Source: https://aidb.si/d/largest-clinical-trials — Data from ClinicalTrials.gov, U.S. National Library of Medicine (clinicaltrials.gov), aggregated by AIDB.
| NCT number | Study | Conditions | Phase | Status | Start | Enrollment | Enrollment type | Sponsor type | Record |
|---|---|---|---|---|---|---|---|---|---|
| NCT06358872 | Azithromycin for Child Survival in Niger II | Phase 4 | Recruiting | 2024-04-29 | 3300000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06358872 | |
| NCT04224987 | Azithromycin for Child Survival in Niger: Mortality and Resistance Trial | Phase 4 | Completed | 2020-11-24 | 864493 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04224987 | |
| NCT00222547 | Deworming and Enhanced Vitamin A Every 6 Month in Rural Indian Children Aged 1-6 | Phase 4 | Completed | 1999-01 | 720000 | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00222547 | ||
| NCT04716712 | Infant Mortality Reduction by the Mass Administration of Azithromycin | Phase 4 | Active not recruiting | 2021-10-04 | 694400 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04716712 | |
| NCT06684743 | Vaccine Effectiveness of a Bivalent RSV Prefusion F Protein-Based Vaccine for Preventing RSV Hospitalizations in Adults | Respiratory Tract Diseases | Phase 4 | Active not recruiting | 2024-11-18 | 690000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06684743 |
| NCT05148845 | Sisonke 2 - A COVID-19 Vaccine Boost Open Label Study. | COVID-19 | Phase 3 | Completed | 2021-11-10 | 500000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05148845 |
| NCT04838795 | Sisonke (Together): OPEN LABEL TRIAL COVID-19 | Severe Acute Respiratory Syndrome | Phase 3 | Completed | 2021-02-17 | 477102 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04838795 |
| NCT06506812 | Pooled Analysis of Methodologically Harmonized Pragmatic Randomized Trials of High-Dose vs. Standard-Dose Influenza Vaccine Against Severe Clinical Outcomes | Influenza, Human; Pneumonia | Phase 4 | Completed | 2025-05-31 | 466320 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06506812 |
| NCT07790523 | Effectiveness of An Influenza/COVID-19 Vaccine (mCombriax [mRNA-1083]) in Adults ≥ 65 Years | COVID-19; Influenza, Human; Respiratory Tract Diseases | Phase 4 | Not yet recruiting | 2026-09-01 | 410000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07790523 |
| NCT06934239 | A Trial Comparing Screening Mammography With and Without Assistance From Artificial Intelligence for Breast Cancer Detection and Recall Rates in Adult Patients | Phase 4 | Recruiting | 2025-10-15 | 400000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06934239 | |
| NCT02556242 | Targeted Indoor Residual Spraying Against Malaria | Malaria | Phase 4 | Completed | 2015-10 | 393387 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02556242 |
| NCT03014167 | Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH) | Helminthiasis; Filariasis | Phase 3 | Completed | 2017-10-04 | 357716 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03014167 |
| NCT03140423 | Mupirocin-Iodophor ICU Decolonization Swap Out Trial | Staphylococcal Infections; Cross Infection | Phase 4 | Completed | 2017-05-01 | 353323 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03140423 |
| NCT05517174 | A Pragmatic Randomized Trial to Evaluate the Effectiveness of High-Dose Quadrivalent Influenza Vaccine vs. Standard-Dose Quadrivalent Influenza Vaccine in Older Adults | Influenza, Human; Pneumonia | Phase 4 | Completed | 2022-09-22 | 332438 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05517174 |
| NCT03335072 | Kebele Elimination of Trachoma for Ocular Health | Trachoma | Phase 4 | Active not recruiting | 2022-02-07 | 320000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03335072 |
| NCT04177043 | Model Towards Elimination of Hepatitis C Infection in Egypt: Feasibility and Effectiveness in 73 Villages | Hepatitis C, Chronic | Phase 4 | Completed | 2015-06 | 221855 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04177043 |
| NCT02027207 | Single Dose Oral Cholera Vaccine Study in Dhaka, Bangladesh | Cholera | Phase 3 | Completed | 2012-12-09 | 204438 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02027207 |
| NCT00203749 | Community Mobilization, Mobile Testing, Same-Day Results, and Post-Test Support for HIV in Sub-Saharan Africa and Thailand | HIV Infections | Phase 3 | Completed | 2004-12 | 192814 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00203749 |
| NCT02047981 | Mortality Reduction After Oral Azithromycin: Mortality Study | Infections | Phase 4 | Completed | 2014-12 | 190238 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02047981 |
| NCT05288023 | Azithromycin for Child Survival in Niger: Programmatic Trial (AVENIR) | Phase 4 | Terminated | 2022-12-01 | 169707 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05288023 | |
| NCT07485283 | Recombinant Herpes Zoster Vaccine for Prevention of Cardiovascular Events and Dementia | Cardiovascular Diseases; Dementia; Herpes Zoster | Phase 4 | Active not recruiting | 2026-04-28 | 168460 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07485283 |
| NCT02079701 | Effectiveness of the Pneumococcal Polysaccharide Vaccine in Military Recruits | Pneumonia | Phase 4 | Completed | 2000-10 | 152723 | Actual | U.S. federal | https://clinicaltrials.gov/study/NCT02079701 |
| NCT07314307 | Vaccine Effectiveness of One Dose of the Nonavalent Human Papillomavirus (HPV) Vaccine Among Young-adult Women in Sweden Among Women Participating in a Clinical Trial of Concomitant HPV Vaccination and Screening | Phase 4 | Active not recruiting | 2021-05-03 | 150000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07314307 | |
| NCT04910802 | Concomitant HPV Vaccination and HPV Screening HPV Infection and Cervical Cancer in Sweden | Papillomavirus Infections; Uterine Cervical Neoplasms | Phase 4 | Recruiting | 2021-05-03 | 150000 | Estimated | Other government | https://clinicaltrials.gov/study/NCT04910802 |
| NCT04424511 | Effects of Mass Drug Administration of Azithromycin on Mortality and Other Outcomes Among 1-11 Month Old Infants in Mali | Inflammation; Infections | Phase 3 | Completed | 2020-10-15 | 149201 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04424511 |
| NCT03662022 | Post ExpOsure Prophylaxis for LEprosy in the Comoros and Madagascar | Leprosy | Phase 3 | Completed | 2019-01-02 | 144000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03662022 |
| NCT06141655 | HD vs SD Quadrivalent Influenza Vaccine in Adults Aged 65 to 79 Years in Galicia | Influenza, Human | Phase 4 | Completed | 2023-10-26 | 134476 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06141655 |
| NCT04911790 | Safety of an Inactivated SARS-CoV-2 Vaccine for Prevention of COVID-19 in Adults | COVID-19 | Phase 4 | Completed | 2021-06-05 | 131650 | Actual | Industry | https://clinicaltrials.gov/study/NCT04911790 |
| NCT06719193 | DeMONSTRATE-TB Study in Ethiopia | Phase 2, Phase 3 | Recruiting | 2023-02-27 | 131438 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06719193 | |
| NCT05597280 | Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy | Leprosy | Phase 3 | Recruiting | 2023-03-22 | 124000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05597280 |
| NCT01014845 | Clinical Trial of Recombinant Hepatitis E Vaccine | Hepatitis E | Phase 3 | Completed | 2007-08 | 112604 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01014845 |
| NCT03233191 | Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer | Phase 3 | Active not recruiting | 2017-09-28 | 108508 | Estimated | Network | https://clinicaltrials.gov/study/NCT03233191 | |
| NCT00131820 | Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central Vietnam | Typhoid Fever; Paratyphoid Fever | Phase 4 | Completed | 2001-12 | 100742 | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00131820 | |
| NCT00211341 | Trial of the Impact of Vitamin A on Maternal Mortality | Vitamin A Deficiency; Maternal Death | Phase 3 | Completed | 2000-12 | 100000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00211341 |
| NCT06536855 | Faster Elimination of HPV Infection and Cervical Cancer Using Concomitant HPV Vaccination and HPV Screening: A Demonstration Project in Rwanda | Uterine Cervical Neoplasms | Phase 4 | Unknown | 2024-09-01 | 100000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06536855 |
| NCT05890521 | Safety Study of COVID19 Vaccine on the Market | COVID-19 | Phase 4 | Unknown | 2022-04-02 | 100000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT05890521 |
| NCT04353180 | Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized) | COVID-19 | Phase 3 | Unknown | 2021-08 | 100000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04353180 |
| NCT00712374 | Evaluation of the Public Health Impact of Seasonal Intermittent Preventive Treatment (IPT) in Children in Senegal | Malaria | Phase 4 | Unknown | 2008-09 | 100000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00712374 |
| NCT03909737 | Oral Azithromycin to Prevent Stillbirths and Infant Mortality in Mali | Stillbirth; Infant Death | Phase 4 | Active not recruiting | 2020-09-24 | 99700 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03909737 |
| NCT00131833 | Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, China | Typhoid Fever; Paratyphoid Fever | Phase 4 | Completed | 2001-10 | 96468 | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00131833 | |
| NCT00883792 | The Northern-European Initiative on Colorectal Cancer | Colorectal Neoplasms | Phase 3 | Active not recruiting | 2009-05 | 95000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00883792 |
| NCT02590315 | Tomosynthesis Versus Digital Mammography in a Population-based Screening Program | Breast Neoplasms | Phase 4 | Unknown | 2014-12 | 92000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02590315 |
| NCT01528449 | Babesia Testing in Blood Donors | Phase 3 | Completed | 2011-12 | 90116 | Actual | Industry | https://clinicaltrials.gov/study/NCT01528449 | |
| NCT02987270 | Evaluation of Community-based Mass Screening and Treatment for Malaria in Western Kenya | Malaria, Falciparum; Malaria; Asymptomatic Infections | Phase 3 | Completed | 2013-04 | 90000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02987270 |
| NCT00744263 | Study Evaluating the Effiacy of a 13-Valent Pneumococcal Conjugate Vaccine (13vPnC) in Adults | Pneumonia, Pneumococcal; Pneumococcal Infections | Phase 4 | Completed | 2008-09 | 84496 | Actual | Industry | https://clinicaltrials.gov/study/NCT00744263 |
| NCT00222664 | Qidong Hepatitis B Intervention Study | Hepatitis B; Liver Neoplasms; Liver Diseases | Phase 4 | Completed | 1983-09 | 80000 | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00222664 | |
| NCT07177352 | Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies | Alzheimer Disease; Cognitive Dysfunction | Phase 3 | Recruiting | 2025-07-02 | 80000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07177352 |
| NCT03923699 | Telemedicine Control Tower for the Operating Room: Navigating Information, Care and Safety | Postoperative Complications | Phase 3 | Completed | 2019-07-01 | 79560 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03923699 |
| NCT03676764 | Community Health Azithromycin Trial in Burkina Faso | Phase 4 | Completed | 2019-08-01 | 77664 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03676764 | |
| NCT01241318 | Zambia Chlorhexidine Application Trial | Sepsis | Phase 2, Phase 3 | Completed | 2011-02 | 77535 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01241318 |
| NCT04914832 | Effectiveness of Covid-19 Vaccination in Eswatini Against SARS-CoV-2 Associated Hospitalization and Death | COVID-19; Pneumonia, Viral; Pneumonia | Phase 4 | Completed | 2021-08-30 | 75012 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04914832 |
| NCT00244777 | Introduction of Hypo-osmolar ORS for Routine Use | Diarrhea; Seizures; Hyponatremia | Phase 4 | Completed | 2002-12 | 75000 | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00244777 | |
| NCT07436104 | Mortality Control Program for Economically Productive Age Group in Tribal Area of Melghat. | Hypertension; Diarrhea; Pneumonia | Phase 4 | Completed | 2004-01-01 | 72564 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07436104 |
| NCT05500482 | Vellore Typhoid Vaccine Impact Trial | Typhoid Fever | Phase 4 | Completed | 2023-05-01 | 72400 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05500482 |
| NCT02048007 | Mortality Reduction After Oral Azithromycin: Morbidity Study | Infections; Bacterial Infections; Trachoma | Phase 4 | Completed | 2014-11 | 72000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02048007 |
| NCT06270355 | Stockholm Mammography Risk Stratified Trial | Breast Neoplasms | Phase 3 | Not yet recruiting | 2024-04-08 | 70000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06270355 |
| NCT04381936 | Randomised Evaluation of COVID-19 Therapy | Pneumonia; COVID-19; Community-Acquired Pneumonia | Phase 3 | Recruiting | 2020-03-19 | 70000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04381936 |
| NCT07038837 | Comparison of Two Strategies for Administering the R21-Matrix M Vaccine in a Context of Seasonal Malaria Transmission in Chad | Malaria | Phase 4 | Recruiting | 2025-06-16 | 70000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07038837 |
| NCT00289224 | Randomized Controlled Trial of Killed Oral Cholera Vaccine in Kolkata | Diarrhea; Cholera; Vibrio Infections | Phase 3 | Completed | 2006-07 | 69329 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00289224 |
| NCT00090233 | Rotavirus Efficacy and Safety Trial (REST)(V260-006) | Rotavirus Infections | Phase 3 | Completed | 2001-01 | 69274 | Actual | Industry | https://clinicaltrials.gov/study/NCT00090233 |
| NCT03338244 | Mortality Reduction After Oral Azithromycin Contingency: Mortality Study | Infections | Phase 4 | Completed | 2017-10-20 | 66228 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03338244 |
| NCT02106221 | Transforming Outcomes for Patients Through Medical Home Evaluation & reDesign | Phase 3 | Completed | 2011-07 | 65500 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02106221 | |
| NCT06020560 | Study of Low Molecular Weight Heparins | Venous Thromboembolism | Phase 4 | Unknown | 2023-03-23 | 65000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06020560 |
| NCT00140673 | A Study to Test 2 Doses of the HRV Vaccine in Healthy Infants. | Rotavirus Infections | Phase 3 | Completed | 2003-08-05 | 63227 | Actual | Industry | https://clinicaltrials.gov/study/NCT00140673 |
| NCT01890603 | Enhancing Complex Care Through an Integrated Care Coordination Information System | Phase 3 | Completed | 2008-09 | 60000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01890603 | |
| NCT03244072 | Safety and Efficacy of Intracameral Zimoxin for Prevention of Endophthalmitis After Cataract Surgery | Endophthalmitis | Phase 2, Phase 3 | Not yet recruiting | 2027-06-01 | 60000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT03244072 |
| NCT01908114 | To Develop, Implement and Evaluate the Polio Demonstration Project Comprising of a Community Based Intervention Package for Polio Eradication in Pakistan | Poliomyelitis | Phase 4 | Unknown | 2013-07 | 60000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01908114 |
| NCT00785525 | Filgrastim-Mobilized Stem Cells for Transplantation Using Unrelated Donors | Phase 3 | Recruiting | 1997-02 | 60000 | Estimated | Network | https://clinicaltrials.gov/study/NCT00785525 | |
| NCT00198822 | Impact of Maternal Vitamin A or Beta-Carotene Supplementation on Maternal and Infant Mortality in Bangladesh | Vitamin A Deficiency; Maternal Death; Infant Death | Phase 3 | Completed | 2001-08 | 59666 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00198822 |
| NCT03871491 | Azithromycin-Prevention in Labor Use Study (A-PLUS) | Maternal Death; Neonatal Sepsis; Perinatal Death | Phase 3 | Completed | 2020-09-01 | 58747 | Actual | Network | https://clinicaltrials.gov/study/NCT03871491 |
| NCT00109551 | Community Trial of Zinc Supplementation on Preschool Child Mortality and Morbidity in Southern Nepal | Phase 3 | Completed | 2001-10 | 58000 | NIH | https://clinicaltrials.gov/study/NCT00109551 | ||
| NCT03490123 | Evaluation of an Intensive 3-round MDA Strategy Towards Yaws Eradication | Yaws | Phase 4 | Completed | 2018-04-16 | 56000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03490123 |
| NCT04941300 | ColoRectal Cancer Screening for Southern California Community Health Centers | Colorectal Neoplasms | Phase 3 | Completed | 2021-06-08 | 55999 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04941300 |
| NCT00581711 | Improving Otitis Media Care With Clinical Decision Support | Otitis Media | Phase 3 | Completed | 2007-12 | 55779 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00581711 |
| NCT06976723 | Nerivio Efficacy by Time of Treatment Onset | Migraine Disorders | Phase 4 | Completed | 2025-05-07 | 55261 | Actual | Industry | https://clinicaltrials.gov/study/NCT06976723 |
| NCT02251704 | Epidemiology Study of Malaria Transmission Intensity in Sub-Saharan Africa | Malaria; Malaria, Falciparum | Phase 4 | Completed | 2014-10-22 | 54115 | Actual | Industry | https://clinicaltrials.gov/study/NCT02251704 |
| NCT07805707 | A Study on the Efficacy of a Vaccine Against Influenza in Adults ≥65 Years of Age | Influenza, Human | Phase 3 | Recruiting | 2026-09-02 | 54000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07805707 |
| NCT00047385 | National Lung Screening Trial (NLST) Screening | Lung Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Non-Small-Cell Lung | Phase 3 | Completed | 2002-08 | 53454 | Actual | NIH | https://clinicaltrials.gov/study/NCT00047385 |
| NCT07145736 | Moxidectin Versus Ivermectin as Mass Drug Administration for the Control of Onchocerciasis and Other Neglected Tropical Diseases | Onchocerciasis; Trichuriasis; Hookworm Infections | Phase 4 | Recruiting | 2025-08-04 | 52000 | Estimated | Other government | https://clinicaltrials.gov/study/NCT07145736 |
| NCT02823821 | Randomised Evaluation of Sodium Dialysate Levels on Vascular Events | Kidney Failure, Chronic | Phase 4 | Recruiting | 2016-06 | 50000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02823821 |
| NCT01830283 | The Safety, Immunogenicity and Immune Effect Research of the Varicella Vaccine After the 2nd Dose Vaccination | Chickenpox | Phase 4 | Unknown | 2013-04 | 50000 | Estimated | Other government | https://clinicaltrials.gov/study/NCT01830283 |
| NCT00118443 | Evaluation of a School-Based Training Program for Suicide Prevention | Suicide; Suicide Prevention; Depression | Phase 2, Phase 3 | Completed | 2004-03 | 50000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00118443 |
| NCT00344513 | Organized Program To Initiate Lifesaving Treatment In Hospitalized Patients With Heart Failure (OPTIMIZE-HF) | Heart Failure | Phase 4 | Completed | 2002-12-16 | 50000 | Industry | https://clinicaltrials.gov/study/NCT00344513 | |
| NCT04220515 | Inactivated Poliomyelitis Vaccine Made From Sabin Strain | Poliomyelitis | Phase 4 | Completed | 2018-02-08 | 49731 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04220515 |
| NCT04966702 | Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA) | Malaria | Phase 3 | Completed | 2022-03-17 | 48145 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04966702 |
| NCT05119426 | Effectiveness of a Typhoid Conjugate Vaccine in DRC | Typhoid Fever | Phase 4 | Unknown | 2022-02-11 | 48000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05119426 |
| NCT02754583 | Sanitation, Water, and Instruction in Face-washing for Trachoma I/II | Trachoma | Phase 3 | Completed | 2015-12-05 | 47605 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02754583 |
| NCT04609423 | Cod Liver Oil for Covid-19 Prevention Study | COVID-19; Respiratory Tract Infections | Phase 4 | Completed | 2020-11-10 | 47210 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04609423 |
| NCT04368728 | Study to Describe the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Individuals | COVID-19; Coronavirus Infections | Phase 2, Phase 3 | Completed | 2020-04-29 | 46969 | Actual | Industry | https://clinicaltrials.gov/study/NCT04368728 |
| NCT00222573 | Efficacy and Safety of Adding Clopidogrel to Aspirin or Use of Metoprolol in Myocardial Infarction | Myocardial Infarction | Phase 4 | Completed | 1999-07 | 46000 | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00222573 | |
| NCT05540522 | A Study to Evaluate a Modified RNA Vaccine Against Influenza in Adults 18 Years of Age or Older | Influenza, Human | Phase 3 | Completed | 2022-09-12 | 45789 | Actual | Industry | https://clinicaltrials.gov/study/NCT05540522 |
| NCT05470855 | Protective Effect, Safety and Immunogenicity of Live Attenuated Varicella Vaccine in Anhui Province | Chickenpox | Phase 4 | Unknown | 2022-07-06 | 45400 | Estimated | Industry | https://clinicaltrials.gov/study/NCT05470855 |
| NCT05175014 | Mass Campaigns With Fractional Dose Pneumococcal Vaccines in Sub-Saharan Africa (fPCV) | Phase 4 | Completed | 2021-12-30 | 44618 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05175014 | |
| NCT00860470 | Antenatal Micronutrient Supplementation and Infant Survival | Infant Death; Premature Birth; Perinatal Death | Phase 3 | Completed | 2008-01 | 44567 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00860470 |
| NCT04505722 | A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants | Phase 3 | Completed | 2020-09-07 | 44325 | Actual | Industry | https://clinicaltrials.gov/study/NCT04505722 | |
| NCT04526990 | Phase III Trial of A COVID-19 Vaccine of Adenovirus Vector in Adults 18 Years Old and Above | COVID-19; Alzheimer Disease 5 | Phase 3 | Completed | 2020-09-15 | 44247 | Actual | Industry | https://clinicaltrials.gov/study/NCT04526990 |
| NCT04510207 | A Study to Evaluate The Efficacy, Safety and Immunogenicity of Inactivated SARS-CoV-2 Vaccines (Vero Cell) in Healthy Population Aged 18 Years Old and Above | COVID-19; Coronavirus Infections | Phase 3 | Completed | 2020-07-16 | 44101 | Actual | Industry | https://clinicaltrials.gov/study/NCT04510207 |
| NCT00753272 | Trial to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine GSK2186877A in Adults 65 Year of Age and Older | Influenza, Human | Phase 3 | Completed | 2008-09-15 | 43695 | Actual | Industry | https://clinicaltrials.gov/study/NCT00753272 |
| NCT04512950 | Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients | Hypovolemia | Phase 4 | Completed | 2016-08-15 | 43626 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04512950 |
| NCT06856772 | Randomized Comparison of Morning Versus Bedtime Administration of Statins: A Cardiovascular Circadian Chronotherapy (C3) Trial | Cardiovascular Diseases | Phase 4 | Not yet recruiting | 2025-02-28 | 42000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06856772 |
| NCT00861380 | Evaluation of Effectiveness of GSK Biologicals' Pneumococcal Conjugate Vaccine 1024850A Against Invasive Disease | Streptococcal Infections; Respiratory Tract Infections; Haemophilus Infections | Phase 3 | Completed | 2009-05-04 | 41188 | Actual | Industry | https://clinicaltrials.gov/study/NCT00861380 |
| NCT07279766 | Effectiveness of mRNA-1273 Variant-Containing Vaccine Formulation Against Severe Outcomes in Adults Aged 50-64 Years Without Risk Factors for Severe COVID-19 | COVID-19; Respiratory Tract Diseases | Phase 4 | Completed | 2025-12-11 | 41060 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07279766 |
| NCT06602024 | A Study of mRNA-1010 Compared With a Licensed Influenza Vaccine in Adults ≥50 Years of Age | Influenza, Human | Phase 3 | Completed | 2024-09-16 | 40805 | Actual | Industry | https://clinicaltrials.gov/study/NCT06602024 |
| NCT03001986 | The Phase IVb of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Children | Hand, Foot and Mouth Disease | Phase 4 | Completed | 2016-09 | 40724 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03001986 |
| NCT06788522 | The Effects of Orexin Antagonism on Fear Extinction in PTSD | Sleep Initiation and Maintenance Disorders; Stress Disorders, Post-Traumatic | Phase 4 | Not yet recruiting | 2026-06-01 | 40120 | Estimated | U.S. federal | https://clinicaltrials.gov/study/NCT06788522 |
| NCT00097097 | Neonatal Resuscitation in Zambia | Asphyxia Neonatorum; Hypoxia-Ischemia, Brain; Asphyxia | Phase 3 | Completed | 2004-10 | 40000 | Network | https://clinicaltrials.gov/study/NCT00097097 | |
| NCT00662480 | Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark | Aortic Aneurysm, Abdominal; Peripheral Arterial Disease; Hypertension | Phase 4 | Unknown | 2008-09 | 40000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00662480 |
| NCT03582761 | Efficacy Evaluation for Inactivated Vaccine (Vero Cell) Against EV71 | Hand, Foot and Mouth Disease | Phase 4 | Completed | 2019-05-01 | 40000 | Actual | Network | https://clinicaltrials.gov/study/NCT03582761 |
| NCT06860178 | Integrating Malaria Vaccine With Seasonal Malaria Chemoprevention in West Africa | Malaria | Phase 4 | Recruiting | 2025-06-10 | 40000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06860178 |
| NCT03783299 | Targeted Active Case Detection Among High Risk Populations in Southern Lao Peoples Democratic Republic | Malaria, Falciparum | Phase 4 | Completed | 2017-11-28 | 39968 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03783299 |
| NCT00000479 | Women's Health Study (WHS): A Randomized Trial of Low-dose Aspirin and Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer | Cardiovascular Diseases; Cerebrovascular Disorders; Coronary Disease | Phase 3 | Completed | 1992-09 | 39876 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00000479 |
| NCT04652102 | A Phase 2b/3, Randomized, Observer-Blinded, Placebo-Controlled, Multicenter Clinical Study Evaluating the Efficacy and Safety of Investigational SARS-CoV-2 mRNA Vaccine CVnCoV in Adults 18 Years of Age and Older | COVID-19 | Phase 2, Phase 3 | Completed | 2020-12-11 | 39680 | Actual | Industry | https://clinicaltrials.gov/study/NCT04652102 |
| NCT04904471 | A Global Phase III Clinical Trial of Recombinant COVID- 19 Vaccine (Sf9 Cells) | COVID-19 | Phase 3 | Completed | 2021-06-15 | 39663 | Actual | Industry | https://clinicaltrials.gov/study/NCT04904471 |
| NCT04505098 | A Pragmatic Randomized Trial of Icosapent Ethyl for High-Cardiovascular Risk Adults | COVID-19; Atherosclerosis; Cardiovascular Diseases | Phase 4 | Terminated | 2020-08-07 | 39600 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04505098 |
| NCT05035212 | Study to Evaluate the Efficacy, Immunogenicity, and Safety of RSVpreF in Adults. | Phase 3 | Active not recruiting | 2021-08-31 | 38861 | Actual | Industry | https://clinicaltrials.gov/study/NCT05035212 | |
| NCT06087640 | A Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of an Adjuvanted Influenza Vaccine Compared to a Non-adjuvanted Influenza Vaccine in Adults ≥65 Years of Age | Influenza, Human | Phase 3 | Completed | 2023-10-23 | 38769 | Actual | Industry | https://clinicaltrials.gov/study/NCT06087640 |
| NCT00007501 | Shingles Prevention Study | Herpes Zoster; Neuralgia, Postherpetic | Phase 3 | Completed | 1998-11 | 38456 | Actual | U.S. federal | https://clinicaltrials.gov/study/NCT00007501 |
| NCT06567808 | Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial | Surgical Wound Infection | Phase 4 | Not yet recruiting | 2026-03-01 | 38000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06567808 |
| NCT05460429 | Immunogenicity, Safety and Protective Effect of Live Attenuated Varicella Vaccine and Study on Antibody Level and Etiology of Varicella Zoster Virus | Chickenpox | Phase 4 | Unknown | 2022-07-30 | 37920 | Estimated | Industry | https://clinicaltrials.gov/study/NCT05460429 |
| NCT06592794 | A Study to Investigate the Safety and Efficacy of mRNA-1403 in Participants ≥18 Years of Age for the Prevention of Acute Gastroenteritis | Phase 3 | Active not recruiting | 2024-09-24 | 37864 | Actual | Industry | https://clinicaltrials.gov/study/NCT06592794 | |
| NCT00125008 | Evaluation of the Vi Polysaccharide Vaccine Against Typhoid Fever | Typhoid Fever; Paratyphoid Fever | Phase 4 | Completed | 2003-05 | 37673 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00125008 |
| NCT01528852 | Chlorhexidine Cordcare for Reduction in Neonatal Mortality and Omphalitis | Phase 3 | Completed | 2011-05-19 | 36911 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01528852 | |
| NCT05127434 | A Study to Evaluate the Safety and Efficacy of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus (RSV) in Adults ≥60 Years of Age | Virus Diseases | Phase 2, Phase 3 | Completed | 2021-11-17 | 36814 | Actual | Industry | https://clinicaltrials.gov/study/NCT05127434 |
| NCT00006392 | S0000 Selenium and Vitamin E in Preventing Prostate Cancer | Prostatic Neoplasms | Phase 3 | Completed | 2001-07 | 35533 | Actual | Network | https://clinicaltrials.gov/study/NCT00006392 |
| NCT01949857 | The Immunogenicity and Safety of Inactivated and Live Attenuated Hepatitis A Vaccines | Hepatitis A | Phase 4 | Completed | 2013-09 | 35000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01949857 |
| NCT01363765 | Xpert MTB/Rif, a New Tool for the Diagnosis of Pulmonary Tuberculosis in Two Municipalities in Brazil | Tuberculosis; Disease | Phase 4 | Completed | 2012-02 | 34758 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01363765 |
| NCT05634759 | Enhancing the A in SAFE for Trachoma | Trachoma | Phase 4 | Completed | 2022-05-04 | 34630 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05634759 |
| NCT03089086 | South Australian Meningococcal B Vaccine Herd Immunity Study | Meningococcal Infections | Phase 4 | Completed | 2017-04-01 | 34489 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03089086 |
| NCT00534638 | Effectiveness, Safety and Immunogenicity of GSK Biologicals' HPV Vaccine GSK580299 (Cervarix) Administered in Healthy Adolescents | Papillomavirus Infections; Uterine Cervical Neoplasms | Phase 4 | Completed | 2007-10-04 | 34412 | Actual | Industry | https://clinicaltrials.gov/study/NCT00534638 |
