy, Safety, and Immunogenicity Study of CHIKV VLP Vaccine for the Prevention of Chikungunya Disease in Adolescents and Adults Chikungunya Fever Phase 3 Recruiting 2026-05-26 6144 Estimated Industry https://clinicaltrials.gov/study/NCT07467707 NCT04869982 Efficacy, Immunogenicity and Safety Study of GSKs Recombinant Zoster Vaccine Shingrix (GSK1437173A) in Chinese Adults Aged ≥50 Years Herpes Zoster Phase 4 Completed 2021-05-14 6138 Actual Industry https://clinicaltrials.gov/study/NCT04869982 NCT01117441 International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia Leukemia Phase 3 Completed 2010-06 6136 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01117441 NCT04537663 Prevention Of Respiratory Tract Infection And Covid-19 Through BCG Vaccination In Vulnerable Older Adults Respiratory Tract Infections; COVID-19 Phase 4 Completed 2020-09-07 6112 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04537663 NCT05093933 A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035) Phase 3 Completed 2021-11-02 6106 Actual Industry https://clinicaltrials.gov/study/NCT05093933 NCT07876492 A Study to Evaluate Cenvacibart (REGN7508) for Secondary Stroke Prevention in Adult Participants Stroke; Ischemic Stroke Phase 3 Not yet recruiting 2026-11-20 6106 Estimated Industry https://clinicaltrials.gov/study/NCT07876492 NCT00220987 Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE - SUGAR STUDY) Hyperglycemia; Critical Illness; Hypoglycemia Phase 4 Completed 2005-04 6104 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00220987 NCT01346592 Safety, Tolerability, and Immunogenicity of the Adjuvanted Trivalent Subunit Influenza Vaccine and the Non-Adjuvanted Trivalent Subunit Influenza Vaccine Compared to the Non-Adjuvanted Trivalent Split Influenza Vaccine in Children 6 to < 72 Months of Age Influenza, Human Phase 3 Completed 2011-04 6104 Actual Industry https://clinicaltrials.gov/study/NCT01346592 NCT01243424 CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes Diabetes Mellitus, Type 2 Phase 3 Completed 2010-11-11 6103 Actual Industry https://clinicaltrials.gov/study/NCT01243424 NCT05415462 A Study of mRNA-1010 Seasonal Influenza Vaccine in Adults Phase 3 Completed 2022-06-06 6102 Actual Industry https://clinicaltrials.gov/study/NCT05415462 NCT03635749 Intensive Medical Therapy for High-risk Intracranial or Extracranial Atherosclerosis Stroke; Ischemic Attack, Transient Phase 3 Unknown 2018-09-17 6100 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03635749 NCT00127205 S0307 Phase III Trial of Bisphosphonates as Adjuvant Therapy for Primary Breast Cancer. Breast Neoplasms Phase 3 Completed 2005-07 6097 Actual Network https://clinicaltrials.gov/study/NCT00127205 NCT01690338 A Study of Residual Curarization Incidence in China Postoperative Complications; Delayed Emergence from Anesthesia Phase 4 Unknown 2012-10 6090 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01690338 NCT04006990 The Bed Rest Avoidance Study Phase 3 Completed 2017-03-20 6089 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04006990 NCT00749450 Combination Chemotherapy After Surgery in Treating Patients With High-Risk Stage II or Stage III Colorectal Cancer Colorectal Neoplasms; Colonic Neoplasms; Rectal Neoplasms Phase 3 Completed 2008-03 6088 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00749450 NCT00687349 Improving Clinician Communication Skills (ICCS) Pulmonary Disease, Chronic Obstructive; Heart Failure; End Stage Liver Disease Phase 3 Completed 2007-04 6086 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00687349 NCT01160809 Effect of a Combined Use of Mosquito Repellent and Insecticide Treated Net on Malaria in Ethiopia Malaria Phase 4 Completed 2008-09 6082 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01160809 NCT00779766 Efficacy, Immunogenicity and Safety of GSK Biologicals' HPV GSK 580299 Vaccine in Healthy Chinese Female Subjects Papillomavirus Infections; Uterine Cervical Neoplasms Phase 3 Completed 2008-10-22 6081 Actual Industry https://clinicaltrials.gov/study/NCT00779766 NCT06280144 Post-marketing Study of Lyophilized Nasal Spray Live Attenuated Influenza Vaccine Phase 4 Unknown 2023-09-22 6080 Estimated Industry https://clinicaltrials.gov/study/NCT06280144 NCT01147250 Evaluation of Cardiovascular Outcomes in Patients With Type 2 Diabetes After Acute Coronary Syndrome During Treatment With AVE0010 (Lixisenatide) Acute Coronary Syndrome Phase 3 Completed 2010-06 6068 Actual Industry https://clinicaltrials.gov/study/NCT01147250 NCT01188135 Antidepressant Adherence Via AD_IVR Depressive Disorder, Major; Depression Phase 3 Completed 2011-02 6058 