| NCT04659239 | The Efficacy, Safety and Immunogenicity Study of Inactivated SARS-CoV-2 Vaccine for Preventing Against COVID-19 | COVID-19 | Phase 3 | Unknown | 2021-01-28 | 34020 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04659239 |
| NCT05682638 | A Global Multi-center Clinical Study of SARS-CoV-2 mRNA Vaccine for the Prevention of COVID-19 | Phase 3 | Unknown | 2023-01-30 | 34000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT05682638 | |
| NCT04530396 | Clinical Trial of Efficacy, Safety, and Immunogenicity of Gam-COVID-Vac Vaccine Against COVID-19 | COVID-19 | Phase 3 | Unknown | 2020-09-07 | 33758 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04530396 |
| NCT07502560 | A Study to Evaluate the Effect of Recombinant Zoster Vaccine on New Diagnosis of Dementia in an Older Adult Population Aged 76 Years or Older in Finland | Herpes Zoster; Alzheimer Disease | Phase 4 | Recruiting | 2026-03-31 | 33609 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07502560 |
| NCT01665690 | Washington State Community Expedited Partner Treatment (EPT) Trial | Gonorrhea; Chlamydia Infections | Phase 4 | Completed | 2007-07 | 33222 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01665690 |
| NCT04137887 | Study to Evaluate the Effectiveness of a High-Dose Quadrivalent Influenza Vaccine (QIV-HD) Compared to a Standard-Dose Quadrivalent Influenza Vaccine (QIV-SD) in Adults 65 Years of Age and Older | Influenza, Human | Phase 3 | Terminated | 2019-11-04 | 33096 | Actual | Industry | https://clinicaltrials.gov/study/NCT04137887 |
| NCT00322972 | Trachoma Amelioration in Northern Amhara (TANA) | Trachoma; Chlamydia Infections; Bacterial Infections | Phase 4 | Completed | 2006-06 | 33000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00322972 |
| NCT01119482 | Study on the Impact of Vaccination With a Conjugate Vaccine on Meningococcal Carriage | Meningitis | Phase 4 | Completed | 2010-05 | 33000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01119482 |
| NCT04611802 | A Study to Evaluate the Efficacy, Immune Response, and Safety of a COVID-19 Vaccine in Adults ≥ 18 Years With a Pediatric Expansion in Adolescents (12 to<18 Years) at Risk for SARS-CoV-2 | Severe Acute Respiratory Syndrome; COVID-19; Coronavirus Infections | Phase 3 | Completed | 2020-12-27 | 33000 | Actual | Industry | https://clinicaltrials.gov/study/NCT04611802 |
| NCT05932472 | Randomized Comparison of Morning Versus Bedtime Administration of Aspirin: A Cardiovascular Circadian Chronotherapy (C3) Trial | Atherosclerosis; Cardiovascular Diseases | Phase 4 | Recruiting | 2024-01-15 | 32706 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05932472 |
| NCT07886281 | Humanitarian Evaluation of Spatial Emanators for Malaria Control | Malaria | Phase 4 | Not yet recruiting | 2026-10-26 | 32584 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07886281 |
| NCT07282665 | A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older | Phase 3 | Recruiting | 2025-12-10 | 32500 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07282665 | |
| NCT04516746 | Phase III Double-blind, Placebo-controlled Study of AZD1222 for the Prevention of COVID-19 in Adults | COVID-19 | Phase 3 | Completed | 2020-08-28 | 32450 | Actual | Industry | https://clinicaltrials.gov/study/NCT04516746 |
| NCT04974138 | China Stroke Primary Prevention Trial 2 for Participants With H-type Hypertension and MTHFR 677 CC/CT Genotype (CSPPT2-CC/CT) | Hypertension; Ischemic Stroke | Phase 4 | Recruiting | 2024-08-22 | 32000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT04974138 |
| NCT01427309 | A Study of Fluzone® High-Dose Vaccine Compared With Fluzone® Vaccine In Elderly Adults | Influenza, Human | Phase 4 | Completed | 2011-09 | 31989 | Actual | Industry | https://clinicaltrials.gov/study/NCT01427309 |
| NCT04614948 | A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-mediated COVID-19 in Adults | Phase 3 | Completed | 2020-11-12 | 31835 | Actual | Industry | https://clinicaltrials.gov/study/NCT04614948 | |
| NCT00153101 | Effectiveness and Safety of Ramipril Alone Compared With Telmisartan Alone and in Combination With Ramipril in Patients at High Risk for Cardiovascular Events. Patients Intolerant to Ramipril Were Entered in TRANSCEND, Telmisartan Compared to Placebo. | Cardiovascular Diseases | Phase 4 | Completed | 2001-11 | 31546 | Actual | Industry | https://clinicaltrials.gov/study/NCT00153101 |
| NCT04672395 | A Controlled Phase 2/3 Study of Adjuvanted Recombinant SARS-CoV-2 Trimeric S-protein Vaccine (SCB-2019) for the Prevention of COVID-19 | COVID-19 | Phase 2, Phase 3 | Completed | 2021-03-24 | 31454 | Actual | Industry | https://clinicaltrials.gov/study/NCT04672395 |
| NCT04992208 | Safety of an Inactivated SARS-CoV-2 Vaccine for Prevention of COVID-19 in Children and Adolescents | COVID-19 | Phase 4 | Completed | 2021-07-24 | 31041 | Actual | Industry | https://clinicaltrials.gov/study/NCT04992208 |
| NCT04636697 | Study of a Recombinant Coronavirus-Like Particle COVID-19 Vaccine in Adults | COVID-19 | Phase 2, Phase 3 | Active not recruiting | 2020-11-19 | 30918 | Estimated | Industry | https://clinicaltrials.gov/study/NCT04636697 |
| NCT00663598 | Levitra® - Real Life Safety and Efficacy of Levitra | Erectile Dysfunction | Phase 4 | Completed | 2003-10 | 30825 | Actual | Industry | https://clinicaltrials.gov/study/NCT00663598 |
| NCT01252953 | REVEAL: Randomized EValuation of the Effects of Anacetrapib Through Lipid-modification | Atherosclerosis; Vascular Diseases; Inhibition, Psychological | Phase 3 | Active not recruiting | 2011-06 | 30449 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01252953 |
| NCT04470427 | A Study to Evaluate Efficacy, Safety, and Immunogenicity of mRNA-1273 Vaccine in Adults Aged 18 Years and Older to Prevent COVID-19 | Coronavirus Infections; Virus Diseases; COVID-19 | Phase 3 | Completed | 2020-07-27 | 30415 | Actual | Industry | https://clinicaltrials.gov/study/NCT04470427 |
| NCT01506986 | Helicobacter Eradication Aspirin Trial | Phase 4 | Completed | 2012-03 | 30024 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01506986 | |
| NCT02047994 | Multicentric Randomized Study of H. Pylori Eradication and Pepsinogen Testing for Prevention of Gastric Cancer Mortality | Gastritis, Atrophic; Stomach Neoplasms | Phase 4 | Recruiting | 2013-03 | 30000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02047994 |
| NCT07266558 | A Study to Evaluate the Efficacy and Safety of mRNA-1283 and mRNA-1273 in Participants 50 to 64 Years of Age Without High-Risk Conditions for Severe Coronavirus Disease 2019 (COVID-19) | Coronavirus Infections; COVID-19 | Phase 4 | Active not recruiting | 2025-11-26 | 30000 | Actual | Industry | https://clinicaltrials.gov/study/NCT07266558 |
| NCT04035837 | The Clinical Cure Project of Chronic Hepatitis B in China | Hepatitis B, Chronic | Phase 4 | Active not recruiting | 2018-05-16 | 30000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04035837 |
| NCT03314103 | Efficacy Trial of a Vaccine to Prevent Herpes Zoster in Adults Over 40 Years of Age | Herpes Zoster | Phase 3 | Completed | 2017-10-06 | 30000 | Actual | Network | https://clinicaltrials.gov/study/NCT03314103 |
| NCT06306300 | Safety and Efficacy of Decentralized HCV Treatment vs Standard-of-Care in Rio de Janeiro (Brazil) | Hepatitis C | Phase 4 | Recruiting | 2022-07-04 | 30000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06306300 |
| NCT05562609 | Tranexamic Acid to Prevent Heavy Bleeding After Childbirth in Women At Higher Risk | Postpartum Hemorrhage; Hemorrhage | Phase 3 | Recruiting | 2024-04-22 | 30000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05562609 |
| NCT03299426 | Clinical Efficacy of Typhoid Conjugate Vaccine (Vi-TCV) Among Children Age 9 Months Through 12 Years in Blantyre, Malawi | Typhoid Fever | Phase 3 | Active not recruiting | 2018-02-21 | 30000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03299426 |
| NCT05059106 | EFFECTIVENESS, SAFETY AND IMMUNOGENICITY OF THE HALF DOSE OF THE VACCINE ChadOx1 nCoV-19 (AZD1222) for COVID-19 | COVID-19 | Phase 2, Phase 3 | Unknown | 2021-06-01 | 29637 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05059106 |
| NCT01177111 | Impact of Sunflower Seed Oil Massage on Neonatal Mortality and Morbidity in Nepal | Neonatal Sepsis | Phase 3 | Completed | 2010-11-01 | 29260 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01177111 |
| NCT00138294 | Control of Epidemic Influenza Through a School-based Influenza Vaccination Program | Influenza, Human | Phase 4 | Completed | 1998-10 | 29255 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00138294 |
| NCT01202331 | Tripartite International Research for the Elimination of Trachoma | Trachoma; Chlamydia Infections; Bacterial Infections | Phase 4 | Completed | 2010-11 | 29000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01202331 |
| NCT05407142 | An Open Comprative Study of the Prophylactic Efficacy and a Non-comparative Study of the Immunogenicity and Safety of the Inactivated Whole-virion Concentrated Purified Coronavirus Vaccine (CoviVac) | Coronavirus Infections; COVID-19 | Phase 3 | Unknown | 2021-07-07 | 29000 | Estimated | Other government | https://clinicaltrials.gov/study/NCT05407142 |
| NCT04646590 | A Phase III Clinical Trial to Determine the Safety and Efficacy of ZF2001 for Prevention of COVID-19 | Phase 3 | Unknown | 2020-12-16 | 28904 | Actual | Industry | https://clinicaltrials.gov/study/NCT04646590 | |
| NCT00434408 | Impact of Umbilical Cord Cleansing With 4.0% Chlorhexidine on Neonatal Mortality | Infections; Infant Death | Phase 3 | Completed | 2007-05 | 28797 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00434408 |
| NCT01453621 | Traumatic Brain Injury - Knowledge Translation | Brain Injuries, Traumatic | Phase 3 | Completed | 2011-11 | 28669 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01453621 |
| NCT03460002 | Vaccine Campaign Effects on General Hospital Admissions and Mortality Among Children | Phase 4 | Completed | 2016-11 | 28612 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03460002 | |
| NCT01713517 | Impact of Insecticide Resistance on Vector Control | Malaria, Falciparum | Phase 4 | Unknown | 2011-04 | 28000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01713517 |
| NCT04847102 | A Phase III Clinical Study of a SARS-CoV-2 Messenger Ribonucleic Acid (mRNA) Vaccine Candidate Against COVID-19 in Population Aged 18 Years and Above | COVID-19 | Phase 3 | Unknown | 2021-07-22 | 28000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT04847102 |
| NCT04852705 | A Study to Evaluate the Efficacy, Safety and Immunogenicity of SARS-CoV-2 Vaccine (Vero Cells), Inactivated in Healthy Adults Aged 18 Years and Older (COVID-19) | COVID-19 | Phase 3 | Unknown | 2021-05 | 28000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT04852705 |
| NCT00490932 | New Hypo-Osmolar ORS (Recommended by WHO) for Routine Use in the Diarrhea Management- Surveillance Study for Adverse Effects | Diarrhea; Dysentery | Phase 4 | Completed | 2005-03 | 27966 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00490932 |
| NCT03180034 | Comparing One or Two Doses of the Human Papillomavirus Vaccine for the Prevention of Human Papillomavirus Infection, ESCUDDO Study | Papillomavirus Infections | Phase 4 | Active not recruiting | 2017-11-29 | 27945 | Actual | NIH | https://clinicaltrials.gov/study/NCT03180034 |
| NCT04747821 | An Effectiveness Study of the Sinovac's Adsorbed COVID-19 (Inactivated) Vaccine | COVID-19 | Phase 4 | Completed | 2021-02-07 | 27711 | Actual | Other government | https://clinicaltrials.gov/study/NCT04747821 |
| NCT01764633 | Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk | Dyslipidemias; Hypercholesterolemia | Phase 3 | Completed | 2013-02-08 | 27564 | Actual | Industry | https://clinicaltrials.gov/study/NCT01764633 |
| NCT01776424 | Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease | Coronary Artery Disease; Peripheral Arterial Disease; Stroke | Phase 3 | Completed | 2013-02-28 | 27395 | Actual | Industry | https://clinicaltrials.gov/study/NCT01776424 |
| NCT00125047 | Combined Vi Vaccination and Health Education Program on the Burden of Typhoid in Childhood | Typhoid Fever; Paratyphoid Fever; Salmonella Infections | Phase 4 | Completed | 2001-10 | 27231 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00125047 |
| NCT04886596 | Efficacy Study of GSK's Investigational Respiratory Syncytial Virus (RSV) Vaccine in Adults Aged 60 Years and Above | Respiratory Syncytial Virus Infections | Phase 3 | Completed | 2021-05-25 | 26675 | Actual | Industry | https://clinicaltrials.gov/study/NCT04886596 |
| NCT00526474 | Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Patients With Atherosclerosis (TRA 2°P - TIMI 50) (P04737) | Atherosclerosis; Ischemia; Myocardial Infarction | Phase 3 | Completed | 2007-09-01 | 26449 | Actual | Industry | https://clinicaltrials.gov/study/NCT00526474 |
| NCT01169259 | Vitamin D and Omega-3 Trial (VITAL) | Neoplasms; Cardiovascular Diseases | Phase 3 | Active not recruiting | 2010-07 | 25871 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01169259 |
| NCT02271230 | Intervention With Vitamin D and Omega-3 Supplements and Incident Heart Failure | Heart Failure | Phase 3 | Completed | 2014-08 | 25871 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02271230 |
| NCT04641481 | An Efficacy and Safety Clinical Trial of an Investigational COVID-19 Vaccine (BBV152) in Adult Volunteers | COVID-19; Severe Acute Respiratory Syndrome | Phase 3 | Unknown | 2020-11-16 | 25800 | Actual | Industry | https://clinicaltrials.gov/study/NCT04641481 |
| NCT00977938 | The Dual Antiplatelet Therapy Study (DAPT Study) | Coronary Artery Disease; Acute Coronary Syndrome; Myocardial Infarction | Phase 4 | Completed | 2009-10 | 25682 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00977938 |
| NCT00461630 | Treatment of HDL to Reduce the Incidence of Vascular Events HPS2-THRIVE | Cardiovascular Diseases; Peripheral Arterial Disease; Diabetes Mellitus | Phase 3 | Completed | 2007-01 | 25673 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00461630 |
| NCT04666792 | PrEParing Family Planning Clinics to Streamline Integration of HIV Prevention Services for Young Women in Kenya | HIV Infections; Sexually Transmitted Diseases | Phase 4 | Completed | 2021-03-01 | 25457 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04666792 |
| NCT03287882 | Effect of Micronutrients and Life Skills Education on the Health and Nutrition of Adolescent and Young Women in Pakistan | Anemia; Empowerment | Phase 3 | Unknown | 2017-06-30 | 25447 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03287882 |
| NCT04908683 | A Study of an Adenovirus Serotype 26 Pre-fusion Conformation-stabilized F Protein (Ad26. RSV. preF) Based Respiratory Syncytial Virus (RSV) Vaccine in the Prevention of Lower Respiratory Tract Disease in Adults Aged 60 Years and Older | Phase 3 | Completed | 2021-07-21 | 25236 | Actual | Industry | https://clinicaltrials.gov/study/NCT04908683 | |
| NCT02178410 | VITAL Rhythm Study | Cardiovascular Diseases; Atrial Fibrillation | Phase 3 | Active not recruiting | 2012-10 | 25119 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02178410 |
| NCT00335452 | Clopidogrel Optimal Loading Dose Usage to Reduce Recurrent EveNTs/Optimal Antiplatelet Strategy for InterventionS | Angina, Unstable | Phase 3 | Completed | 2006-06 | 25086 | Actual | Industry | https://clinicaltrials.gov/study/NCT00335452 |
| NCT01024426 | Impact of Enhanced Health Facility Care in Uganda | Malaria | Phase 4 | Completed | 2010-12 | 25000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01024426 |
| NCT04334577 | Study on Efficacy of Attenuated Zoster Vaccine, Live | Herpes Zoster | Phase 3 | Completed | 2020-04-20 | 25000 | Actual | Industry | https://clinicaltrials.gov/study/NCT04334577 |
| NCT07272434 | Phase III Clinical Trial of the Recombinant Respiratory Syncytial Virus Vaccine ( CHO Cell) | Phase 3 | Recruiting | 2025-10-22 | 25000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07272434 | |
| NCT04957719 | Selatogrel Outcome Study in Suspected Acute Myocardial Infarction | Phase 3 | Enrolling by invitation | 2021-08-14 | 25000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT04957719 | |
| NCT07860216 | Phase III Clinical Trial of Recombinant Respiratory Syncytial Virus Vaccine (CHO Cells) | Phase 3 | Recruiting | 2026-08-21 | 25000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07860216 | |
| NCT06447779 | Efficacy, Safety and Immunogenicity Study of Recombinant Zoster Vaccine(CHO Cell) in Adults Aged 40 Years and Older | Herpes Zoster | Phase 3 | Active not recruiting | 2024-07-13 | 25000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT06447779 |
| NCT00686205 | Evaluation of a Human Immunodeficiency Virus (HIV) Blood Screening Assay | HIV Seropositivity | Phase 3 | Completed | 2007-08 | 24111 | Actual | Industry | https://clinicaltrials.gov/study/NCT00686205 |
| NCT00346216 | Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen | Arthritis, Rheumatoid | Phase 4 | Completed | 2006-10-04 | 24081 | Actual | Industry | https://clinicaltrials.gov/study/NCT00346216 |
| NCT04844905 | Adjunctive Ivermectin Mass Drug Administration for Malaria Control | Malaria, Falciparum; Neglected Diseases; Strongyloidiasis | Phase 3 | Unknown | 2021-05-03 | 24000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04844905 |
| NCT04974151 | China Stroke Primary Prevention Trial 2 for Participants With Hypertension and MTHFR 677 TT Genotype | Hypertension; Ischemic Stroke | Phase 4 | Recruiting | 2024-08-22 | 24000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT04974151 |
| NCT00466947 | COMPAS (Clinical Otitis Media & Pneumonia Study): Pneumonia & Acute Otitis Media (AOM ) Efficacy Study of the Pneumococcal Conjugate Vaccine | Streptococcal Infections; Otitis Media; Pneumonia | Phase 3 | Completed | 2007-06-28 | 23802 | Actual | Industry | https://clinicaltrials.gov/study/NCT00466947 |
| NCT01372748 | Continuous Chest Compressions vs AHA Standard CPR of 30:2 | Out-of-Hospital Cardiac Arrest; Heart Arrest | Phase 4 | Completed | 2011-06 | 23711 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01372748 |
| NCT04904549 | Study of Monovalent and Bivalent Recombinant Protein Vaccines Against COVID-19 in Adults 18 Years of Age and Older | COVID-19 | Phase 3 | Terminated | 2021-05-26 | 23670 | Actual | Industry | https://clinicaltrials.gov/study/NCT04904549 |
| NCT00250445 | A Study to Evaluate the Safety of an Investigational Drug (Etoricoxib) in Patients With Osteoarthritis (OA) or Rheumatoid Arthritis (RA)(0663-066) | Arthritis, Rheumatoid; Osteoarthritis | Phase 3 | Completed | 2003-01 | 23498 | Actual | Industry | https://clinicaltrials.gov/study/NCT00250445 |
| NCT04852185 | Evaluation of Typhoid Conjugate Vaccine Effectiveness in Ghana | Typhoid Fever | Phase 4 | Unknown | 2021-08-24 | 23000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04852185 |
| NCT04658680 | Can BCG Vaccination at First Health-facility Contact Reduce Early Infant Mortality? | Infant Death | Phase 4 | Active not recruiting | 2021-02-25 | 22800 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04658680 |
| NCT00923702 | Trial of Two Versus Three Doses of Human Papillomavirus (HPV) Vaccine in India | Uterine Cervical Neoplasms | Phase 4 | Unknown | 2009-09 | 22729 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00923702 |
| NCT05566639 | A Study of mRNA-1010 Seasonal Influenza Vaccine in Adults 50 Years Old and Older | Influenza, Human | Phase 3 | Completed | 2022-09-14 | 22502 | Actual | Industry | https://clinicaltrials.gov/study/NCT05566639 |
| NCT05096845 | Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01) Phase III | COVID-19 | Phase 3 | Unknown | 2021-08-25 | 22500 | Estimated | Industry | https://clinicaltrials.gov/study/NCT05096845 |
| NCT00534248 | Study to Evaluate the Safety and Effectiveness of Zostavax™ in Subjects 50 - 59 Years of Age (V211-022) | Herpes Zoster | Phase 3 | Completed | 2007-10 | 22439 | Actual | Industry | https://clinicaltrials.gov/study/NCT00534248 |
| NCT01697852 | The Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) for Malaria Prevention | Malaria | Phase 4 | Unknown | 2011-01 | 22300 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01697852 |
| NCT01633177 | Study of Vitamin D and Omega-3 Supplementation for Preventing Diabetes | Diabetes Mellitus, Type 2; Insulin Resistance | Phase 3 | Completed | 2011-11 | 22220 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01633177 |
| NCT02211729 | A Trial of Seasonal Malaria Chemoprevention Plus Azithromycin in African Children | Malaria; Respiratory Tract Infections | Phase 3 | Completed | 2014-05 | 22090 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02211729 |
| NCT03350516 | Non-inferiority of Lower Dose Calcium Supplementation During Pregnancy | Phase 3 | Completed | 2018-11-30 | 22000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03350516 | |
| NCT00133692 | INVEST: INternational VErapamil SR Trandolapril STudy | Hypertension; Coronary Artery Disease; Diabetes Mellitus | Phase 4 | Completed | 1997-09 | 22000 | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00133692 | |
| NCT00741585 | Prognostic Value of the Circadian Pattern of Ambulatory Blood Pressure for Multiple Risk Assessment | Essential Hypertension; Cardiovascular Diseases; Stroke | Phase 4 | Completed | 2008-09-01 | 21983 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00741585 |
| NCT03682653 | Neonates and Azithromycin, an Innovation in the Treatment of Children in Burkina Faso | Phase 4 | Completed | 2019-04-11 | 21832 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03682653 | |
| NCT00070720 | Improving Perinatal Care in Latin America | Phase 4 | Completed | 2003-09 | 21780 | Network | https://clinicaltrials.gov/study/NCT00070720 | ||
| NCT02397772 | Impact of Alternative Treatment Strategies and Delivery Systems for Soil-transmitted Helminths in Kenya | Helminthiasis; Nematode Infections; Communicable Diseases | Phase 4 | Completed | 2015-03 | 21761 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02397772 |
| NCT02422745 | COcoa Supplement and Multivitamin Outcomes Study | Cardiovascular Diseases; Neoplasms | Phase 4 | Completed | 2015-06 | 21442 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02422745 |
| NCT05510375 | Cocoa Supplementation, Inflammaging, and Epigenetic Aging | Inflammation; Cardiovascular Diseases | Phase 4 | Unknown | 2015-06 | 21442 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05510375 |
| NCT03205202 | Cataract and AMD in a Trial of a Multivitamin and Cocoa Extract | Cataract; Macular Degeneration | Phase 4 | Unknown | 2015-06-01 | 21442 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03205202 |
| NCT01225562 | Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin | Myocardial Infarction; Thrombosis; Stroke | Phase 3 | Completed | 2010-10 | 21379 | Actual | Industry | https://clinicaltrials.gov/study/NCT01225562 |
| NCT05441267 | A Study of Cardiovascular Events iN Diabetes Plus | Diabetes Mellitus, Type 2 | Phase 4 | Active not recruiting | 2023-03-13 | 21296 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05441267 |
| NCT00781391 | Global Study to Assess the Safety and Effectiveness of Edoxaban (DU-176b) vs Standard Practice of Dosing With Warfarin in Patients With Atrial Fibrillation | Stroke; Atrial Fibrillation; Embolism | Phase 3 | Completed | 2008-11 | 21105 | Actual | Industry | https://clinicaltrials.gov/study/NCT00781391 |
| NCT06126614 | Infection Prophylaxis in Total Joint Replacement | Phase 3 | Recruiting | 2024-05-07 | 21006 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06126614 | |
| NCT05156528 | Efficacy, Immunogenicity and Safety of S. Flexneriza-S. Sonnei Bivalent Conjugate Vaccine in Volunteers Aged From 6 Months to 5 Years | Dysentery; Dysentery, Bacillary | Phase 3 | Unknown | 2021-12-11 | 21000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT05156528 |
| NCT00412984 | Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation | Atrial Fibrillation; Atrial Flutter | Phase 3 | Completed | 2006-12-31 | 20976 | Actual | Industry | https://clinicaltrials.gov/study/NCT00412984 |
| NCT02889497 | Safety, Three Batches Consistency and Immunity Duration of the Post-marketing Inactivated Enterovirus Type 71 (EV71) Vaccine in Children Aged 6-71 Months | Hand, Foot and Mouth Disease | Phase 4 | Unknown | 2016-09 | 20900 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02889497 |
| NCT01374516 | Study of a Novel Tetravalent Dengue Vaccine in Healthy Children and Adolescents Aged 9 to 16 Years in Latin America | Dengue; Severe Dengue | Phase 3 | Completed | 2011-06-08 | 20869 | Actual | Industry | https://clinicaltrials.gov/study/NCT01374516 |
| NCT02999828 | The Phase IVa of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell, KMB-17) | Phase 4 | Unknown | 2016-09 | 20770 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02999828 | |
| NCT02185417 | Diuretic Comparison Project | Hypertension | Phase 3 | Completed | 2016-06-15 | 20723 | Actual | U.S. federal | https://clinicaltrials.gov/study/NCT02185417 |
| NCT00794885 | China Stroke Primary Prevention Trial | Essential Hypertension; Hypertension; Stroke | Phase 4 | Completed | 2008-05 | 20702 | Actual | Industry | https://clinicaltrials.gov/study/NCT00794885 |
| NCT04235816 | Improving Care Through Azithromycin Research for Infants in Africa | Malaria | Phase 3 | Active not recruiting | 2021-03-15 | 20560 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04235816 |
| NCT00077792 | Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment Thrombolysis in Myocardial Infarction - Study 25 (ExTRACT-TIMI25) | Myocardial Infarction | Phase 3 | Completed | 2002-10 | 20506 | Actual | Industry | https://clinicaltrials.gov/study/NCT00077792 |
| NCT04152486 | Effectiveness and Safety of a Heterologous, Two-dose Ebola Vaccine in the DRC | Hemorrhagic Fever, Ebola | Phase 3 | Unknown | 2019-11-14 | 20426 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04152486 |
| NCT05238025 | MVA-BN-RSV Vaccine Trial | Respiratory Syncytial Virus Infections | Phase 3 | Terminated | 2022-04-19 | 20419 | Actual | Industry | https://clinicaltrials.gov/study/NCT05238025 |
| NCT02536222 | Accelerating the Reduction of Malaria Transmission in Kanel, Ranérou and Linguère Districts | Malaria | Phase 4 | Completed | 2015-09 | 20379 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02536222 |
| NCT00153062 | PRoFESS - Prevention Regimen For Effectively Avoiding Second Strokes | Stroke | Phase 4 | Completed | 2003-08 | 20332 | Actual | Industry | https://clinicaltrials.gov/study/NCT00153062 |
| NCT05757869 | A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation | Atrial Fibrillation | Phase 3 | Active not recruiting | 2023-04-11 | 20284 | Actual | Industry | https://clinicaltrials.gov/study/NCT05757869 |
| NCT00375258 | Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage | Hemorrhage | Phase 3 | Completed | 2005-05 | 20211 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00375258 |
| NCT02747927 | Efficacy, Safety and Immunogenicity of Takeda's Tetravalent Dengue Vaccine (TDV) in Healthy Children | Phase 3 | Completed | 2016-04-26 | 20099 | Actual | Industry | https://clinicaltrials.gov/study/NCT02747927 | |
| NCT06062238 | Study to Assess Efficacy and Safety of M72/AS01E-4 Mycobacterium Tuberculosis (Mtb) Vaccine in Adolescents and Adults | Tuberculosis | Phase 3 | Active not recruiting | 2024-03-05 | 20080 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06062238 |
| NCT00139815 | Michelangelo - Oasis 5 | Thromboembolism; Angina, Unstable; Acute Coronary Syndrome | Phase 3 | Completed | 2003-04 | 20078 | Actual | Industry | https://clinicaltrials.gov/study/NCT00139815 |
| NCT00872469 | World Maternal Antifibrinolytic Trial | Postpartum Hemorrhage | Phase 3 | Completed | 2009-05 | 20060 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00872469 |
| NCT02389036 | Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients | Critical Illness; Sepsis; Shock, Septic | Phase 3 | Completed | 2017-05-01 | 20010 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02389036 |
| NCT07784569 | APEX-STROKE Adaptive Platform Trial for Stroke | Stroke | Phase 3 | Not yet recruiting | 2026-09-01 | 20000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07784569 |
| NCT00000432 | Lyme Disease Prevention Program | Lyme Disease; Tick-Borne Diseases | Phase 3 | Completed | 1997-04 | 20000 | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00000432 | |
| NCT02735707 | Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia | Community-Acquired Pneumonia; Influenza, Human; COVID-19 | Phase 3 | Recruiting | 2016-04-11 | 20000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02735707 |
| NCT00003016 | Prolonged Tamoxifen Compared With Shorter Tamoxifen in Treating Patients Who Have Breast Cancer | Breast Neoplasms | Phase 3 | Unknown | 1995-10 | 20000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00003016 |
| NCT00003678 | Tamoxifen in Treating Women With Breast Cancer | Breast Neoplasms | Phase 3 | Unknown | 1991-05 | 20000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00003678 |
| NCT00221364 | Trachoma Elimination Follow-up | Trachoma; Chlamydia Infections | Phase 4 | Completed | 2003-03 | 20000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00221364 |
| NCT06072300 | Effects of Physical Activity Calorie Equivalent Labelling on Hot Drink Vending Transactions | Phase 3 | Unknown | 2023-10-30 | 20000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06072300 | |
| NCT06282315 | Real World Evaluation of an Albendazole-Ivermectin Coformulation Safety and Effectiveness | Hookworm Infections | Phase 3 | Recruiting | 2025-09-01 | 20000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT06282315 |
| NCT06352632 | ACT-GLOBAL Adaptive Platform Trial for Stroke | Stroke; Ischemic Stroke; Cerebral Hemorrhage | Phase 3 | Recruiting | 2024-09-26 | 20000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06352632 |
| NCT03275584 | Safety of PET MPI Using the CRCHUM N-13 Ammonia | Phase 4 | Recruiting | 2018-01-30 | 20000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03275584 | |
| NCT07903350 | BRAVO is a Phased Outbreak-response Study in the DRC Evaluating ERVEBO® Vaccination in ~20,000 Frontline Workers During the 2026 BDV Outbreak, Step A Assesses Real-world Effectiveness, Safety, and Impact on Severe Disease and Mortality, While Generating Evidence for Future BDV Vaccination Strategies | Hemorrhagic Fever, Ebola; Communicable Diseases, Emerging | Phase 4 | Recruiting | 2026-09-19 | 20000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07903350 |
| NCT03676140 | Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs ) | Trachoma; Yaws; Elephantiasis, Filarial | Phase 3 | Completed | 2018-10-01 | 20000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03676140 |
| NCT04262206 | Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults | Cognitive Dysfunction; Dementia; Cardiovascular Diseases | Phase 4 | Recruiting | 2020-09-01 | 20000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04262206 |
| NCT02806531 | Safety Study of Enterovirus 71 Vaccine in Children Aged 6-35 Months Old | Phase 4 | Unknown | 2016-07 | 20000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02806531 | |
| NCT01251666 | Comparison of Hemoccult, Magstream and OC-Sensor Faecal Occult Blood Tests in Colorectal Cancer Screening | Colorectal Neoplasms | Phase 3 | Completed | 2008-06 | 19797 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01251666 |
| NCT00003906 | Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer in Postmenopausal Women | Breast Neoplasms | Phase 3 | Completed | 1999-05 | 19747 | Actual | Network | https://clinicaltrials.gov/study/NCT00003906 |
| NCT05012943 | The ARCT-154 Self-Amplifying RNA Vaccine Efficacy Study (ARCT-154-01) | COVID-19 | Phase 2, Phase 3 | Completed | 2021-08-15 | 19474 | Actual | Industry | https://clinicaltrials.gov/study/NCT05012943 |
| NCT02759991 | Effectiveness Trial to Evaluate Protection of Pregnant Women by Hepatitis E Vaccine in Bangladesh. | Phase 4 | Completed | 2017-10-02 | 19460 | Actual | Other government | https://clinicaltrials.gov/study/NCT02759991 | |
| NCT01991795 | A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus | Diabetes Mellitus, Type 2; Diabetes Mellitus; Coronary Artery Disease | Phase 3 | Completed | 2014-02-10 | 19271 | Actual | Industry | https://clinicaltrials.gov/study/NCT01991795 |
| NCT06923592 | Serological Testing and Treatment for Plasmodium Vivax Malaria: a Trial in Ethiopia and Madagascar | Malaria, Vivax; Malaria, Falciparum | Phase 3 | Recruiting | 2025-05-12 | 19200 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06923592 |
| NCT02446990 | Effects of Ivabradine in Patients With Stable Coronary Artery Disease Without Clinical Heart Failure | Coronary Artery Disease | Phase 3 | Completed | 2009-09 | 19102 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02446990 |
| NCT00133744 | Impact of Prenatal Vitamin/Mineral Supplements on Perinatal Mortality | Perinatal Death; Stillbirth; Anemia | Phase 3 | Completed | 2006-05 | 18962 | Actual | U.S. federal | https://clinicaltrials.gov/study/NCT00133744 |
| NCT01663402 | ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab | Atherosclerosis | Phase 3 | Completed | 2012-10 | 18924 | Actual | Industry | https://clinicaltrials.gov/study/NCT01663402 |
| NCT02810704 | Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement | Pulmonary Embolism; Venous Thrombosis; Venous Thromboembolism | Phase 4 | Completed | 2016-12 | 18883 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02810704 |
| NCT00122681 | Human Papilloma Virus (HPV) Vaccine Efficacy Trial Against Cervical Pre-cancer in Young Adults With GlaxoSmithKline (GSK) Biologicals HPV-16/18 | Papillomavirus Infections | Phase 3 | Completed | 2004-05-06 | 18729 | Actual | Industry | https://clinicaltrials.gov/study/NCT00122681 |
| NCT02538952 | Evaluating Accuracy, Impact, and Operational Challenges of GeneXpert Use for TB Case Finding Among HIV-infected Persons | Tuberculosis; Acquired Immunodeficiency Syndrome; Tooth, Impacted | Phase 4 | Completed | 2012-08-01 | 18696 | Actual | U.S. federal | https://clinicaltrials.gov/study/NCT02538952 |
| NCT00263042 | Comprehensive Rimonabant Evaluation Study of Cardiovascular ENDpoints and Outcomes | Cardiovascular Diseases; Myocardial Infarction; Stroke | Phase 3 | Terminated | 2005-12 | 18695 | Actual | Industry | https://clinicaltrials.gov/study/NCT00263042 |
| NCT02961231 | Evaluation of PCV Schedules in a Naive Population in Vietnam | Pneumonia, Pneumococcal | Phase 4 | Completed | 2016-10-01 | 18652 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02961231 |
| NCT00391872 | A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome | Acute Coronary Syndrome; Myocardial Infarction; Angina, Unstable | Phase 3 | Completed | 2006-10 | 18624 | Actual | Industry | https://clinicaltrials.gov/study/NCT00391872 |
| NCT01895517 | CervIcal Cancer Screening Trial by Randomization of HPV Testing Intervention for Upcoming Screening （CITRUS Study） | Uterine Cervical Neoplasms | Phase 4 | Completed | 2013-06-07 | 18471 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01895517 |
| NCT06917040 | Enhancing Protection Against Vector-borne Diseases in Forcibly Displaced Communities: Evaluating the Efficacy of Spatial Repellents for Cutaneous Leishmaniasis Control in North-East Syria | Leishmaniasis, Cutaneous; Vector Borne Diseases | Phase 3 | Completed | 2021-02-01 | 18404 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06917040 |
| NCT00712647 | Carotene and Retinol Efficacy Trial | Lung Neoplasms | Phase 4 | Completed | 1985-05 | 18314 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00712647 |
| NCT00418171 | Large Simple Trial (LST) Of Cardiovascular Safety Of Ziprasidone And Olanzapine- (Zodiac) | Schizophrenia | Phase 4 | Completed | 2002-02 | 18239 | Actual | Industry | https://clinicaltrials.gov/study/NCT00418171 |
| NCT03473223 | Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome | Acute Coronary Syndrome; Coronary Artery Disease; Heart Diseases | Phase 3 | Completed | 2018-03-21 | 18226 | Actual | Industry | https://clinicaltrials.gov/study/NCT03473223 |
| NCT01107886 | Does Saxagliptin Reduce the Risk of Cardiovascular Events When Used Alone or Added to Other Diabetes Medications | Diabetes Mellitus, Type 2 | Phase 4 | Completed | 2010-05 | 18206 | Actual | Industry | https://clinicaltrials.gov/study/NCT01107886 |
| NCT01680679 | Influenza Immunization of Children in India | Influenza, Human | Phase 4 | Completed | 2012-05 | 18163 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01680679 |
| NCT00710060 | Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk Populations | HIV Infections; Sexually Transmitted Diseases | Phase 3 | Completed | 2002-09 | 18147 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00710060 |
| NCT00202878 | IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome: Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (P04103) | Hypercholesterolemia; Myocardial Infarction; Acute Coronary Syndrome | Phase 3 | Completed | 2005-10-17 | 18144 | Actual | Industry | https://clinicaltrials.gov/study/NCT00202878 |
| NCT00262600 | Randomized Evaluation of Long Term Anticoagulant Therapy (RE-LY) With Dabigatran Etexilate | Atrial Fibrillation; Stroke | Phase 3 | Completed | 2005-12 | 18113 | Actual | Industry | https://clinicaltrials.gov/study/NCT00262600 |
| NCT06596577 | Nudging Effective and Equitable Delivery of Specialty Palliative Care | Phase 3 | Enrolling by invitation | 2025-08-06 | 18000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06596577 | |
| NCT06041061 | A Study to Evaluate the Efficacy, Safety, and Immunogenicity of SCT1000 in Healthy Women Aged 18-45 Years | Papillomavirus Infections | Phase 3 | Active not recruiting | 2023-08-13 | 18000 | Actual | Industry | https://clinicaltrials.gov/study/NCT06041061 |
| NCT06802224 | The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery | Acute Kidney Injury | Phase 4 | Recruiting | 2025-04-01 | 18000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06802224 |
| NCT05602558 | The Phase Ⅱ/Ⅲ Trial of LYB001 | COVID-19 | Phase 2, Phase 3 | Unknown | 2022-12 | 18000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT05602558 |
| NCT00231738 | Protective Effect of EPA on Cardiovascular Events | Myocardial Infarction; Angina, Unstable; Death, Sudden, Cardiac | Phase 4 | Completed | 1996-11 | 18000 | Industry | https://clinicaltrials.gov/study/NCT00231738 | |
| NCT07817108 | Phase III Clinical Trial of Lyophilized Herpes Zoster mRNA Vaccine in Adults Aged 40 Years or Above | Chickenpox | Phase 3 | Recruiting | 2026-06-27 | 18000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07817108 |
| NCT00239681 | JUPITER - Crestor 20mg Versus Placebo in Prevention of Cardiovascular (CV) Events | Cardiovascular Diseases | Phase 3 | Terminated | 2003-02 | 17802 | Actual | Industry | https://clinicaltrials.gov/study/NCT00239681 |
| NCT04899336 | A Study of Vaccination With 9-valent Extraintestinal Pathogenic Escherichia Coli Vaccine (ExPEC9V) in the Prevention of Invasive Extraintestinal Pathogenic Escherichia Coli Disease in Adults Aged 60 Years And Older With a History of Urinary Tract Infection in the Past 2 Years | Phase 3 | Completed | 2021-06-30 | 17797 | Actual | Industry | https://clinicaltrials.gov/study/NCT04899336 | |
| NCT03574597 | Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity | Overweight; Obesity | Phase 3 | Completed | 2018-10-24 | 17604 | Actual | Industry | https://clinicaltrials.gov/study/NCT03574597 |
| NCT03090191 | Clostridium Difficile Vaccine Efficacy Trial | Clostridium Infections | Phase 3 | Completed | 2017-03-29 | 17535 | Actual | Industry | https://clinicaltrials.gov/study/NCT03090191 |
| NCT03400878 | Comparing Morbidity and Mortality Effects of Two Different Strains of BCG | Infant Death | Phase 4 | Completed | 2017-10-14 | 17505 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03400878 |
| NCT00107887 | TB (Tuberculosis) Preventive Therapy for HIV Patients With Access to HAART (Highly Active Antiretroviral Therapy) | Tuberculosis; HIV Infections | Phase 4 | Completed | 2005-06 | 17415 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00107887 |
| NCT06292013 | A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a) | Atherosclerosis | Phase 3 | Active not recruiting | 2024-03-05 | 17300 | Estimated | Industry | https://clinicaltrials.gov/study/NCT06292013 |
| NCT06642272 | A Pragmatic Trial Comparing Empagliflozin and Dapagliflozin Through Cluster Randomization Embedded in the Electronic Health Record | Diabetes Mellitus, Type 2; Heart Failure; Renal Insufficiency, Chronic | Phase 4 | Recruiting | 2024-10-10 | 17200 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06642272 |
| NCT01730534 | Multicenter Trial to Evaluate the Effect of Dapagliflozin on the Incidence of Cardiovascular Events | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 2013-04-25 | 17190 | Actual | Industry | https://clinicaltrials.gov/study/NCT01730534 |
| NCT01126437 | Comparison of Tiotropium in the HandiHaler Versus the Respimat in Chronic Obstructive Pulmonary Disease | Pulmonary Disease, Chronic Obstructive | Phase 3 | Completed | 2010-05 | 17183 | Actual | Industry | https://clinicaltrials.gov/study/NCT01126437 |
| NCT05183178 | Switching From Ticagrelor to Prasugrel in Patients With Acute Coronary Syndrome | Acute Coronary Syndrome | Phase 4 | Completed | 2022-02-01 | 17095 | Actual | Other government | https://clinicaltrials.gov/study/NCT05183178 |
| NCT05030428 | Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease | Atherosclerosis; Hypercholesterolemia; Dyslipidemias | Phase 3 | Active not recruiting | 2021-11-23 | 17004 | Actual | Industry | https://clinicaltrials.gov/study/NCT05030428 |
| NCT00109616 | Community Trial of Newborn Skin and Umbilical Cord Cleansing on Neonatal Mortality in Nepal | Phase 3 | Completed | 2002-10 | 17000 | NIH | https://clinicaltrials.gov/study/NCT00109616 | ||
| NCT06526507 | PrEPARE-SCALE: Scaling up Integrated PrEP Delivery in Kenyan Maternal and Child Health Clinics | Acquired Immunodeficiency Syndrome | Phase 4 | Enrolling by invitation | 2025-01-01 | 17000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06526507 |
| NCT02406729 | Phase III Trial to Evaluate Efficacy and Safety of a Tetravalent Dengue Vaccine | Dengue | Phase 3 | Unknown | 2016-02-22 | 16935 | Estimated | Other government | https://clinicaltrials.gov/study/NCT02406729 |
| NCT05005559 | Phase III Clinical Trial of CinnaGen COVID-19 Vaccine (SpikoGen) | COVID-19 | Phase 3 | Completed | 2021-08-07 | 16876 | Actual | Industry | https://clinicaltrials.gov/study/NCT05005559 |
| NCT01975376 | The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects | Cardiovascular Diseases; Myocardial Infarction; Stroke | Phase 3 | Terminated | 2013-10-29 | 16784 | Actual | Industry | https://clinicaltrials.gov/study/NCT01975376 |
| NCT01313676 | Study to Evaluate the Effect of Fluticasone Furoate/Vilanterol on Survival in Subjects With Chronic Obstructive Pulmonary Disease | Pulmonary Disease, Chronic Obstructive; Cardiovascular Diseases | Phase 3 | Completed | 2011-01-25 | 16568 | Actual | Industry | https://clinicaltrials.gov/study/NCT01313676 |
| NCT02409667 | Plaque Psoriasis Efficacy and Safety With Secukinumab | Plaque, Amyloid; Psoriasis | Phase 3 | Completed | 2015-05-07 | 16487 | Actual | Industry | https://clinicaltrials.gov/study/NCT02409667 |
| NCT00223080 | HIV Vaccine Trial in Thai Adults | HIV Infections | Phase 3 | Completed | 2003-10 | 16402 | Actual | U.S. federal | https://clinicaltrials.gov/study/NCT00223080 |
| NCT07872046 | A Study on the Impact of Recombinant Zoster Vaccine on Major Adverse Cardiovascular Events in Adults >=50 Years of Age With Established Cardiovascular Disease or With >=2 Cardiovascular Risk Factors | Cardiovascular Diseases | Phase 3 | Not yet recruiting | 2026-11-30 | 16390 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07872046 |
| NCT04383925 | Trial to Compare Two Strains of BCG | Infant Death | Phase 4 | Completed | 2020-05-04 | 16390 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04383925 |
| NCT04955626 | To Evaluate the Safety, Tolerability, Efficacy and Immunogenicity of BNT162b2 Boosting Strategies Against COVID-19 in Participants ≥12 Years of Age. | COVID-19; Coronavirus Infections | Phase 3 | Completed | 2021-07-01 | 16372 | Actual | Industry | https://clinicaltrials.gov/study/NCT04955626 |
| NCT05726084 | Immunogenicity, Efficacy and Safety Trial of the Convacell Vaccine in Healthy Volunteers Aged 18 Years and Older | COVID-19; Coronavirus Infections; Respiratory Tract Infections | Phase 2, Phase 3 | Unknown | 2022-10-24 | 16304 | Estimated | Other government | https://clinicaltrials.gov/study/NCT05726084 |
| NCT06578572 | Seasonal R21 Mass Vaccination for Malaria Elimination | Malaria | Phase 3 | Unknown | 2024-05-30 | 16200 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06578572 |
| NCT01165177 | Study to Evaluate Efficacy, Safety and Immunogenicity of GSK Biologicals' Herpes Zoster (HZ) Vaccine GSK1437173A in Adults Aged 50 Years and Older | Herpes Zoster | Phase 3 | Completed | 2010-08-02 | 16165 | Actual | Industry | https://clinicaltrials.gov/study/NCT01165177 |
| NCT03705234 | A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Disease | Atherosclerosis | Phase 3 | Active not recruiting | 2018-10-30 | 16124 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03705234 |
| NCT00529373 | A Study of MK-0822 in Postmenopausal Women With Osteoporosis to Assess Fracture Risk (MK-0822-018) | Osteoporosis, Postmenopausal | Phase 3 | Terminated | 2007-09-13 | 16071 | Actual | Industry | https://clinicaltrials.gov/study/NCT00529373 |
| NCT02270151 | Improving DEtection of Atrial fibriLlation in Primary Care With the MyDiagnostick | Atrial Fibrillation; Disease | Phase 3 | Completed | 2014-11 | 16000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02270151 |
| NCT05599516 | Recombinant COVID-19 Vaccine (CHO Cell, NVSI-06-09) Phase III Clinical Trial | COVID-19; Coronavirus Infections | Phase 3 | Unknown | 2022-11-04 | 16000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT05599516 |
| NCT01955252 | Effect of WHO-yaws Elimination Strategy in Lihir Island, Papua New Guinea | Yaws | Phase 3 | Completed | 2013-03 | 16000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01955252 |
| NCT01813435 | GLOBAL LEADERS: A Clinical Study Comparing Two Forms of Anti-platelet Therapy After Stent Implantation | Coronary Artery Disease | Phase 3 | Completed | 2013-07-01 | 15991 | Actual | Industry | https://clinicaltrials.gov/study/NCT01813435 |
| NCT00128557 | Community Trial of Newborn Vitamin A Supplementation to Reduce Infant Mortality in Rural Bangladesh | Vitamin A Deficiency; Infant Death | Phase 3 | Completed | 2004-01 | 15937 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00128557 |
| NCT00658515 | A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome | Coronary Disease | Phase 3 | Completed | 2008-04 | 15871 | Actual | Industry | https://clinicaltrials.gov/study/NCT00658515 |
| NCT00799903 | The Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial | Atherosclerosis; Heart Diseases; Cardiovascular Diseases | Phase 3 | Completed | 2008-12-01 | 15828 | Actual | Industry | https://clinicaltrials.gov/study/NCT00799903 |
| NCT03074435 | Insecticide Resistance Management in Burkina Faso and Côte D'Ivoire | Malaria | Phase 3 | Completed | 2016-07 | 15776 | Actual | Other government | https://clinicaltrials.gov/study/NCT03074435 |
| NCT05485051 | Daily Chlorexidine Bath for Health Care Associated Infection Prevention | Cross Infection; Pneumonia, Ventilator-Associated | Phase 3 | Completed | 2022-08-03 | 15730 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05485051 |
| NCT00050817 | Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) | Arteriosclerosis; Embolism | Phase 3 | Completed | 2002-10 | 15603 | Actual | Industry | https://clinicaltrials.gov/study/NCT00050817 |
| NCT00809965 | An Efficacy and Safety Study for Rivaroxaban in Patients With Acute Coronary Syndrome | Acute Coronary Syndrome; Myocardial Infarction; Myocardial Ischemia | Phase 3 | Completed | 2008-11 | 15526 | Actual | Industry | https://clinicaltrials.gov/study/NCT00809965 |
| NCT03903926 | Efficacy Trial of a Commercial EV71 Vaccine | Hand, Foot and Mouth Disease | Phase 4 | Completed | 2019-03-26 | 15500 | Actual | Industry | https://clinicaltrials.gov/study/NCT03903926 |
| NCT00135226 | ASCEND: A Study of Cardiovascular Events iN Diabetes | Diabetes Mellitus; Cardiovascular Diseases; Diabetes Mellitus, Type 1 | Phase 4 | Active not recruiting | 2005-03 | 15480 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00135226 |
| NCT00866619 | Efficacy of GSK Biologicals' Candidate Malaria Vaccine 257049 Against Malaria Disease in Infants and Children in Africa | Malaria | Phase 3 | Completed | 2009-03-27 | 15459 | Actual | Industry | https://clinicaltrials.gov/study/NCT00866619 |
| NCT03734237 | A Pragmatic Assessment of Influenza Vaccine Effectiveness in the DoD | Influenza, Human | Phase 4 | Active not recruiting | 2018-11-06 | 15448 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03734237 |
| NCT05556512 | A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity | Obesity; Overweight | Phase 3 | Active not recruiting | 2022-10-11 | 15374 | Actual | Industry | https://clinicaltrials.gov/study/NCT05556512 |
| NCT07626411 | Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation | Atrial Fibrillation; Hemorrhage; Stroke | Phase 3 | Recruiting | 2026-08-10 | 15364 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07626411 |
| NCT06395194 | Effects of Valsartan vs Amlodipine and Low BP on Kidney Outcomes in Essential Hypertension | Essential Hypertension; Hypertension; Kidney Diseases | Phase 3 | Completed | 1997-09-27 | 15313 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06395194 |
| NCT04583995 | A Study Looking at the Effectiveness, Immune Response, and Safety of a COVID-19 Vaccine in Adults in the United Kingdom | COVID-19; Coronavirus Infections | Phase 3 | Completed | 2020-09-28 | 15185 | Actual | Industry | https://clinicaltrials.gov/study/NCT04583995 |
| NCT07665853 | Optimizing the Use of Aspirin for the Prevention of Preeclampsia | Pre-Eclampsia | Phase 3 | Not yet recruiting | 2026-07-01 | 15160 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07665853 |
| NCT07000357 | A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event | Cardiovascular Diseases; Atherosclerosis | Phase 3 | Recruiting | 2025-06-04 | 15100 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07000357 |
| NCT03475342 | World Maternal Antifibrinolytic Trial_2 | Anemia; Postpartum Hemorrhage; Pain | Phase 3 | Completed | 2019-08-24 | 15068 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03475342 |
| NCT00134264 | A Study Examining Torcetrapib/Atorvastatin And Atorvastatin Effects On Clinical CV Events In Patients With Heart Disease | Coronary Disease; Diabetes Mellitus | Phase 3 | Terminated | 2004-07 | 15067 | Actual | Industry | https://clinicaltrials.gov/study/NCT00134264 |
| NCT00060476 | Treatment With MK0966 for the Prevention of Prostate Cancer (0966-201) | Prostatic Neoplasms | Phase 3 | Completed | 2003-01-08 | 15000 | Actual | Industry | https://clinicaltrials.gov/study/NCT00060476 |
| NCT00623337 | Ghana Newborn Home Visits Neonatal Mortality Trial | Phase 3 | Completed | 2009-01 | 15000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00623337 | |
| NCT00001127 | Study of a Flu Vaccine in Children | Influenza, Human | Phase 3 | Completed | 15000 | NIH | https://clinicaltrials.gov/study/NCT00001127 | ||
| NCT05169021 | Folic Acid and Intensive Antihypertensive Therapy for Hypertension With CSVD | Cerebral Small Vessel Diseases; Stroke; Hypertension | Phase 4 | Not yet recruiting | 2021-12-31 | 15000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05169021 |
| NCT00438919 | A Multi-center Post-Market Surveillance Registry | Coronary Artery Disease | Phase 4 | Completed | 2006-05 | 15000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT00438919 |
| NCT01050972 | Effectiveness of a Cognitive and Physical Intervention to Reduce Head and Muscle Pain in a Large Population | Migraine Disorders; Tension-Type Headache; Neck Pain | Phase 3 | Unknown | 2009-06 | 15000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01050972 |
| NCT05397678 | Trial to Compare BCG-Bulgaria and BCG-Denmark | Perinatal Death; Infant Death | Phase 4 | Unknown | 2022-10-21 | 15000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05397678 |
| NCT00543543 | Broad Spectrum HPV (Human Papillomavirus) Vaccine Study in 16-to 26-Year-Old Women (V503-001) | Uterine Cervical Neoplasms; Vulvar Neoplasms; Vaginal Neoplasms | Phase 3 | Completed | 2007-09-24 | 14840 | Actual | Industry | https://clinicaltrials.gov/study/NCT00543543 |
| NCT05643573 | A Study to Learn How Well the Study Treatment Asundexian Works and How Safe it is Compared to Apixaban to Prevent Stroke or Systemic Embolism in People With Irregular and Often Rapid Heartbeat (Atrial Fibrillation), and at Risk for Stroke | Atrial Fibrillation | Phase 3 | Terminated | 2022-12-05 | 14830 | Actual | Industry | https://clinicaltrials.gov/study/NCT05643573 |
| NCT01165229 | Study to Evaluate Efficacy, Safety and Immunogenicity of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster (HZ) Vaccine GSK1437173A in Adults Aged 70 Years and Older | Herpes Zoster | Phase 3 | Completed | 2010-08-02 | 14819 | Actual | Industry | https://clinicaltrials.gov/study/NCT01165229 |
| NCT01144338 | Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL): A Trial To Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly In Patients With Type 2 Diabetes Mellitus | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 2010-06-18 | 14752 | Actual | Industry | https://clinicaltrials.gov/study/NCT01144338 |
| NCT04424316 | A Trial to Evaluate the Efficacy and Safety of RSVpreF in Infants Born to Women Vaccinated During Pregnancy. | Respiratory Tract Infections | Phase 3 | Completed | 2020-06-17 | 14727 | Actual | Industry | https://clinicaltrials.gov/study/NCT04424316 |
| NCT02019264 | A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors | Cardiovascular Diseases; Obesity; Overweight | Phase 4 | Completed | 2014-01-24 | 14673 | Actual | Industry | https://clinicaltrials.gov/study/NCT02019264 |
| NCT00790205 | Sitagliptin Cardiovascular Outcomes Study (MK-0431-082) | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 2008-12-10 | 14671 | Actual | Industry | https://clinicaltrials.gov/study/NCT00790205 |
| NCT06008756 | Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Cardiovascular Outcomes Study (MK-0616-015) CORALreef Outcomes | Arteriosclerosis; Hypercholesterolemia | Phase 3 | Active not recruiting | 2023-10-09 | 14550 | Estimated | Industry | https://clinicaltrials.gov/study/NCT06008756 |
| NCT01968798 | ASPREE Cancer Endpoints Study | Neoplasms | Phase 4 | Unknown | 2013-09 | 14500 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01968798 |
| NCT00403767 | An Efficacy and Safety Study of Rivaroxaban With Warfarin for the Prevention of Stroke and Non-Central Nervous System Systemic Embolism in Patients With Non-Valvular Atrial Fibrillation | Atrial Fibrillation; Stroke; Embolism | Phase 3 | Completed | 2006-12 | 14269 | Actual | Industry | https://clinicaltrials.gov/study/NCT00403767 |
| NCT05168813 | Efficacy Study of COVID-19 mRNA Vaccine in Regions With SARS-CoV-2 Variants of Concern | COVID-19; HIV Infections | Phase 2, Phase 3 | Completed | 2021-12-01 | 14237 | Actual | Network | https://clinicaltrials.gov/study/NCT05168813 |
| NCT05754957 | A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome | Acute Coronary Syndrome | Phase 3 | Completed | 2023-04-07 | 14194 | Actual | Industry | https://clinicaltrials.gov/study/NCT05754957 |
| NCT05636319 | A Study to Evaluate the Efficacy, Safety, and Immunogenicity of SARS-CoV-2 Variant (BA.4 /5) mRNA Vaccine | COVID-19 | Phase 2, Phase 3 | Unknown | 2022-11-23 | 14168 | Actual | Industry | https://clinicaltrials.gov/study/NCT05636319 |
| NCT01256658 | A Community Setting Study of Malaria After Systematic Treatment of Symptomatic Carriers of P. Falciparum With COA566 (Coartem®) | Malaria; Trigeminal Neuralgia | Phase 4 | Completed | 2010-11 | 14075 | Actual | Industry | https://clinicaltrials.gov/study/NCT01256658 |
| NCT00114868 | Vitamin A Supplementation in Newborns Study | Phase 3 | Completed | 1998-06 | 14035 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00114868 | |
| NCT05739383 | A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients. | Cardiovascular Diseases; Myocardial Infarction; Stroke | Phase 3 | Active not recruiting | 2023-03-09 | 14012 | Actual | Industry | https://clinicaltrials.gov/study/NCT05739383 |
| NCT00376155 | Comparison of Two Strategies for the Delivery of IPTc | Malaria | Phase 4 | Completed | 2006-05 | 14000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00376155 |
| NCT02625155 | Standard of Care Versus Urine Testing With Selective PHarmacogenomics for Effective Drug and Dosing REgimens | Muscle Hypotonia | Phase 4 | Unknown | 2015-12 | 14000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT02625155 |
| NCT07890415 | Using an Artificial Intelligence (AI) Tool for Melanoma Diagnosis | Melanoma; Hemangioma; Nevus, Pigmented | Phase 3 | Recruiting | 2026-10-15 | 14000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07890415 |
| NCT02993406 | Evaluation of Major Cardiovascular Events in Participants With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant Treated With Bempedoic Acid (ETC-1002) or Placebo | Cardiovascular Diseases | Phase 3 | Completed | 2016-12-22 | 13970 | Actual | Industry | https://clinicaltrials.gov/study/NCT02993406 |
| NCT03118232 | Project PROTECT: Protecting Nursing Homes From Infections and Hospitalization | Infections | Phase 4 | Completed | 2017-04-03 | 13952 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03118232 |
| NCT01732822 | A Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease | Peripheral Arterial Disease | Phase 3 | Completed | 2012-12-04 | 13885 | Actual | Industry | https://clinicaltrials.gov/study/NCT01732822 |
| NCT00093158 | Comparison of Angiomax Versus Heparin in Acute Coronary Syndromes (ACS) | Angina, Unstable; Myocardial Infarction; Acute Disease | Phase 3 | Completed | 2003-08 | 13800 | Industry | https://clinicaltrials.gov/study/NCT00093158 | |
| NCT07706673 | ESCUDDO Long Term Follow Up | Papillomavirus Infections | Phase 4 | Enrolling by invitation | 2026-08-11 | 13700 | Estimated | NIH | https://clinicaltrials.gov/study/NCT07706673 |
| NCT00097591 | A Comparison of Prasugrel (CS-747) and Clopidogrel in Acute Coronary Syndrome Subjects Who Are to Undergo Percutaneous Coronary Intervention | Coronary Artery Disease; Acute Coronary Syndrome | Phase 3 | Completed | 2004-11 | 13619 | Actual | Industry | https://clinicaltrials.gov/study/NCT00097591 |
| NCT05815498 | A Study of mRNA-1283 Injection Compared With mRNA-1273 Injection in Participants ≥12 Years of Age to Prevent COVID-19 | COVID-19; Coronavirus Infections; Virus Diseases | Phase 3 | Completed | 2023-03-28 | 13553 | Actual | Industry | https://clinicaltrials.gov/study/NCT05815498 |
| NCT01011660 | Effects of Angiotensin II Receptor Blocker Compared With Diuretics in High-risk Hypertensive Patients | Essential Hypertension; Hypertension | Phase 4 | Unknown | 2007-10 | 13542 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01011660 |
| NCT03570814 | Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin | Trachoma; Elephantiasis, Filarial | Phase 4 | Completed | 2021-12-01 | 13511 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03570814 |
| NCT02601040 | Immunogenicity and Safety of Inactivated and Live Attenuated Hepatitis A Vaccines | Hepatitis A | Phase 4 | Completed | 2011-11 | 13500 | Actual | Network | https://clinicaltrials.gov/study/NCT02601040 |