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01188135 NCT03629886 Safety and Protective Effect Study of GSK Biologicals' Human Papillomavirus (Types 16, 18) Vaccine, Adsorbed (GSK580299) in Healthy Female Subjects From the HPV-039 Study Uterine Cervical Dysplasia; Uterine Cervical Neoplasms Phase 4 Completed 2018-08-22 6051 Actual Industry https://clinicaltrials.gov/study/NCT03629886 NCT04199689 Efficacy Against Oral Persistent Infection, Immunogenicity and Safety of the 9-valent Human Papillomavirus Vaccine (9vHPV) in Men Aged 20-45 Years (V503-049) Papillomavirus Infections Phase 3 Active not recruiting 2020-02-27 6033 Actual Industry https://clinicaltrials.gov/study/NCT04199689 NCT00931736 Randomized Clinical Trial Comparing 4RIF vs. 9INH for LTBI Treatment-effectiveness Latent Tuberculosis; Tuberculosis Phase 3 Completed 2009-08 6031 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00931736 NCT05284747 EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction Cardiovascular Diseases; Myocardial Infarction; Stroke Phase 4 Active not recruiting 2022-10-26 6019 Actual Industry https://clinicaltrials.gov/study/NCT05284747 NCT04435626 Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40% Heart Failure Phase 3 Completed 2020-09-14 6016 Actual Industry https://clinicaltrials.gov/study/NCT04435626 NCT02311231 Bivalirudin vs Heparin in NSTEMI and STEMI in Patients on Modern Antiplatelet Therapy in SWEDEHEART ST Elevation Myocardial Infarction Phase 4 Completed 2014-06 6012 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02311231 NCT04609111 ShorT and OPtimal Duration of Dual AntiPlatelet Therapy-3 Study Acute Coronary Syndrome; Hemorrhage Phase 4 Unknown 2021-01-29 6002 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04609111 NCT01385982 Improving Management of Outpatient Actionable Test Results Phase 3 Completed 2011-07 6000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01385982 NCT01511744 Phase IV Clinical Trial of an Inactivated Influenza Split Vaccine Influenza, Human; Respiratory Tract Infections; Orthomyxoviridae Infections Phase 4 Completed 2011-11 6000 Actual Industry https://clinicaltrials.gov/study/NCT01511744 NCT07890454 Study of a Combination SARS-CoV-2 Recombinant Spike and High-Dose Inactivated Influenza Vaccine With Matrix-M Adjuvant in Adult Participants 60 Years of Age and Older Influenza, Human Phase 3 Not yet recruiting 2026-11-09 6000 Estimated Industry https://clinicaltrials.gov/study/NCT07890454 NCT03998254 Efficacy, Immunogenicity and Safety of V503 in Chinese Women Aged 20-45 Years (V503-023) Papillomavirus Infections Phase 3 Active not recruiting 2019-06-26 6000 Estimated Industry https://clinicaltrials.gov/study/NCT03998254 NCT00002582 Tamoxifen, Ovarian Ablation, and/or Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA Breast Cancer Breast Neoplasms Phase 3 Completed 1993-06 6000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00002582 NCT07300462 A Post-marketing Observational Study of Oral Cholera Vaccine Diarrhea Phase 4 Enrolling by invitation 2026-04-10 6000 Estimated Industry https://clinicaltrials.gov/study/NCT07300462 NCT07160244 BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies Phase 3 Recruiting 2025-08-25 6000 Estimated Industry https://clinicaltrials.gov/study/NCT07160244 NCT00682825 Study Evaluating Whether the Bispectral Index Prevents Patients at Higher Risk From Being Awake During Surgery and Anesthesia Phase 4 Completed 2008-03 6000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00682825 NCT05683561 A Phase III Clinical Trial to Evaluate the Efficacy and Safety of SCTV01E in Healthy People Phase 3 Unknown 2023-01-25 6000 Estimated Industry https://clinicaltrials.gov/study/NCT05683561 NCT07005726 BCG Revaccination With the Third Dose of Diphtheria-tetanus-pertussis Vaccine and Infant Mortality in Africa Infant Death Phase 4 Enrolling by invitation 2025-05-09 6000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07005726 NCT00436176 Improving Diabetes Care for African Americans Diabetes Mellitus Phase 3 Completed 2007-06 6000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00436176 NCT05560945 2-year Caries Clinical Study: Arginine Fluoride-Free Toothpastes vs. NaF Toothpaste Dental Caries Phase 3 Completed 2019-04-15 6000 Actual Industry https://clinicaltrials.gov/study/NCT05560945 NCT05390892 PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes Phase 4 Recruiting 2022-09-26 6000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05390892 NCT06909565 Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention Coronary Artery Disease; Hypercholesterolemia; Cardiovascular Diseases Phase 4 Recruiting 2025-07-23 