| NCT05262010 | A Phase III Clinical Trial of a 11-valent Recombinant Human Papillomavirus Vaccine (Hansenulapolymorpha) in Chinese Women Aged 18-45 Years | Papillomavirus Infections | Phase 3 | Active not recruiting | 2022-06-04 | 13500 | Estimated | Industry | https://clinicaltrials.gov/study/NCT05262010 |
| NCT00784225 | S0000B: Vitamin E and/or Selenium in Preventing Cataract and Age-Related Macular Degeneration in Men on SELECT SWOG-S0000 | Cataract; Macular Degeneration | Phase 3 | Completed | 2004-07 | 13475 | Actual | Network | https://clinicaltrials.gov/study/NCT00784225 |
| NCT01994720 | [SOCRATES -Acute Stroke Or Transient IsChaemic Attack TReated With Aspirin or Ticagrelor and Patient OutcomES] | Ischemic Attack, Transient | Phase 3 | Completed | 2014-01-07 | 13307 | Actual | Industry | https://clinicaltrials.gov/study/NCT01994720 |
| NCT04255433 | A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes | Diabetes Mellitus, Type 2; Diabetes Mellitus; Glucose Metabolism Disorders | Phase 3 | Completed | 2020-05-29 | 13299 | Actual | Industry | https://clinicaltrials.gov/study/NCT04255433 |
| NCT00004800 | Phase III Randomized, Double-Blind, Placebo-Controlled Study of Acellular and Whole-Cell Pertussis Vaccines | Whooping Cough; Bacterial Infections; Immune System Diseases | Phase 3 | Completed | 1992-09 | 13250 | NIH | https://clinicaltrials.gov/study/NCT00004800 | |
| NCT01076764 | Effect of Otamixaban Versus Unfractionated Heparin + Eptifibatide in Patients With Unstable Angina/Non ST Elevation Myocardial Infarction Undergoing Early Invasive Strategy | Acute Coronary Syndrome | Phase 3 | Completed | 2010-04 | 13220 | Actual | Industry | https://clinicaltrials.gov/study/NCT01076764 |
| NCT02104817 | Outcomes Study to Assess STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia | Phase 3 | Completed | 2014-10-30 | 13078 | Actual | Industry | https://clinicaltrials.gov/study/NCT02104817 | |
| NCT01000727 | The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial | Acute Coronary Syndrome; Atherosclerosis; Heart Diseases | Phase 3 | Completed | 2009-12-01 | 13026 | Actual | Industry | https://clinicaltrials.gov/study/NCT01000727 |
| NCT04922788 | Study to Evaluate the Safety, Immunogenicity, and Efficacy of Nanocovax Vaccine Against COVID-19 | COVID-19 | Phase 3 | Completed | 2021-06-07 | 13006 | Actual | Industry | https://clinicaltrials.gov/study/NCT04922788 |
| NCT00152204 | The Community Effectiveness of IPTi in Southern Tanzania | Malaria, Falciparum; Anemia; Patient Acceptance of Health Care | Phase 3 | Unknown | 2005-03 | 13000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00152204 |
| NCT00272428 | Primary Prevention Trial of the Health Effects of Antioxidant Vitamins and Minerals. | Neoplasms | Phase 3 | Completed | 1994-10 | 13000 | Other government | https://clinicaltrials.gov/study/NCT00272428 | |
| NCT05946642 | Innovative Intermittent Preventive Treatment Approaches to Reduce Malaria Burden in School-age Children in Burkina Faso | Malaria | Phase 3 | Unknown | 2023-07-15 | 13000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05946642 |
| NCT04962451 | Comparison of the Efficacy of Ticagrelor Combined With ASA to ASA Alone in Patients With Stroke | Stroke | Phase 4 | Completed | 2017-09-01 | 13000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04962451 |
| NCT06955728 | A Clinical Trial on Safety in Pregnant Women and How Well the Infant is Protected Against RSV-associated Lower Respiratory Tract Infection When the Pregnant Woman Receives the Approved RSV Vaccine Compared to a Placebo. | Respiratory Syncytial Virus Infections; Obstetric Labor, Premature | Phase 3 | Recruiting | 2025-09-03 | 13000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06955728 |
| NCT04311671 | Safety of a Single Dose of Moxidectin Compared With Ivermectin in Individuals Living in Onchocerciasis Endemic Areas and in Individuals Living in Onchocerciasis Endemic Areas With High Levels of Lymphatic Filariasis Co-endemicity Receiving Concomitant Albendazole | Onchocerciasis | Phase 3 | Completed | 2021-05-03 | 12979 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04311671 |
| NCT00527943 | Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Particpants With Acute Coronary Syndrome (TRA•CER) (Study P04736) | Atherosclerosis; Myocardial Ischemia; Myocardial Infarction | Phase 3 | Terminated | 2007-12-01 | 12944 | Actual | Industry | https://clinicaltrials.gov/study/NCT00527943 |
| NCT04256798 | Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery | Infections; Pneumonia; Surgical Wound Infection | Phase 3 | Recruiting | 2020-11-13 | 12942 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04256798 |
| NCT00973362 | Clinical Evaluation of the APTIMA® HPV Assay Using the TIGRIS® System | Papillomavirus Infections; Uterine Cervical Neoplasms; Uterine Cervical Dysplasia | Phase 3 | Completed | 2008-03 | 12896 | Actual | Industry | https://clinicaltrials.gov/study/NCT00973362 |
| NCT01628666 | Prevention of Arrhythmia Device Infection Trial (PADIT) | Arrhythmias, Cardiac; Infections | Phase 4 | Completed | 2012-12 | 12814 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01628666 |
| NCT07037433 | Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity | Atherosclerosis; Overweight; Obesity | Phase 3 | Active not recruiting | 2025-07-25 | 12800 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07037433 |
| NCT03739112 | Efficacy of a Plant-derived Quadrivalent Virus-like Particle (VLP) Vaccine in the Elderly | Virus Diseases; RNA Virus Infections; Respiratory Tract Diseases | Phase 3 | Completed | 2018-09-18 | 12794 | Actual | Industry | https://clinicaltrials.gov/study/NCT03739112 |
| NCT01402882 | Clinical Randomisation of an Antifibrinolytic in Significant Head Injury | Brain Injuries, Traumatic | Phase 3 | Completed | 2012-07 | 12737 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01402882 |
| NCT00468923 | Heart Outcomes Prevention Evaluation-3 | Cardiovascular Diseases; Stroke | Phase 4 | Completed | 2007-05 | 12705 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00468923 |
| NCT04456595 | Clinical Trial of Efficacy and Safety of Sinovac's Adsorbed COVID-19 (Inactivated) Vaccine in Healthcare Professionals | COVID-19 | Phase 3 | Completed | 2020-07-21 | 12688 | Actual | Other government | https://clinicaltrials.gov/study/NCT04456595 |
| NCT05477524 | An Efficacy, Safety, Tolerability, Immunogenicity, and Lot-Consistency Clinical Trial of a 6-Valent OspA-Based Lyme Disease Vaccine (VLA15) | Lyme Disease | Phase 3 | Completed | 2022-08-04 | 12546 | Actual | Industry | https://clinicaltrials.gov/study/NCT05477524 |
| NCT00501059 | A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease | Stroke | Phase 3 | Completed | 2007-07-05 | 12546 | Actual | Industry | https://clinicaltrials.gov/study/NCT00501059 |
| NCT00069784 | The ORIGIN Trial (Outcome Reduction With Initial Glargine Intervention) | Diabetes Mellitus, Type 2; Glucose Intolerance | Phase 3 | Completed | 2003-08 | 12537 | Actual | Industry | https://clinicaltrials.gov/study/NCT00069784 |
| NCT05702034 | A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE | Ischemic Stroke | Phase 3 | Active not recruiting | 2023-02-15 | 12523 | Actual | Industry | https://clinicaltrials.gov/study/NCT05702034 |
| NCT00317707 | Risk and Prevention Study: Evaluation of the Efficacy of n-3 PUFA in Subjects at High Cardiovascular Risk | Cardiovascular Diseases; Diabetes Mellitus; Hypertension | Phase 3 | Completed | 2004-02 | 12513 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00317707 |
| NCT05150808 | Vectron T500 (Broflanilide 50WP) for IRS in Tanzania Tanzania | Malaria, Falciparum | Phase 3 | Unknown | 2020-10-01 | 12500 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05150808 |
| NCT01444430 | A 6 Month Safety Study Comparing Symbicort With Inhaled Corticosteroid Only in Asthmatic Adults and Adolescents | Asthma | Phase 3 | Completed | 2011-12 | 12460 | Actual | Industry | https://clinicaltrials.gov/study/NCT01444430 |
| NCT03450915 | A Pivotal Trial to Assess the Safety and Clinical Efficacy of the M-001 as a Standalone Universal Flu Vaccine | Influenza, Human | Phase 3 | Completed | 2018-08-01 | 12460 | Actual | Industry | https://clinicaltrials.gov/study/NCT03450915 |
| NCT05669625 | A Phase III Clinical Trial to Evaluate the Efficacy and Safety of the Live Attenuated Varicella Vaccine | Chickenpox | Phase 3 | Unknown | 2022-12-26 | 12440 | Actual | Industry | https://clinicaltrials.gov/study/NCT05669625 |
| NCT02984384 | PREVENTion of Clot in Orthopaedic Trauma | Thrombosis; Wounds and Injuries; Venous Thromboembolism | Phase 3 | Completed | 2017-04-24 | 12424 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02984384 |
| NCT05683821 | BREATHE 2 Clinic Stop-Smoking Treatment Outreach Study | Smoking Cessation; Cigarette Smoking | Phase 4 | Completed | 2023-07-24 | 12376 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05683821 |
| NCT05686070 | A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke | Phase 3 | Completed | 2023-01-26 | 12327 | Actual | Industry | https://clinicaltrials.gov/study/NCT05686070 | |
| NCT03872401 | Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke | Coronary Disease; Multiple Endocrine Neoplasia Type 1 | Phase 3 | Completed | 2019-06-11 | 12301 | Actual | Industry | https://clinicaltrials.gov/study/NCT03872401 |
| NCT01295203 | Internet-based Physical Activity Intervention | Motor Activity | Phase 3 | Completed | 2008-05 | 12287 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01295203 |
| NCT04263363 | Applying Best Clinical Practices to Patients at High Risk of Respiratory Complications | Sleep Apnea, Obstructive | Phase 4 | Completed | 2022-02-18 | 12248 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04263363 |
| NCT00092534 | Cervical Intraepithelial Neoplasm (CIN) in Women (Gardasil) (V501-015) | Uterine Cervical Neoplasms; Condylomata Acuminata | Phase 3 | Completed | 2002-06-14 | 12167 | Actual | Industry | https://clinicaltrials.gov/study/NCT00092534 |
| NCT01687998 | A Study of Evacetrapib in High-Risk Vascular Disease | Cardiovascular Diseases | Phase 3 | Terminated | 2012-10 | 12092 | Actual | Industry | https://clinicaltrials.gov/study/NCT01687998 |
| NCT00064428 | OASIS-6 : The Safety and Efficacy of Fondaparinux Versus Control Therapy in Patients With ST Segment Elevation Acute Myocardial Infarction | Thromboembolism; ST Elevation Myocardial Infarction; Acute Coronary Syndrome | Phase 3 | Completed | 2003-08 | 12092 | Actual | Industry | https://clinicaltrials.gov/study/NCT00064428 |
| NCT00124072 | Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine | Cardiovascular Diseases; Myocardial Infarction; Coronary Disease | Phase 3 | Completed | 1998-07 | 12064 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00124072 |
| NCT01439360 | An Efficacy Study of GlaxoSmithKline (GSK) Biologicals' Candidate Influenza Vaccine GSK2321138A in Children | Influenza, Human | Phase 3 | Completed | 2011-10-01 | 12046 | Actual | Industry | https://clinicaltrials.gov/study/NCT01439360 |
| NCT02111564 | A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients | Heart Failure; Respiratory Insufficiency; Stroke | Phase 3 | Completed | 2014-01-07 | 12024 | Actual | Industry | https://clinicaltrials.gov/study/NCT02111564 |
| NCT01658124 | Haemorrhage Alleviation With Tranexamic Acid- Intestinal System | Gastrointestinal Hemorrhage; Hemorrhage | Phase 3 | Completed | 2013-07 | 12009 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01658124 |
| NCT02447536 | Trial of Two Strains of BCG | Phase 4 | Completed | 2014-12-08 | 12006 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02447536 | |
| NCT01569581 | A Protected Study of Inactivated EV71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants and Children | Hand, Foot and Mouth Disease | Phase 3 | Completed | 2012-03 | 12000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01569581 |
| NCT05055908 | Efficacy and Biomarker Development for Lung Cancer Treated With Immune Checkpoint Inhibitors | Lung Neoplasms | Phase 3 | Recruiting | 2021-10-01 | 12000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05055908 |
| NCT01108614 | Injecting Drug Use Community Intervention Trial | Hepatitis C; Syphilis; HIV Infections | Phase 3 | Unknown | 2009-06 | 12000 | Estimated | Other government | https://clinicaltrials.gov/study/NCT01108614 |
| NCT04646954 | DNA Methylation Testing for the Screening of Uterine Cervical Lesion | Uterine Cervical Neoplasms; Uterine Cervical Dysplasia | Phase 3 | Unknown | 2020-11-26 | 12000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04646954 |
| NCT02033187 | Daily Chlorhexidine Bathing and Infection Rates in Critically-ill Patients | Cross Infection | Phase 4 | Completed | 2012-07 | 12000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02033187 |
| NCT05668572 | A Phase III Trial Evaluates the Efficacy, Immunogenicity and Safety Profile of HPV Vaccine | Papillomavirus Infections | Phase 3 | Unknown | 2020-12-05 | 12000 | Actual | Industry | https://clinicaltrials.gov/study/NCT05668572 |
| NCT04837170 | Safety and Efficacy Evaluation of S (+) - Ketamine in Adults | Pain, Postoperative; Acute Pain; Depression | Phase 4 | Unknown | 2021-05-01 | 12000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04837170 |
| NCT02733068 | A Phase III Study of Human Papillomavirus (HPV)-16/18 Vaccine. | Uterine Cervical Dysplasia | Phase 3 | Completed | 2014-11-02 | 12000 | Actual | Industry | https://clinicaltrials.gov/study/NCT02733068 |
| NCT04612972 | Efficacy, Safety and Immunogenicity of Inactivated SARS-CoV-2 Vaccines (Vero Cell) to Prevent COVID-19 in Healthy Adult Population In Peru Healthy Adult Population In Peru | COVID-19 | Phase 3 | Completed | 2020-09-09 | 12000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04612972 |
| NCT07013487 | A Study to Evaluate V181 Dengue Vaccine in Healthy Participants 2 to 17 Years of Age (V181-005/MOBILIZE-1) | Phase 3 | Active not recruiting | 2025-06-11 | 12000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07013487 | |
| NCT00242047 | Randomized Controlled Trial of Percutaneous and Intradermal BCG Vaccination. | Tuberculosis | Phase 4 | Unknown | 2001-03 | 12000 | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00242047 | |
| NCT00164580 | Community Intervention Trial for Youth (CITY) Study | HIV Infections; Homosexuality, Male | Phase 2, Phase 3 | Completed | 1996-10 | 12000 | U.S. federal | https://clinicaltrials.gov/study/NCT00164580 | |
| NCT07293065 | A Phase III Clinical Trial to Evaluate Long-Term Protective Efficacy of Recombinant Zoster Vaccine (CHO Cell) | Herpes Zoster | Phase 3 | Active not recruiting | 2025-12-15 | 12000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07293065 |
| NCT04591405 | Phase II/III of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Healthy Children Aged 5-11 | Mumps | Phase 2, Phase 3 | Unknown | 2020-10-12 | 11999 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04591405 |
| NCT00550745 | ZOSTAVAX™ Safety Study in Subjects ≥ 60 Years of Age (V211-020) | Herpes Zoster | Phase 4 | Completed | 2007-09 | 11999 | Actual | Industry | https://clinicaltrials.gov/study/NCT00550745 |
| NCT00268476 | Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy | Prostatic Neoplasms | Phase 2, Phase 3 | Active not recruiting | 2005-07-08 | 11992 | Actual | Other government | https://clinicaltrials.gov/study/NCT00268476 |
| NCT03199547 | Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis & Death | Neonatal Sepsis | Phase 3 | Completed | 2017-10-21 | 11985 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03199547 |
| NCT04796896 | A Study to Evaluate Safety and Effectiveness of mRNA-1273 COVID-19 Vaccine in Healthy Children Between 6 Months of Age and Less Than 12 Years of Age | Coronavirus Infections; Virus Diseases; COVID-19 | Phase 2, Phase 3 | Completed | 2021-03-15 | 11942 | Actual | Industry | https://clinicaltrials.gov/study/NCT04796896 |
| NCT04126486 | A Study to Determine if Identification of Undiagnosed Atrial Fibrillation in People at Least 70 Years of Age Reduces the Risk of Stroke | Atrial Fibrillation; Atrial Flutter | Phase 4 | Completed | 2019-12-17 | 11931 | Actual | Industry | https://clinicaltrials.gov/study/NCT04126486 |
| NCT02608502 | A Study to Evaluate the Efficacy of an RSV F Vaccine in Older Adults | Phase 3 | Completed | 2015-11 | 11850 | Actual | Industry | https://clinicaltrials.gov/study/NCT02608502 | |
| NCT04816643 | Study to Evaluate the Safety, Tolerability, and Immunogenicity of an RNA Vaccine Candidate Against COVID-19 in Healthy Children | COVID-19 | Phase 3 | Completed | 2021-03-24 | 11837 | Actual | Industry | https://clinicaltrials.gov/study/NCT04816643 |
| NCT00290875 | Implementation of the Canadian C-Spine Rule | Phase 3 | Completed | 2003-01 | 11824 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00290875 | |
| NCT07064473 | EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease | Diabetes Mellitus, Type 2; Hypertension; Cardiovascular Diseases | Phase 3 | Recruiting | 2025-07-22 | 11800 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07064473 |
| NCT01475721 | SAS115359: A 6-month Study to Assess the Safety and Benefit of Inhaled Fluticasone Propionate/Salmeterol Combination Compared With Inhaled Fluticasone Propionate in the Treatment of Adolescents and Adults (12 Years of Age and Older) With Asthma. | Asthma | Phase 4 | Completed | 2011-11-18 | 11751 | Actual | Industry | https://clinicaltrials.gov/study/NCT01475721 |
| NCT01471340 | A Serious Asthma Outcome Study With Mometasone Furoate/Formoterol Versus Mometasone Furoate in Asthmatics 12 Years and Over (P06241) | Asthma | Phase 4 | Completed | 2012-01-09 | 11744 | Actual | Industry | https://clinicaltrials.gov/study/NCT01471340 |
| NCT00394706 | Resuscitation Outcomes Consortium (ROC) Prehospital Resuscitation Using an Impedance Valve | Heart Arrest | Phase 3 | Terminated | 2007-06 | 11738 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00394706 |
| NCT00170950 | Avoiding Cardiovascular Events Through Combination Therapy in Patients Living With Systolic Hypertension | Hypertension | Phase 3 | Terminated | 2003-10 | 11506 | Actual | Industry | https://clinicaltrials.gov/study/NCT00170950 |
| NCT02151578 | Home Management of Malaria and Pneumonia | Malaria; Pneumonia | Phase 4 | Completed | 2009-01 | 11500 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02151578 |
| NCT03264352 | Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes | Diabetes Mellitus, Type 2; Prehypertension | Phase 4 | Recruiting | 2018-02-01 | 11414 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03264352 |
| NCT00630331 | Efficacy Study of Two Influenza Vaccines and Placebo in Healthy Adult Subjects | Influenza, Human | Phase 3 | Completed | 2007-10 | 11404 | Actual | Industry | https://clinicaltrials.gov/study/NCT00630331 |
| NCT04992260 | Efficacy, Immunogenicity and Safety of COVID-19 Vaccine , Inactivated in Children and Adolescents | COVID-19 | Phase 3 | Completed | 2021-09-10 | 11349 | Actual | Industry | https://clinicaltrials.gov/study/NCT04992260 |
| NCT06677060 | Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin | Heart Failure | Phase 3 | Recruiting | 2025-03-14 | 11300 | Estimated | Industry | https://clinicaltrials.gov/study/NCT06677060 |
| NCT04605159 | A Phase III, Double-blind Study to Assess Safety and Efficacy of an RSV Maternal Unadjuvanted Vaccine, in Pregnant Women and Infants Born to Vaccinated Mothers | Respiratory Syncytial Virus Infections | Phase 3 | Terminated | 2020-11-20 | 11194 | Actual | Industry | https://clinicaltrials.gov/study/NCT04605159 |
| NCT01156571 | A Clinical Trial Comparing Cangrelor to Clopidogrel Standard Therapy in Subjects Who Require Percutaneous Coronary Intervention (PCI) (CHAMPION PHOENIX) | Atherosclerosis; Acute Coronary Syndrome | Phase 3 | Completed | 2010-09 | 11145 | Actual | Industry | https://clinicaltrials.gov/study/NCT01156571 |
| NCT00145925 | Blood Pressure and Glucose Lowering for the Prevention of Vascular Disease in High Risk Patients With Type 2 Diabetes | Diabetes Mellitus, Type 2; Stroke | Phase 3 | Completed | 2001-06 | 11140 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00145925 |
| NCT05845489 | Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- CloPidogREl for Primary preVENTION (HOST-PREVENTION) | Coronary Artery Disease | Phase 4 | Recruiting | 2023-03-22 | 11086 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05845489 |
| NCT06840756 | Effects of Donor-recipient Sex-matched Blood Transfusion on Patient Outcomes | Phase 4 | Recruiting | 2025-09-11 | 11082 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06840756 | |
| NCT02875873 | Balanced Solution Versus Saline in Intensive Care Study | Critical Illness; Acute Kidney Injury | Phase 3 | Completed | 2017-05-27 | 11075 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02875873 |
| NCT03354429 | THALES - Acute STroke or Transient IscHaemic Attack Treated With TicAgreLor and ASA for PrEvention of Stroke and Death | Ischemic Attack, Transient; Stroke | Phase 3 | Completed | 2018-01-22 | 11016 | Actual | Industry | https://clinicaltrials.gov/study/NCT03354429 |
| NCT02406677 | Affordability and Real-world Antiplatelet Treatment Effectiveness After Myocardial Infarction Study | Acute Coronary Syndrome; Myocardial Infarction; ST Elevation Myocardial Infarction | Phase 4 | Completed | 2015-06-05 | 11001 | Actual | Industry | https://clinicaltrials.gov/study/NCT02406677 |
| NCT07136012 | OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events | Cardiovascular Diseases; Coronary Disease; Myocardial Infarction | Phase 3 | Recruiting | 2025-08-22 | 11000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07136012 |
| NCT02804815 | Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours | Neoplasms; Breast Neoplasms; Prostatic Neoplasms | Phase 3 | Active not recruiting | 2015-10 | 11000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02804815 |
| NCT03129490 | The Danish Non-vitamin K Antagonist Oral Anticoagulation Study in Patients With Atrial Fibrillation | Atrial Fibrillation; Atrial Flutter | Phase 4 | Active not recruiting | 2023-04-01 | 11000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03129490 |
| NCT03364491 | Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean | Hemorrhage | Phase 3 | Completed | 2018-03-15 | 11000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03364491 |
| NCT00168636 | Different Doses of Vitamin A Supplementation and Male and Female Morbidity and Mortality | Coitus | Phase 4 | Completed | 2004-11 | 11000 | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00168636 | |
| NCT07181109 | Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease | Hypertension; Cardiovascular Diseases | Phase 3 | Recruiting | 2025-09-06 | 11000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07181109 |
| NCT04885530 | ACTIV-6: COVID-19 Study of Repurposed Medications | COVID-19 | Phase 3 | Completed | 2021-06-08 | 10956 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04885530 |
| NCT04774991 | Azithromycin for Child Survival in Niger: Delivery Trial | Phase 4 | Completed | 2021-06-28 | 10925 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04774991 | |
| NCT00143507 | The BEAUTIFUL Study: Effects of Ivabradine in Patients With Stable Coronary Artery Disease and Left Ventricular Systolic Dysfunction | Coronary Disease; Ventricular Dysfunction, Left | Phase 3 | Completed | 2004-12 | 10917 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00143507 |
| NCT05715944 | Incidence of COVID-19 Following Vaccination in Botswana Against SARS CoV 2 | COVID-19 | Phase 3 | Completed | 2021-09-15 | 10888 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05715944 |
| NCT00123760 | Study of 18F-Fluorodeoxyglucose (FluGlucoScan) in Patients With Cancer or Suspected Cancer | Brain Neoplasms; Lung Neoplasms; Thyroid Neoplasms | Phase 2, Phase 3 | Completed | 2004-02 | 10838 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00123760 |
| NCT04400838 | Investigating a Vaccine Against COVID-19 | Coronavirus Infections; COVID-19 | Phase 2, Phase 3 | Completed | 2020-05-28 | 10811 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04400838 |
| NCT00234832 | A Long Term Study of Sibutramine and the Role of Obesity Management in Relation to Cardiovascular Disease in Overweight and Obese Patients | Obesity | Phase 3 | Completed | 2003-01 | 10777 | Actual | Industry | https://clinicaltrials.gov/study/NCT00234832 |
| NCT02009215 | School-Based Treatment With ACT to Reduce Transmission | Malaria | Phase 4 | Completed | 2014-02 | 10746 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02009215 |
| NCT06468202 | Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL | Pre-Eclampsia; Hypertension, Pregnancy-Induced | Phase 4 | Recruiting | 2024-10-18 | 10742 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06468202 |
| NCT00197210 | A Study to Test 2 Doses of GSK Biologicals' Oral Live Attenuated Human Rotavirus (HRV) Vaccine in Healthy Infants | Rotavirus Infections | Phase 3 | Completed | 2003-12 | 10708 | Actual | Industry | https://clinicaltrials.gov/study/NCT00197210 |
| NCT01964989 | Clinical Study to Evaluate the Safety, Immunogenicity and Efficacy of Investigational Flu Vaccine Compared to Approved Flu Vaccine in Children. | Influenza, Human | Phase 3 | Completed | 2013-11 | 10644 | Actual | Industry | https://clinicaltrials.gov/study/NCT01964989 |
| NCT03315143 | Effect of Sotagliflozin on Cardiovascular and Renal Events in Participants With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk | Heart Failure; Diabetes Mellitus, Type 2; Renal Insufficiency, Chronic | Phase 3 | Terminated | 2017-12-19 | 10584 | Actual | Industry | https://clinicaltrials.gov/study/NCT03315143 |
| NCT01975389 | The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects | Cardiovascular Diseases; Myocardial Infarction; Stroke | Phase 3 | Terminated | 2013-10-29 | 10564 | Actual | Industry | https://clinicaltrials.gov/study/NCT01975389 |
| NCT03071692 | Pemafibrate to Reduce Cardiovascular OutcoMes by Reducing Triglycerides IN patiENts With diabeTes (PROMINENT) | Dyslipidemias | Phase 3 | Terminated | 2017-03-23 | 10544 | Actual | Industry | https://clinicaltrials.gov/study/NCT03071692 |
| NCT01821911 | The Post-Marketing Safety and Immunogenicity Research of Speeda® Rabies Vaccine for Human Use | Phase 4 | Completed | 2012-07 | 10500 | Actual | Other government | https://clinicaltrials.gov/study/NCT01821911 | |
| NCT07157774 | Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a) | Atherosclerosis | Phase 3 | Recruiting | 2025-09-02 | 10450 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07157774 |
| NCT04953130 | Adding Male Single Dose HPV Vaccination to Female HPV Vaccination in Tanzania | Papillomavirus Infections; Vaccine-Preventable Diseases | Phase 4 | Recruiting | 2022-08-01 | 10400 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04953130 |
| NCT05096832 | Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01) Booster Study | COVID-19 | Phase 3 | Completed | 2021-11-03 | 10381 | Actual | Industry | https://clinicaltrials.gov/study/NCT05096832 |
| NCT02164513 | A Study Comparing the Efficacy, Safety and Tolerability of Fixed Dose Combination (FDC) of FF/UMEC/VI With the FDC of FF/VI and UMEC/VI; Administered Once-daily Via a Dry Powder Inhaler (DPI) in Subjects With Chronic Obstructive Pulmonary Disease (COPD) | Pulmonary Disease, Chronic Obstructive | Phase 3 | Completed | 2014-06-30 | 10355 | Actual | Industry | https://clinicaltrials.gov/study/NCT02164513 |
| NCT06516042 | Targeted Antimalarial Drug Administration for Seasonal Migrant Populations in Amhara Region, Ethiopia | Malaria, Falciparum; Malaria | Phase 3 | Active not recruiting | 2024-08-21 | 10350 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06516042 |
| NCT04791423 | Study of GRAd-COV2 for the Prevention of COVID-19 in Adults | COVID-19 | Phase 2, Phase 3 | Completed | 2021-03-15 | 10300 | Actual | Industry | https://clinicaltrials.gov/study/NCT04791423 |
| NCT04536051 | A Study of a Candidate COVID-19 Vaccine (COV003) | Coronavirus Infections; COVID-19 | Phase 3 | Unknown | 2020-06-02 | 10300 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04536051 |
| NCT05204589 | Heterologous Boost Immunization with an Aerosolised Ad5-nCoV After Two-dose Priming with an Inactivated SARS-CoV-2 Vaccine | COVID-19 | Phase 3 | Completed | 2022-01-22 | 10285 | Actual | Network | https://clinicaltrials.gov/study/NCT05204589 |
| NCT01373281 | Study of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia | Dengue; Severe Dengue | Phase 3 | Completed | 2011-06-03 | 10275 | Actual | Industry | https://clinicaltrials.gov/study/NCT01373281 |
| NCT00310180 | Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial) | Breast Neoplasms | Phase 3 | Active not recruiting | 2006-04-07 | 10273 | Actual | NIH | https://clinicaltrials.gov/study/NCT00310180 |
| NCT00000620 | Action to Control Cardiovascular Risk in Diabetes (ACCORD) | Atherosclerosis; Cardiovascular Diseases; Hypercholesterolemia | Phase 3 | Completed | 1999-09 | 10251 | Actual | NIH | https://clinicaltrials.gov/study/NCT00000620 |
| NCT01508247 | A Clinical Trial to Assess the Efficacy and Safety of an Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Aged 6-35 Months | Hand, Foot and Mouth Disease; Herpangina | Phase 3 | Completed | 2012-01 | 10245 | Actual | Network | https://clinicaltrials.gov/study/NCT01508247 |
| NCT04582344 | Clinical Trial For SARS-CoV-2 Vaccine (COVID-19) | COVID-19 | Phase 3 | Completed | 2020-09-14 | 10214 | Actual | Other government | https://clinicaltrials.gov/study/NCT04582344 |
| NCT06534892 | An Extension and Crossover Vaccination Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus Given to Adults 60 Years of Age and Above Who Participated in RSV OA=ADJ-006 Study | Respiratory Syncytial Virus Infections | Phase 3 | Active not recruiting | 2024-08-01 | 10212 | Actual | Industry | https://clinicaltrials.gov/study/NCT06534892 |
| NCT03301051 | Efficacy, Safety, and Immunogenicity of a Plant-Derived Quadrivalent Virus-Like Particles (VLPs) Influenza Vaccine in Adults | Virus Diseases; RNA Virus Infections; Respiratory Tract Diseases | Phase 3 | Completed | 2017-08-31 | 10160 | Actual | Industry | https://clinicaltrials.gov/study/NCT03301051 |
| NCT00135707 | Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS) | Pre-Eclampsia; Hypertension | Phase 3 | Completed | 2003-06 | 10154 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00135707 |
| NCT06581965 | inDividual, Targeted thrombosIS Prophylaxis Versus the Standard 'One Size Fits All' Approach in Patients Undergoing Total hIp or Total kNee replaCemenT | Venous Thromboembolism; Venous Thrombosis; Pulmonary Embolism | Phase 4 | Recruiting | 2024-11-11 | 10078 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06581965 |
| NCT04425629 | Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for the Treatment of Ambulatory Adult and Pediatric Patients With COVID-19 | COVID-19; Coronavirus Infections | Phase 3 | Terminated | 2020-06-16 | 10078 | Actual | Industry | https://clinicaltrials.gov/study/NCT04425629 |
| NCT01507857 | An Efficacy Trial in Inactivated Enterovirus Type 71 (EV71) Vaccine | Hand, Foot and Mouth Disease | Phase 3 | Completed | 2012-01 | 10077 | Actual | Industry | https://clinicaltrials.gov/study/NCT01507857 |
| NCT01327846 | Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events) | Atherosclerosis; Myocardial Infarction; Stroke | Phase 3 | Completed | 2011-04-11 | 10066 | Actual | Industry | https://clinicaltrials.gov/study/NCT01327846 |
| NCT06370273 | Thromboprophylaxis in Lower Limb Immobilisation | Thrombosis; Leg Injuries | Phase 3 | Recruiting | 2024-11-12 | 10044 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06370273 |
| NCT01738074 | Phase Three Clinical Trials of Trivalent Rotavirus Genetic Reassortment Vaccine | Phase 3 | Unknown | 2012-08 | 10020 | Actual | Other government | https://clinicaltrials.gov/study/NCT01738074 | |
| NCT05563675 | Once Daily Long-Acting Muscarinic Antagonists Administered in the Evening for Prevention of Chronic Obstructive Pulmonary Disease Exacerbations Requiring Hospitalization or Death from Any Cause | Phase 4 | Completed | 2023-01-27 | 10011 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05563675 | |
| NCT01082874 | PeriOperative ISchemic Evaluation-2 Trial | Cardiovascular Diseases | Phase 3 | Completed | 2010-07 | 10010 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01082874 |
| NCT03073863 | Evaluation of Statin Mechanism Preventing Cardiovascular Disease by Post-hoc Analysis of Treating to New Targets Study | Cardiovascular Diseases | Phase 4 | Completed | 1998-04-03 | 10001 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03073863 |
| NCT00004799 | Phase III Randomized, Double-Blind, Placebo-Controlled Study of Acellular and Whole-Cell Pertussis Vaccines | Whooping Cough; Bacterial Infections; Immune System Diseases | Phase 3 | Completed | 1991-04 | 10000 | NIH | https://clinicaltrials.gov/study/NCT00004799 | |
| NCT01184638 | Long-term Outcome of General Anesthesia on Dysgnosia | Delirium; Dementia; Cognitive Dysfunction | Phase 4 | Unknown | 2010-08 | 10000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01184638 |
| NCT05308576 | A Study to Evaluate the Efficacy and Safety of SCTV01E (a COVID-19 Vaccine) in Population Aged ≥18 Years | COVID-19 | Phase 3 | Unknown | 2022-12-26 | 10000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT05308576 |
| NCT02251899 | A Disease Management Study Targeted to Reduce Health Care Utilization for Patients With Congestive Heart Failure | Phase 3 | Unknown | 2010-01 | 10000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02251899 | |
| NCT06953726 | Comparing the Safety and Efficacy of Apixaban and Rivaroxaban | Atrial Fibrillation; Ischemic Stroke; Hemorrhage | Phase 4 | Recruiting | 2026-06-01 | 10000 | Estimated | U.S. federal | https://clinicaltrials.gov/study/NCT06953726 |
| NCT06667999 | The Intensive Care Platform Trial | Critical Illness | Phase 4 | Recruiting | 2025-06-26 | 10000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06667999 |
| NCT00893906 | Inactivated Influenza Vaccine Effectiveness in Tropical Africa | Influenza, Human | Phase 4 | Completed | 2009-05 | 10000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00893906 |
| NCT07619729 | Evaluate the Efficacy of an Oral Health Behavioral Intervention in People With Diabetes | Diabetes Mellitus, Type 2; Periodontal Diseases | Phase 4 | Enrolling by invitation | 2026-05-26 | 10000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07619729 |
| NCT02992457 | Safety and Efficacy of Sofosbuvir-Based Regimens in the Treatment of Egyptian Patients With Hepatitis C Infection | Hepatitis C | Phase 4 | Completed | 2015-01 | 10000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02992457 |
| NCT00190593 | Raloxifene Use for The Heart | Cardiovascular Diseases; Breast Neoplasms | Phase 3 | Completed | 1998-06 | 10000 | Industry | https://clinicaltrials.gov/study/NCT00190593 | |
| NCT06068530 | Mass Vaccine and Drug Administration, Bangladesh | Malaria, Falciparum | Phase 4 | Recruiting | 2025-02-15 | 10000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06068530 |
| NCT00225849 | Japanese Primary Prevention Project With Aspirin | Hypertension; Hyperlipidemias; Diabetes Mellitus | Phase 4 | Unknown | 2005-03 | 10000 | Other government | https://clinicaltrials.gov/study/NCT00225849 | |
| NCT00248469 | MEMA Kwa Vijana Trial: Impact of an Adolescent Sexual and Reproductive Health Intervention in Mwanza, Tanzania | HIV Infections; Sexually Transmitted Diseases; Sexual Behavior | Phase 3 | Completed | 1998-07 | 10000 | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00248469 | |
| NCT06118281 | ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack | Phase 3 | Active not recruiting | 2024-06-25 | 10000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT06118281 | |
| NCT05855408 | Effectiveness of a Second COVID-19 Vaccine Booster in Chinese Adults | COVID-19 | Phase 4 | Unknown | 2023-05-18 | 10000 | Estimated | Network | https://clinicaltrials.gov/study/NCT05855408 |
| NCT04615156 | 18F-2-fluoro-2-deoxy-D-glucose in Positron Emission Tomography Computed Tomography | Solitary Pulmonary Nodule; Neoplasms | Phase 3 | Not yet recruiting | 2020-11-01 | 10000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04615156 |
| NCT05633810 | COLchicine and Non-enteric Coated Aspirin in the Cardiovascular Outcomes Trial of Patients With Type 2 Diabetes | Diabetes Mellitus, Type 2; Cardiovascular Diseases; Heart Diseases | Phase 3 | Recruiting | 2022-12-21 | 10000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05633810 |
| NCT05002530 | Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell. | Anosmia | Phase 4 | Unknown | 2021-11 | 10000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05002530 |
| NCT00098709 | Fetal Pulse Oximetry Trial (FOX) | Phase 3 | Terminated | 2002-05 | 10000 | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00098709 | ||
| NCT07159763 | A Study to Evaluate the Safety and Efficacy of MK-1406/CD388 for Prevention of Influenza (MK-1406-005/CD388.SQ.3.06) | Influenza, Human | Phase 3 | Recruiting | 2025-09-25 | 10000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07159763 |
| NCT01979900 | Phase III Clinical Study of Efficacy and Safety of Vaccae™ to Prevent Tuberculosis | Tuberculosis | Phase 3 | Completed | 2013-10 | 10000 | Actual | Industry | https://clinicaltrials.gov/study/NCT01979900 |
| NCT01924325 | Apixaban Versus Dual-antiplatelet Therapy (Clopidogrel and Aspirin) in Acute Non-disabling Cerebrovascular Events | Ischemic Stroke | Phase 2, Phase 3 | Unknown | 2014-01 | 10000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01924325 |
| NCT01203813 | A Risk Based Approach to Improving Chronic Kidney Disease Management | Renal Insufficiency, Chronic | Phase 3 | Completed | 2011-05 | 10000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01203813 |
| NCT03418974 | Safety and Efficacy of Statins for Chinese Patients With Dyslipidemia | Dyslipidemias; Cardiovascular Diseases; Hypertension | Phase 4 | Unknown | 2017-11-01 | 10000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03418974 |
| NCT06383390 | The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes) | Atherosclerosis; Renal Insufficiency, Chronic; Cardiovascular Diseases | Phase 3 | Active not recruiting | 2024-04-30 | 10000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT06383390 |
| NCT03851445 | Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer | Phase 2, Phase 3 | Recruiting | 2019-02-06 | 10000 | Estimated | Network | https://clinicaltrials.gov/study/NCT03851445 | |
| NCT01293071 | Effect of Antibiotic Rotation in the ICU on the Prevalence of Antibiotic Resistant Gram-negative Colonisation | Infections | Phase 4 | Completed | 2011-01 | 10000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01293071 |
| NCT01981967 | Post-licensure Safety Study of IMOJEV® in Thailand | Encephalitis, Japanese | Phase 4 | Completed | 2013-11 | 10000 | Actual | Industry | https://clinicaltrials.gov/study/NCT01981967 |
| NCT02099123 | A Clinical Trial of STAtin Therapy for Reducing Events in the Elderly (STAREE) | Cardiovascular Diseases; Diabetes Mellitus; Dementia | Phase 4 | Active not recruiting | 2015-07 | 9971 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02099123 |
| NCT05212948 | A Study of S-268019 for the Prevention of COVID-19 | Phase 3 | Completed | 2021-12-25 | 9902 | Actual | Industry | https://clinicaltrials.gov/study/NCT05212948 | |
| NCT01394952 | Researching Cardiovascular Events With a Weekly Incretin in Diabetes (REWIND) | Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes Mellitus | Phase 3 | Completed | 2011-07-22 | 9901 | Actual | Industry | https://clinicaltrials.gov/study/NCT01394952 |
| NCT02610400 | Evaluation of Reactive Focal Mass Drug Administration (rfMDA) +/- Reactive Focal Vector Control (RAVC) in Namibia | Malaria | Phase 3 | Completed | 2016-02 | 9845 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02610400 |
| NCT00856583 | Safety Study of Sertindole Versus Risperidone Under Normal Conditions of Use | Schizophrenia | Phase 3 | Completed | 2002-07 | 9809 | Actual | Industry | https://clinicaltrials.gov/study/NCT00856583 |
| NCT00682006 | Topical Application of Chlorhexidine to the Umbilical Cord for Prevention of Omphalitis and Neonatal Mortality in Rural District of Pakistan | Phase 3 | Completed | 2008-01 | 9800 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00682006 | |
| NCT05812014 | Clinical Trail of SARS-CoV-2 Bivalent mRNA Vaccine (LVRNA021) in Participants Aged 18 Years and Older | Phase 3 | Unknown | 2023-03-25 | 9800 | Estimated | Industry | https://clinicaltrials.gov/study/NCT05812014 | |
| NCT00036270 | Randomized Phase III Study Of Exemestane (Aromasin) For 5 Years Versus Tamoxifen for 2.5 to 3 Years Followed By Exemestane | Breast Neoplasms | Phase 3 | Completed | 2001-08 | 9779 | Actual | Industry | https://clinicaltrials.gov/study/NCT00036270 |
| NCT00279448 | Exemestane As Treatment In Adjuvant For Post-Menopausal Patients With Non-Metastatic Breast Cancer | Breast Neoplasms | Phase 3 | Completed | 2002-01 | 9779 | Actual | Industry | https://clinicaltrials.gov/study/NCT00279448 |
| NCT02870790 | Expanded PrEP Implementation in Communities in NSW | Sexually Transmitted Diseases | Phase 3 | Completed | 2016-03 | 9733 | Actual | Other government | https://clinicaltrials.gov/study/NCT02870790 |
| NCT03914326 | A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 2019-06-17 | 9651 | Actual | Industry | https://clinicaltrials.gov/study/NCT03914326 |
| NCT07798232 | Penicillin to Prevent Early Rheumatic Heart Disease in School-Aged Children | Rheumatic Heart Disease | Phase 3 | Not yet recruiting | 2027-02-01 | 9622 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07798232 |
| NCT07153744 | Efficacy and Safety of Shexiang Baoxin Pill(MUSKARDIA) in the Treatment of Acute Myocardial Infarction | Phase 4 | Not yet recruiting | 2025-09-01 | 9588 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07153744 | |
| NCT05202509 | Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Disease | Atherosclerosis | Phase 3 | Active not recruiting | 2022-02-07 | 9541 | Actual | Industry | https://clinicaltrials.gov/study/NCT05202509 |
| NCT03505723 | PeriOperative ISchemic Evaluation-3 Trial | Venous Thrombosis; Hypotension; Hypertension | Phase 3 | Completed | 2018-06-27 | 9535 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03505723 |
| NCT04975737 | Study of the Safety and Efficacy of the Subunit Recombinant Tuberculosis Vaccine GamTBvac | Tuberculosis | Phase 3 | Active not recruiting | 2022-01-20 | 9500 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04975737 |
| NCT00514891 | Impact of the WHO Recommended Vitamin A Supplementation at Immunisation Contacts | Phase 4 | Terminated | 2007-08 | 9500 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00514891 | |
| NCT02465515 | Effect of Albiglutide, When Added to Standard Blood Glucose Lowering Therapies, on Major Cardiovascular Events in Subjects With Type 2 Diabetes Mellitus | Diabetes Mellitus; Diabetes Mellitus, Type 2 | Phase 4 | Completed | 2015-07-01 | 9463 | Actual | Industry | https://clinicaltrials.gov/study/NCT02465515 |
| NCT00125593 | Study of Heart and Renal Protection | Renal Insufficiency, Chronic; Cardiovascular Diseases; Atherosclerosis | Phase 4 | Completed | 2003-06 | 9438 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00125593 |
| NCT00089895 | EARLY ACS: Early Glycoprotein IIb/IIIa Inhibition in Patients With Non-ST-segment Elevation Acute Coronary Syndrome (Study P03684AM2)(COMPLETED) | Myocardial Ischemia; Acute Coronary Syndrome; Myocardial Infarction | Phase 3 | Completed | 2004-11-01 | 9406 | Actual | Industry | https://clinicaltrials.gov/study/NCT00089895 |
| NCT00262106 | Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection | HIV Infections; Gonorrhea; Chlamydia Infections | Phase 3 | Completed | 2005-10 | 9404 | Actual | Industry | https://clinicaltrials.gov/study/NCT00262106 |
| NCT00088010 | Effects of Arzoxifene on Bone Fractures and Incidence of Breast Cancer | Osteoporosis, Postmenopausal | Phase 3 | Completed | 2004-06 | 9369 | Actual | Industry | https://clinicaltrials.gov/study/NCT00088010 |
| NCT00849030 | ATAC - Arimidex, Tamoxifen Alone or in Combination | Breast Neoplasms | Phase 3 | Completed | 1996-07 | 9358 | Actual | Industry | https://clinicaltrials.gov/study/NCT00849030 |
| NCT00784862 | ATAC - Pharmacokinetics (PK) Sub-Protocol | Breast Neoplasms | Phase 3 | Completed | 1998-06 | 9358 | Actual | Industry | https://clinicaltrials.gov/study/NCT00784862 |
| NCT01190930 | Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma | Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Down Syndrome | Phase 3 | Completed | 2010-08-11 | 9350 | Actual | Network | https://clinicaltrials.gov/study/NCT01190930 |
| NCT00549003 | Efficacy and Cost Effectiveness of Malaria Diagnosis Procedures and the Rational Use of ACT in Zanzibar | Malaria | Phase 4 | Completed | 2005-02 | 9346 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00549003 |
| NCT01179048 | Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results | Diabetes Mellitus; Diabetes Mellitus, Type 2 | Phase 3 | Completed | 2010-08-31 | 9341 | Actual | Industry | https://clinicaltrials.gov/study/NCT01179048 |
| NCT04537156 | Efficacy, Immunogenicity and Safety Study of Recombinant Human Papillomavirus Vaccine(6,11,16,18,31,33,45,52,58 Type)(E.Coli) | Uterine Cervical Dysplasia; Uterine Cervical Neoplasms; Condylomata Acuminata | Phase 3 | Active not recruiting | 2020-09-05 | 9327 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04537156 |
| NCT00699998 | A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects | Acute Coronary Syndrome | Phase 3 | Completed | 2008-06 | 9326 | Actual | Industry | https://clinicaltrials.gov/study/NCT00699998 |
| NCT06291857 | A Study to Evaluate the Safety and Immunogenicity of COVID-19 Vaccine and Influenza Combination Vaccine | COVID-19; Influenza, Human | Phase 3 | Completed | 2024-12-09 | 9320 | Actual | Industry | https://clinicaltrials.gov/study/NCT06291857 |
| NCT00097786 | Long-term Study of Nateglinide+Valsartan to Prevent or Delay Type II Diabetes Mellitus and Cardiovascular Complications | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 2002-01 | 9306 | Actual | Industry | https://clinicaltrials.gov/study/NCT00097786 |
| NCT01887912 | Study of a Candidate Clostridium Difficile Toxoid Vaccine in Subjects at Risk for C. Difficile Infection | Clostridium Infections | Phase 3 | Terminated | 2013-07-30 | 9302 | Actual | Industry | https://clinicaltrials.gov/study/NCT01887912 |
| NCT06866574 | A Phase III Trial to Evaluate the Efficacy, Immunogenicity and Safety of a Recombinant Human Papillomavirus 9-Valent (Types 6, 11, 16, 18, 31, 33, 45, 52, 58) Vaccine (E.Coli) in Chinese Males | Anus Neoplasms; Condylomata Acuminata | Phase 3 | Active not recruiting | 2025-04-11 | 9300 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06866574 |
| NCT07551492 | A Phase III Study To Evaluate the Efficacy And Safety Of HRS9531 In Participants With Atherosclerotic Cardiovascular Disease | Atherosclerosis | Phase 3 | Recruiting | 2026-05-29 | 9262 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07551492 |
| NCT03665207 | Tight Versus Liberal Blood Glucose Control in Adult Critically Ill Patients | Critical Illness; Hyperglycemia | Phase 3 | Active not recruiting | 2018-09-18 | 9230 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03665207 |
| NCT07140211 | Short-term Low-dose Low-molecular-weight Heparin to Prevent Postpartum Thrombosis | Venous Thromboembolism | Phase 3 | Recruiting | 2025-10-15 | 9200 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07140211 |
| NCT05330884 | BCG Revaccination in Children and Adolescents | Latent Tuberculosis; Tuberculosis | Phase 3 | Suspended | 2024-07-15 | 9200 | Estimated | Other government | https://clinicaltrials.gov/study/NCT05330884 |
| NCT05447559 | Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study | Surgical Wound Infection | Phase 4 | Recruiting | 2023-02-07 | 9180 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05447559 |
| NCT00976027 | Multi-Year Study of Fluzone High-Dose Influenza Vaccine Compared With Fluzone® Vaccine in Adults Aged 65 Years and Older | Influenza, Human; Respiratory Tract Infections | Phase 3 | Terminated | 2009-09 | 9172 | Actual | Industry | https://clinicaltrials.gov/study/NCT00976027 |
| NCT04381143 | ASPIrin in Reducing Events in Dialysis ( ASPIRED ) | Renal Insufficiency, Chronic; Kidney Failure, Chronic | Phase 4 | Active not recruiting | 2020-07-30 | 9082 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04381143 |
| NCT04102371 | Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis | Shock; Sepsis; Shock, Septic | Phase 3 | Completed | 2020-08-25 | 9041 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04102371 |
| NCT00249795 | Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE I) | Atrial Fibrillation; Cardiovascular Diseases | Phase 3 | Completed | 2003-06 | 9016 | Actual | Industry | https://clinicaltrials.gov/study/NCT00249795 |
| NCT02270242 | Ticagrelor With Aspirin or Alone in High-Risk Patients After Coronary Intervention | Cardiovascular Diseases | Phase 4 | Completed | 2015-07 | 9006 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02270242 |
| NCT02285998 | Protective Efficacy of Flublok® Quadrivalent Versus Licensed Inactivated Influenza Vaccine in Adults ≥50 Years of Age | Influenza, Human | Phase 3 | Completed | 2014-10 | 9003 | Actual | Industry | https://clinicaltrials.gov/study/NCT02285998 |
| NCT06465914 | A Phase III Study to Evaluate the Efficacy, Immunogenicity and Safety of the 9-valent HPV Vaccine in Chinese Males | Condylomata Acuminata; Penile Neoplasms; Anus Neoplasms | Phase 3 | Active not recruiting | 2024-07-11 | 9000 | Actual | Industry | https://clinicaltrials.gov/study/NCT06465914 |
| NCT02964065 | A Trial on the Efficacy, Safety and Immunogenicity of Live-Attenuated Influenza Vaccine (LAIV) | Influenza, Human | Phase 3 | Completed | 2016-11 | 9000 | Actual | Industry | https://clinicaltrials.gov/study/NCT02964065 |
| NCT02000089 | The Cancer of the Pancreas Screening-5 CAPS5)Study | Pancreatic Neoplasms; Peutz-Jeghers Syndrome; Colorectal Neoplasms, Hereditary Nonpolyposis | Phase 3 | Recruiting | 2014-01-06 | 9000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02000089 |
| NCT01601704 | Cardiovascular Outcomes Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects With Cardiovascular Risk Factors (The Light Study) | Obesity; Overweight; Body Weight | Phase 3 | Terminated | 2012-06 | 8910 | Actual | Industry | https://clinicaltrials.gov/study/NCT01601704 |
| NCT00305162 | A Clinical Trial to Demonstrate the Efficacy of Cangrelor | Myocardial Infarction; Acute Coronary Syndrome; Non-ST Elevated Myocardial Infarction | Phase 3 | Terminated | 2006-04 | 8882 | Actual | Industry | https://clinicaltrials.gov/study/NCT00305162 |
| NCT06472908 | Efficacy and Safety of Colchicine After PCI | Coronary Disease | Phase 3 | Active not recruiting | 2024-07-09 | 8862 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06472908 |
| NCT02276755 | Vitamin D Supplementation in TB Prevention | Latent Tuberculosis | Phase 3 | Completed | 2015-09 | 8851 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02276755 |
| NCT03344887 | An Innovative Trial Assessing Donor Sex on Recipient Mortality | Anemia | Phase 4 | Unknown | 2018-09-04 | 8850 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03344887 |
| NCT04984408 | Efficacy, Immunogenicity and Safety of BBIBP-CorV Vaccine Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. | Phase 3 | Unknown | 2021-10-01 | 8825 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04984408 | |
| NCT06494878 | The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity | Venous Thromboembolism; Venous Thrombosis; Pulmonary Embolism | Phase 3 | Recruiting | 2026-06-04 | 8805 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06494878 |
| NCT07543458 | Therapeutics for Moderate and Severe Dengue | Dengue; Severe Dengue; Mosquito-Borne Diseases | Phase 3 | Not yet recruiting | 2026-10-01 | 8800 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07543458 |
| NCT06178991 | A Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Combined Modified RNA Vaccine Candidate Against COVID-19 and Influenza. | Influenza, Human; COVID-19 | Phase 3 | Completed | 2023-12-20 | 8795 | Actual | Industry | https://clinicaltrials.gov/study/NCT06178991 |
| NCT00476957 | Randomized Study Comparing Endeavor With Cypher Stents (PROTECT) | Myocardial Ischemia | Phase 4 | Completed | 2007-06 | 8709 | Actual | Industry | https://clinicaltrials.gov/study/NCT00476957 |
| NCT00329745 | Year 3 Extension for Efficacy Follow-up in Subjects Vaccinated in Studies Rota-028, 029 or 030 (NCT00197210) | Rotavirus Infections | Phase 3 | Completed | 2007-01 | 8687 | Actual | Industry | https://clinicaltrials.gov/study/NCT00329745 |
| NCT02690207 | Cross-vaccination Study of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine (GSK 1437173A) in Subjects Who Previously Received Placebo in ZOSTER-006 (NCT01165177) and ZOSTER-022 (NCT01165229) Studies. | Herpes Zoster | Phase 3 | Completed | 2016-03-16 | 8687 | Actual | Industry | https://clinicaltrials.gov/study/NCT02690207 |
| NCT06223919 | Efficacy/Effectiveness, Safety, and Immunogenicity of LC16m8 Mpox Vaccine in Colombia | Mpox, Monkeypox | Phase 3 | Active not recruiting | 2023-12-16 | 8686 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06223919 |
| NCT02654912 | Community-led Responses for Elimination: Controlled Trial of Reactive Case Detection Versus Reactive Drug Administration | Malaria | Phase 4 | Completed | 2016-02 | 8682 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02654912 |
| NCT02208154 | Ecological Effects of Decolonisation Strategies in Intensive Care | Phase 3 | Completed | 2013-12-01 | 8665 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02208154 | |
| NCT02378753 | STRIVE (Sierra Leone Trial to Introduce a Vaccine Against Ebola) | Hemorrhagic Fever, Ebola | Phase 2, Phase 3 | Completed | 2015-04 | 8651 | Actual | U.S. federal | https://clinicaltrials.gov/study/NCT02378753 |
| NCT00549757 | Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints (Core and Extension Phases) | Diabetes Mellitus, Type 2; Cardiovascular Diseases | Phase 3 | Terminated | 2007-10 | 8606 | Actual | Industry | https://clinicaltrials.gov/study/NCT00549757 |
| NCT00327691 | A Study to Determine the Degree of Additional Reduction in CV Risk in Lowering LDL Below Minimum Target Levels | Cardiovascular Diseases; Stroke; Coronary Disease | Phase 4 | Completed | 1998-04 | 8600 | Industry | https://clinicaltrials.gov/study/NCT00327691 | |
| NCT00159835 | Atorvastatin Versus Simvastatin In The Prevention Of Coronary Heart Disease (CHD) In Patients With Known CHD | Cardiovascular Diseases | Phase 4 | Completed | 1999-02 | 8600 | Industry | https://clinicaltrials.gov/study/NCT00159835 | |
| NCT06098079 | Effect of Naltrexone Hydrochloride ER and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on Major Adverse Cardiovascular Events (MACE) | Obesity | Phase 4 | Active not recruiting | 2024-01-03 | 8600 | Estimated | Industry | https://clinicaltrials.gov/study/NCT06098079 |
| NCT02465567 | Study to Assess the Efficacy and Safety of PT010 Relative to PT003 and PT009 in Subjects With Moderate to Very Severe COPD (Ethos) | Pulmonary Disease, Chronic Obstructive | Phase 3 | Completed | 2015-06-30 | 8588 | Actual | Industry | https://clinicaltrials.gov/study/NCT02465567 |
| NCT03201770 | Cohort Event Monitoring Study of Pyramax® | Malaria, Falciparum | Phase 4 | Completed | 2017-06-22 | 8572 | Actual | Industry | https://clinicaltrials.gov/study/NCT03201770 |
| NCT00141323 | Postmenopausal Evaluation and Risk-reduction With Lasofoxifene (PEARL) | Osteoporosis | Phase 3 | Completed | 2001-11 | 8556 | Estimated | Industry | https://clinicaltrials.gov/study/NCT00141323 |
| NCT05155137 | Polypill and RiscOMeter to Prevent StrOke and CogniTive ImpairmEnt (PROMOTE) | Stroke; Cognitive Dysfunction | Phase 3 | Recruiting | 2021-12-20 | 8518 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05155137 |
| NCT02130856 | Newborn Kit to Save Lives in Pakistan | Phase 3 | Completed | 2014-04 | 8518 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02130856 | |
| NCT03596385 | TREatment With Beta-blockers After myOcardial Infarction withOut Reduced Ejection fracTion" | Myocardial Infarction | Phase 4 | Completed | 2018-10-31 | 8505 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03596385 |
| NCT07861100 | A Research Study to Look at How Well Zenagamtide Works Compared to Placebo in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity | Obesity | Phase 3 | Not yet recruiting | 2026-10-26 | 8500 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07861100 |
| NCT00128167 | Trivalent, Live, Cold Adapted Influenza Vaccine (CAIV-T) Against Inactivated Influenza Vaccine (TIV) in Children 6-59 Months of Age | Influenza, Human | Phase 3 | Completed | 2004-10 | 8500 | Industry | https://clinicaltrials.gov/study/NCT00128167 | |
| NCT03523962 | Pre-operative Alcohol Skin Solutions in Fractured Extremities | Surgical Wound Infection; Hip Fractures; Fractures, Open | Phase 4 | Completed | 2018-08-21 | 8485 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03523962 |
| NCT00197548 | A Trial of Micronutrients and Adverse Pregnancy Outcomes | Premature Birth | Phase 3 | Completed | 2001-08 | 8468 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00197548 |
| NCT01035255 | This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure | Phase 3 | Terminated | 2009-12 | 8442 | Actual | Industry | https://clinicaltrials.gov/study/NCT01035255 | |
| NCT00463866 | Local Phase 4 Pan-European SMART Study | Asthma | Phase 4 | Completed | 2007-03 | 8424 | Actual | Industry | https://clinicaltrials.gov/study/NCT00463866 |
| NCT04803747 | A Trial of a Hospital Policy of Tranexamic Acid Use to Reduce Transfusion in Major Non-cardiac Surgery | Venous Thromboembolism; Venous Thrombosis | Phase 4 | Completed | 2022-02-16 | 8421 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04803747 |
| NCT05827978 | Study of mRNA-1010 Seasonal Influenza Vaccine in Adults | Virus Diseases; Influenza, Human | Phase 3 | Completed | 2023-04-17 | 8411 | Actual | Industry | https://clinicaltrials.gov/study/NCT05827978 |
| NCT01271985 | Prevention of Cardiovascular Disease in Middle-aged and Elderly Iranians Using a Single PolyPill | Cardiovascular Diseases | Phase 3 | Completed | 2011-02 | 8410 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01271985 |
| NCT00115869 | Hutchinson Smoking Prevention Project | Tobacco Use Cessation | Phase 3 | Completed | 1984-09 | 8388 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00115869 |
| NCT00490139 | ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D | Breast Neoplasms | Phase 3 | Completed | 2007-05-16 | 8381 | Actual | Industry | https://clinicaltrials.gov/study/NCT00490139 |
| NCT02117934 | Safety and Immunogenicity Study of the Hepatitis B Vaccine, HEPLISAV™, Compared to Engerix-B® Vaccine | Hepatitis B; Hepatitis | Phase 3 | Completed | 2014-04 | 8374 | Actual | Industry | https://clinicaltrials.gov/study/NCT02117934 |
| NCT06531824 | EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin) | Renal Insufficiency, Chronic | Phase 3 | Active not recruiting | 2024-08-30 | 8371 | Actual | Industry | https://clinicaltrials.gov/study/NCT06531824 |
| NCT00182039 | POISE Trial: Perioperative Ischemic Evaluation Study | Cardiovascular Diseases | Phase 3 | Terminated | 2002-10 | 8351 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00182039 |
| NCT05439356 | Colchicine in High-risk Patients With Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3) | Ischemic Stroke | Phase 3 | Completed | 2022-08-11 | 8343 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05439356 |