6000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06909565 NCT07258251 Strengthening Hepatitis B Screening, Linkage to Care and Long-Term Monitoring in Phichit Province, Thailand: A Birth Bohort Approach Hepatitis B, Chronic; Hepatitis B Phase 4 Not yet recruiting 2026-01-01 6000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07258251 NCT04741061 Study to Evaluate Efficacy, Immunogenicity and Safety of the Sputnik-Light COVID-19 Phase 3 Unknown 2021-02-19 6000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04741061 NCT07424846 Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial Premature Birth; Periodontitis; Gingivitis Phase 2, Phase 3 Recruiting 2026-03-26 6000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07424846 NCT00066898 ARISE - Aggressive Reduction of Inflammation Stops Events Atherosclerosis; Coronary Artery Disease; Myocardial Infarction Phase 3 Unknown 2003-06 6000 Industry https://clinicaltrials.gov/study/NCT00066898 NCT05149248 Prevention and Control of Neoplasms Associated With HPV in High-risk Groups in Mexico City: The Condesa Study Uterine Cervical Neoplasms; Neoplasms Phase 2, Phase 3 Completed 2018-05-30 6000 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05149248 NCT07611513 Protective Efficacy , Immunogenicity and Safety of the Tetravalent Inactivated Enterovirus Vaccine (Vero Cell). Hand, Foot and Mouth Disease; Herpangina Phase 3 Not yet recruiting 2026-05 6000 Estimated Industry https://clinicaltrials.gov/study/NCT07611513 NCT04534959 Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients Critical Illness; Wounds and Injuries; Disease Attributes Phase 3 Active not recruiting 2020-10-15 6000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04534959 NCT05845424 High-intensity Statin and Ezetimibe Therapy for Asymptomatic Patients With Positive Coronary Calcium Metabolic Syndrome; Dyslipidemias Phase 4 Recruiting 2023-07-03 6000 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05845424 NCT00092703 Investigational Drug Versus an Approved Drug in Patients With Osteoarthritis (0663-061)(COMPLETED) Osteoarthritis Phase 3 Completed 2002-06-27 6000 Industry https://clinicaltrials.gov/study/NCT00092703 NCT02981836 A Blind, Randomized and Controlled Study of Live Attenuated Varicella Vaccines Chickenpox Phase 3 Completed 2016-08 5997 Actual Industry https://clinicaltrials.gov/study/NCT02981836 NCT00144339 Evaluation of the Long- Term Effects of Spiriva on Lung Function in COPD Patients Pulmonary Disease, Chronic Obstructive Phase 3 Completed 2002-12 5993 Actual Industry https://clinicaltrials.gov/study/NCT00144339 NCT02181985 Full Dose Tenecteplase (TNK-tPA) Together With Heparin Sodium, Full Dose Tenecteplase With Enoxaparin, Half Dose Tenecteplase Together With Abciximab and Heparin Sodium in Patients With Acute Myocardial Infarction (AMI) Myocardial Infarction Phase 3 Completed 2000-05 5989 Actual Industry https://clinicaltrials.gov/study/NCT02181985 NCT03057951 EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved) Heart Failure Phase 3 Completed 2017-03-02 5988 Actual Industry https://clinicaltrials.gov/study/NCT03057951 NCT00224484 Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old Herpes Simplex Phase 3 Completed 2004-04-07 5960 Actual Industry https://clinicaltrials.gov/study/NCT00224484 NCT03959085 Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy Burkitt Lymphoma; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Biphenotypic, Acute Phase 3 Recruiting 2019-10-31 5951 Estimated Network https://clinicaltrials.gov/study/NCT03959085 NCT02883049 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations Burkitt Lymphoma Phase 3 Completed 2012-02-29 5949 Actual NIH https://clinicaltrials.gov/study/NCT02883049 NCT03143218 Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ) Malaria, Falciparum; Malaria Phase 3 Completed 2017-04-17 5920 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03143218 NCT00808067 RELY-ABLE Long Term Multi-center Extension of Dabigatran Treatment in Patients With Atrial Fibrillation Who Completed RE-LY Trial Atrial Fibrillation Phase 3 Completed 2008-11 5897 Actual Industry https://clinicaltrials.gov/study/NCT00808067 NCT00168558 Early Two-dose Measles Vaccination Trial Measles; Infant Death Phase 4 Completed 2003-07 5879 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00168558 NCT05463419 A Phase II/III Study of PIKA Recombinant SARS-CoV-2 Vaccine as a Booster Dose. Phase 2, Phase 3 Completed 2022-10-03 5860 Actual Industry https://clinicaltrials.gov/study/NCT05463419 NCT00566774 A Randomized Evaluation of First-dollar Coverage for Post-MI Secondary Preventive Therapies Myocardial Infarction; Coronary Artery Disease Phase 4 Completed 2007-11 5860 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00566774 NCT03568383 Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients Tuberculosis, Multidrug-Resistant; Tuberculosis Phase 3 Active not recruiting 2019-06-03 5832 Actual NIH https://clinicaltrials.gov/study/NCT03568383 NCT03927131 Safety and Immunogenicity of the Butantan Quadrivalent Influenza Vaccine Influenza, Human Phase 3 Completed 2021-05-12 5822 Actual Other government https://clinicaltrials.gov/study/NCT03927131 NCT01989754 A Study of the Effects of Canagliflozin (JNJ-28431754) on Renal Endpoints in Adult Participants With Type 2 Diabetes Mellitus Diabetes Mellitus, Type 2; Albuminuria Phase 4 Completed 2014-01-16 5813 Actual Industry https://clinicaltrials.gov/study/NCT01989754 NCT00226499 Evaluate Vaccine Against Chickenpox and a Combined Vaccine Against 4 Viral Childhood Diseases: Measles, Mumps, Rubella and Chickenpox Chickenpox Phase 3 Completed 2005-09-01 5803 Actual Industry https://clinicaltrials.gov/study/NCT00226499 NCT06184659 Empirical Meropenem Versus Piperacillin/Tazobactam for Adult Patients With Sepsis Sepsis; Shock, Septic Phase 4 Recruiting 2025-06-26 5800 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06184659 NCT06200844 The Efficacy of Oral Rotavirus Vaccine 116E (ROTAVAC 5D) in Chilean Infants Phase 3 Active not recruiting 2023-07-07 5800 Estimated Industry https://clinicaltrials.gov/study/NCT06200844 NCT02216383 Intramuscular Oxytocics: A Randomised Control Trial Postpartum Hemorrhage Phase 3 Completed 2015-02 5798 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02216383 NCT02513394 PALbociclib CoLlaborative Adjuvant Study Breast Neoplasms Phase 3 Active not recruiting 2015-08 5796 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02513394 NCT01975064 Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia Breast Neoplasms; Colonic Neoplasms; Rectal Neoplasms Phase 4 Completed 2013-11 5774 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01975064 NCT00092521 Cervical Intraepithelial Neoplasm (CIN)-Warts Efficacy Trial in Women (Gardasil)(V501-013)(COMPLETED) Uterine Cervical Neoplasms; Condylomata Acuminata Phase 3 Completed 2001-12 5759 Actual Industry https://clinicaltrials.gov/study/NCT00092521 NCT00294047 Study to Evaluate the Efficacy of the Human Papillomavirus Vaccine in Healthy Adult Women of 26 Years of Age and Older Papillomavirus Infections; Uterine Cervical Neoplasms Phase 3 Completed 2006-02-16 5752 Actual Industry https://clinicaltrials.gov/study/NCT00294047 NCT00091637 Pexelizumab in Conjunction With Angioplasty in Acute Myocardial Infarction (APEX-AMI) Phase 3 Completed 2004-04 5745 Actual Industry https://clinicaltrials.gov/study/NCT00091637 NCT02540993 Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease Renal Insufficiency, Chronic; Diabetic Nephropathies; Diabetes Mellitus, Type 2 Phase 3 Completed 2015-09-17 5734 Actual Industry https://clinicaltrials.gov/study/NCT02540993 NCT03932682 Efficacy Study With QIVc in Pediatric Subjects Influenza, Human Phase 3 Completed 2019-05-13 5723 Actual Industry https://clinicaltrials.gov/study/NCT03932682 NCT00435890 Triage Liaison Physician - Evaluation of a Novel Approach to Address Emergency Department Overcrowding Phase 4 Completed 2005-12 5718 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00435890 NCT01352793 A Global Phase 3 Safety Study of 120 mcg rLP2086 Vaccine in Adolescents and Young Adults Aged 10 to 25 Years Meningitis, Meningococcal Phase 3 Completed 2012-11 5715 Actual Industry https://clinicaltrials.gov/study/NCT01352793 NCT07517263 An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230) Cardiovascular Diseases; Myocardial Infarction; Stroke Phase 3 Active not recruiting 2026-05-11 5700 Estimated Industry https://clinicaltrials.gov/study/NCT07517263 NCT02085044 Non Randomized Controlled Intervention Study Comparing Two Interventions of Nutritional Supplement on Malnutrition, Health and Mortality Malnutrition Phase 4 Completed 2012-02 5700 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02085044 NCT07243704 Reducing the Burden of Cardiovascular Events With Antiplatelet Therapy in Patients With IntraCerebral Haemorrhage Cerebral Hemorrhage; Stroke Phase 3 Recruiting 2026-02-16 5676 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07243704 NCT02924727 Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI Ventricular Dysfunction, Left; ST Elevation Myocardial Infarction; Non-ST Elevated Myocardial Infarction Phase 3 Completed 2016-12-09 5669 Actual Industry https://clinicaltrials.gov/study/NCT02924727 NCT00132938 PERSPECTIVE: Telithromycin - Acute Exacerbation of Chronic Bronchitis Bronchitis, Chronic Phase 4 Completed 2004-01 5660 Industry https://clinicaltrials.gov/study/NCT00132938 NCT00549393 Study of Bathing With Chlorhexidine Impregnated Cloths on Nosocomial Infections in the Pediatric Intensive Care Unit Cross Infection Phase 2, Phase 3 Completed 2008-02 5659 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00549393 NCT00264901 Comparison of Self Adjustment Versus Standard of Care Treatment in Subjects With Type 2 Diabetes Diabetes Mellitus; Diabetes Mellitus, Type 2 Phase 4 Completed 2005-10 5652 Actual Industry https://clinicaltrials.gov/study/NCT00264901 NCT03155997 Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer Breast Neoplasms Phase 3 Active not recruiting 2017-07-12 5637 Actual Industry https://clinicaltrials.gov/study/NCT03155997 NCT00654537 STELLAR-Rosuvastatin vs. Atorvastatin, Pravastatin, Simvastatin Across Dose Ranges Hypercholesterolemia Phase 3 Completed 2001-04 5625 Estimated Industry https://clinicaltrials.gov/study/NCT00654537 NCT00643201 Efficacy and Safety Study of Apixaban for the Treatment of Deep Vein Thrombosis or Pulmonary Embolism Venous Thrombosis Phase 3 Completed 2008-07 5614 Actual Industry https://clinicaltrials.gov/study/NCT00643201 NCT00003830 Surgery to Remove Sentinel Lymph Nodes With or Without Removing Lymph Nodes in the Armpit in Treating Women With Breast Cancer Breast Neoplasms Phase 3 Completed 1999-05 5611 Actual Network https://clinicaltrials.gov/study/NCT00003830 NCT07567001 A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity Obesity; Heart Failure Phase 3 Recruiting 2026-05-11 5610 Estimated Industry https://clinicaltrials.gov/study/NCT07567001 NCT01709305 A Study of the Safety and Efficacy of Glimepiride, Gliclazide, Repaglinide or Acarbose When Added to Sitagliptin + Metformin Combination Therapy in Chinese Participants With Diabetes (MK-0431-313) Diabetes Mellitus, Type 2 Phase 4 Completed 2012-11-08 5570 Actual Industry https://clinicaltrials.gov/study/NCT01709305 NCT07272122 Reducing Filth Fly Populations and Transmission of Diarrhoeal Pathogens in Harsh Settings Phase 3 Recruiting 2026-08-17 5556 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07272122 NCT01173900 Delivery, Uptake and Acceptability of HPV Vaccination in Tanzanian Girls Uterine Cervical Neoplasms Phase 4 Completed 2010-08 5532 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01173900 NCT06077864 A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT) Obesity Phase 3 Completed 2023-11-20 5530 Actual Industry https://clinicaltrials.gov/study/NCT06077864 NCT02044250 Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- EXtended Antiplatelet Monotherapy (HOST-EXAM) Coronary Disease Phase 4 Completed 2014-02 5530 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02044250 NCT04296396 Opioid Prescription After Cesarean Trial Pain Phase 3 Completed 2020-09-21 5521 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04296396 NCT05952557 An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2) Breast Neoplasms Phase 3 Active not recruiting 2023-10-05 5511 Actual Industry https://clinicaltrials.gov/study/NCT05952557 NCT04418479 SMart Angioplasty Research Team: CHoice of Optimal Anti-Thrombotic Strategy in Patients Undergoing Implantation of Coronary Drug-Eluting Stents 3 Coronary Artery Disease Phase 4 Completed 2020-08-10 5506 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04418479 NCT06084234 National Liver Cancer Screening Trial Carcinoma, Hepatocellular; Liver Neoplasms; Liver Cirrhosis Phase 4 Recruiting 2023-12-26 5500 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06084234 NCT07349069 A Phase III Trial Comparing HRS-8080 With Standard Endocrine Therapy in Patients With Intermediate or High Risk Early Breast Cancer Breast Neoplasms Phase 3 Recruiting 2026-03-04 5500 Estimated Industry https://clinicaltrials.gov/study/NCT07349069 NCT06605144 Canadian Critical Care Comparative Effectiveness Platform Phase 3 Recruiting 2025-03-23 5500 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06605144 NCT00219687 Dispatcher-Assisted Resuscitation Trial (DART) Heart Arrest Phase 3 Completed 2004-06 5494 Actual Other government https://clinicaltrials.gov/study/NCT00219687 NCT03700749 FALCON Trial Testing Measures to Reduce Surgical Site Infection Surgical Wound Infection Phase 3 Unknown 2018-11-29 5480 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03700749 NCT02674438 Comparison of Outcomes and Access to Care for Heart Failure Trial Heart Failure Phase 3 Completed 2016-09 5452 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02674438 NCT06225752 Probucol for