| NCT00622648 | Study to Evaluate the Mortality Reduction of Enoxaparin in Hospitalized Acutely Ill Medical Receiving Enoxaparin | Phase 4 | Completed | 2008-01 | 8329 | Actual | Industry | https://clinicaltrials.gov/study/NCT00622648 | |
| NCT04023552 | Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD | Cardiovascular Diseases; Myocardial Infarction; Stroke | Phase 3 | Completed | 2019-12-12 | 8323 | Actual | Industry | https://clinicaltrials.gov/study/NCT04023552 |
| NCT00057330 | HerpeVac Trial for Young Women | Herpes Simplex | Phase 3 | Completed | 2003-01-14 | 8323 | Actual | Industry | https://clinicaltrials.gov/study/NCT00057330 |
| NCT00986154 | Comparative Investigation of Low Molecular Weight (LMW) Heparin/Edoxaban Tosylate (DU176b) Versus (LMW) Heparin/Warfarin in the Treatment of Symptomatic Deep-Vein Blood Clots and/or Lung Blood Clots. (The Edoxaban Hokusai-VTE Study). | Venous Thromboembolism; Venous Thrombosis; Pulmonary Embolism | Phase 3 | Completed | 2009-10 | 8292 | Actual | Industry | https://clinicaltrials.gov/study/NCT00986154 |
| NCT03130114 | Antibiotics for Children With Severe Diarrhoea | Diarrhea | Phase 3 | Completed | 2017-05-13 | 8268 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03130114 |
| NCT02929329 | Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction | Heart Failure | Phase 3 | Completed | 2017-01-06 | 8256 | Actual | Industry | https://clinicaltrials.gov/study/NCT02929329 |
| NCT04624854 | Dual Anti-Platelet Therapy in Patients With Coronary Multi-Vessel Disease (DAPT-MVD) | Coronary Artery Disease; Myocardial Ischemia; Acute Coronary Syndrome | Phase 4 | Completed | 2020-10-28 | 8250 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04624854 |
| NCT01986881 | Cardiovascular Outcomes Following Ertugliflozin Treatment in Type 2 Diabetes Mellitus Participants With Vascular Disease, The VERTIS CV Study (MK-8835-004) | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 2013-11-04 | 8246 | Actual | Industry | https://clinicaltrials.gov/study/NCT01986881 |
| NCT00056407 | "REDUCE" - A Clinical Research Study To Reduce The Incidence Of Prostate Cancer In Men Who Are At Increased Risk | Prostatic Neoplasms | Phase 3 | Completed | 2003-03 | 8231 | Actual | Industry | https://clinicaltrials.gov/study/NCT00056407 |
| NCT04010448 | A Trial to Assess the Safety, Immunogenicity and Efficacy of a Trivalent Rotavirus P2-VP8 Subunit Vaccine in Prevention of Severe Rotavirus Gastroenteritis in Healthy Infants in Africa and India | Phase 3 | Unknown | 2019-10-10 | 8200 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04010448 | |
| NCT01492361 | A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin | Cardiovascular Diseases; Coronary Artery Disease; Myocardial Ischemia | Phase 3 | Completed | 2011-11 | 8179 | Actual | Industry | https://clinicaltrials.gov/study/NCT01492361 |
| NCT01456936 | Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders | Smoking Cessation; Mental Disorders | Phase 4 | Completed | 2011-11 | 8144 | Actual | Industry | https://clinicaltrials.gov/study/NCT01456936 |
| NCT00571649 | Venous Thromboembolic Event (VTE) Prophylaxis in Medically Ill Patients | Venous Thromboembolism; Venous Thrombosis; Pulmonary Embolism | Phase 3 | Completed | 2007-12 | 8101 | Actual | Industry | https://clinicaltrials.gov/study/NCT00571649 |
| NCT05285826 | Efficacy, Immunogenicity, and Safety of V503 in Chinese Males (V503-052) | Papillomavirus Infections | Phase 3 | Active not recruiting | 2022-02-18 | 8100 | Estimated | Industry | https://clinicaltrials.gov/study/NCT05285826 |
| NCT07507500 | Dual Antiplatelet Therapy Strategies After Acute Myocardial Infarction Undergoing PCI: Prasugrel vs Ticagrelor & 12 Months vs 1-3 Months | Myocardial Infarction; Acute Coronary Syndrome; Infarction | Phase 4 | Recruiting | 2026-09-02 | 8100 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07507500 |
| NCT00706121 | S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000 | Colorectal Neoplasms; Precancerous Conditions; Colonic Neoplasms | Phase 3 | Completed | 2008-06 | 8094 | Actual | Network | https://clinicaltrials.gov/study/NCT00706121 |
| NCT00373685 | GI-Reasons- A Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS) | Osteoarthritis | Phase 4 | Completed | 2006-10 | 8067 | Actual | Industry | https://clinicaltrials.gov/study/NCT00373685 |
| NCT06097273 | A Study of mRNA-1083 (SARS-CoV-2 and Influenza) Vaccine in Healthy Adult Participants, ≥50 Years of Age | Influenza, Human; Coronavirus Infections; Virus Diseases | Phase 3 | Completed | 2023-10-19 | 8061 | Actual | Industry | https://clinicaltrials.gov/study/NCT06097273 |
| NCT05437510 | Study of a Single Intramuscular Dose of Nirsevimab in the Prevention of Hospitalizations Due to Respiratory Syncytial Virus (RSV) Infection in Healthy Term and Preterm Infants During the First Year of Life | Phase 3 | Completed | 2022-08-08 | 8057 | Actual | Industry | https://clinicaltrials.gov/study/NCT05437510 | |
| NCT00023452 | Three Months of Weekly Rifapentine and Isoniazid for M. Tuberculosis Infection | Tuberculosis | Phase 3 | Completed | 2001-06 | 8053 | Actual | U.S. federal | https://clinicaltrials.gov/study/NCT00023452 |
| NCT00518687 | Efficacy, Immunogenicity, and Safety of a Single Dose of V710 in Adult Patients Scheduled for Cardiothoracic Surgery (V710-003 AM2) | Staphylococcal Infections; Bacteremia; Mediastinitis | Phase 2, Phase 3 | Terminated | 2007-12 | 8031 | Actual | Industry | https://clinicaltrials.gov/study/NCT00518687 |
| NCT00004205 | Letrozole or Tamoxifen in Treating Postmenopausal Women With Breast Cancer | Breast Neoplasms; Breast Carcinoma In Situ; Carcinoma, Ductal, Breast | Phase 3 | Completed | 1998-03 | 8028 | Actual | Network | https://clinicaltrials.gov/study/NCT00004205 |
| NCT06838195 | Clinical Trial of the S. Flexneri-S. Sonnei Bivalent Conjugate Vaccine | Dysentery; Dysentery, Bacillary | Phase 3 | Active not recruiting | 2025-05-12 | 8000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT06838195 |
| NCT05916326 | Phase III Clinical Trial to Evaluate the Human Norovirus Bivalent (GⅠ.1/GⅡ.4)Vaccine，Recombinant (Hansenula Polymorpha) | Caliciviridae Infections | Phase 3 | Completed | 2023-06-30 | 8000 | Actual | Industry | https://clinicaltrials.gov/study/NCT05916326 |
| NCT00043784 | SYNERGY: Open Study of Enoxaparin Versus Unfractionated Heparin in Patients With Acute Coronary Syndromes | Angina, Unstable; Myocardial Infarction; Myocardial Ischemia | Phase 3 | Completed | 2001-08 | 8000 | Industry | https://clinicaltrials.gov/study/NCT00043784 | |
| NCT00379249 | Rosuvastatin ORBITAL Germany | Hypercholesterolemia; Patient Compliance | Phase 3 | Completed | 2002-02 | 8000 | Industry | https://clinicaltrials.gov/study/NCT00379249 | |
| NCT05137119 | Staphylococcus Aureus Network Adaptive Platform Trial | Staphylococcal Infections | Phase 4 | Recruiting | 2022-02-16 | 8000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05137119 |
| NCT00479726 | Lilly's Emotional and Physical Symptoms of Depression Study (LEAPS) | Depressive Disorder, Major | Phase 4 | Completed | 2004-08 | 8000 | Industry | https://clinicaltrials.gov/study/NCT00479726 | |
| NCT05580666 | Reducing Mortality in Adults With Advanced HIV Disease (REVIVE) | Acquired Immunodeficiency Syndrome | Phase 3 | Recruiting | 2023-05-08 | 8000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05580666 |
| NCT06605118 | Azithromycin Prophylaxis for PRElabor CEsarean DElivery Trial | Infections | Phase 3 | Recruiting | 2024-11-06 | 8000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06605118 |
| NCT05688579 | Effect of MRA on Cardiovascular Disease in Patients With Hypertension and Hyperaldosteronemia | Hypertension; Hyperaldosteronism | Phase 4 | Enrolling by invitation | 2023-04-16 | 8000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05688579 |
| NCT00950430 | Imaging of Brain Amyloid Plaques in the Aging Population | Alzheimer Disease; Lewy Body Disease; Frontotemporal Dementia | Phase 4 | Enrolling by invitation | 2008-04 | 8000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00950430 |
| NCT01196260 | Combination Chemotherapy Treatments in Patients With Colorectal Cancer Stage II and III | Colorectal Neoplasms | Phase 2, Phase 3 | Unknown | 2004-01 | 8000 | Estimated | Network | https://clinicaltrials.gov/study/NCT01196260 |
| NCT00674375 | Risk Score Alerts for Chest Pain Care | Chest Pain | Phase 3 | Completed | 2008-11 | 8000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00674375 |
| NCT00211705 | Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese(MEGA Study) | Hyperlipidemias; Coronary Disease; Stroke | Phase 4 | Completed | 1994-02 | 8000 | Industry | https://clinicaltrials.gov/study/NCT00211705 | |
| NCT00442442 | Clinical Evaluation of Mosquito Coils to Control Malaria in China | Malaria | Phase 3 | Unknown | 2007-04 | 8000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00442442 |
| NCT00159848 | Effect Of A Treatment Optimization Program To Improve Satisfaction With Viagra | Erectile Dysfunction | Phase 4 | Completed | 2003-09 | 8000 | Industry | https://clinicaltrials.gov/study/NCT00159848 | |
| NCT04422366 | Evaluate the Efficacy, Immunogenicity and Safety of 9-valent HPV Recombinant Vaccine in Chinese Healthy Females | Uterine Cervical Neoplasms; Vulvar Neoplasms; Vaginal Neoplasms | Phase 3 | Recruiting | 2020-04-28 | 8000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT04422366 |
| NCT05514054 | A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer | Breast Neoplasms | Phase 3 | Active not recruiting | 2022-10-04 | 8000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT05514054 |
| NCT06734832 | Efficacy, Safety, and Immunogenicity of the Bivalent Inactivated Enterovirus Vaccine (Vero Cell) | Hand, Foot and Mouth Disease | Phase 3 | Recruiting | 2024-12-13 | 8000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT06734832 |
| NCT05173324 | Integration of HPV Vaccination and HPV-based Cervical Screening Into ARV Clinics: the H2VICTORY Trial | Papillomavirus Infections; HIV Infections | Phase 3 | Not yet recruiting | 2023-02-01 | 8000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05173324 |
| NCT00136370 | Prevention of Perinatal Sepsis (PoPS): Evaluation of Chlorhexidine Wipes of Birth Canal and Newborn | Infant, Newborn, Diseases; Sepsis; Puerperal Infection | Phase 3 | Unknown | 2004-04 | 8000 | Estimated | U.S. federal | https://clinicaltrials.gov/study/NCT00136370 |
| NCT02296138 | Comparing the Efficacy of Tiotropium + Olodaterol (5/5 µg) Fixed Dose Combination (FDC) Over Tiotropium 5µg in Reducing Moderate to Severe Exacerbations in Patients With Severe to Very Severe Chronic Obstructive Pulmonary Disease. | Pulmonary Disease, Chronic Obstructive | Phase 3 | Completed | 2015-01-13 | 7903 | Actual | Industry | https://clinicaltrials.gov/study/NCT02296138 |
| NCT00961337 | Evaluation of a School-based Influenza Vaccination Program | Influenza, Human | Phase 4 | Completed | 2008-10 | 7854 | Actual | Other government | https://clinicaltrials.gov/study/NCT00961337 |
| NCT01794143 | A Comparative Effectiveness Study of Major Glycemia-lowering Medications for Treatment of Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 2013-05 | 7850 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01794143 |
| NCT04727424 | Repurposed Approved and Under Development Therapies for Patients With Early-Onset COVID-19 and Mild Symptoms | COVID-19; Severe Acute Respiratory Syndrome | Phase 3 | Unknown | 2021-01-19 | 7819 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04727424 |
| NCT00089791 | A Study to Evaluate Denosumab in the Treatment of Postmenopausal Osteoporosis | Osteoporosis; Osteoporosis, Postmenopausal | Phase 3 | Completed | 2004-08-01 | 7808 | Actual | Industry | https://clinicaltrials.gov/study/NCT00089791 |
| NCT00168662 | Non-Specific Effects of Standard Titre Measles Vaccination | Measles; Infant Death | Phase 4 | Completed | 1995-03 | 7800 | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00168662 | |
| NCT07186634 | PeRiOperative Medicine Platform Trial | Phase 4 | Recruiting | 2026-04-06 | 7800 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07186634 | |
| NCT01646437 | The International Polycap Study 3 (TIPS-3) | Cardiovascular Diseases; Fractures, Bone; Neoplasms | Phase 3 | Completed | 2012-06 | 7793 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01646437 |
| NCT02344290 | Evaluating the Use of Pitavastatin to Reduce the Risk of Cardiovascular Disease in HIV-Infected Adults | Cardiovascular Diseases; Myocardial Infarction; Inflammation | Phase 3 | Completed | 2015-03-26 | 7769 | Actual | NIH | https://clinicaltrials.gov/study/NCT02344290 |
| NCT03431142 | Optimal antiPlatelet Therapy for High Bleeding and Ischemic RISK Patients Trial | Hemorrhage | Phase 4 | Completed | 2018-02-12 | 7758 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03431142 |
| NCT00806195 | Study to Evaluate the Safety of Novartis MenACWY Conjugate Vaccine When Administered With Routine Infant Vaccinations to Healthy Infants | Meningitis; Meningococcal Infections | Phase 3 | Completed | 2008-12 | 7744 | Actual | Industry | https://clinicaltrials.gov/study/NCT00806195 |
| NCT06015282 | The Celljuvant Study: A Phase 3 Immunogenicity and Safety Study of aQIVc Vaccine in Adults Aged 50 Years and Older | Influenza, Human | Phase 3 | Completed | 2023-11-03 | 7741 | Actual | Industry | https://clinicaltrials.gov/study/NCT06015282 |
| NCT06930885 | Polypill and Colchicine for Risk Reduction in Atherosclerotic Cardiovascular Disease | Atherosclerosis | Phase 3 | Recruiting | 2025-06-12 | 7713 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06930885 |
| NCT00670319 | Comparison of Raloxifene Hydrochloride and Placebo in the Treatment of Postmenopausal Women With Osteoporosis | Osteoporosis, Postmenopausal | Phase 3 | Completed | 1994-11 | 7705 | Actual | Industry | https://clinicaltrials.gov/study/NCT00670319 |
| NCT00049829 | HORIZON-PFT: Pivotal Fracture Trial | Osteoporosis | Phase 3 | Completed | 2002-01 | 7700 | Industry | https://clinicaltrials.gov/study/NCT00049829 | |
| NCT00336180 | Adolescent Drug and HIV Prevention in South Africa | Substance-Related Disorders; Sexually Transmitted Diseases; Adolescent Behavior | Phase 2, Phase 3 | Completed | 2003-09 | 7695 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00336180 |
| NCT01959529 | A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular Events | Diabetes Mellitus; Diabetes Mellitus, Type 2 | Phase 3 | Completed | 2013-10-29 | 7637 | Actual | Industry | https://clinicaltrials.gov/study/NCT01959529 |
| NCT00363870 | A Study to Demonstrate the Efficacy of GSK Biologicals' Influenza Vaccine in Adults | Influenza, Human | Phase 4 | Completed | 2006-09 | 7632 | Industry | https://clinicaltrials.gov/study/NCT00363870 | |
| NCT05398848 | Efficacy, Safety and Immunogenicity Study of the Recombinant Two-component COVID-19 Vaccine (CHO Cell)(Recov) | COVID-19 | Phase 3 | Completed | 2022-10-31 | 7623 | Actual | Industry | https://clinicaltrials.gov/study/NCT05398848 |
| NCT00663806 | A Phase IV Study of Cipro XR in Uncomplicated UTI | Urinary Tract Infections | Phase 4 | Completed | 2003-02 | 7614 | Actual | Industry | https://clinicaltrials.gov/study/NCT00663806 |
| NCT00205777 | Study Evaluating Bazedoxifene Acetate In Osteoporosis In Postmenopausal Women | Osteoporosis | Phase 3 | Completed | 2001-12 | 7609 | Actual | Industry | https://clinicaltrials.gov/study/NCT00205777 |
| NCT03848312 | Preventing Alzheimer's With Cognitive Training | Alzheimer Disease | Phase 3 | Active not recruiting | 2019-02-19 | 7600 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03848312 |
| NCT04760132 | National Cohort Study of Effectiveness and Safety of SARS-CoV-2/COVID-19 Vaccines (ENFORCE) | Severe Acute Respiratory Syndrome; COVID-19 | Phase 4 | Completed | 2021-02-08 | 7600 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04760132 |
| NCT00168610 | Vitamin A Supplementation With Bacille Calmette Guerin (BCG) Vaccine | Infant Death | Phase 4 | Unknown | 2004-11 | 7600 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00168610 |
| NCT00066573 | Exemestane or Anastrozole in Treating Postmenopausal Women Who Have Undergone Surgery for Primary Breast Cancer | Breast Neoplasms | Phase 3 | Completed | 2003-06-06 | 7576 | Actual | Network | https://clinicaltrials.gov/study/NCT00066573 |
| NCT00249873 | Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE A) | Atrial Fibrillation | Phase 3 | Completed | 2003-06 | 7554 | Actual | Industry | https://clinicaltrials.gov/study/NCT00249873 |
| NCT02723773 | A Long-term Follow-up Study (ZOE-LTFU) of Two Studies 110390 (ZOSTER-006) and 113077 (ZOSTER-022) to Assess the Efficacy, Safety, and Immunogenicity Persistence of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine and Assessment of 1 or 2 Additional Doses in Two Subgroups of Older Adults | Herpes Zoster | Phase 3 | Completed | 2016-04-16 | 7539 | Actual | Industry | https://clinicaltrials.gov/study/NCT02723773 |
| NCT05690841 | FocaL Mass Drug Administration for Vivax Malaria Elimination | Malaria, Vivax; Malaria; Parasitic Diseases | Phase 3 | Recruiting | 2024-10-14 | 7530 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05690841 |
| NCT01583218 | Acute Medically Ill VTE Prevention With Extended Duration Betrixaban Study (The APEX Study) | Venous Thromboembolism | Phase 3 | Completed | 2012-03 | 7513 | Actual | Industry | https://clinicaltrials.gov/study/NCT01583218 |
| NCT00427388 | Steroids In caRdiac Surgery Trial (SIRS Trial) | Systemic Inflammatory Response Syndrome; Myocardial Infarction | Phase 4 | Unknown | 2007-06 | 7507 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00427388 |
| NCT00362648 | Developing World Study for RotaTeq™ (V260-015)(COMPLETED) | Vomiting; Diarrhea; Fever | Phase 3 | Completed | 2007-03 | 7504 | Actual | Industry | https://clinicaltrials.gov/study/NCT00362648 |
| NCT07035405 | Colchicine for Secondary Prevention After Ischemic Stroke (CHANCE-3 EX) | Stroke | Phase 3 | Not yet recruiting | 2025-07-04 | 7500 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07035405 |
| NCT02133690 | A Clinical Trial to Study the Effect and Safety of Rotavirus Vaccine Against Severe Rotavirus Gastroenteritis in Healthy Indian Infants | Phase 3 | Completed | 2014-05 | 7500 | Actual | Industry | https://clinicaltrials.gov/study/NCT02133690 | |
| NCT00562484 | A Study of the Efficacy, Safety and Tolerability Profile of CSL Limited's Influenza Virus Vaccine (CSL's IVV) Administered Intramuscularly in Healthy Adults | Influenza, Human | Phase 4 | Completed | 2008-03 | 7500 | Actual | Industry | https://clinicaltrials.gov/study/NCT00562484 |
| NCT05746611 | Phase IV Clinical Study of Recombinant Mycobacterium Tuberculosis Fusion Protein | Latent Tuberculosis | Phase 4 | Completed | 2023-04-17 | 7500 | Actual | Industry | https://clinicaltrials.gov/study/NCT05746611 |
| NCT00831441 | Phase III Acute Coronary Syndrome | Acute Coronary Syndrome | Phase 3 | Terminated | 2009-03 | 7484 | Actual | Industry | https://clinicaltrials.gov/study/NCT00831441 |
| NCT00128661 | Vaccine To Prevent Cervical Intraepithelial Neoplasia or Cervical Cancer in Younger Healthy Participants | Uterine Cervical Neoplasms; Precancerous Conditions; Uterine Cervical Dysplasia | Phase 3 | Completed | 2004-06-30 | 7466 | Actual | Industry | https://clinicaltrials.gov/study/NCT00128661 |
| NCT00698568 | Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects | Herpes Simplex | Phase 3 | Completed | 1996-10 | 7460 | Actual | Industry | https://clinicaltrials.gov/study/NCT00698568 |
| NCT05085366 | A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of Age | Cytomegalovirus Infections; Virus Diseases; DNA Virus Infections | Phase 3 | Terminated | 2021-10-26 | 7454 | Actual | Industry | https://clinicaltrials.gov/study/NCT05085366 |
| NCT06722521 | GUIDE-CAC: Statin-Ezetimibe Without Aspirin vs. Statin Monotherapy With Aspirin in High Coronary Calcification | Vascular Calcification; Cardiovascular Diseases | Phase 4 | Recruiting | 2025-07-09 | 7435 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06722521 |
| NCT02915198 | Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes | Prediabetic State; Atherosclerosis; Coronary Artery Disease | Phase 4 | Recruiting | 2023-04-03 | 7410 | Estimated | U.S. federal | https://clinicaltrials.gov/study/NCT02915198 |
| NCT00216242 | Study of the Protective Effect of an Injectable Influenza Vaccine Against Influenza Illness in Adults Under 50 y.o. | Influenza, Human | Phase 3 | Unknown | 2005-09 | 7400 | Industry | https://clinicaltrials.gov/study/NCT00216242 | |
| NCT00399724 | A Trial Comparing Lantus Algorithms to Achieve Normal Blood Glucose Targets in Subjects With Uncontrolled Blood Sugar With Type 2 Diabetes Mellitus | Diabetes Mellitus, Type 2 | Phase 4 | Completed | 2002-03 | 7376 | Industry | https://clinicaltrials.gov/study/NCT00399724 | |
| NCT00563381 | Tiotropium Once Daily 18 Mcg Versus Salmeterol Twice Daily 50 Mcg on Time to First Exacerbation in COPD Patients. | Pulmonary Disease, Chronic Obstructive | Phase 4 | Completed | 2008-01 | 7376 | Actual | Industry | https://clinicaltrials.gov/study/NCT00563381 |
| NCT01735006 | Efficacy and Immunogenicity Study of Recombinant Human Papillomavirus Bivalent（Type 16/18 ）Vaccine | Uterine Cervical Dysplasia; Uterine Cervical Neoplasms; Persistent Infection | Phase 3 | Completed | 2012-11-22 | 7372 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01735006 |
| NCT02545049 | Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease | Diabetic Nephropathies; Diabetes Mellitus, Type 2; Kidney Diseases | Phase 3 | Completed | 2015-09-17 | 7352 | Actual | Industry | https://clinicaltrials.gov/study/NCT02545049 |
| NCT05700877 | Screening and Intervention for Subclinical Coronary Artery Disease in Patients With Type 2 Diabetes | Diabetes Mellitus, Type 2; Cardiovascular Diseases | Phase 4 | Recruiting | 2023-01-12 | 7300 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05700877 |
| NCT01803841 | Korea Transradial Coronary Intervention Prospective Registry (KOTRI) | Coronary Artery Disease | Phase 4 | Completed | 2013-02 | 7300 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01803841 |
| NCT05581303 | Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial | Atherosclerosis | Phase 3 | Active not recruiting | 2022-12-14 | 7297 | Actual | Industry | https://clinicaltrials.gov/study/NCT05581303 |
| NCT00447759 | The Standard Care Versus Celecoxib Outcome Trial | Osteoarthritis; Arthritis, Rheumatoid; Arthritis | Phase 4 | Completed | 2007-06 | 7297 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00447759 |
| NCT00324350 | Intensive Glycemic Control and Skeletal Health Study | Atherosclerosis; Cardiovascular Diseases; Hypercholesterolemia | Phase 3 | Completed | 2003-10 | 7287 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00324350 |
| NCT03048825 | Colchicine and Spironolactone in Patients with MI / SYNERGY Stent Registry | ST Elevation Myocardial Infarction; Non-ST Elevated Myocardial Infarction | Phase 3 | Completed | 2018-02-01 | 7264 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03048825 |
| NCT00493922 | Trial of Rapid Diagnostic Tests in Rural Ghana | Malaria; Bacterial Infections; Disease | Phase 4 | Completed | 2007-07 | 7263 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00493922 |
| NCT00800605 | Immunogenicity Study of an Inactivated Influenza Vaccine (Split Virus, Vero Cell Derived) to Prevent Culture Confirmed Influenza Infection | Influenza, Human | Phase 3 | Completed | 2008-12 | 7250 | Actual | Industry | https://clinicaltrials.gov/study/NCT00800605 |
| NCT01042769 | A Study With Aleglitazar in Patients With a Recent Acute Coronary Syndrome and Type 2 Diabetes Mellitus | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 2010-02 | 7226 | Actual | Industry | https://clinicaltrials.gov/study/NCT01042769 |
| NCT02313909 | Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS) | Stroke; Ischemic Stroke; Ischemic Attack, Transient | Phase 3 | Terminated | 2014-12-23 | 7213 | Actual | Industry | https://clinicaltrials.gov/study/NCT02313909 |
| NCT00740935 | Impact of Systematic Infants Vaccination Against Rotavirus on Gastroenteritis Hospitalization: a Prospective Study in Brest District, France. | Gastroenteritis | Phase 4 | Completed | 2007-05 | 7204 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00740935 |
| NCT00942812 | Community Based Intervention and Evaluation of the Impact of Social Marketing of a Diarrhea Management Pack | Diarrhea | Phase 4 | Completed | 2009-07 | 7200 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00942812 |
| NCT01433627 | Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX | Acute Coronary Syndrome; ST Elevation Myocardial Infarction; Non-ST Elevated Myocardial Infarction | Phase 3 | Unknown | 2011-10 | 7200 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01433627 |
| NCT03984591 | A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart Failure | Heart Failure, Systolic | Phase 4 | Enrolling by invitation | 2020-11-01 | 7200 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03984591 |
| NCT01088958 | Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya | Anemia, Iron-Deficiency; Child Nutrition Disorders | Phase 4 | Completed | 2007-01 | 7200 | Actual | U.S. federal | https://clinicaltrials.gov/study/NCT01088958 |
| NCT05728775 | REmimazolam vs Propofol Total Intravenous Anesthesia on Outcomes After Major Noncardiac SurgEry | Phase 4 | Recruiting | 2023-04-03 | 7188 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05728775 | |
| NCT01575834 | Efficacy and Safety of Romosozumab Treatment in Postmenopausal Women With Osteoporosis | Osteoporosis, Postmenopausal; Osteoporosis; Bone Diseases, Metabolic | Phase 3 | Completed | 2012-03-15 | 7180 | Actual | Industry | https://clinicaltrials.gov/study/NCT01575834 |
| NCT00002644 | Tamoxifen for the Prevention of Breast Cancer in High-Risk Women | Breast Neoplasms | Phase 3 | Completed | 1994-01 | 7154 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00002644 |
| NCT00475852 | A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure | Heart Failure; Dyspnea | Phase 3 | Completed | 2007-05 | 7141 | Actual | Industry | https://clinicaltrials.gov/study/NCT00475852 |
| NCT07241390 | A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes) | Renal Insufficiency, Chronic; Heart Diseases; Kidney Diseases | Phase 3 | Recruiting | 2025-12-01 | 7140 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07241390 |
| NCT00233727 | Screen and Treat for Cervical Cancer Prevention | Uterine Cervical Neoplasms; Uterine Cervical Dysplasia | Phase 3 | Terminated | 2000-01 | 7123 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00233727 |
| NCT05112900 | Health Information Technology for COVID-19 Testing in Schools (SCALE-UP Counts) | COVID-19 | Phase 3 | Completed | 2022-01-11 | 7122 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05112900 |
| NCT04975178 | Efficacy, Safety and Immunogenicity Evaluation of MTBVAC in Newborns in Sub-Saharan Africa | Tuberculosis | Phase 3 | Recruiting | 2022-10-17 | 7120 | Estimated | Industry | https://clinicaltrials.gov/study/NCT04975178 |
| NCT04193215 | V114 and Acute Otitis Media (V114-032/PNEU-ERA) | Otitis Media | Phase 3 | Completed | 2020-09-12 | 7119 | Actual | Industry | https://clinicaltrials.gov/study/NCT04193215 |
| NCT00430989 | The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial | Coronary Artery Disease | Phase 4 | Completed | 2007-04 | 7112 | Actual | Other government | https://clinicaltrials.gov/study/NCT00430989 |
| NCT01162122 | Safety and Immunogenicity of MF59C.1 Adjuvanted Trivalent Subunit Influenza Vaccine in Elderly Subjects | Influenza, Human | Phase 3 | Completed | 2010-08 | 7109 | Actual | Industry | https://clinicaltrials.gov/study/NCT01162122 |
| NCT04210349 | Study of Shenzhen Quadrivalent Inactivated Influenza Vaccine Versus the Shenzhen Trivalent Inactivated Influenza Vaccine in Chinese Subjects From 6 Months of Age | Influenza, Human | Phase 3 | Completed | 2020-01-09 | 7106 | Actual | Industry | https://clinicaltrials.gov/study/NCT04210349 |
| NCT05669755 | REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels | Cardiovascular Diseases | Phase 3 | Active not recruiting | 2023-03-01 | 7101 | Actual | Industry | https://clinicaltrials.gov/study/NCT05669755 |
| NCT02277990 | World-wide Randomized Antibiotic Envelope Infection Prevention Trial | Phase 4 | Completed | 2015-01 | 7075 | Actual | Industry | https://clinicaltrials.gov/study/NCT02277990 | |
| NCT01131676 | BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME). | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 2010-07 | 7064 | Actual | Industry | https://clinicaltrials.gov/study/NCT01131676 |
| NCT00853658 | Efficacy and Safety of Aliskiren and Aliskiren/Enalapril Combination on Morbidity-mortality in Patients With Chronic Heart Failure | Phase 3 | Completed | 2009-03 | 7064 | Actual | Industry | https://clinicaltrials.gov/study/NCT00853658 | |
| NCT07318610 | Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery Disease | Peripheral Arterial Disease; Thrombosis | Phase 3 | Recruiting | 2026-07-10 | 7050 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07318610 |
| NCT01014273 | A Trial of Trans-radial Versus Trans-femoral Percutaneous Coronary Intervention (PCI) Access Site Approach in Patients With Unstable Angina or Myocardial Infarction Managed With an Invasive Strategy | Acute Coronary Syndrome | Phase 3 | Completed | 2006-06 | 7021 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01014273 |
| NCT00047411 | Home Use of Automatic External Defibrillators to Treat Sudden Cardiac Arrest | Cardiovascular Diseases; Myocardial Infarction; Heart Diseases | Phase 3 | Completed | 2002-09 | 7001 | Estimated | NIH | https://clinicaltrials.gov/study/NCT00047411 |
| NCT00935168 | Crystalloid Versus Hydroxyethyl Starch Trials | Phase 3 | Completed | 2009-12 | 7000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00935168 | |