Symptomatic Intracranial and Extracranial Artery Stenosis Ischemic Stroke; Stroke Phase 3 Recruiting 2024-06-15 5452 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06225752 NCT02475850 Strategies to Reduce Injuries and Develop Confidence in Elders Wounds and Injuries Phase 3 Completed 2015-08 5451 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02475850 NCT01562379 Complementary Food Supplements for Reducing Childhood Undernutrition Growth Disorders; Cachexia Phase 2, Phase 3 Completed 2012-09 5449 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01562379 NCT03871517 INdobufen Versus aSpirin in acUte Ischemic stRokE,INSURE Ischemic Stroke Phase 4 Completed 2019-06-03 5438 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03871517 NCT04189744 The ASPIRE Trial - Aiming for Safe Pregnancies by Reducing Malaria and Infections of the Reproductive Tract Vaginosis, Bacterial; Trichomonas Vaginitis Phase 3 Completed 2019-12-15 5436 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04189744 NCT06523959 Avoiding Risks of Thrombosis and Bleeding in Surgery (ARTS) Trial Venous Thromboembolism; Hemorrhage; Venous Thrombosis Phase 4 Recruiting 2024-06-06 5436 Estimated Other government https://clinicaltrials.gov/study/NCT06523959 NCT04075240 VTE Prevention Following Total Hip and Knee Arthroplasty Venous Thromboembolism Phase 3 Completed 2021-02-04 5429 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04075240 NCT00423319 Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Hip Replacement Surgery (ADVANCE-3) Venous Thrombosis; Pulmonary Embolism Phase 3 Completed 2007-03 5407 Actual Industry https://clinicaltrials.gov/study/NCT00423319 NCT02968849 Pivotal Phase 2b/3 ALVAC/Bivalent gp120/MF59 HIV Vaccine Prevention Safety and Efficacy Study in South Africa HIV Infections Phase 2, Phase 3 Completed 2016-10-26 5404 Actual NIH https://clinicaltrials.gov/study/NCT02968849 NCT06424002 The Impact RTS,S/AS01 Vaccine in School Aged Children RTS,S/AS01 Malaria Vaccine in School Aged Children Malaria, Falciparum Phase 4 Unknown 2024-06-01 5400 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06424002 NCT06509893 Ticagrelore Alone Post PCI Coronary Artery Disease Phase 4 Recruiting 2024-08-01 5400 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06509893 NCT00168584 Different Doses of Vitamin A and Childhood Morbidity and Mortality Phase 4 Completed 2002-11 5400 University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00168584 NCT04220671 Measles Vaccination at Health System Contacts Phase 4 Enrolling by invitation 2020-01-08 5400 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04220671 NCT02105610 Volatile Anesthetics to Reduce Mortality in Cardiac Surgery Phase 4 Completed 2014-04-14 5400 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02105610 NCT02842086 Study to Evaluate the Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide (F/TAF) Fixed-Dose Combination Once Daily for Pre-Exposure Prophylaxis in Men and Transgender Women Who Have Sex With Men and Are At Risk of HIV-1 Infection Phase 3 Terminated 2016-09-02 5399 Actual Industry https://clinicaltrials.gov/study/NCT02842086 NCT02239120 Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS) Stroke Phase 3 Completed 2014-11-27 5390 Actual Industry https://clinicaltrials.gov/study/NCT02239120 NCT02787044 INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure Heart Failure; Myocardial Infarction; Influenza, Human Phase 4 Completed 2016-08-01 5388 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT02787044 NCT07419828 A Phase III Clinical Study on the Efficacy and Safety of HRS-1780 in the Treatment of Patients With Chronic Kidney Disease Renal Insufficiency, Chronic Phase 3 Recruiting 2026-03-13 5386 Estimated Industry https://clinicaltrials.gov/study/NCT07419828 NCT06330038 Anesthesia and Non-small Cell Lung Cancer Recurrence Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Neoplasm Metastasis Phase 4 Recruiting 2024-08-05 5384 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06330038 NCT00968708 Cardiovascular Outcomes Study of Alogliptin in Patients With Type 2 Diabetes and Acute Coronary Syndrome Diabetes Mellitus, Type 2; Acute Coronary Syndrome; Diabetes Mellitus Phase 3 Completed 2009-09 5380 Actual Industry https://clinicaltrials.gov/study/NCT00968708 NCT04028544 The Study of Qishenyiqi Drop Pills in Improving the Prognosis of Heart Failure Patients Heart Failure Phase 4 Unknown 2019-03-26 5380 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT04028544 NCT00103285 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma Phase 3 Completed 2005-04-11 5377 Actual Network