| NCT07640841 | Health Economic Evaluation of Influenza and Pneumococcal Vaccination in COPD Patients | Influenza, Human; Pneumonia | Phase 4 | Not yet recruiting | 2026-06-15 | 7000 | Estimated | Network | https://clinicaltrials.gov/study/NCT07640841 |
| NCT07753993 | A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease. | Renal Insufficiency, Chronic | Phase 3 | Recruiting | 2026-08-21 | 7000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07753993 |
| NCT07795398 | DAN-RELEASE - Reconsidering Long-Term Aspirin in the Elderly Patients With Stable Ischemic Heart Disease | Myocardial Ischemia; Myocardial Infarction | Phase 4 | Recruiting | 2026-09-30 | 7000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07795398 |
| NCT00885404 | Chloride High Level Of Resuscitation Infusion Chloride High Level Of Resuscitation Infusion Delivered Evaluation | Shock; Critical Illness; Acidosis | Phase 4 | Unknown | 2009-02 | 7000 | Estimated | Other government | https://clinicaltrials.gov/study/NCT00885404 |
| NCT07854795 | Reconsidering Long-Term Apirin in the Elderly in Secondary Prevention of Coronary Artery Disease Norway | Phase 4 | Not yet recruiting | 2027-02-01 | 7000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07854795 | |
| NCT05164081 | Dual vs. Single-Antibiotic Impregnated Cement in Hemiarthroplasty for Femoral Neck Fracture | Femoral Neck Fractures | Phase 3 | Active not recruiting | 2022-01-01 | 7000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05164081 |
| NCT07015957 | Kupewa: Optimizing Implementation Strategies for Cervical Cancer Prevention | Phase 4 | Active not recruiting | 2025-07-08 | 7000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07015957 | |
| NCT01585298 | STudy to vAlidate telemetRic ECG Systems for firsT Dose Administration of Fingolimod (START) | Multiple Sclerosis | Phase 4 | Completed | 2012-04-29 | 6998 | Actual | Industry | https://clinicaltrials.gov/study/NCT01585298 |
| NCT01897532 | Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA) | Diabetes Mellitus, Type 2 | Phase 4 | Completed | 2013-07-10 | 6991 | Actual | Industry | https://clinicaltrials.gov/study/NCT01897532 |
| NCT00336336 | GISSI-HF- Effects of n-3 PUFA and Rosuvastatin on Mortality-Morbidity of Patients With Symptomatic CHF | Heart Failure | Phase 3 | Completed | 2002-08 | 6975 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00336336 |
| NCT07761117 | A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF | Heart Failure | Phase 3 | Recruiting | 2026-08-24 | 6950 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07761117 |
| NCT04351685 | Evaluation of Efficacy and Safety of VPM1002 in Comparison to BCG in Prevention of Tb Infection in Infants | Tuberculosis; Mycoses | Phase 3 | Completed | 2020-11-09 | 6940 | Actual | Industry | https://clinicaltrials.gov/study/NCT04351685 |
| NCT04327206 | BCG Vaccination to Protect Healthcare Workers Against COVID-19 | COVID-19; Coronavirus Infections | Phase 3 | Completed | 2020-03-30 | 6828 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04327206 |
| NCT05323721 | Effectiveness and Chemoprevention Efficacy of Implementing Seasonal Malaria Chemoprevention in Karamoja Region, Uganda | Malaria | Phase 4 | Unknown | 2022-06-01 | 6805 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05323721 |
| NCT00641914 | Inhaled Steroid Treatment as Regular Therapy in Early Asthma | Asthma | Phase 4 | Completed | 1996-10 | 6800 | Estimated | Industry | https://clinicaltrials.gov/study/NCT00641914 |
| NCT01305109 | A Phase III Clinical Trial to Evaluate the Protective Efficacy of Three Doses of Oral Rotavirus Vaccine (ORV) 116E | Phase 3 | Unknown | 2011-03 | 6800 | Estimated | Industry | https://clinicaltrials.gov/study/NCT01305109 | |
| NCT05680415 | Clinical Trial of Mica | Latent Tuberculosis | Phase 4 | Active not recruiting | 2023-04-19 | 6800 | Estimated | Industry | https://clinicaltrials.gov/study/NCT05680415 |
| NCT02288832 | Medico-economic Impact of Screening Atopobium Vaginae and Gardnerella Vaginalis in Molecular Biology by "Point-of-care" During Pregnancy | Phase 2, Phase 3 | Completed | 2015-03-06 | 6800 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02288832 | |
| NCT05175274 | Colchicine Use for Primary Prevention of Coronary Artery Disease | Coronary Artery Disease | Phase 3 | Not yet recruiting | 2022-12-06 | 6792 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05175274 |
| NCT02587221 | Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of an MF59-Adjuvanted Quadrivalent Influenza Vaccine Compared to Non-influenza Vaccine Comparator in Adults ≥ 65 Years of Age | Influenza, Human | Phase 3 | Completed | 2016-09-30 | 6790 | Actual | Industry | https://clinicaltrials.gov/study/NCT02587221 |
| NCT00457002 | Study of Apixaban for the Prevention of Thrombosis-related Events in Patients With Acute Medical Illness | Venous Thrombosis; Pulmonary Embolism | Phase 3 | Completed | 2007-06 | 6758 | Actual | Industry | https://clinicaltrials.gov/study/NCT00457002 |
| NCT00142246 | Study of the Impact of Intermittent Preventive Treatment in Schools on Malaria, Anaemia and Education. | Malaria, Falciparum; Malaria; Anemia | Phase 3 | Completed | 2005-01 | 6758 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00142246 |
| NCT07572747 | Aspirin Versus Clopidogrel in Chronic Coronary Syndrome in Arabian Gulf Countries | Phase 3 | Not yet recruiting | 2027-04-01 | 6740 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07572747 | |
| NCT03914625 | A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia | Burkitt Lymphoma; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Down Syndrome | Phase 3 | Active not recruiting | 2019-07-03 | 6720 | Estimated | NIH | https://clinicaltrials.gov/study/NCT03914625 |
| NCT06424288 | A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure | Heart Failure | Phase 3 | Recruiting | 2024-06-17 | 6712 | Estimated | Industry | https://clinicaltrials.gov/study/NCT06424288 |
| NCT00243178 | Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE W) | Atrial Fibrillation | Phase 3 | Terminated | 2003-07 | 6706 | Actual | Industry | https://clinicaltrials.gov/study/NCT00243178 |
| NCT05121324 | Pediatric Dose Optimization for Seizures in Emergency Medical Services | Seizures | Phase 3 | Recruiting | 2022-08-08 | 6700 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05121324 |
| NCT02936661 | Tranexamic Acid for Preventing Postpartum Hemorrhage After Cesarean Section | Phase 4 | Unknown | 2017-04 | 6700 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02936661 | |
| NCT07133802 | Clinical Trial to Evaluate the Protective Efficacy and Safety of a Nasal Spray Live Attenuated Influenza Vaccine (LAIV) in Adults Aged 18-59 Years Post-Vaccination | Phase 3 | Not yet recruiting | 2025-08 | 6680 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07133802 | |
| NCT04324463 | Anti-Coronavirus Therapies to Prevent Progression of Coronavirus Disease 2019 (COVID-19) Trial | Coronavirus Infections; Severe Acute Respiratory Syndrome; COVID-19 | Phase 3 | Completed | 2020-04-21 | 6667 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04324463 |
| NCT00922779 | A Study of Ribavirin in Combination With PEGASYS (Peginterferon Alfa-2a (40KD))in Patients With Chronic Hepatitis C | Hepatitis C, Chronic | Phase 4 | Completed | 2002-06 | 6661 | Actual | Industry | https://clinicaltrials.gov/study/NCT00922779 |
| NCT00129766 | Study of MEDI-524 (Motavizumab) for the Prophylaxis of Serious Respiratory Syncytial Virus (RSV) Disease in High-Risk Children | Respiratory Syncytial Virus Infections | Phase 3 | Completed | 2004-11 | 6635 | Actual | Industry | https://clinicaltrials.gov/study/NCT00129766 |
| NCT01787110 | An Efficacy and Outcome Study of Supplemental Oxygen Treatment in Patients With Suspected Myocardial Infarction | Acute Coronary Syndrome; Non-ST Elevated Myocardial Infarction; Myocardial Infarction | Phase 3 | Completed | 2013-04 | 6629 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01787110 |
| NCT03838575 | ROSSINI 2 - Reduction of Surgical Site Infection Using Several Novel Interventions | Surgical Wound Infection | Phase 3 | Unknown | 2019-03-01 | 6610 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03838575 |
| NCT00448383 | A Study to Assess the Safety and Efficacy of Adalimumab When Added to Inadequate Standard Anti-Rheumatic Therapy in Patients With Active Rheumatoid Arthritis | Arthritis, Rheumatoid | Phase 3 | Completed | 2002-09 | 6610 | Actual | Industry | https://clinicaltrials.gov/study/NCT00448383 |
| NCT03594110 | EMPA-KIDNEY (The Study of Heart and Kidney Protection With Empagliflozin) | Renal Insufficiency, Chronic | Phase 3 | Completed | 2019-01-31 | 6609 | Actual | Industry | https://clinicaltrials.gov/study/NCT03594110 |
| NCT00433589 | Genetic Testing or Clinical Assessment in Determining the Need for Chemotherapy in Women With Breast Cancer That Involves No More Than 3 Lymph Nodes | Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular | Phase 3 | Completed | 2007-02 | 6600 | Estimated | Network | https://clinicaltrials.gov/study/NCT00433589 |
| NCT06524947 | Clinical Trial of Protective Efficacy of Quadrivalent Recombinant Norovirus Vaccine (Pichia Pastoris) | Phase 3 | Active not recruiting | 2024-07-27 | 6600 | Actual | Industry | https://clinicaltrials.gov/study/NCT06524947 | |
| NCT01870778 | Efficacy, Safety and Tolerability of Serelaxin When Added to Standard Therapy in AHF | Phase 3 | Completed | 2013-10-02 | 6600 | Actual | Industry | https://clinicaltrials.gov/study/NCT01870778 | |
| NCT00949910 | An Expanded Access Program of Tarceva (Erlotinib) in Participants With Advanced Non-Small Cell Lung Cancer (NSCLC) | Carcinoma, Non-Small-Cell Lung | Phase 4 | Completed | 2004-11 | 6586 | Actual | Industry | https://clinicaltrials.gov/study/NCT00949910 |
| NCT02145000 | Efficacy and Safety of a Pentavalent Rotavirus Vaccine (BRV-PV) Against Severe Rotavirus Gastroenteritis in Niger | Gastroenteritis; Diarrhea | Phase 3 | Completed | 2014-06 | 6586 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02145000 |
| NCT02504216 | Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities | Peripheral Arterial Disease | Phase 3 | Completed | 2015-08-18 | 6564 | Actual | Industry | https://clinicaltrials.gov/study/NCT02504216 |
| NCT00099788 | Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST Elevation Acute Coronary Syndromes | Myocardial Ischemia; Acute Coronary Syndrome; Myocardial Infarction | Phase 3 | Completed | 2004-10 | 6560 | Actual | Industry | https://clinicaltrials.gov/study/NCT00099788 |
| NCT03780179 | MMR at 6 Months Trial | Phase 4 | Completed | 2019-04-15 | 6540 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03780179 | |
| NCT00244673 | Randomized Study of Not Giving Diphteria-tetanus-pertussis Vaccination With or After Measles Vaccination | Coitus | Phase 4 | Completed | 2005-10 | 6534 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00244673 |
| NCT00829660 | Acarbose Cardiovascular Evaluation Trial | Coronary Disease; Acute Coronary Syndrome; Glucose Intolerance | Phase 4 | Completed | 2009-02-17 | 6526 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00829660 |
| NCT04509674 | EMPACT-MI: A Study to Test Whether Empagliflozin Can Lower the Risk of Heart Failure and Death in People Who Had a Heart Attack (Myocardial Infarction) | Myocardial Infarction | Phase 3 | Completed | 2020-12-16 | 6522 | Actual | Industry | https://clinicaltrials.gov/study/NCT04509674 |
| NCT02441218 | Effects of Ivabradine on Cardiovascular Events in Patients With Moderate to Severe Chronic Heart Failure and Left Ventricular Systolic Dysfunction. A Three-year International Multicentre Study | Phase 3 | Completed | 2006-09 | 6505 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02441218 | |
| NCT07086222 | Efficacy and Safety of NVX-CoV2705 | COVID-19 | Phase 4 | Terminated | 2025-11-20 | 6500 | Actual | Industry | https://clinicaltrials.gov/study/NCT07086222 |
| NCT04307576 | A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia | Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia | Phase 3 | Recruiting | 2020-07-13 | 6430 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04307576 |
| NCT00496769 | A Phase III Study of Apixaban in Patients With Atrial Fibrillation | Atrial Fibrillation | Phase 3 | Completed | 2007-08-31 | 6421 | Actual | Industry | https://clinicaltrials.gov/study/NCT00496769 |
| NCT04078737 | Clopidogrel With Aspirin in High-risk Patients With Acute Non-disabling Cerebrovascular Events II | Stroke; Ischemic Attack, Transient | Phase 3 | Completed | 2019-09-23 | 6412 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04078737 |
| NCT04386070 | Preventing Pulmonary Complications in Surgical Patients at Risk of COVID-19 | Severe Acute Respiratory Syndrome; Pneumonia; COVID-19 | Phase 3 | Suspended | 2022-05-16 | 6400 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04386070 |
| NCT00317330 | A Randomized Trial of DOTS Versus Enhanced DOTS for Community Control of Tuberculosis | Tuberculosis | Phase 3 | Completed | 2004-12 | 6400 | NIH | https://clinicaltrials.gov/study/NCT00317330 | |
| NCT05021835 | ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation | Renal Insufficiency, Chronic; Inflammation | Phase 3 | Completed | 2021-08-30 | 6385 | Actual | Industry | https://clinicaltrials.gov/study/NCT05021835 |
| NCT06079918 | Multiple Micronutrient Supplementation for Maternal Anemia Prevention in Tanzania | Anemia | Phase 3 | Recruiting | 2025-03-03 | 6381 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06079918 |
| NCT00139347 | Study of 2 Doses of HRV Vaccine Given Concomitantly With Routine EPI Vaccinations Including OPV in Healthy Infants | Rotavirus Infections | Phase 3 | Completed | 2003-12 | 6360 | Industry | https://clinicaltrials.gov/study/NCT00139347 | |
| NCT06186037 | Clinical Comparison of Low-dose Rosuvastatin Plus Ezetimibe Combination Therapy and High-dose Rosuvastatin Monotherapy in Patients With Minimal to Intermediate Coronary Artery Disease Without Percutaneous Coronary Intervention | Coronary Artery Disease; Dyslipidemias | Phase 4 | Recruiting | 2024-02-01 | 6356 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06186037 |
| NCT01133184 | Improved Prevention of Perinatal Hepatitis B Transmission | Liver Cirrhosis | Phase 4 | Unknown | 2010-09 | 6343 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01133184 |
| NCT01958957 | A Safety Study of Ginkgolides Meglumine Injection in the Treatment of Ischemic Stroke. | Ischemic Stroke | Phase 4 | Completed | 2013-06 | 6300 | Actual | Industry | https://clinicaltrials.gov/study/NCT01958957 |
| NCT04915261 | A Randomized Trial of Lenient Versus Strict Arm Instruction Post Cardiac Device Surgery | Postoperative Complications; Infections; Hematoma | Phase 4 | Recruiting | 2021-08-19 | 6300 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04915261 |
| NCT03430284 | Multifactorial Intervention on Diabetes (MIDiab Study) | Diabetes Mellitus, Type 2; Diabetic Angiopathies | Phase 4 | Unknown | 2018-04-01 | 6300 | Estimated | Other government | https://clinicaltrials.gov/study/NCT03430284 |
| NCT06252285 | Efficacy, Immunogenicity, and Safety Study of a Respiratory Syncytial Virus Vaccine in Infants and Toddlers | Phase 3 | Terminated | 2024-02-06 | 6300 | Actual | Industry | https://clinicaltrials.gov/study/NCT06252285 | |
| NCT00981513 | Direct and Indirect Benefits of Influenza Vaccination in Schools and Households | Phase 4 | Completed | 2009-09 | 6300 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00981513 | |
| NCT00634400 | Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity (CHARM Alternative) | Heart Failure | Phase 3 | Completed | 1999-03 | 6268 | Estimated | Industry | https://clinicaltrials.gov/study/NCT00634400 |
| NCT03619213 | Dapagliflozin Evaluation to Improve the LIVEs of Patients With PReserved Ejection Fraction Heart Failure. | Phase 3 | Completed | 2018-08-27 | 6263 | Actual | Industry | https://clinicaltrials.gov/study/NCT03619213 | |
| NCT04934683 | The GUARDIAN Trial - Induction Agent Sub-Study | Phase 4 | Enrolling by invitation | 2021-07-25 | 6254 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04934683 | |
| NCT04934748 | The GUARDIAN Trial - Vasopressor Sub-Study | Phase 4 | Enrolling by invitation | 2021-07-25 | 6254 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04934748 | |
| NCT01462344 | 6-month Safety and Benefit Study of ADVAIR in Children 4-11 Years Old | Asthma | Phase 4 | Completed | 2011-11-17 | 6250 | Actual | Industry | https://clinicaltrials.gov/study/NCT01462344 |
| NCT06594341 | Optimization of the Simplified Protocol in Mali: a Cluster Randomised Pragmatic Trial | Severe Acute Malnutrition | Phase 4 | Completed | 2023-04-10 | 6249 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06594341 |
| NCT04789356 | Effectiveness of the Adsorbed Vaccine COVID-19 (Coronavac) Among Education and Public Safety Workers With Risk Factors for Severity | COVID-19 | Phase 4 | Unknown | 2021-03-18 | 6233 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04789356 |
| NCT00268216 | Survival Of Subjects With Chronic Obstructive Pulmonary Disease (COPD) | Pulmonary Disease, Chronic Obstructive | Phase 3 | Completed | 2000-09 | 6228 | Actual | Industry | https://clinicaltrials.gov/study/NCT00268216 |
| NCT00497393 | Clinical Decision Unit (CDU) - Evaluation of a Novel Approach to Address Emergency Department Overcrowding | Emergencies; Crowding | Phase 4 | Completed | 2007-07 | 6217 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00497393 |
| NCT00197223 | Post-marketing Study to Evaluate the Efficacy of Influenza Vaccine | Influenza, Human | Phase 3 | Completed | 2005-09 | 6213 | Actual | Industry | https://clinicaltrials.gov/study/NCT00197223 |
| NCT00213083 | Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission | HIV Infections; Acquired Immunodeficiency Syndrome; Sexually Transmitted Diseases | Phase 3 | Completed | 2004-04 | 6203 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00213083 |
| NCT00168623 | Vitamin A Supplementation With Routine Childhood Vaccines and Mortality and Morbidity | Phase 4 | Unknown | 2003-11 | 6200 | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00168623 | ||
| NCT04579640 | Trial of Vitamin D to Reduce Risk and Severity of COVID-19 and Other Acute Respiratory Infections | COVID-19 | Phase 3 | Completed | 2020-10-27 | 6200 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04579640 |
| NCT01021904 | Primary and Secondary Prevention of Human Papillomavirus (HPV) Disease in China | Papillomavirus Infections; Uterine Cervical Neoplasms | Phase 4 | Unknown | 2010-06 | 6200 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01021904 |
| NCT01101035 | Cardiovascular Safety of Febuxostat and Allopurinol in Participants With Gout and Cardiovascular Comorbidities (CARES) | Cardiovascular Diseases; Myocardial Infarction; Stroke | Phase 3 | Completed | 2010-04-23 | 6198 | Actual | Industry | https://clinicaltrials.gov/study/NCT01101035 |
| NCT00839254 | Impact on Carriage, Acute Otitis Media, Immuno & Safety of GSK Biologicals' Pneumococcal Conjugate Vaccine 1024850A | Streptococcal Infections; Otitis Media; Haemophilus Infections | Phase 3 | Completed | 2009-02-18 | 6181 | Actual | Industry | https://clinicaltrials.gov/study/NCT00839254 |
| NCT01051661 | Safety and Efficacy of H1N1 Vaccines in Children Aged 6 Months to Less Than 10 Years of Age | Influenza, Human | Phase 3 | Completed | 2010-02-12 | 6154 | Actual | Industry | https://clinicaltrials.gov/study/NCT01051661 |
| NCT04774159 | Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk | Peripheral Arterial Disease; Inflammation; Myocardial Infarction | Phase 3 | Recruiting | 2021-05-06 | 6150 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04774159 |
| NCT02525939 | Effect of Dalcetrapib vs Placebo on CV Risk in a Genetically Defined Population With a Recent ACS | Acute Coronary Syndrome | Phase 3 | Completed | 2016-04 | 6147 | Actual | Industry | https://clinicaltrials.gov/study/NCT02525939 |
| NCT07467707 | An Efficacy, Safety, and Immunogenicity Study of CHIKV VLP Vaccine for the Prevention of Chikungunya Disease in Adolescents and Adults | Chikungunya Fever | Phase 3 | Recruiting | 2026-05-26 | 6144 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07467707 |
| NCT04869982 | Efficacy, Immunogenicity and Safety Study of GSKs Recombinant Zoster Vaccine Shingrix (GSK1437173A) in Chinese Adults Aged ≥50 Years | Herpes Zoster | Phase 4 | Completed | 2021-05-14 | 6138 | Actual | Industry | https://clinicaltrials.gov/study/NCT04869982 |
| NCT01117441 | International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia | Leukemia | Phase 3 | Completed | 2010-06 | 6136 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01117441 |
| NCT04537663 | Prevention Of Respiratory Tract Infection And Covid-19 Through BCG Vaccination In Vulnerable Older Adults | Respiratory Tract Infections; COVID-19 | Phase 4 | Completed | 2020-09-07 | 6112 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04537663 |
| NCT05093933 | A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035) | Phase 3 | Completed | 2021-11-02 | 6106 | Actual | Industry | https://clinicaltrials.gov/study/NCT05093933 | |
| NCT07876492 | A Study to Evaluate Cenvacibart (REGN7508) for Secondary Stroke Prevention in Adult Participants | Stroke; Ischemic Stroke | Phase 3 | Not yet recruiting | 2026-11-20 | 6106 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07876492 |
| NCT00220987 | Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE - SUGAR STUDY) | Hyperglycemia; Critical Illness; Hypoglycemia | Phase 4 | Completed | 2005-04 | 6104 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00220987 |
| NCT01346592 | Safety, Tolerability, and Immunogenicity of the Adjuvanted Trivalent Subunit Influenza Vaccine and the Non-Adjuvanted Trivalent Subunit Influenza Vaccine Compared to the Non-Adjuvanted Trivalent Split Influenza Vaccine in Children 6 to < 72 Months of Age | Influenza, Human | Phase 3 | Completed | 2011-04 | 6104 | Actual | Industry | https://clinicaltrials.gov/study/NCT01346592 |
| NCT01243424 | CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 2010-11-11 | 6103 | Actual | Industry | https://clinicaltrials.gov/study/NCT01243424 |
| NCT05415462 | A Study of mRNA-1010 Seasonal Influenza Vaccine in Adults | Phase 3 | Completed | 2022-06-06 | 6102 | Actual | Industry | https://clinicaltrials.gov/study/NCT05415462 | |
| NCT03635749 | Intensive Medical Therapy for High-risk Intracranial or Extracranial Atherosclerosis | Stroke; Ischemic Attack, Transient | Phase 3 | Unknown | 2018-09-17 | 6100 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03635749 |
| NCT00127205 | S0307 Phase III Trial of Bisphosphonates as Adjuvant Therapy for Primary Breast Cancer. | Breast Neoplasms | Phase 3 | Completed | 2005-07 | 6097 | Actual | Network | https://clinicaltrials.gov/study/NCT00127205 |
| NCT01690338 | A Study of Residual Curarization Incidence in China | Postoperative Complications; Delayed Emergence from Anesthesia | Phase 4 | Unknown | 2012-10 | 6090 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01690338 |
| NCT04006990 | The Bed Rest Avoidance Study | Phase 3 | Completed | 2017-03-20 | 6089 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04006990 | |
| NCT00749450 | Combination Chemotherapy After Surgery in Treating Patients With High-Risk Stage II or Stage III Colorectal Cancer | Colorectal Neoplasms; Colonic Neoplasms; Rectal Neoplasms | Phase 3 | Completed | 2008-03 | 6088 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00749450 |
| NCT00687349 | Improving Clinician Communication Skills (ICCS) | Pulmonary Disease, Chronic Obstructive; Heart Failure; End Stage Liver Disease | Phase 3 | Completed | 2007-04 | 6086 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00687349 |
| NCT01160809 | Effect of a Combined Use of Mosquito Repellent and Insecticide Treated Net on Malaria in Ethiopia | Malaria | Phase 4 | Completed | 2008-09 | 6082 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01160809 |
| NCT00779766 | Efficacy, Immunogenicity and Safety of GSK Biologicals' HPV GSK 580299 Vaccine in Healthy Chinese Female Subjects | Papillomavirus Infections; Uterine Cervical Neoplasms | Phase 3 | Completed | 2008-10-22 | 6081 | Actual | Industry | https://clinicaltrials.gov/study/NCT00779766 |
| NCT06280144 | Post-marketing Study of Lyophilized Nasal Spray Live Attenuated Influenza Vaccine | Phase 4 | Unknown | 2023-09-22 | 6080 | Estimated | Industry | https://clinicaltrials.gov/study/NCT06280144 | |
| NCT01147250 | Evaluation of Cardiovascular Outcomes in Patients With Type 2 Diabetes After Acute Coronary Syndrome During Treatment With AVE0010 (Lixisenatide) | Acute Coronary Syndrome | Phase 3 | Completed | 2010-06 | 6068 | Actual | Industry | https://clinicaltrials.gov/study/NCT01147250 |
| NCT01188135 | Antidepressant Adherence Via AD_IVR | Depressive Disorder, Major; Depression | Phase 3 | Completed | 2011-02 | 6058 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01188135 |
| NCT03629886 | Safety and Protective Effect Study of GSK Biologicals' Human Papillomavirus (Types 16, 18) Vaccine, Adsorbed (GSK580299) in Healthy Female Subjects From the HPV-039 Study | Uterine Cervical Dysplasia; Uterine Cervical Neoplasms | Phase 4 | Completed | 2018-08-22 | 6051 | Actual | Industry | https://clinicaltrials.gov/study/NCT03629886 |
| NCT04199689 | Efficacy Against Oral Persistent Infection, Immunogenicity and Safety of the 9-valent Human Papillomavirus Vaccine (9vHPV) in Men Aged 20-45 Years (V503-049) | Papillomavirus Infections | Phase 3 | Active not recruiting | 2020-02-27 | 6033 | Actual | Industry | https://clinicaltrials.gov/study/NCT04199689 |
| NCT00931736 | Randomized Clinical Trial Comparing 4RIF vs. 9INH for LTBI Treatment-effectiveness | Latent Tuberculosis; Tuberculosis | Phase 3 | Completed | 2009-08 | 6031 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00931736 |
| NCT05284747 | EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Cardiovascular Diseases; Myocardial Infarction; Stroke | Phase 4 | Active not recruiting | 2022-10-26 | 6019 | Actual | Industry | https://clinicaltrials.gov/study/NCT05284747 |
| NCT04435626 | Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40% | Heart Failure | Phase 3 | Completed | 2020-09-14 | 6016 | Actual | Industry | https://clinicaltrials.gov/study/NCT04435626 |
| NCT02311231 | Bivalirudin vs Heparin in NSTEMI and STEMI in Patients on Modern Antiplatelet Therapy in SWEDEHEART | ST Elevation Myocardial Infarction | Phase 4 | Completed | 2014-06 | 6012 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02311231 |
| NCT04609111 | ShorT and OPtimal Duration of Dual AntiPlatelet Therapy-3 Study | Acute Coronary Syndrome; Hemorrhage | Phase 4 | Unknown | 2021-01-29 | 6002 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04609111 |
| NCT01385982 | Improving Management of Outpatient Actionable Test Results | Phase 3 | Completed | 2011-07 | 6000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01385982 | |
| NCT01511744 | Phase IV Clinical Trial of an Inactivated Influenza Split Vaccine | Influenza, Human; Respiratory Tract Infections; Orthomyxoviridae Infections | Phase 4 | Completed | 2011-11 | 6000 | Actual | Industry | https://clinicaltrials.gov/study/NCT01511744 |
| NCT07890454 | Study of a Combination SARS-CoV-2 Recombinant Spike and High-Dose Inactivated Influenza Vaccine With Matrix-M Adjuvant in Adult Participants 60 Years of Age and Older | Influenza, Human | Phase 3 | Not yet recruiting | 2026-11-09 | 6000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07890454 |
| NCT03998254 | Efficacy, Immunogenicity and Safety of V503 in Chinese Women Aged 20-45 Years (V503-023) | Papillomavirus Infections | Phase 3 | Active not recruiting | 2019-06-26 | 6000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT03998254 |
| NCT00002582 | Tamoxifen, Ovarian Ablation, and/or Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA Breast Cancer | Breast Neoplasms | Phase 3 | Completed | 1993-06 | 6000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00002582 |
| NCT07300462 | A Post-marketing Observational Study of Oral Cholera Vaccine | Diarrhea | Phase 4 | Enrolling by invitation | 2026-04-10 | 6000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07300462 |
| NCT07160244 | BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies | Phase 3 | Recruiting | 2025-08-25 | 6000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07160244 | |
| NCT00682825 | Study Evaluating Whether the Bispectral Index Prevents Patients at Higher Risk From Being Awake During Surgery and Anesthesia | Phase 4 | Completed | 2008-03 | 6000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00682825 | |
| NCT05683561 | A Phase III Clinical Trial to Evaluate the Efficacy and Safety of SCTV01E in Healthy People | Phase 3 | Unknown | 2023-01-25 | 6000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT05683561 | |
| NCT07005726 | BCG Revaccination With the Third Dose of Diphtheria-tetanus-pertussis Vaccine and Infant Mortality in Africa | Infant Death | Phase 4 | Enrolling by invitation | 2025-05-09 | 6000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07005726 |
| NCT00436176 | Improving Diabetes Care for African Americans | Diabetes Mellitus | Phase 3 | Completed | 2007-06 | 6000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00436176 |
| NCT05560945 | 2-year Caries Clinical Study: Arginine Fluoride-Free Toothpastes vs. NaF Toothpaste | Dental Caries | Phase 3 | Completed | 2019-04-15 | 6000 | Actual | Industry | https://clinicaltrials.gov/study/NCT05560945 |
| NCT05390892 | PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes | Phase 4 | Recruiting | 2022-09-26 | 6000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05390892 | |
| NCT06909565 | Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention | Coronary Artery Disease; Hypercholesterolemia; Cardiovascular Diseases | Phase 4 | Recruiting | 2025-07-23 | 6000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06909565 |
| NCT07258251 | Strengthening Hepatitis B Screening, Linkage to Care and Long-Term Monitoring in Phichit Province, Thailand: A Birth Bohort Approach | Hepatitis B, Chronic; Hepatitis B | Phase 4 | Not yet recruiting | 2026-01-01 | 6000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07258251 |
| NCT04741061 | Study to Evaluate Efficacy, Immunogenicity and Safety of the Sputnik-Light | COVID-19 | Phase 3 | Unknown | 2021-02-19 | 6000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04741061 |
| NCT07424846 | Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial | Premature Birth; Periodontitis; Gingivitis | Phase 2, Phase 3 | Recruiting | 2026-03-26 | 6000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07424846 |
| NCT00066898 | ARISE - Aggressive Reduction of Inflammation Stops Events | Atherosclerosis; Coronary Artery Disease; Myocardial Infarction | Phase 3 | Unknown | 2003-06 | 6000 | Industry | https://clinicaltrials.gov/study/NCT00066898 | |
| NCT05149248 | Prevention and Control of Neoplasms Associated With HPV in High-risk Groups in Mexico City: The Condesa Study | Uterine Cervical Neoplasms; Neoplasms | Phase 2, Phase 3 | Completed | 2018-05-30 | 6000 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05149248 |
| NCT07611513 | Protective Efficacy , Immunogenicity and Safety of the Tetravalent Inactivated Enterovirus Vaccine (Vero Cell). | Hand, Foot and Mouth Disease; Herpangina | Phase 3 | Not yet recruiting | 2026-05 | 6000 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07611513 |
| NCT04534959 | Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients | Critical Illness; Wounds and Injuries; Disease Attributes | Phase 3 | Active not recruiting | 2020-10-15 | 6000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04534959 |
| NCT05845424 | High-intensity Statin and Ezetimibe Therapy for Asymptomatic Patients With Positive Coronary Calcium | Metabolic Syndrome; Dyslipidemias | Phase 4 | Recruiting | 2023-07-03 | 6000 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05845424 |
| NCT00092703 | Investigational Drug Versus an Approved Drug in Patients With Osteoarthritis (0663-061)(COMPLETED) | Osteoarthritis | Phase 3 | Completed | 2002-06-27 | 6000 | Industry | https://clinicaltrials.gov/study/NCT00092703 | |
| NCT02981836 | A Blind, Randomized and Controlled Study of Live Attenuated Varicella Vaccines | Chickenpox | Phase 3 | Completed | 2016-08 | 5997 | Actual | Industry | https://clinicaltrials.gov/study/NCT02981836 |
| NCT00144339 | Evaluation of the Long- Term Effects of Spiriva on Lung Function in COPD Patients | Pulmonary Disease, Chronic Obstructive | Phase 3 | Completed | 2002-12 | 5993 | Actual | Industry | https://clinicaltrials.gov/study/NCT00144339 |
| NCT02181985 | Full Dose Tenecteplase (TNK-tPA) Together With Heparin Sodium, Full Dose Tenecteplase With Enoxaparin, Half Dose Tenecteplase Together With Abciximab and Heparin Sodium in Patients With Acute Myocardial Infarction (AMI) | Myocardial Infarction | Phase 3 | Completed | 2000-05 | 5989 | Actual | Industry | https://clinicaltrials.gov/study/NCT02181985 |
| NCT03057951 | EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved) | Heart Failure | Phase 3 | Completed | 2017-03-02 | 5988 | Actual | Industry | https://clinicaltrials.gov/study/NCT03057951 |
| NCT00224484 | Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old | Herpes Simplex | Phase 3 | Completed | 2004-04-07 | 5960 | Actual | Industry | https://clinicaltrials.gov/study/NCT00224484 |
| NCT03959085 | Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy | Burkitt Lymphoma; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Biphenotypic, Acute | Phase 3 | Recruiting | 2019-10-31 | 5951 | Estimated | Network | https://clinicaltrials.gov/study/NCT03959085 |
| NCT02883049 | Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations | Burkitt Lymphoma | Phase 3 | Completed | 2012-02-29 | 5949 | Actual | NIH | https://clinicaltrials.gov/study/NCT02883049 |
| NCT03143218 | Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ) | Malaria, Falciparum; Malaria | Phase 3 | Completed | 2017-04-17 | 5920 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03143218 |
| NCT00808067 | RELY-ABLE Long Term Multi-center Extension of Dabigatran Treatment in Patients With Atrial Fibrillation Who Completed RE-LY Trial | Atrial Fibrillation | Phase 3 | Completed | 2008-11 | 5897 | Actual | Industry | https://clinicaltrials.gov/study/NCT00808067 |
| NCT00168558 | Early Two-dose Measles Vaccination Trial | Measles; Infant Death | Phase 4 | Completed | 2003-07 | 5879 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00168558 |
| NCT05463419 | A Phase II/III Study of PIKA Recombinant SARS-CoV-2 Vaccine as a Booster Dose. | Phase 2, Phase 3 | Completed | 2022-10-03 | 5860 | Actual | Industry | https://clinicaltrials.gov/study/NCT05463419 | |
| NCT00566774 | A Randomized Evaluation of First-dollar Coverage for Post-MI Secondary Preventive Therapies | Myocardial Infarction; Coronary Artery Disease | Phase 4 | Completed | 2007-11 | 5860 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00566774 |
| NCT03568383 | Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients | Tuberculosis, Multidrug-Resistant; Tuberculosis | Phase 3 | Active not recruiting | 2019-06-03 | 5832 | Actual | NIH | https://clinicaltrials.gov/study/NCT03568383 |
| NCT03927131 | Safety and Immunogenicity of the Butantan Quadrivalent Influenza Vaccine | Influenza, Human | Phase 3 | Completed | 2021-05-12 | 5822 | Actual | Other government | https://clinicaltrials.gov/study/NCT03927131 |
| NCT01989754 | A Study of the Effects of Canagliflozin (JNJ-28431754) on Renal Endpoints in Adult Participants With Type 2 Diabetes Mellitus | Diabetes Mellitus, Type 2; Albuminuria | Phase 4 | Completed | 2014-01-16 | 5813 | Actual | Industry | https://clinicaltrials.gov/study/NCT01989754 |
| NCT00226499 | Evaluate Vaccine Against Chickenpox and a Combined Vaccine Against 4 Viral Childhood Diseases: Measles, Mumps, Rubella and Chickenpox | Chickenpox | Phase 3 | Completed | 2005-09-01 | 5803 | Actual | Industry | https://clinicaltrials.gov/study/NCT00226499 |
| NCT06184659 | Empirical Meropenem Versus Piperacillin/Tazobactam for Adult Patients With Sepsis | Sepsis; Shock, Septic | Phase 4 | Recruiting | 2025-06-26 | 5800 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06184659 |
| NCT06200844 | The Efficacy of Oral Rotavirus Vaccine 116E (ROTAVAC 5D) in Chilean Infants | Phase 3 | Active not recruiting | 2023-07-07 | 5800 | Estimated | Industry | https://clinicaltrials.gov/study/NCT06200844 | |
| NCT02216383 | Intramuscular Oxytocics: A Randomised Control Trial | Postpartum Hemorrhage | Phase 3 | Completed | 2015-02 | 5798 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02216383 |
| NCT02513394 | PALbociclib CoLlaborative Adjuvant Study | Breast Neoplasms | Phase 3 | Active not recruiting | 2015-08 | 5796 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02513394 |
| NCT01975064 | Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia | Breast Neoplasms; Colonic Neoplasms; Rectal Neoplasms | Phase 4 | Completed | 2013-11 | 5774 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01975064 |
| NCT00092521 | Cervical Intraepithelial Neoplasm (CIN)-Warts Efficacy Trial in Women (Gardasil)(V501-013)(COMPLETED) | Uterine Cervical Neoplasms; Condylomata Acuminata | Phase 3 | Completed | 2001-12 | 5759 | Actual | Industry | https://clinicaltrials.gov/study/NCT00092521 |
| NCT00294047 | Study to Evaluate the Efficacy of the Human Papillomavirus Vaccine in Healthy Adult Women of 26 Years of Age and Older | Papillomavirus Infections; Uterine Cervical Neoplasms | Phase 3 | Completed | 2006-02-16 | 5752 | Actual | Industry | https://clinicaltrials.gov/study/NCT00294047 |
| NCT00091637 | Pexelizumab in Conjunction With Angioplasty in Acute Myocardial Infarction (APEX-AMI) | Phase 3 | Completed | 2004-04 | 5745 | Actual | Industry | https://clinicaltrials.gov/study/NCT00091637 | |
| NCT02540993 | Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease | Renal Insufficiency, Chronic; Diabetic Nephropathies; Diabetes Mellitus, Type 2 | Phase 3 | Completed | 2015-09-17 | 5734 | Actual | Industry | https://clinicaltrials.gov/study/NCT02540993 |
| NCT03932682 | Efficacy Study With QIVc in Pediatric Subjects | Influenza, Human | Phase 3 | Completed | 2019-05-13 | 5723 | Actual | Industry | https://clinicaltrials.gov/study/NCT03932682 |
| NCT00435890 | Triage Liaison Physician - Evaluation of a Novel Approach to Address Emergency Department Overcrowding | Phase 4 | Completed | 2005-12 | 5718 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00435890 | |
| NCT01352793 | A Global Phase 3 Safety Study of 120 mcg rLP2086 Vaccine in Adolescents and Young Adults Aged 10 to 25 Years | Meningitis, Meningococcal | Phase 3 | Completed | 2012-11 | 5715 | Actual | Industry | https://clinicaltrials.gov/study/NCT01352793 |
| NCT07517263 | An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230) | Cardiovascular Diseases; Myocardial Infarction; Stroke | Phase 3 | Active not recruiting | 2026-05-11 | 5700 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07517263 |
| NCT02085044 | Non Randomized Controlled Intervention Study Comparing Two Interventions of Nutritional Supplement on Malnutrition, Health and Mortality | Malnutrition | Phase 4 | Completed | 2012-02 | 5700 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02085044 |
| NCT07243704 | Reducing the Burden of Cardiovascular Events With Antiplatelet Therapy in Patients With IntraCerebral Haemorrhage | Cerebral Hemorrhage; Stroke | Phase 3 | Recruiting | 2026-02-16 | 5676 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07243704 |
| NCT02924727 | Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI | Ventricular Dysfunction, Left; ST Elevation Myocardial Infarction; Non-ST Elevated Myocardial Infarction | Phase 3 | Completed | 2016-12-09 | 5669 | Actual | Industry | https://clinicaltrials.gov/study/NCT02924727 |
| NCT00132938 | PERSPECTIVE: Telithromycin - Acute Exacerbation of Chronic Bronchitis | Bronchitis, Chronic | Phase 4 | Completed | 2004-01 | 5660 | Industry | https://clinicaltrials.gov/study/NCT00132938 | |
| NCT00549393 | Study of Bathing With Chlorhexidine Impregnated Cloths on Nosocomial Infections in the Pediatric Intensive Care Unit | Cross Infection | Phase 2, Phase 3 | Completed | 2008-02 | 5659 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00549393 |
| NCT00264901 | Comparison of Self Adjustment Versus Standard of Care Treatment in Subjects With Type 2 Diabetes | Diabetes Mellitus; Diabetes Mellitus, Type 2 | Phase 4 | Completed | 2005-10 | 5652 | Actual | Industry | https://clinicaltrials.gov/study/NCT00264901 |
| NCT03155997 | Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer | Breast Neoplasms | Phase 3 | Active not recruiting | 2017-07-12 | 5637 | Actual | Industry | https://clinicaltrials.gov/study/NCT03155997 |
| NCT00654537 | STELLAR-Rosuvastatin vs. Atorvastatin, Pravastatin, Simvastatin Across Dose Ranges | Hypercholesterolemia | Phase 3 | Completed | 2001-04 | 5625 | Estimated | Industry | https://clinicaltrials.gov/study/NCT00654537 |
| NCT00643201 | Efficacy and Safety Study of Apixaban for the Treatment of Deep Vein Thrombosis or Pulmonary Embolism | Venous Thrombosis | Phase 3 | Completed | 2008-07 | 5614 | Actual | Industry | https://clinicaltrials.gov/study/NCT00643201 |
| NCT00003830 | Surgery to Remove Sentinel Lymph Nodes With or Without Removing Lymph Nodes in the Armpit in Treating Women With Breast Cancer | Breast Neoplasms | Phase 3 | Completed | 1999-05 | 5611 | Actual | Network | https://clinicaltrials.gov/study/NCT00003830 |
| NCT07567001 | A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity | Obesity; Heart Failure | Phase 3 | Recruiting | 2026-05-11 | 5610 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07567001 |
| NCT01709305 | A Study of the Safety and Efficacy of Glimepiride, Gliclazide, Repaglinide or Acarbose When Added to Sitagliptin + Metformin Combination Therapy in Chinese Participants With Diabetes (MK-0431-313) | Diabetes Mellitus, Type 2 | Phase 4 | Completed | 2012-11-08 | 5570 | Actual | Industry | https://clinicaltrials.gov/study/NCT01709305 |
| NCT07272122 | Reducing Filth Fly Populations and Transmission of Diarrhoeal Pathogens in Harsh Settings | Phase 3 | Recruiting | 2026-08-17 | 5556 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07272122 | |
| NCT01173900 | Delivery, Uptake and Acceptability of HPV Vaccination in Tanzanian Girls | Uterine Cervical Neoplasms | Phase 4 | Completed | 2010-08 | 5532 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01173900 |
| NCT06077864 | A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT) | Obesity | Phase 3 | Completed | 2023-11-20 | 5530 | Actual | Industry | https://clinicaltrials.gov/study/NCT06077864 |
| NCT02044250 | Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- EXtended Antiplatelet Monotherapy (HOST-EXAM) | Coronary Disease | Phase 4 | Completed | 2014-02 | 5530 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02044250 |
| NCT04296396 | Opioid Prescription After Cesarean Trial | Pain | Phase 3 | Completed | 2020-09-21 | 5521 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04296396 |
| NCT05952557 | An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2) | Breast Neoplasms | Phase 3 | Active not recruiting | 2023-10-05 | 5511 | Actual | Industry | https://clinicaltrials.gov/study/NCT05952557 |
| NCT04418479 | SMart Angioplasty Research Team: CHoice of Optimal Anti-Thrombotic Strategy in Patients Undergoing Implantation of Coronary Drug-Eluting Stents 3 | Coronary Artery Disease | Phase 4 | Completed | 2020-08-10 | 5506 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04418479 |
| NCT06084234 | National Liver Cancer Screening Trial | Carcinoma, Hepatocellular; Liver Neoplasms; Liver Cirrhosis | Phase 4 | Recruiting | 2023-12-26 | 5500 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06084234 |
| NCT07349069 | A Phase III Trial Comparing HRS-8080 With Standard Endocrine Therapy in Patients With Intermediate or High Risk Early Breast Cancer | Breast Neoplasms | Phase 3 | Recruiting | 2026-03-04 | 5500 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07349069 |
| NCT06605144 | Canadian Critical Care Comparative Effectiveness Platform | Phase 3 | Recruiting | 2025-03-23 | 5500 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06605144 | |
| NCT00219687 | Dispatcher-Assisted Resuscitation Trial (DART) | Heart Arrest | Phase 3 | Completed | 2004-06 | 5494 | Actual | Other government | https://clinicaltrials.gov/study/NCT00219687 |
| NCT03700749 | FALCON Trial Testing Measures to Reduce Surgical Site Infection | Surgical Wound Infection | Phase 3 | Unknown | 2018-11-29 | 5480 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03700749 |
| NCT02674438 | Comparison of Outcomes and Access to Care for Heart Failure Trial | Heart Failure | Phase 3 | Completed | 2016-09 | 5452 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02674438 |
| NCT06225752 | Probucol for Symptomatic Intracranial and Extracranial Artery Stenosis | Ischemic Stroke; Stroke | Phase 3 | Recruiting | 2024-06-15 | 5452 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06225752 |
| NCT02475850 | Strategies to Reduce Injuries and Develop Confidence in Elders | Wounds and Injuries | Phase 3 | Completed | 2015-08 | 5451 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02475850 |
| NCT01562379 | Complementary Food Supplements for Reducing Childhood Undernutrition | Growth Disorders; Cachexia | Phase 2, Phase 3 | Completed | 2012-09 | 5449 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01562379 |
| NCT03871517 | INdobufen Versus aSpirin in acUte Ischemic stRokE,INSURE | Ischemic Stroke | Phase 4 | Completed | 2019-06-03 | 5438 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03871517 |
| NCT04189744 | The ASPIRE Trial - Aiming for Safe Pregnancies by Reducing Malaria and Infections of the Reproductive Tract | Vaginosis, Bacterial; Trichomonas Vaginitis | Phase 3 | Completed | 2019-12-15 | 5436 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04189744 |
| NCT06523959 | Avoiding Risks of Thrombosis and Bleeding in Surgery (ARTS) Trial | Venous Thromboembolism; Hemorrhage; Venous Thrombosis | Phase 4 | Recruiting | 2024-06-06 | 5436 | Estimated | Other government | https://clinicaltrials.gov/study/NCT06523959 |
| NCT04075240 | VTE Prevention Following Total Hip and Knee Arthroplasty | Venous Thromboembolism | Phase 3 | Completed | 2021-02-04 | 5429 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04075240 |
| NCT00423319 | Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Hip Replacement Surgery (ADVANCE-3) | Venous Thrombosis; Pulmonary Embolism | Phase 3 | Completed | 2007-03 | 5407 | Actual | Industry | https://clinicaltrials.gov/study/NCT00423319 |
| NCT02968849 | Pivotal Phase 2b/3 ALVAC/Bivalent gp120/MF59 HIV Vaccine Prevention Safety and Efficacy Study in South Africa | HIV Infections | Phase 2, Phase 3 | Completed | 2016-10-26 | 5404 | Actual | NIH | https://clinicaltrials.gov/study/NCT02968849 |
| NCT06424002 | The Impact RTS,S/AS01 Vaccine in School Aged Children RTS,S/AS01 Malaria Vaccine in School Aged Children | Malaria, Falciparum | Phase 4 | Unknown | 2024-06-01 | 5400 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06424002 |
| NCT06509893 | Ticagrelore Alone Post PCI | Coronary Artery Disease | Phase 4 | Recruiting | 2024-08-01 | 5400 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06509893 |
| NCT00168584 | Different Doses of Vitamin A and Childhood Morbidity and Mortality | Phase 4 | Completed | 2002-11 | 5400 | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00168584 | ||
| NCT04220671 | Measles Vaccination at Health System Contacts | Phase 4 | Enrolling by invitation | 2020-01-08 | 5400 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04220671 | |
| NCT02105610 | Volatile Anesthetics to Reduce Mortality in Cardiac Surgery | Phase 4 | Completed | 2014-04-14 | 5400 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02105610 | |
| NCT02842086 | Study to Evaluate the Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide (F/TAF) Fixed-Dose Combination Once Daily for Pre-Exposure Prophylaxis in Men and Transgender Women Who Have Sex With Men and Are At Risk of HIV-1 Infection | Phase 3 | Terminated | 2016-09-02 | 5399 | Actual | Industry | https://clinicaltrials.gov/study/NCT02842086 | |
| NCT02239120 | Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS) | Stroke | Phase 3 | Completed | 2014-11-27 | 5390 | Actual | Industry | https://clinicaltrials.gov/study/NCT02239120 |
| NCT02787044 | INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure | Heart Failure; Myocardial Infarction; Influenza, Human | Phase 4 | Completed | 2016-08-01 | 5388 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT02787044 |
| NCT07419828 | A Phase III Clinical Study on the Efficacy and Safety of HRS-1780 in the Treatment of Patients With Chronic Kidney Disease | Renal Insufficiency, Chronic | Phase 3 | Recruiting | 2026-03-13 | 5386 | Estimated | Industry | https://clinicaltrials.gov/study/NCT07419828 |
| NCT06330038 | Anesthesia and Non-small Cell Lung Cancer Recurrence | Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Neoplasm Metastasis | Phase 4 | Recruiting | 2024-08-05 | 5384 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06330038 |
| NCT00968708 | Cardiovascular Outcomes Study of Alogliptin in Patients With Type 2 Diabetes and Acute Coronary Syndrome | Diabetes Mellitus, Type 2; Acute Coronary Syndrome; Diabetes Mellitus | Phase 3 | Completed | 2009-09 | 5380 | Actual | Industry | https://clinicaltrials.gov/study/NCT00968708 |
| NCT04028544 | The Study of Qishenyiqi Drop Pills in Improving the Prognosis of Heart Failure Patients | Heart Failure | Phase 4 | Unknown | 2019-03-26 | 5380 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT04028544 |
| NCT00103285 | Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | Precursor Cell Lymphoblastic Leukemia-Lymphoma | Phase 3 | Completed | 2005-04-11 | 5377 | Actual | Network | https://clinicaltrials.gov/study/NCT00103285 |
| NCT04994509 | Pre-Exposure Prophylaxis Study of Lenacapavir and Emtricitabine/Tenofovir Alafenamide in Adolescent Girls and Young Women at Risk of HIV Infection | Phase 3 | Active not recruiting | 2021-08-30 | 5368 | Actual | Industry | https://clinicaltrials.gov/study/NCT04994509 | |
| NCT00385138 | Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition. | Atherosclerosis; Acute Coronary Syndrome | Phase 3 | Terminated | 2006-09 | 5364 | Actual | Industry | https://clinicaltrials.gov/study/NCT00385138 |
| NCT01084213 | Intermittent Preventive Treatment Versus Scheduled Screening and Treatment of Malaria in Pregnancy | Malaria; Anemia | Phase 4 | Completed | 2010-06 | 5354 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01084213 |
| NCT00003782 | Combination Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA (cT1-3, N0-1, M0) Breast Cancer and Positive Axillary Lymph Nodes | Breast Neoplasms | Phase 3 | Completed | 1999-03 | 5351 | Actual | Network | https://clinicaltrials.gov/study/NCT00003782 |
| NCT05836987 | The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation | Atrial Fibrillation; Ischemic Stroke | Phase 3 | Recruiting | 2023-07-13 | 5350 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05836987 |
| NCT02683239 | Long-Term Safety and Efficacy Study of Fasinumab in Patients With Pain Due to Osteoarthritis (OA) of the Knee or Hip | Osteoarthritis, Knee | Phase 3 | Completed | 2016-02-17 | 5331 | Actual | Industry | https://clinicaltrials.gov/study/NCT02683239 |
| NCT01254630 | A Study to Evaluate the Safety and Efficacy of Inactivated Varicella-zoster Vaccine (VZV) as a Preventative Treatment for Herpes Zoster (HZ) and HZ-related Complications in Adult Participants With Solid Tumor or Hematologic Malignancy (V212-011) | Herpes Zoster; Hematologic Neoplasms | Phase 3 | Completed | 2011-06-24 | 5305 | Actual | Industry | https://clinicaltrials.gov/study/NCT01254630 |
| NCT03683667 | Protein Plus: Improving Infant Growth Through Diet and Enteric Health | Growth Disorders; Kwashiorkor; Campylobacter Infections | Phase 2, Phase 3 | Completed | 2018-09-23 | 5283 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT03683667 |
| NCT01767870 | Efficacy Combined Fecal Immunochemical Test-Sigmoidoscopy for the Detection of Advanced Colorectal Neoplasia | Phase 4 | Unknown | 2012-08 | 5282 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01767870 | |
| NCT01742117 | Tailored Antiplatelet Therapy Following PCI | Coronary Artery Disease; Acute Coronary Syndrome; Constriction, Pathologic | Phase 4 | Completed | 2013-05 | 5276 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01742117 |
| NCT07119918 | PCSK9 Inhibitor for Intracranial Atherosclerotic Symptomatic Stenosis | Phase 3 | Not yet recruiting | 2025-09-01 | 5276 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07119918 | |
| NCT04842617 | Phase III Study ：SHR6390/Placebo Combined With Endocrine Therapy for the Adjuvant Treatment of Hormone Receptor Positive,Human Epidermal Receptor 2 Negative | Phase 3 | Active not recruiting | 2021-04-30 | 5274 | Actual | Industry | https://clinicaltrials.gov/study/NCT04842617 | |
| NCT07554573 | Assessment of Biosignature Classification of DCIS for RadioTherapy Benefit Post Lumpectomy (ABCD RT) | Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating | Phase 3 | Not yet recruiting | 2027-01-30 | 5270 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07554573 |
| NCT07383155 | Bivalirudin Versus Heparin During PCI in High Bleeding Risk Patients With Acute Coronary Syndromes | Acute Coronary Syndrome | Phase 4 | Not yet recruiting | 2026-02-01 | 5270 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07383155 |
| NCT01703884 | ANC & Malaria Diagnostic in Pregnancy | Malaria | Phase 4 | Completed | 2012-08 | 5254 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01703884 |
| NCT06283966 | A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease | Pulmonary Disease, Chronic Obstructive | Phase 3 | Recruiting | 2024-02-21 | 5250 | Estimated | Industry | https://clinicaltrials.gov/study/NCT06283966 |
| NCT03518034 | A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men | Hypogonadism; Cardiovascular Diseases; Disease | Phase 4 | Completed | 2018-05-03 | 5246 | Actual | Industry | https://clinicaltrials.gov/study/NCT03518034 |
| NCT07300839 | A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age | COVID-19 | Phase 3 | Completed | 2025-12-10 | 5240 | Actual | Industry | https://clinicaltrials.gov/study/NCT07300839 |
| NCT00252733 | Diabetic Retinopathy Candesartan Trials | Diabetes Mellitus, Type 1 | Phase 3 | Completed | 2001-06 | 5238 | Actual | Industry | https://clinicaltrials.gov/study/NCT00252733 |
| NCT02112214 | Helicobacter Pylori Eradication for Gastric Cancer Prevention in the General Population | Stomach Neoplasms | Phase 3 | Active not recruiting | 2014-06 | 5224 | Estimated | Other government | https://clinicaltrials.gov/study/NCT02112214 |
| NCT01218308 | A Study to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine in Children | Influenza, Human | Phase 3 | Completed | 2010-12-09 | 5220 | Actual | Industry | https://clinicaltrials.gov/study/NCT01218308 |
| NCT07478003 | Prehospital Pulse-dose Glucocorticoid in Patients With ST-segment Elevation Myocardial Infarction 2 - The PULSE-MI 2 Trial | ST Elevation Myocardial Infarction | Phase 3 | Recruiting | 2026-04-20 | 5204 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07478003 |
| NCT06008197 | A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients | Heart Failure | Phase 3 | Recruiting | 2024-01-17 | 5200 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06008197 |
| NCT05105321 | Cardiovascular Diseases and Diabetes Prevention Programme in Metabolic Syndrome (CDPP) | Metabolic Syndrome; Cardiovascular Diseases; Diabetes Mellitus | Phase 4 | Not yet recruiting | 2021-12 | 5200 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05105321 |
| NCT00124878 | Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community | HIV Infections; Sexually Transmitted Diseases; Papillomavirus Infections | Phase 3 | Unknown | 2003-08 | 5200 | Actual | Individual | https://clinicaltrials.gov/study/NCT00124878 |
| NCT04625725 | Phase III Double-blind, Placebo-controlled Study of AZD7442 for Pre-exposure Prophylaxis of COVID-19 in Adult. | COVID-19 | Phase 3 | Completed | 2020-11-21 | 5197 | Actual | Industry | https://clinicaltrials.gov/study/NCT04625725 |
| NCT01130246 | VISTA-16 Trial: Evaluation of Safety and Efficacy of Short-term A-002 Treatment in Subjects With Acute Coronary Syndrome | Acute Coronary Syndrome | Phase 3 | Terminated | 2010-05 | 5189 | Actual | Industry | https://clinicaltrials.gov/study/NCT01130246 |
| NCT00003140 | Letrozole After Tamoxifen in Treating Women With Breast Cancer | Breast Neoplasms | Phase 3 | Completed | 1998-08-24 | 5187 | Actual | Network | https://clinicaltrials.gov/study/NCT00003140 |
| NCT01467466 | Prevention of Serious Adverse Events Following Angiography | Acute Kidney Injury; Kidney Diseases; Coronary Artery Disease | Phase 3 | Completed | 2013-10-07 | 5177 | Actual | U.S. federal | https://clinicaltrials.gov/study/NCT01467466 |
| NCT04927065 | A Study to Evaluate the Immunogenicity and Safety of mRNA Vaccine Boosters for SARS-CoV-2 (COVID-19) Variants | Coronavirus Infections; Virus Diseases; COVID-19 | Phase 2, Phase 3 | Completed | 2021-05-28 | 5161 | Actual | Industry | https://clinicaltrials.gov/study/NCT04927065 |
| NCT05182970 | Metformin and Prevention of Cardiovascular Events in Patients With Acute Myocardial Infarction and Prediabetes (MIMET) | Prediabetic State; Non-ST Elevated Myocardial Infarction; ST Elevation Myocardial Infarction | Phase 3 | Unknown | 2021-12-02 | 5160 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT05182970 |
| NCT00454662 | Combination of OLMesartan and CCB or Low Dose Diuretics in High Risk Elderly Hypertensive Patients Study (COLM-Study) | Hypertension; Cardiovascular Diseases; Diabetes Mellitus | Phase 4 | Completed | 2007-04 | 5141 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00454662 |
| NCT06853535 | Precision Antiplatelet Therapy Guided by Platelet Aggregation Function in Patients With Acute Ischemic STROKE | Ischemic Stroke | Phase 3 | Recruiting | 2025-05-23 | 5138 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT06853535 |
| NCT01858532 | Study Of Diabetic Nephropathy With Atrasentan | Diabetic Nephropathies; Diabetes Mellitus; Kidney Diseases | Phase 3 | Terminated | 2013-05-17 | 5107 | Actual | Industry | https://clinicaltrials.gov/study/NCT01858532 |
| NCT00139542 | AED Use in Out-of-Hospital Cardiac Arrest: A New Algorithm Named "One Shock Per Minute" | Heart Arrest; Ventricular Fibrillation | Phase 3 | Completed | 2005-09 | 5107 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00139542 |
| NCT03701334 | A Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer | Breast Neoplasms | Phase 3 | Active not recruiting | 2018-12-07 | 5101 | Actual | Industry | https://clinicaltrials.gov/study/NCT03701334 |
| NCT07159373 | Better Options for Lymphatic Filariasis Treatment | Elephantiasis, Filarial; Scabies; Strongyloidiasis | Phase 3 | Recruiting | 2026-09-28 | 5100 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT07159373 |
| NCT01534221 | The COOPerative Establishment for Necessary Investigation in Clinical Outcome After Stenting | Myocardial Ischemia | Phase 4 | Unknown | 2012-03 | 5100 | Estimated | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT01534221 |
| NCT00979589 | Clopidogrel in High-risk Patients With Acute Non-disabling Cerebrovascular Events | Stroke; Ischemic Attack, Transient | Phase 3 | Completed | 2009-12 | 5100 | Actual | University, hospital or nonprofit | https://clinicaltrials.gov/study/NCT00979589 |
| NCT00045032 | Herceptin (Trastuzumab) in Treating Women With Human Epidermal Growth Factor Receptor (HER) 2-Positive Primary Breast Cancer | Breast Neoplasms | Phase 3 | Completed | 2001-11 | 5099 | Actual | Industry | https://clinicaltrials.gov/study/NCT00045032 |