https://clinicaltrials.gov/study/NCT00103285 NCT04994509 Pre-Exposure Prophylaxis Study of Lenacapavir and Emtricitabine/Tenofovir Alafenamide in Adolescent Girls and Young Women at Risk of HIV Infection Phase 3 Active not recruiting 2021-08-30 5368 Actual Industry https://clinicaltrials.gov/study/NCT04994509 NCT00385138 Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition. Atherosclerosis; Acute Coronary Syndrome Phase 3 Terminated 2006-09 5364 Actual Industry https://clinicaltrials.gov/study/NCT00385138 NCT01084213 Intermittent Preventive Treatment Versus Scheduled Screening and Treatment of Malaria in Pregnancy Malaria; Anemia Phase 4 Completed 2010-06 5354 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01084213 NCT00003782 Combination Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA (cT1-3, N0-1, M0) Breast Cancer and Positive Axillary Lymph Nodes Breast Neoplasms Phase 3 Completed 1999-03 5351 Actual Network https://clinicaltrials.gov/study/NCT00003782 NCT05836987 The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation Atrial Fibrillation; Ischemic Stroke Phase 3 Recruiting 2023-07-13 5350 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05836987 NCT02683239 Long-Term Safety and Efficacy Study of Fasinumab in Patients With Pain Due to Osteoarthritis (OA) of the Knee or Hip Osteoarthritis, Knee Phase 3 Completed 2016-02-17 5331 Actual Industry https://clinicaltrials.gov/study/NCT02683239 NCT01254630 A Study to Evaluate the Safety and Efficacy of Inactivated Varicella-zoster Vaccine (VZV) as a Preventative Treatment for Herpes Zoster (HZ) and HZ-related Complications in Adult Participants With Solid Tumor or Hematologic Malignancy (V212-011) Herpes Zoster; Hematologic Neoplasms Phase 3 Completed 2011-06-24 5305 Actual Industry https://clinicaltrials.gov/study/NCT01254630 NCT03683667 Protein Plus: Improving Infant Growth Through Diet and Enteric Health Growth Disorders; Kwashiorkor; Campylobacter Infections Phase 2, Phase 3 Completed 2018-09-23 5283 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT03683667 NCT01767870 Efficacy Combined Fecal Immunochemical Test-Sigmoidoscopy for the Detection of Advanced Colorectal Neoplasia Phase 4 Unknown 2012-08 5282 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01767870 NCT01742117 Tailored Antiplatelet Therapy Following PCI Coronary Artery Disease; Acute Coronary Syndrome; Constriction, Pathologic Phase 4 Completed 2013-05 5276 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01742117 NCT07119918 PCSK9 Inhibitor for Intracranial Atherosclerotic Symptomatic Stenosis Phase 3 Not yet recruiting 2025-09-01 5276 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07119918 NCT04842617 Phase III Study ：SHR6390/Placebo Combined With Endocrine Therapy for the Adjuvant Treatment of Hormone Receptor Positive,Human Epidermal Receptor 2 Negative Phase 3 Active not recruiting 2021-04-30 5274 Actual Industry https://clinicaltrials.gov/study/NCT04842617 NCT07554573 Assessment of Biosignature Classification of DCIS for RadioTherapy Benefit Post Lumpectomy (ABCD RT) Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating Phase 3 Not yet recruiting 2027-01-30 5270 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07554573 NCT07383155 Bivalirudin Versus Heparin During PCI in High Bleeding Risk Patients With Acute Coronary Syndromes Acute Coronary Syndrome Phase 4 Not yet recruiting 2026-02-01 5270 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07383155 NCT01703884 ANC & Malaria Diagnostic in Pregnancy Malaria Phase 4 Completed 2012-08 5254 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01703884 NCT06283966 A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease Pulmonary Disease, Chronic Obstructive Phase 3 Recruiting 2024-02-21 5250 Estimated Industry https://clinicaltrials.gov/study/NCT06283966 NCT03518034 A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men Hypogonadism; Cardiovascular Diseases; Disease Phase 4 Completed 2018-05-03 5246 Actual Industry https://clinicaltrials.gov/study/NCT03518034 NCT07300839 A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age COVID-19 Phase 3 Completed 2025-12-10 5240 Actual Industry https://clinicaltrials.gov/study/NCT07300839 NCT00252733 Diabetic Retinopathy Candesartan Trials Diabetes Mellitus, Type 1 Phase 3 Completed 2001-06 5238 Actual Industry https://clinicaltrials.gov/study/NCT00252733 NCT02112214 Helicobacter Pylori Eradication for Gastric Cancer Prevention in the General Population Stomach Neoplasms Phase 3 Active not recruiting 2014-06 5224 Estimated Other government https://clinicaltrials.gov/study/NCT02112214 NCT01218308 A Study to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine in Children Influenza, Human Phase 3 Completed 2010-12-09 5220 Actual Industry https://clinicaltrials.gov/study/NCT01218308 NCT07478003 Prehospital Pulse-dose Glucocorticoid in Patients With ST-segment Elevation Myocardial Infarction 2 - The PULSE-MI 2 Trial ST Elevation Myocardial Infarction Phase 3 Recruiting 2026-04-20 5204 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07478003 NCT06008197 A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients Heart Failure Phase 3 Recruiting 2024-01-17 5200 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06008197 NCT05105321 Cardiovascular Diseases and Diabetes Prevention Programme in Metabolic Syndrome (CDPP) Metabolic Syndrome; Cardiovascular Diseases; Diabetes Mellitus Phase 4 Not yet recruiting 2021-12 5200 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05105321 NCT00124878 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community HIV Infections; Sexually Transmitted Diseases; Papillomavirus Infections Phase 3 Unknown 2003-08 5200 Actual Individual https://clinicaltrials.gov/study/NCT00124878 NCT04625725 Phase III Double-blind, Placebo-controlled Study of AZD7442 for Pre-exposure Prophylaxis of COVID-19 in Adult. COVID-19 Phase 3 Completed 2020-11-21 5197 Actual Industry https://clinicaltrials.gov/study/NCT04625725 NCT01130246 VISTA-16 Trial: Evaluation of Safety and Efficacy of Short-term A-002 Treatment in Subjects With Acute Coronary Syndrome Acute Coronary Syndrome Phase 3 Terminated 2010-05 5189 Actual Industry https://clinicaltrials.gov/study/NCT01130246 NCT00003140 Letrozole After Tamoxifen in Treating Women With Breast Cancer Breast Neoplasms Phase 3 Completed 1998-08-24 5187 Actual Network https://clinicaltrials.gov/study/NCT00003140 NCT01467466 Prevention of Serious Adverse Events Following Angiography Acute Kidney Injury; Kidney Diseases; Coronary Artery Disease Phase 3 Completed 2013-10-07 5177 Actual U.S. federal https://clinicaltrials.gov/study/NCT01467466 NCT04927065 A Study to Evaluate the Immunogenicity and Safety of mRNA Vaccine Boosters for SARS-CoV-2 (COVID-19) Variants Coronavirus Infections; Virus Diseases; COVID-19 Phase 2, Phase 3 Completed 2021-05-28 5161 Actual Industry https://clinicaltrials.gov/study/NCT04927065 NCT05182970 Metformin and Prevention of Cardiovascular Events in Patients With Acute Myocardial Infarction and Prediabetes (MIMET) Prediabetic State; Non-ST Elevated Myocardial Infarction; ST Elevation Myocardial Infarction Phase 3 Unknown 2021-12-02 5160 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT05182970 NCT00454662 Combination of OLMesartan and CCB or Low Dose Diuretics in High Risk Elderly Hypertensive Patients Study (COLM-Study) Hypertension; Cardiovascular Diseases; Diabetes Mellitus Phase 4 Completed 2007-04 5141 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00454662 NCT06853535 Precision Antiplatelet Therapy Guided by Platelet Aggregation Function in Patients With Acute Ischemic STROKE Ischemic Stroke Phase 3 Recruiting 2025-05-23 5138 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT06853535 NCT01858532 Study Of Diabetic Nephropathy With Atrasentan Diabetic Nephropathies; Diabetes Mellitus; Kidney Diseases Phase 3 Terminated 2013-05-17 5107 Actual Industry https://clinicaltrials.gov/study/NCT01858532 NCT00139542 AED Use in Out-of-Hospital Cardiac Arrest: A New Algorithm Named "One Shock Per Minute" Heart Arrest; Ventricular Fibrillation Phase 3 Completed 2005-09 5107 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00139542 NCT03701334 A Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer Breast Neoplasms Phase 3 Active not recruiting 2018-12-07 5101 Actual Industry https://clinicaltrials.gov/study/NCT03701334 NCT07159373 Better Options for Lymphatic Filariasis Treatment Elephantiasis, Filarial; Scabies; Strongyloidiasis Phase 3 Recruiting 2026-09-28 5100 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT07159373 NCT01534221 The COOPerative Establishment for Necessary Investigation in Clinical Outcome After Stenting Myocardial Ischemia Phase 4 Unknown 2012-03 5100 Estimated University, hospital or nonprofit https://clinicaltrials.gov/study/NCT01534221 NCT00979589 Clopidogrel in High-risk Patients With Acute Non-disabling Cerebrovascular Events Stroke; Ischemic Attack, Transient Phase 3 Completed 2009-12 5100 Actual University, hospital or nonprofit https://clinicaltrials.gov/study/NCT00979589 NCT00045032 Herceptin (Trastuzumab) in Treating Women With Human Epidermal Growth Factor Receptor (HER) 2-Positive Primary Breast Cancer Breast Neoplasms Phase 3 Completed 2001-11 5099 Actual Industry https://clinicaltrials.gov/study/NCT00045032